Retromer: A Master Conductor of Endosome Sorting
Open accessAbstract
The endosomal network comprises an interconnected network of membranous compartments whose primary function is to receive, dissociate, and sort cargo that originates from the plasma membrane and the biosynthetic pathway. A major challenge in cell biology is to achieve a thorough molecular description of how this network operates, and in so doing, how defects contribute to the etiology and pathology of human disease. We discuss the increasing body of evidence that implicates an ancient evolutionary conserved complex, termed "retromer," as a master conductor in the complex orchestration of multiple cargo-sorting events within the endosomal network.
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Impaired endocytic signaling has been observed during C9ORF72 mutated conditions in C9ORF72 ALS/FTD patients as well as the SH-SY5Y cell line model, suggesting that expression of C9ORF72 modulates endocytosis.
“Interestingly, the impaired endocytic signaling has been observed during C9ORF72 mutated conditions in C9ORF72 ALS/FTD patients as well as the SH-SY5Y cell line model, suggesting that the expression of C9ORF72 modulates endocytosis [172,173].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [173]
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- Authors
- Burd, C., & Cullen, P. J.
- Affiliations
- Yale University (US)
- University of Bristol (GB)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-02-01
- Volume
- 6
- Issue
- 2
- Pages
- a016774-a016774
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3941235
- OpenAlex
- W2110337011
- Cited by
- 435
- References
- 3
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 30 · 2023: 19 · 2022: 33 · 2021: 53 · 2020: 68 · 2019: 36 · 2018: 47 · 2017: 39 · 2016: 31 · 2015: 27 · 2014: 20
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Funders
- Wellcome Trust (083474, 089928)
- China Scholarship Council
- National Institutes of Health (GM061221)
- Directorate for Biological Sciences
- Medical Research Council (MR/K018299/1)
- Biotechnology and Biological Sciences Research Council (BB/I011412/1)
- National Institute of General Medical Sciences (R01GM061221, GM061221)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- retromer complex, endosomal sorting, cargo sorting, membrane trafficking, endosomes, biosynthetic pathway, etiology
- MeSH terms
- Humans, Endosomes, Protein Transport, trans-Golgi Network, Vesicular Transport Proteins
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