The DOI matches its Crossref record; 104 of the 106 references it cites were found in a registry or an index.
HIV: Cell Binding and Entry
Open accessAbstract
The first step of the human immunodeficiency virus (HIV) replication cycle-binding and entry into the host cell-plays a major role in determining viral tropism and the ability of HIV to degrade the human immune system. HIV uses a complex series of steps to deliver its genome into the host cell cytoplasm while simultaneously evading the host immune response. To infect cells, the HIV protein envelope (Env) binds to the primary cellular receptor CD4 and then to a cellular coreceptor. This sequential binding triggers fusion of the viral and host cell membranes, initiating infection. Revealing the mechanism of HIV entry has profound implications for viral tropism, transmission, pathogenesis, and therapeutic intervention. Here, we provide an overview into the mechanism of HIV entry, provide historical context to key discoveries, discuss recent advances, and speculate on future directions in the field.
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“As HIV is only capable of infecting CD4+ T cells (Wilen et al, 2012), it is possible that the virus directly induces VIS in these cells.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Wilen et al, 2012
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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
Feng, Y. Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5263.872 · Cited by 4,169
Identification of a major co-receptor for primary isolates of HIV-1
Deng, H., Liu, R., Ellmeier, W., Choe, S. S., Unutmaz, D., Burkhart, M. D., Marzio, P. D., Marmon, S., Sutton, R. E., Hill, C. M., et al. (1996) · Nature · doi:10.1038/381661a0 · Cited by 3,640
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y., Nagashima, K. A., Cayanan, C. S., Maddon, P. J., Koup, R. A., Moore, J. P., et al. (1996) · Nature · doi:10.1038/381667a0 · Cited by 3,173
Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A., & Landau, N. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80110-5 · Cited by 3,074
Kwong, P. D., Wyatt, R. T., Robinson, J. E., Sweet, R. W., Sodroski, J., & Hendrickson, W. A. (1998) · Nature · doi:10.1038/31405 · Cited by 2,963
Samson, M., Libert, F., Doranz, B. J., Rucker, J. B., Liesnard, C., Farber, C., Saragosti, S., Lapouméroulie, C., Cognaux, J., Forceille, C., et al. (1996) · Nature · doi:10.1038/382722a0 · Cited by 2,885
Self-citationCocchi, F., DeVico, A. L., Demo, A. G., Arya, S. K., Gallo, R. C., & Lusso, P. (1995) · Science · doi:10.1126/science.270.5243.1811 · Cited by 2,867
Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men
Gottlieb, M. S., Schroff, R. W., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,723
CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1
Alkhatib, G., Combadière, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5270.1955 · Cited by 2,703
Dean, M. C., Carrington, M. N., Winkler, C. A., Huttley, G. A., Smith, M. W., Allikmets, R. L., Goedert, J. J., Buchbinder, S., Vittinghoff, E., Gomperts, E. D., et al. (1996) · Science · doi:10.1126/science.273.5283.1856 · Cited by 2,503
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Gantner, P. (2018) · theses.fr (ABES) · doi:10.70675/c836a9afz1fd0z4a59z933fz98f5f471f52a
Amine, R. E. (2017) · theses.fr (ABES) · doi:10.70675/79702f70za566z4f62z8665zfa738acf7b3f
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Schatz, M. (2018) · theses.fr (ABES) · doi:10.70675/2dd44b60z26baz42e9zb74azde8c15215c4a
KAP1 : un nouveau facteur répresseur de la transcription du VIH-1
Aït-Ammar, A. (2018) · theses.fr (ABES) · doi:10.70675/bef49303zbb98z444bzb86azf445aa0a34db
Klingler, J. (2019) · theses.fr (ABES) · doi:10.70675/8ab46952z7743z4999zb432zf1bf23dd682f
Impact de stratégies thérapeutiques sur le réservoir viral cellulaire dans l'infection par le VIH-1
Delagreverie, H. M. (2018) · theses.fr (ABES) · doi:10.70675/bbe21e26zf0ccz49d6zb633zc127a9338ff2
DNA vaccination amplifiers HLA-DR cross-restricted public TCR clonotypes shared with HIV controllers
Mukhopadhyay, M. (2017) · theses.fr (ABES) · doi:10.70675/a42f696ez8360z43b6z95a3z984bca393809
Molecular architecture and fate of HIV-1 pre-integration
Blanco-Rodriguez, G. (2019) · theses.fr (ABES) · doi:10.70675/8643077az5a0fz4f20zbabazb129e8359d96
Engineering of biomolecular systems for anti-tumoral immunotherapy
Todaro, B. (2020) · theses.fr (ABES) · doi:10.70675/ca7dd944zc8a6z41a4z9300z0e208d8a6b88
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Efficacité et évolution de la réponse lymphocytaire T CD8 au cours de l'infection par VIH-1
White, E. (2022) · theses.fr (ABES) · doi:10.70675/46537244ze125z43e1z9c39z92cf9f645f78
Etude de la transmission intercellulaire du VIH-1 vers les macrophages par fusion cellule-cellule
Mascarau, R. (2022) · theses.fr (ABES) · doi:10.70675/2e3aacaazcd4fz49a5zb350zcd4933447d78
Said, M. A. (2023) · theses.fr (ABES) · doi:10.70675/a9c4a87dz9e77z48d7zbd35z5893bdb5df28
Rôle des 2'-O-méthylations internes du génome ARN du VIH-1 dans la réplication virale
Decombe, A. (2023) · theses.fr (ABES) · doi:10.70675/82535ee7z2ed0z457ezb976za900d3f7241a
Yoon, S.-Y., & Park, J.-E. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121782
Manivannan, P., da Costa, C. S., Tang, Y., Wang, X., Swanson, J. A., Murakami, T., Ono, A., & King, P. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.27.721102
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Cromarty, R. T., Clain, J. A., Soigner, Y., Dasgupta, T., Dixon, K., Nguyen, K., Flores, H. E., Eungard, E. M., Walker, J. T., Bjorgen, J., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102847
The many faces of superinfection exclusion
Dang, A., Hain, K. S., & Taylor, M. P. (2026) · Future Virology · doi:10.1080/17460794.2026.2684531
Abernathy, K., Wang, S. W., Feng, C., Mancini, J., Zong, G., González‐Montalbán, N., Wang, L., & Vasta, G. R. (2026) · Biomolecules · doi:10.3390/biom16060882
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Lionel, G., Binnington, B., Wong, R., Cochrane, A., Jin, J., & Branch, D. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.26.734695
Drug-drug interactions in patients living with HIV and major depression
Antwi, I., & Cory, T. J. (2026) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2026.2704520
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Safaei, Z., Bellizzi, A., Liu, H., Huang, Y., Sariyer, I. K., & Khalili, K. (2026) · Human Gene Therapy · doi:10.1177/10430342261463565
Engineering Protein-Based HIV Entry Inhibitors: Advances, Challenges, and Translational Strategies
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Wang, W., Cai, Y., Yang, X., & Xu, H. (2026) · Immunity & Inflammation · doi:10.1007/s44466-026-00050-4
HIV cure: from early therapies to cutting-edge strategies
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Gandi, A., Adari, H., Savana, A., Polisetty, S. C. D., Paila, P., & Yarguntla, S. R. (2026) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2026.102578
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BindingDB (2021) · UC San Diego · doi:10.7270/q2ms3x5p
Metadata
- Authors
- Wilen, C. B., Tilton, J. C., & Doms, R. W.
- Affiliations
- University of Pennsylvania (US)
- Case Western Reserve University (US)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-04-10
- Volume
- 2
- Issue
- 8
- Pages
- a006866-a006866
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC3405824
- OpenAlex
- W2118545611
- Cited by
- 654
- References
- 106
- Citations by year
- 2026: 19 · 2025: 33 · 2024: 49 · 2023: 49 · 2022: 58 · 2021: 73 · 2020: 66 · 2019: 61 · 2018: 68 · 2017: 47 · 2016: 43 · 2015: 33 · 2014: 21 · 2013: 25 · 2012: 8
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (T32 AI000632, R01AI040880, F32AI077370, F32 1F32AI077370)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- HIV entry, CD4 receptor, co-receptors, viral envelope glycoprotein, membrane fusion, viral tropism, HIV pathogenesis, HIV transmission, host immune evasion, HIV replication cycle
- MeSH terms
- Cell Transformation, Viral, HIV, Humans, Protein Binding, Virion, Signal Transduction, CD4-Positive T-Lymphocytes, HIV Infections, HIV Envelope Protein gp120, CD4 Antigens, Integrins, Receptors, CCR5, env Gene Products, Human Immunodeficiency Virus, Receptors, CCR4
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