Classical Cadherins Regulate Desmosome Formation

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

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E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

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E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

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Hyperproliferation and Defects in Epithelial Polarity upon Conditional Ablation of α-Catenin in Skin

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Catenins: Keeping Cells from Getting Their Signals Crossed

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Precocious Mammary Gland Development in P-Cadherin–deficient Mice

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Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin

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Regulation of desmosome assembly and adhesion

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Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin

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Cadherin Function Is Required for Human Keratinocytes to Assemble Desmosomes and Stratify in Response to Calcium

Lewis, J. E., Jensen, P. J., & Wheelock, M. J. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12382690 · Cited by 175 · see citing works

Genetic Diseases of Junctions

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New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity

Tinkle, C. L., Pasolli, H. A., Stokes, N., & Fuchs, E. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807374105 · Cited by 134 · see citing works

Conditional Inactivation of the E-Cadherin Gene in Thyroid Follicular Cells Affects Gland Development but Does Not Impair Junction Formation

Calı̀, G., Zannini, M., Rubini, P., Tacchetti, C., D’Andrea, B., Affuso, A., Wintermantel, T. M., Boussadia, O., Terracciano, D., Silberschmidt, D., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1344 · Cited by 41 · see citing works

Tissue Organization by Cadherin Adhesion Molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation

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Intercellular Junction Assembly, Dynamics, and HomeostasisPreprint

Green, K. J., Getsios, S., Troyanovsky, S. M., & Godsel, L. M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000125 · Cited by 259 · see citing works

Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces

Mertz, A. F., Che, Y., Banerjee, S., Goldstein, J. M., Rosowski, K. A., Revilla, S. F., Niessen, C. M., Marchetti, M. C., Dufresne, E. R., & Horsley, V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217279110 · Cited by 243 · see citing works

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

Rübsam, M., Mertz, A. F., Kubo, A., Marg, S., Jüngst, C., Goranci-Buzhala, G., Schauss, A. C., Horsley, V., Dufresne, E. R., Moser, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01170-7 · Cited by 210 · see citing works

Desmosome assembly and dynamics

Nekrasova, O. E., & Green, K. J. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.06.004 · Cited by 177 · see citing works

Five Functional Aspects of the Epidermal Barrier

Lefèvre‐Utile, A., Braun, C., Haftek, M., & Aubin, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111676 · Cited by 161 · see citing works

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary PerspectivePreprint

Rübsam, M., Broussard, J. A., Wickström, S. A., Nekrasova, O. E., Green, K. J., & Niessen, C. M. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029207 · Cited by 148 · see citing works

Crosstalk between Cell Adhesion Complexes in Regulation of Mechanotransduction

Zuidema, A., Wang, W., & Sonnenberg, A. (2020) · BioEssays · doi:10.1002/bies.202000119 · Cited by 128 · see citing works

Desmosomes: Essential contributors to an integrated intercellular junction network

Green, K. J., Jaiganesh, A., & Broussard, J. A. (2019) · F1000Research · doi:10.12688/f1000research.20942.1 · Cited by 94 · see citing works

Desmosomal Cadherins in Health and Disease

Hegazy, M., Perl, A. L., Svoboda, S. A., & Green, K. J. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-092912 · Cited by 92 · see citing works

E-cadherin binds to desmoglein to facilitate desmosome assembly

Shafraz, O. M., Rübsam, M., Stahley, S. N., Caldara, A. L., Kowalczyk, A. P., Niessen, C. M., & Sivasankar, S. (2018) · eLife · doi:10.7554/elife.37629 · Cited by 88 · see citing works

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome

Ferone, G., Mollo, M. R., Thomason, H. A., Antonini, D., Zhou, H., Ambrosio, R., Rosa, L. D., Salvatore, D., Getsios, S., van Bokhoven, H., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds464 · Cited by 79 · see citing works

E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion

Rötzer, V., Hartlieb, E., Vielmuth, F., Gliem, M., Spindler, V., & Waschke, J. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1977-0 · Cited by 73 · see citing works

Desmosomes and Extradesmosomal Adhesive Signaling Contacts in Pemphigus

Waschke, J., & Spindler, V. (2014) · Medicinal Research Reviews · doi:10.1002/med.21310 · Cited by 73 · see citing works

Unmasking the molecular link between arrhythmogenic cardiomyopathy and Brugada syndrome

Moncayo, J., & Brugada, R. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.103 · Cited by 64 · see citing works

Structural and Functional Diversity of Desmosomes

Harmon, R. M., & Green, K. J. (2013) · Cell Communication & Adhesion · doi:10.3109/15419061.2013.855204 · Cited by 62 · see citing works

The Evolving Story of Autoantibodies in Pemphigus Vulgaris: Development of the “Super Compensation Hypothesis”

Sinha, A. A., & Sajda, T. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00218 · Cited by 62 · see citing works

New insights into desmosome regulation and pemphigus blistering as a desmosome‐remodeling disease

Kitajima, Y. (2012) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2012.08.001 · Cited by 56 · see citing works

150thAnniversary Series: Desmosomes and Autoimmune Disease, Perspective of Dynamic Desmosome Remodeling and Its Impairments in Pemphigus

Kitajima, Y. (2014) · Cell Communication & Adhesion · doi:10.3109/15419061.2014.943397 · Cited by 52 · see citing works

E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

Gosavi, P., Kundu, S. T., Khapare, N., Sehgal, L., Karkhanis, M. S., & Dalal, S. N. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0531-3 · Cited by 51 · see citing works

The epidermal polarity protein Par3 is a non–cell autonomous suppressor of malignant melanoma

Mescher, M., Jeong, P., Knapp, S. K., Rübsam, M., Saynisch, M., Kranen, M., Landsberg, J., Schlaak, M. S., Mauch, C., Tüting, T., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160596 · Cited by 45 · see citing works

Mapping transmembrane binding partners for E-cadherin ectodomains

Shafraz, O. M., Xie, B., Yamada, S., & Sivasankar, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010209117 · Cited by 43 · see citing works

Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2

Raya‐Sandino, A., Luissint, A., Kusters, D. H. M., Narayanan, V., Flemming, S., García‐Hernández, V., Godsel, L. M., Green, K. J., Hagen, S. J., Conway, D. E., et al. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-12-0775 · Cited by 43 · see citing works

Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function

Brandner, J. M., Haftek, M., & Niessen, C. M. (2010) · The Open Dermatology Journal · doi:10.2174/1874372201004010014 · Cited by 43 · see citing works

Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions on epithelial differentiation

Noethel, B., Ramms, L., Dreissen, G., Hoffmann, M., Springer, R., Rübsam, M., Ziegler, W. H., Niessen, C. M., Merkel, R., & Hoffmann, B. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0387 · Cited by 39 · see citing works

Transcriptional mechanisms coordinating tight junction assembly during epithelial differentiation

Boivin, F. J., & Schmidt-Ott, K. M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13367 · Cited by 38 · see citing works

Desmosomes undergo dynamic architectural changes during assembly and maturation

Beggs, R. R., Rao, T. C., Dean, W. F., Kowalczyk, A. P., & Mattheyses, A. L. (2022) · Tissue Barriers · doi:10.1080/21688370.2021.2017225 · Cited by 33 · see citing works

Epidermal Polarity Genes in Health and Disease

Tellkamp, F., Vorhagen, S., & Niessen, C. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015255 · Cited by 33 · see citing works

Cell-Cell Adhesions and Cell Contractility Are Upregulated upon Desmosome Disruption

Sumigray, K., Zhou, K., & Lechler, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101824 · Cited by 32 · see citing works

Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation

Rahn, E., Thier, K., Petermann, P., Rübsam, M., Staeheli, P., Iden, S., Niessen, C. M., & Knebel-Mörsdorf, D. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.11.027 · Cited by 31 · see citing works

AJUBA: A regulator of epidermal homeostasis and cancer

Schleicher, K., & Schramek, D. (2020) · Experimental Dermatology · doi:10.1111/exd.14272 · Cited by 21 · see citing works

14-3-3γ meditated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo

Sehgal, L., Mukhopadhyay, A., Rajan, A., Khapare, N., Sawant, M., Vishal, S. S., Bhatt, K., Ambatipudi, S., Antao, N. V., Alam, H., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.125807 · Cited by 20 · see citing works

Meeting report – Desmosome dysfunction and disease: Alpine desmosome disease meeting

Spindler, V., Gerull, B., Green, K. J., Kowalczyk, A. P., Leube, R. E., Marian, A. J., Milting, H., Müller, E. J., Niessen, C. M., Payne, A. S., et al. (2023) · Journal of Cell Science · doi:10.1242/jcs.260832 · Cited by 19 · see citing works

Polarity signaling balances epithelial contractility and mechanical resistance

Rübsam, M., Püllen, R., Tellkamp, F., Bianco, A., Peskoller, M., Bloch, W., Green, K. J., Merkel, R., Hoffmann, B., Wickström, S. A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-33485-5 · Cited by 18 · see citing works

The aberrant expression or disruption of desmocollin2 in human diseases

Sun, C., Wang, L., Yang, X., Jiang, Y.-H., & Guo, X. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.041 · Cited by 18 · see citing works

Patterning in stratified epithelia depends on cell–cell adhesion

Mai, Y., Kobayashi, Y., Kitahata, H., Seo, T., Nohara, T., Itamoto, S., Mai, S., Kumamoto, J., Nagayama, M., Nishie, W., et al. (2024) · Life Science Alliance · doi:10.26508/lsa.202402893 · Cited by 13 · see citing works

Single-molecule studies of classical and desmosomal cadherin adhesion

Priest, A. V., Koirala, R., & Sivasankar, S. (2019) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2019.08.006 · Cited by 13 · see citing works

Cytoskeletal anchorage of different Dsg3 pools revealed by combination of hybrid STED/SMFS-AFM

Fuchs, M. T., Radeva, M. Y., Spindler, V., Vielmuth, F., Kugelmann, D., & Waschke, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04681-9 · Cited by 13 · see citing works

Desmosomes in Developing Human Epidermis

Peltonen, S. A., Raiko, L., & Peltonen, J. T. K. (2010) · Dermatology Research and Practice · doi:10.1155/2010/698761 · Cited by 13 · see citing works

Desmoglein-driven dynamic signaling in pemphigus vulgaris: a systematic review of pathogenic pathways

Rahimi, S., Hariton, W. V. J., Khalaj, F., Ludwig, R. J., Borradori, L., & Müller, E. J. (2025) · npj Regenerative Medicine · doi:10.1038/s41536-025-00426-x · Cited by 12 · see citing works

Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2

Gurjar, M., Raychaudhuri, K., Mahadik, S. S., Reddy, D., Atak, A., Shetty, T., Rao, K., Karkhanis, M. S., Gosavi, P., Sehgal, L., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.085 · Cited by 12 · see citing works

Attachment of Cancer Urothelial Cells to the Bladder Epithelium Occurs on Uroplakin-Negative Cells and Is Mediated by Desmosomal and Not by Classical Cadherins

Jerman, U. D., Višnjar, T., Hafner‐Bratkovič, I., Resnik, N., Pavlin, M., Veranič, P., & Kreft, M. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115565 · Cited by 11 · see citing works

Epidermal cell junctions and their regulation by p63 in health and disease

Ferone, G., Mollo, M. R., & Missero, C. (2015) · Cell and Tissue Research · doi:10.1007/s00441-014-2108-1 · Cited by 11 · see citing works

Adherens Junctions in Mammalian Development, Homeostasis and Disease: Lessons from Mice

Boggetti, B., & Niessen, C. M. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4186-7_14 · Cited by 10 · see citing works

Architectural characterization of organotypic cultures of H400 and primary rat keratinocytes

Khan, E., Shelton, R. M., Cooper, P. R., Hamburger, J., & Landini, G. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34263 · Cited by 8 · see citing works

A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

Hariton, W. V. J., Schulze, K., Rahimi, S., Shojaeian, T., Feldmeyer, L., Schwob, R., Overmiller, A. M., Sayar, B. S., Borradori, L., Mahoney, M. G., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108568 · Cited by 7 · see citing works

Cross-Talk between Hemidesmosomes and Focal Contacts: Understanding Subepidermal Blistering Diseases

Kitajima, Y. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.77 · Cited by 4 · see citing works

Soft substrate and decreased cytoskeleton contractility promote coupling and morphology maintenance of pluripotent stem cells

Lu, M., Cao, J., Zhai, Y., Zhao, P., Yao, J., Gong, Y., Du, J., & Fan, Y. (2021) · Acta Mechanica Sinica · doi:10.1007/s10409-021-01118-7 · Cited by 4 · see citing works

Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites

Lhamo, S., Bharathan, N. K., Giang, W., Levental, K. R., Simpson, C. L., Zimmer, S. E., Saba, T., Beaucousin, J., Heuzé, M. L., & Kowalczyk, A. P. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117608 · Cited by 1 · see citing works

Characterisation of 2D and 3D oral keratinocyte cultures

Khan, E. (2012) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1 · see citing works

Adherens Junctions

Michels, C., & Niessen, C. M. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0020876 · Cited by 1 · see citing works

The story of redundant catenins and their roles in cell-cell adhesion in the liver

Wickline, E. D. (2013) · D-Scholarship@Pitt (University of Pittsburgh)

Faculty Opinions recommendation of p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.

Payne, A. S. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717962803.793464815

P-cadherin and desmoglein-2 interact as strand-swap dimers and facilitate desmosome assemblyPreprint

Xu, S., Mudiyanselage, N. H., & Sivasankar, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.15.676363

Desmosome Assembly Regulates Apical‐Basal Polarization and Nuclear Shape in Simple Epithelial Cells

Nita, T., Hayase, J., Kohda, A., Shiose, A., Sumimoto, H., & Kamakura, S. (2026) · Genes to Cells · doi:10.1111/gtc.70085

Importance of AJ and cell polarity in the regulation of Fas signaling

Awina, H. (2019) · theses.fr (ABES) · doi:10.70675/7b0a762dzd645z4e23z9222z2abee196c637

Role of classical cadherins in epidermal junction and barrier formation

Michels, C. (2010) · Kölner Universitäts PublikationsServer (Universität zu Köln)

870 E-cadherin binds desmoglein to facilitate desmosome assembly

Rübsam, M., Shafraz, O. M., Stanley, S., Kowalczyk, A. P., Niessen, C. M., & Sivasankar, S. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.03.881 · Cited by 3 · see citing works

E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion

Rötzer, V., Hartlieb, E., Vielmuth, F., Gliem, M., Spindler, V., & Waschke, J. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1977-0 · Cited by 73 · see citing works

Cadherin Function Is Required for Human Keratinocytes to Assemble Desmosomes and Stratify in Response to Calcium

Lewis, J. E., Jensen, P. J., & Wheelock, M. J. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12382690 · Cited by 175 · see citing works

Cross-Talk between Adherens Junctions and Desmosomes Depends on Plakoglobin

Lewis, J. E., Wahl, J. K., Sass, K. M., Jensen, P. J., Johnson, K. R., & Wheelock, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.4.919 · Cited by 277 · see citing works