The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages
Open accessAbstract
Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues.Tooth organogenesis is regulated by an intricate network of cell -cell signaling during all steps of development.The dental hard tissues, dentin, enamel, and cementum, are formed by unique cell types whose differentiation is intimately linked with morphogenesis.During evolution the capacity for tooth replacement has been reduced in mammals, whereas teeth have acquired more complex shapes.Mammalian teeth contain stem cells but they may not provide a source for bioengineering of human teeth.Therefore it is likely that nondental cells will have to be reprogrammed for the purpose of clinical tooth regeneration.Obviously this will require understanding of the mechanisms of normal development.The signaling networks mediating the epithelial-mesenchymal interactions during morphogenesis are well characterized but the molecular signatures of the odontogenic tissues remain to be uncovered.Outline 1 Morphogenesis and cell differentiation during tooth development 2 Signal networks and signaling centers 3 Regulation of the identity and differentiation of odontogenic mesenchymal and epithelial cell lineages 4 Regulation of tooth replacement, continuous growth, and stem cells in teeth 5 Future challenges: stem cell-based bioengineering of teeth
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Cites
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Investigation of multipotent postnatal stem cells from human periodontal ligament
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In vivo reprogramming of adult pancreatic exocrine cells to β-cells
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Ten Cate's Oral Histology: Development, Structure, and Function
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Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
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WNT Signals Are Required for the Initiation of Hair Follicle Development
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Self-citationSonic hedgehog regulates growth and morphogenesis of the tooth
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Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
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Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer
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Cited by
Wnt Signaling in Renal Cell Carcinoma
Xu, Q., Krause, M., Samoylenko, A., & Vainio, S. (2016) · Cancers · doi:10.3390/cancers8060057 · Cited by 99
Aman, A. J., Saunders, L. M., Carr, A. A., Srivatasan, S., Eberhard, C., Carrington, B., Watkins-Chow, D., Pavan, W. J., Trapnell, C., & Parichy, D. M. (2023) · eLife · doi:10.7554/elife.86670 · Cited by 30
Metadata
- Authors
- Jussila, M., & Thesleff, I.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-03-13
- Volume
- 4
- Issue
- 4
- Pages
- a008425-a008425
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2123728260
- Cited by
- 263
- References
- 78
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Jussila, M., & Thesleff, I. (2012). Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a008425
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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