The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Meiotic Recombination: The Essence of Heredity
Open accessAbstract
The study of homologous recombination has its historical roots in meiosis. In this context, recombination occurs as a programmed event that culminates in the formation of crossovers, which are essential for accurate chromosome segregation and create new combinations of parental alleles. Thus, meiotic recombination underlies both the independent assortment of parental chromosomes and genetic linkage. This review highlights the features of meiotic recombination that distinguish it from recombinational repair in somatic cells, and how the molecular processes of meiotic recombination are embedded and interdependent with the chromosome structures that characterize meiotic prophase. A more in-depth review presents our understanding of how crossover and noncrossover pathways of meiotic recombination are differentiated and regulated. The final section of this review summarizes the studies that have defined defective recombination as a leading cause of pregnancy loss and congenital disease in humans.
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Citations
Cites
Germline rates of de novo meiotic deletions and duplications causing several genomic disorders
Turner, D. J., Miretti, M., Rajan, D., Fiegler, H., Carter, N. P., Blayney, M. L., Beck, S., & Hurles, M. E. (2008) · Nature Genetics · doi:10.1038/ng.2007.40 · Cited by 320
Goodman, M. F., & Woodgate, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010363 · Cited by 317
Genome analyses of single human oocytes
Hou, Y., Fan, W., Yan, L., Li, R., Lian, Y., Huang, J., Li, J., Xu, L., Tang, F., Xie, X. S., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.040 · Cited by 302
Phylogenomic analysis of the GIY-YIG nuclease superfamily
Dunin-Horkawicz, S., Feder, M., & Bujnicki, J. M. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-98 · Cited by 133
Flott, S., Alabert, C., Toh, G. W., Toth, R., Sugawara, N., Campbell, D. G., Haber, J. E., Pasero, P., & Rouse, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00135-07 · Cited by 107 · cited 2×
“…with MUS81–EME1 and XPF–ERCC1 to assemble and regulate composite nuclease ensembles (budding yeast Slx4 interacts with XPF–ERCC1 ortholog, Rad1–Rad10, but not Mus81–Mms4) (Flott et al. 2007; Fekairi et al. 2009; Munoz et al. 2009; Svendsen et al. 2009; Castor et al. 2013; Wyatt et al. 2013).”
BackgroundAnalysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms
Abyzov, A., Li, S., Kim, D. R., Mohiyuddin, M., Stütz, A. M., Parrish, N. F., Mu, X. J., Clark, W., Chen, K., Hurles, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8256 · Cited by 91
Cited by
FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination
Fernandes, J. B., Duhamel, M., Seguéla-Arnaud, M., Froger, N., Girard, C., Choinard, S., Solier, V., De Winne, N., De Jaeger, G., Gevaert, K., et al. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007317 · Cited by 116
“Class I COs are dependent on the activity of a group of proteins collectively called ZMM (for Zip1-4, Msh4-5, Mer3) [11], which stabilize D-loop intermediates to promote formation of the double-Holliday junction intermediates [12].”
BackgroundStructural and functional characterization of the Spo11 core complex
Claeys Bouuaert, C., Tischfield, S. E., Pu, S., Mimitou, E. P., Arias-Palomo, E., Berger, J. M., & Keeney, S. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-00534-w · Cited by 87
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice
Zhu, J., Yang, Q., Li, H., Wang, Y., Jiang, Y., Wang, H., Cong, L., Xu, J., Shen, Z., Chen, W., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.324 · Cited by 64
The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly
Pyatnitskaya, A., Andreani, J., Guérois, R., De Muyt, A., & Borde, V. (2022) · Genes & Development · doi:10.1101/gad.348973.121 · Cited by 51
Felipe-Medina, N., Caburet, S., Sánchez-Sáez, F., Condezo, Y. B., de Rooij, D. G., Gómez-H, L., Garcia-Valiente, R., Todeschini, A. L., Duque, P., Sánchez-Martin, M. A., et al. (2020) · eLife · doi:10.7554/elife.56996 · Cited by 45
TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
Nore, A., Juarez-Martinez, A. B., Clément, J., Brun, C., Diagouraga, B., Laroussi, H., Grey, C., Bourbon, H. M., Kadlec, J., Robert, T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34799-0 · Cited by 43
Laroussi, H., Juarez‐Martinez, A. B., Le Roy, A., Boeri Erba, E., Gabel, F., de Massy, B., & Kadlec, J. (2023) · The EMBO Journal · doi:10.15252/embj.2023113866 · Cited by 22
BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode
(2024) · doi:10.1038/s41467-024-52699-3 · Cited by 21
Petassi, M., Shin, Y., Jessop, A. M., Morse, K., Kim, S. Y., Kuppa, S., Matei, R., Raina, V. B., & Greene, E. C. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.111019 · Cited by 2
Exportin-mediated nucleocytoplasmic transport maintains Pch2 homeostasis during meiosis
Herruzo, E., Sánchez-Díaz, E., González-Arranz, S., Santos, B., Carballo, J. A., & San-Segundo, P. A. (2023) · PLOS Genetics · doi:10.1371/journal.pgen.1011026 · Cited by 2
Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
(2025) · doi:10.1093/narmme/ugaf019
Metadata
- Authors
- Hunter, N.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-10-28
- Volume
- 7
- Issue
- 12
- Pages
- a016618
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W1876047377
- Cited by
- 780
- References
- 6
- Type
- posted content
- Language
- en
- Open access
- bronze
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