The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Signaling and Transcriptional Networks in Heart Development and Regeneration
Open accessAbstract
The mammalian heart is the first functional organ, the first indicator of life. Its normal formation and function are essential for fetal life. Defects in heart formation lead to congenital heart defects, underscoring the finesse with which the heart is assembled. Understanding the regulatory networks controlling heart development have led to significant insights into its lineage origins and morphogenesis and illuminated important aspects of mammalian embryology, while providing insights into human congenital heart disease. The mammalian heart has very little regenerative potential, and thus, any damage to the heart is life threatening and permanent. Knowledge of the developing heart is important for effective strategies of cardiac regeneration, providing new hope for future treatments for heart disease. Although we still have an incomplete picture of the mechanisms controlling development of the mammalian heart, our current knowledge has important implications for embryology and better understanding of human heart disease.
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Cites
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Cited by
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Self-organizing human cardiac microchambers mediated by geometric confinement
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Multi-chamber cardioids unravel human heart development and cardiac defects
(2023) · doi:10.1016/j.cell.2023.10.030 · Cited by 205
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Metadata
- Authors
- Bruneau, B. G.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-03-01
- Volume
- 5
- Issue
- 3
- Pages
- a008292-a008292
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2113897048
- Cited by
- 280
- References
- 13
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Bruneau, B. G. (2013). Signaling and Transcriptional Networks in Heart Development and Regeneration. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a008292
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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