Cited by 658HIV Research and TreatmentHIV/AIDS drug development and treatmentT-cell and Retrovirus Studies

The DOI matches its Crossref record; 104 of the 106 references it cites were found in a registry or an index.

HIV: Cell Binding and Entry

Open access

Wilen, C. B., Tilton, J. C., Doms, R. W.·2012·Cold Spring Harbor Perspectives in Medicine

DOI 10.1101/cshperspect.a006866PMC PMC3405824

Open this paper in CoChat — free account Open PDF

Abstract

The first step of the human immunodeficiency virus (HIV) replication cycle-binding and entry into the host cell-plays a major role in determining viral tropism and the ability of HIV to degrade the human immune system. HIV uses a complex series of steps to deliver its genome into the host cell cytoplasm while simultaneously evading the host immune response. To infect cells, the HIV protein envelope (Env) binds to the primary cellular receptor CD4 and then to a cellular coreceptor. This sequential binding triggers fusion of the viral and host cell membranes, initiating infection. Revealing the mechanism of HIV entry has profound implications for viral tropism, transmission, pathogenesis, and therapeutic intervention. Here, we provide an overview into the mechanism of HIV entry, provide historical context to key discoveries, discuss recent advances, and speculate on future directions in the field.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/cshperspect.a006866

Cites

104 of 104 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
Feng, Y. Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5263.872 · Cited by 4,169
Identification of a major co-receptor for primary isolates of HIV-1
Deng, H., Liu, R., Ellmeier, W., Choe, S. S., Unutmaz, D., Burkhart, M. D., Marzio, P. D., Marmon, S., Sutton, R. E., Hill, C. M., et al. (1996) · Nature · doi:10.1038/381661a0 · Cited by 3,640
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y., Nagashima, K. A., Cayanan, C. S., Maddon, P. J., Koup, R. A., Moore, J. P., et al. (1996) · Nature · doi:10.1038/381667a0 · Cited by 3,173
Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection
Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A., & Landau, N. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80110-5 · Cited by 3,074
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
Kwong, P. D., Wyatt, R. T., Robinson, J. E., Sweet, R. W., Sodroski, J., & Hendrickson, W. A. (1998) · Nature · doi:10.1038/31405 · Cited by 2,963
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
Samson, M., Libert, F., Doranz, B. J., Rucker, J. B., Liesnard, C., Farber, C., Saragosti, S., Lapouméroulie, C., Cognaux, J., Forceille, C., et al. (1996) · Nature · doi:10.1038/382722a0 · Cited by 2,885
Self-citation
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T Cells
Cocchi, F., DeVico, A. L., Demo, A. G., Arya, S. K., Gallo, R. C., & Lusso, P. (1995) · Science · doi:10.1126/science.270.5243.1811 · Cited by 2,867
Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men
Gottlieb, M. S., Schroff, R. W., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,723
CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1
Alkhatib, G., Combadière, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5270.1955 · Cited by 2,703
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Dean, M. C., Carrington, M. N., Winkler, C. A., Huttley, G. A., Smith, M. W., Allikmets, R. L., Goedert, J. J., Buchbinder, S., Vittinghoff, E., Gomperts, E. D., et al. (1996) · Science · doi:10.1126/science.273.5283.1856 · Cited by 2,503

Flagged first, then by citations

Show all 106 references

2 of the 106 references couldn’t be matched to a known paper.

Sorted by citations

HIV-1 Antiretroviral Drug TherapyPreprint
Arts, E. J., & Hazuda, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007161 · Cited by 949
HIV-1 Reverse TranscriptionPreprint
Hu, W.-S., & Hughes, S. H. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006882 · Cited by 597
Virus–Receptor Interactions: The Key to Cellular Invasion
Maginnis, M. S. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.06.024 · Cited by 424
Fusion of Enveloped Viruses in Endosomes
White, J. M., & Whittaker, G. R. (2016) · Traffic · doi:10.1111/tra.12389 · Cited by 419
HIV TransmissionPreprint
Shaw, G. M., & Hunter, E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006965 · Cited by 383
Rapid manufacturing of non-activated potent CAR T cells
Ghassemi, S., Durgin, J. S., Nuñez-Cruz, S., Patel, J., Leferovich, J. M., Pinzone, M. R., Shen, F., Cummins, K. D., Plesa, G., Cantu, V. A., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00842-6 · Cited by 316
Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells
Milewska, A., Zarębski, M., Nowak, P., Stożek, K., Potempa, J., & Pyrć, K. (2014) · Journal of Virology · doi:10.1128/jvi.02078-14 · Cited by 292
Antiviral surfaces and coatings and their mechanisms of action
Rakowska, P. D., Tiddia, M., Faruqui, N., Bankier, C., Pei, Y., Pollard, A. J., Zhang, J., & Gilmore, I. S. (2021) · Communications Materials · doi:10.1038/s43246-021-00153-y · Cited by 275
Wuhan to World: The COVID-19 Pandemic
Kumar, A., Singh, R. G., Kaur, J., Pandey, S., Sharma, V., Thakur, L., Sati, S., Mani, S., Asthana, S., Sharma, T. K., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.596201 · Cited by 247
Maraviroc: a review of its use in HIV infection and beyond
Kanmogne, G. D., & Woollard, S. M. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s90580 · Cited by 221
Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives
Xiao, S., Tian, Z., Wang, Y., Si, L., Zhang, L., & Zhou, D. (2018) · Medicinal Research Reviews · doi:10.1002/med.21484 · Cited by 215
Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives
Pawig, L., Klasen, C., Weber, C., Bernhagen, J., & Noels, H. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00429 · Cited by 229
Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments
Menéndez‐Arias, L. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.01.007 · Cited by 217
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses
Ma, Y., Frutos-Beltrán, E., Kang, D., Pannecouque, C. C., Clercq, E. D., Menéndez‐Arias, L., Liu, X., & Zhan, P. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01084g · Cited by 215
Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide
Yan, H., Peng, X., He, W., Zhong, G., Qi, Y., Ren, B., Gao, Z., Jing, Z., Song, M. L., Xu, G., et al. (2013) · Journal of Virology · doi:10.1128/jvi.03540-12 · Cited by 202
HIV-1 target cells in the CNS
Joseph, S., Arrildt, K. T., Sturdevant, C. B., & Swanstrom, R. I. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0287-x · Cited by 201
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction
Foster, T. L., Wilson, H., Iyer, S. S., Coss, K. P., Doores, K. J., Smith, S. E., Kellam, P., Finzi, A., Borrow, P., Hahn, B. H., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.08.006 · Cited by 172
Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives
Roychoudhury, S., Das, A., Sengupta, P., Dutta, S., Roychoudhury, S., Roychoudhury, S., Ahmed, A. B. F., Bhattacharjee, S., & Sláma, P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249411 · Cited by 167
Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion
Yang, S., Kiessling, V., & Tamm, L. K. (2016) · Nature Communications · doi:10.1038/ncomms11401 · Cited by 159
Synthetic Peptides as Protein Mimics
Groß, A., Hashimoto, C., Sticht, H., & Eichler, J. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2015.00211 · Cited by 160
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
Zhao, A., Crutchley, R. D., Guduru, R. C., Ton, K., Lam, T., & Min, A. (2022) · Retrovirology · doi:10.1186/s12977-022-00608-1 · Cited by 136
HIV-1 Pathogenesis: The VirusPreprint
Swanstrom, R., & Coffin, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007443 · Cited by 134
Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine
Zaitseva, E., Zaitsev, E. N., Melikov, K., Arakelyan, A., Marin, M., Villasmil, R., Margolis, L. B., Melikyan, G. B., & Chernomordik, L. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.06.012 · Cited by 134
Glycan–protein interactions in viral pathogenesis
Raman, R., Tharakaraman, K., Sasisekharan, V., & Sasisekharan, R. (2016) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2016.10.003 · Cited by 131
New Insights into the Pathology of Podocyte Loss
Liapis, H., Romagnani, P., & Anders, H. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.06.033 · Cited by 133
Medicinal chemistry strategies toward host targeting antiviral agents
Ji, X., & Li, Z. (2020) · Medicinal Research Reviews · doi:10.1002/med.21664 · Cited by 125
Nano-based approach to combat emerging viral (NIPAH virus) infection
Kerry, R. G., Malik, S., Redda, Y. T., Sahoo, S., Patra, J. K., & Majhi, S. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.03.004 · Cited by 124
HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2
Pham, T. N. Q., Lukhele, S., Hajjar, F., Routy, J., & Cohen, É. A. (2014) · Retrovirology · doi:10.1186/1742-4690-11-15 · Cited by 116
MicroRNAs and HIV-1 Infection: Antiviral Activities and Beyond
Swaminathan, G., Navas, S., & Martín‐García, J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.12.017 · Cited by 116
Exosome Biogenesis and Biological Function in Response to Viral Infections
Crenshaw, B. J., Gu, L., Sims, B., & Matthews, Q. L. (2018) · The Open Virology Journal · doi:10.2174/1874357901812010134 · Cited by 119
HIV virions sense plasma membrane heterogeneity for cell entry
Yang, S., Kreutzberger, A. J. B., Kiessling, V., Ganser‐Pornillos, B. K., White, J. M., & Tamm, L. K. (2017) · Science Advances · doi:10.1126/sciadv.1700338 · Cited by 109
HIV–Host Cell Interactions
Masenga, S. K., Mweene, B. C., Luwaya, E. L., Muchaili, L., Chona, M., & Kirabo, A. (2023) · Cells · doi:10.3390/cells12101351 · Cited by 114
HIV-1 Maturation: Lessons Learned from Inhibitors
Kleinpeter, A. B., & Freed, E. O. (2020) · Viruses · doi:10.3390/v12090940 · Cited by 106
Quantitative Phosphoproteomics Reveals Extensive Cellular Reprogramming During HIV-1 Entry
Wojcechowskyj, J. A., Didigu, C. A., Lee, J. Y., Parrish, N., Sinha, R., Hahn, B., Bushman, F., Jensen, S. T., Seeholzer, S., & Doms, R. (2013) · Cell Host and Microbe · doi:10.1016/j.chom.2013.04.011 · Cited by 109
Self-citation
Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist
Courter, J. R., Madani, N., Sodroski, J., Schön, A., Freire, E., Kwong, P. D., Hendrickson, W. A., CHAIKEN, I. M., LaLonde, J. M., & Smith, A. B. (2014) · Accounts of Chemical Research · doi:10.1021/ar4002735 · Cited by 93
HIV Genome-Wide Protein Associations: a Review of 30 Years of Research
Li, G., & Clercq, E. D. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00065-15 · Cited by 105
HIV-1 envelope glycoprotein structure
Merk, A., & Subramaniam, S. (2013) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2013.03.007 · Cited by 99
Astrocytes as an HIV Reservoir: Mechanism of HIV Infection
Li, G., Henderson, L. J., & Nath, A. (2016) · Current HIV Research · doi:10.2174/1570162x14666161006121455 · Cited by 90
Phosphatidylserine exposure in living cells
Shin, H., & Takatsu, H. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1758624 · Cited by 88
Cellular Nanosponges for Biological Neutralization
Wang, S., Wang, D., Duan, Y., Zhou, Z., Gao, W., & Zhang, L. (2021) · Advanced Materials · doi:10.1002/adma.202107719 · Cited by 89
HIV-associated cellular senescence: A contributor to accelerated aging
Cohen, J., & Torres, C. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.004 · Cited by 93
Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection
Chen, H., Fang, Z., Chen, Y., Chen, Y., Yao, B., Cheng, J.-Y., Chien, C.-Y., Chang, Y., & Hu, C. J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b09931 · Cited by 79
Mechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic Controllers.
Gonzalo-Gil, E., Ikediobi, U., & Sutton, R. E. (2017) · Europe PMC (PubMed Central) · Cited by 75
The role of miR‐146a in viral infection
Nahand, J. S., Karimzadeh, M. R., Nezamnia, M., Fatemipour, M., Khatami, A., Jamshidi, S., Moghoofei, M., Taghizadieh, M., Hajighadimi, S., Shafiee, A., et al. (2019) · IUBMB Life · doi:10.1002/iub.2222 · Cited by 81
Norovirus Attachment and Entry
Graziano, V. R., Wei, J., & Wilen, C. B. (2019) · Viruses · doi:10.3390/v11060495 · Cited by 78
Self-citation
Virus-inspired nucleic acid delivery system: Linking virus and viral mimicry
Ni, R., Zhou, J., Hossain, N., & Chau, Y. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.005 · Cited by 82
Are microRNAs Important Players in HIV-1 Infection? An Update
Balasubramaniam, M., Pandhare, J., & Dash, C. (2018) · Viruses · doi:10.3390/v10030110 · Cited by 80
Novel activities of safe-in-human broad-spectrum antiviral agents
Ianevski, A., Žusinaite, E., Kuivanen, S. H., Strand, M., Lysvand, H., Teppor, M., Kakkola, L., Paavilainen, H., Laajala, M., Kallio‐Kokko, H., et al. (2018) · Antiviral Research · doi:10.1016/j.antiviral.2018.04.016 · Cited by 71
Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis
Reynolds, D., Huesemann, M. H., Edmundson, S. J., Sims, A. M., Hurst, B. L., Cady, S. L., Beirne, N., Freeman, J., Berger, A., & Gao, S. (2021) · Algal Research · doi:10.1016/j.algal.2021.102331 · Cited by 78
Current ARTs, Virologic Failure, and Implications for AIDS Management: A Systematic Review
Foka, F. E. T., & Mufhandu, H. T. (2023) · Viruses · doi:10.3390/v15081732 · Cited by 83
A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Distribution and Mobility.
Sakin, V., Hanne, J., Dunder, J., Anders-Össwein, M., Laketa, V., Nikić, I., Kräusslich, H., Lemke, E., & Müller, B. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.04.007 · Cited by 65
Intercellular Communication in the Nervous System Goes Viral
Hantak, M. P., Einstein, J. R., Kearns, R. B., & Shepherd, J. D. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.12.003 · Cited by 74
Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges
Voshavar, C. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190619115243 · Cited by 75
Recent Insights into the HIV/AIDS Pandemic
Becerra, J. C., Bildstein, L. S., & Gach, J. S. (2016) · Microbial Cell · doi:10.15698/mic2016.09.529 · Cited by 70
Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity
Lee, J., Nyenhuis, D. A., Nelson, E. A., Cafiso, D. S., White, J. M., & Tamm, L. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708052114 · Cited by 69
Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy
Petrina, M., Martin, J., & Basta, S. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.001 · Cited by 67
Role of autophagy in HIV infection and pathogenesis
Nardacci, R., Ciccosanti, F., Marsella, C., Ippolito, G., Piacentini, M., & Fimia, G. M. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12596 · Cited by 71
The Fertilization Enigma: How Sperm and Egg Fuse
Deneke, V. E., & Pauli, A. (2021) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120219-021751 · Cited by 69
Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses—A Review
Lomartire, S., & Gonçalves, A. M. M. (2022) · Marine Drugs · doi:10.3390/md20060385 · Cited by 73
HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
Li, W., Qin, Z., Nand, E., Grunst, M. W., Grover, J. R., Bess, J. W., Lifson, J. D., Zwick, M. B., Tagare, H. D., Uchil, P. D., et al. (2023) · Nature · doi:10.1038/s41586-023-06762-6 · Cited by 70
HIV infection of non-classical cells in the brain
Wahl, A. R., & Al‐Harthi, L. (2023) · Retrovirology · doi:10.1186/s12977-023-00616-9 · Cited by 63
Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications
Chaudhary, P., Mitra, D., MOHAPATRA, P. K. D., Docea, A. O., Myo, E. M., Janmeda, P., Martorell, M., Iriti, M., Ibrayeva, M., Sharifi‐Rad, J., et al. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104680 · Cited by 63
Biomedical nanoparticle design: What we can learn from viruses
Figueroa, S. M., Fleischmann, D., & Göpferich, A. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.045 · Cited by 60
Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies
Singh, A. K., & Das, K. (2022) · Viruses · doi:10.3390/v14051027 · Cited by 58
Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer’s disease?
Fülöp, T., Witkowski, J. M., Larbi, A., Khalil, A., Herbein, G., & Frost, E. H. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00732-3 · Cited by 59
Bioinspired Underwater Propulsors
Buren, T. W. V., Floryan, D., & Smits, A. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139058995.006 · Cited by 57
The nsp2 Hypervariable Region of Porcine Reproductive and Respiratory Syndrome Virus Strain JXwn06 Is Associated with Viral Cellular Tropism to Primary Porcine Alveolar Macrophages
Song, J., Gao, P., Kong, C., Zhou, L., Ge, X., Guo, X., Han, J., & Yang, H. (2019) · Journal of Virology · doi:10.1128/jvi.01436-19 · Cited by 59
The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization
Salimi, H., Johnson, J., Flores, M. G., Zhang, M. S., O’Malley, Y., Houtman, J. C. D., Schlievert, P. M., & Haim, H. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009481 · Cited by 55
Maternal natural killer cells at the intersection between reproduction and mucosal immunity
Shmeleva, E. V., & Colucci, F. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-00374-3 · Cited by 58
HIV-Infected Dendritic Cells Present Endogenous MHC Class II–Restricted Antigens to HIV-Specific CD4+ T Cells
Coulon, P.-G. A., Richetta, C., Rouers, A., Blanchet, F. P., Urrutia, A., Guerbois, M., Piguet, V., Theodorou, I. D., Bet, A., Schwartz, O., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600286 · Cited by 62
Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
Maïssa, N., Covarelli, V., Janel, S., Durel, B., Simpson, N., Bernard, S. C., Pardo‐López, L., Bouzinba-Ségard, H., Faure, C., Scott, M. G. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15764 · Cited by 61
Immune Control of HIV
Balasubramaniam, M., Pandhare, J., & Dash, C. (2019) · JoLS Journal of Life Sciences · doi:10.36069/jols/20190603 · Cited by 55
How virus size and attachment parameters affect the temperature sensitivity of virus binding to host cells: Predictions of a thermodynamic model for arboviruses and HIV
Gale, P. (2020) · Microbial Risk Analysis · doi:10.1016/j.mran.2020.100104 · Cited by 53
Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120
Yolitz, J., Schwing, C., Chang, J., Ryk, D. V., Nawaz, F., Wei, D., Cicala, C., Arthos, J. A., & Fauci, A. S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722627115 · Cited by 55
The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52
Recent Developments in Electrochemical-Impedimetric Biosensors for Virus Detection
Štukovnik, Z., & Bren, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415922 · Cited by 53
Dual Role of CD4 in Peripheral T Lymphocytes
Glatzová, D., & Cebecauer, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00618 · Cited by 52
Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41
Yi, H. A., Fochtman, B. C., Rizzo, R. C., & Jacobs, A. (2016) · Current HIV Research · doi:10.2174/1570162x14999160224103908 · Cited by 55
Glycerol Monolaurate, an Analogue to a Factor Secreted by Lactobacillus , Is Virucidal against Enveloped Viruses, Including HIV-1
Welch, J. L., Xiang, J., Okeoma, C. M., Schlievert, P. M., & Stapleton, J. T. (2020) · mBio · doi:10.1128/mbio.00686-20 · Cited by 51
Tea catechin as antiviral agent via apoptosis agonist and triple inhibitor mechanism against HIV-1 infection: A bioinformatics approach
Kharisma, V. D., Widyananda, M. H., Ansori, A. N. M., Nege, A. S., Naw, S. W., & Nugraha, A. P. (2021) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres21.1009_9.4.435 · Cited by 54
Optimal management of cervical cancer in HIV ‐positive patients: a systematic review
Ntekim, A., Campbell, O. B., & Rothenbacher, D. (2015) · Cancer Medicine · doi:10.1002/cam4.485 · Cited by 50
HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women
Kovács, L., Kress, T. C., & de Chantemèle, E. J. B. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.10.017 · Cited by 49
HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth
Acharya, P., Lusvarghi, S., Bewley, C. A., & Kwong, P. D. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1010513 · Cited by 48
HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication
Tirumuru, N., & Wu, L. J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005608 · Cited by 47
Vehicles of intercellular communication: exosomes and HIV-1
Welch, J. L., Stapleton, J. T., & Okeoma, C. M. (2019) · Journal of General Virology · doi:10.1099/jgv.0.001193 · Cited by 49
Functional organization of the HIV lipid envelope
Huarte, N., Carravilla, P., Cruz, A., Lorizate, M., Nieto‐Garai, J. A., Kräusslich, H., Pérez‐Gil, J., Requejo‐Isidro, J., & Nieva, J. L. (2016) · Scientific Reports · doi:10.1038/srep34190 · Cited by 52
Biomimetic Nanomaterial Strategies for Virus Targeting: Antiviral Therapies and Vaccines
Jackman, J. A., Yoon, B. K., Ouyang, L., Wang, N., Ferhan, A. R., Kim, J., Majima, T., & Cho, N. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202008352 · Cited by 46
Chemokine Oligomerization in Cell Signaling and Migration
Wang, X., Sharp, J. S., Handel, T. M., & Prestegard, J. H. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386931-9.00020-9 · Cited by 52
HIV internalization into oral and genital epithelial cells by endocytosis and macropinocytosis leads to viral sequestration in the vesicles
Yasen, A., Herrera, R., Rosbe, K. W., Lien, K., & Tugizov, S. M. (2017) · Virology · doi:10.1016/j.virol.2017.12.012 · Cited by 45
PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex
Balasubramaniam, M., Zhou, J., Addai, A. B., Martinez, P., Pandhare, J., Aiken, C., & Dash, C. (2018) · Journal of Virology · doi:10.1128/jvi.01741-18 · Cited by 43
Comparative mapping of host–pathogen protein–protein interactions
Shah, P. S., Wojcechowskyj, J. A., Eckhardt, M., & Krogan, N. J. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.07.008 · Cited by 42
Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4posT cells and macrophages
Varchetta, S., Lusso, P., Hudspeth, K. L., Mikulak, J., Mele, D., Paolucci, S., Cimbro, R., Malnati, M., Riva, A., Maserati, R., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-154 · Cited by 44
Co-receptor signaling in the pathogenesis of neuroHIV
Nickoloff-Bybel, E. A., Festa, L. K., Meucci, O., & Gaskill, P. J. (2021) · Retrovirology · doi:10.1186/s12977-021-00569-x · Cited by 46
Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set
Onnis, A., Finetti, F., & Baldari, C. T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00050 · Cited by 45
Altered Immune Cytokine Expression Associated with KoRV B Infection and Season in Captive Koalas
Maher, I. E., & Higgins, D. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163780 · Cited by 42
Unprecedented Role of Hybrid N- Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies
Shivatare, V. S., Shivatare, S. S., Lee, C.-C. D., Liang, C. J., Liao, K., Cheng, Y., Saidachary, G., Wu, C., Lin, N., Kwong, P. D., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b00896 · Cited by 43
Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120
Curreli, F., Belov, D. S., Kwon, Y. D., Ramesh, R. R., Furimsky, A. M., O’Loughlin, K. G., Byrge, P. C., Iyer, L., Mirsalis, J. C., Kurkin, A. V., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.062 · Cited by 43
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors
Ibrahim, T. S., Bokhtia, R. M., Al‐Mahmoudy, A. M. M., Taher, E. S., AlAwadh, M. A., Elagawany, M., Abdel‐Aal, E. H., Panda, S. S., Gouda, A. M., Asfour, H. Z., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103782 · Cited by 43
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses
Li, J. R., & Boix, E. (2021) · Virulence · doi:10.1080/21505594.2021.1871823 · Cited by 42
An Overview of Human Immunodeficiency Virus-1 Antiretroviral Drugs: General Principles and Current Status
Shin, Y. H., Park, C. M., & Yoon, C. (2021) · Infection and Chemotherapy · doi:10.3947/ic.2020.0100 · Cited by 43

Authors: Wilen, C. B., Tilton, J. C., & Doms, R. W.
Affiliations: University of Pennsylvania (US)
Case Western Reserve University (US)
ORCID: Wilen, C. B.
Tilton, J. C.
Venue: Cold Spring Harbor Perspectives in Medicine
Publisher: Cold Spring Harbor Laboratory
Published: 2012-04-10
Volume: 2
Issue: 8
Pages: a006866-a006866
ISSN: 2157-1422 (ISSN-L)
DOI: 10.1101/cshperspect.a006866
PMC: PMC3405824
OpenAlex: W2118545611
Cited by: 654
References: 106
Citations by year: 2026: 19 · 2025: 33 · 2024: 49 · 2023: 49 · 2022: 58 · 2021: 73 · 2020: 66 · 2019: 61 · 2018: 68 · 2017: 47 · 2016: 43 · 2015: 33 · 2014: 21 · 2013: 25 · 2012: 8
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Cold Spring Harbor Perspectives in Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (T32 AI000632, R01AI040880, F32AI077370, F32 1F32AI077370)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords: HIV entry, CD4 receptor, co-receptors, viral envelope glycoprotein, membrane fusion, viral tropism, HIV pathogenesis, HIV transmission, host immune evasion, HIV replication cycle
MeSH terms: Cell Transformation, Viral, HIV, Humans, Protein Binding, Virion, Signal Transduction, CD4-Positive T-Lymphocytes, HIV Infections, HIV Envelope Protein gp120, CD4 Antigens, Integrins, Receptors, CCR5, env Gene Products, Human Immunodeficiency Virus, Receptors, CCR4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

HIV: Cell Binding and Entry

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks