Epidermal Polarity Genes in Health and Disease
Open accessAbstract
The epidermis of the skin is a highly polarized, metabolic tissue with important innate immune functions. The polarity of the epidermis is, for example, reflected in controlled changes in cell shape that accompany differentiation, oriented cell division, and the planar orientation of hair follicles and cilia. The establishment and maintenance of polarity is organized by a diverse set of polarity proteins that include transmembrane adhesion proteins, cytoskeletal scaffold proteins, and kinases. Although polarity proteins have been extensively studied in cell culture and in vivo in simple epithelia of lower organisms, their role in mammalian tissue biology is only slowly evolving. This article will address the importance of polarizing processes and their molecular regulators in epidermal morphogenesis and homeostasis and discuss how alterations in polarity may contribute to skin disease.
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Many of the molecular players required for barrier formation are shared between simple and multi-layered epithelia.
“even though many of the molecular players required for barrier formation are shared between simple and multi-layered epithelia2”
From E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning (2017) · cites this paper as [2]
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Self-citationAsymmetric cell divisions promote Notch-dependent epidermal differentiation
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Research works printed but not linked: 2
- Martin-Belmonte F, Perez-Moreno M. 2012. Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer 12: 23-38. Epidermal Polarity Genes in Health and Disease Cite this article as Cold Spring Harb Perspect Med 2014;4:a015255 Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, et al. 2003. PKC-l in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest 112: 935-944.
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Rübsam, M., Mertz, A. F., Kubo, A., Marg, S., Jüngst, C., Goranci-Buzhala, G., Schauss, A. C., Horsley, V., Dufresne, E. R., Moser, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01170-7 · Cited by 210 · see citing works
Self-citationCastellano-Pellicena, I., Morrison, C. G., Bell, M., O’Connor, C., & Tobin, D. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063143 · Cited by 35 · see citing works
- Authors
- Tellkamp, F., Vorhagen, S., & Niessen, C. M.
- Affiliations
- University of Cologne (DE)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-12-01
- Volume
- 4
- Issue
- 12
- Pages
- a015255-a015255
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC4292092
- OpenAlex
- W2134764455
- Cited by
- 33
- References
- 8
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 3 · 2014: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 832, SFB829)
- Deutsche Krebshilfe (SFB832)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- polarity proteins, skin, epidermal morphogenesis, epidermal homeostasis, skin diseases, cell shape, cell division orientation, cilia, adhesion proteins, kinases, innate immunity
- MeSH terms
- Epidermal Cells, Cell Differentiation, Cilia, Epidermis, Humans, Regeneration, Skin Diseases, Skin Neoplasms, Signal Transduction, Cell Polarity, Intercellular Signaling Peptides and Proteins
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