The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Epileptogenesis
Open accessAbstract
Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, a large number of animal models have become available for search of molecular mechanisms of epileptogenesis. The first glimpses of treatment targets and biomarkers that could be developed to become useful in clinic are in sight. However, the heterogeneity of the epilepsy condition, and the dynamics of molecular changes over the course of epileptogenesis remain as challenges to overcome.
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Citations
Cites
Animal models of traumatic brain injury
Xiong, Y., Mahmood, A., & Chopp, M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3407 · Cited by 1,408
National Center for Biotechnology Information
(2019) · Springer Reference Medizin · doi:10.1007/978-3-662-48986-4_301184 · Cited by 1,400
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“…a consequence of the wide variety of pathologies included under each term, including, for example, hemorrhagic versus ischemic stroke or subdural hemorrhage versus cortical contusion for TBI (Annegers et al. 1998; Hesdorffer et al. 1998; Saatman et al. 2008; Arntz et al. 2013; Graham et al. 2013).”
A population-based study of seizures after traumatic brain injuries
Annegers, J. F., Hauser, W. A., Coan, S. P., & Rocca, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801013380104 · Cited by 1,090
Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
Tauck, D., & Nadler, J. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-01016.1985 · Cited by 1,083
On the nature of seizure dynamics
Jirsa, V. K., Stacey, W. C., Quilichini, P. P., Ivanov, A. I., & Bernard, C. (2014) · Brain · doi:10.1093/brain/awu133 · Cited by 770
A synaptic organizing principle for cortical neuronal groups
Perin, R., Berger, T. K., & Markram, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016051108 · Cited by 718 · cited 1×
“We are just beginning to discover the strategies that neurons use to connect to other neurons (Bonefazzi et al. 2011; Perin et al. 2011), and we have essentially no data regarding the strategies used to restore neural connections after injury.”
Mechanisms of epileptogenesis and potential treatment targets
Pitkänen, A., & Lukasiuk, K. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70310-0 · Cited by 614
Self-citationEpileptogenesis in the immature brain: emerging mechanisms
Rakhade, S. N., & Jensen, F. E. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.80 · Cited by 552
Cited by
Seizures and Epilepsy: An Overview for Neuroscientists
Stafstrom, C. E., & Carmant, L. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022426 · Cited by 933
Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students
Lepeta, K., Lourenco, M. V., Schweitzer, B. C., Martino Adami, P. V., Banerjee, P., Catuara‐Solarz, S., de La Fuente Revenga, M., Guillem, A. M., Haidar, M., Ijomone, O. M., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13713 · Cited by 386
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein, P., Dingledine, R., Aronica, E., Bernard, C., Blümcke, I., Boison, D., Brodie, M. J., Brooks‐Kayal, A. R., Engel, J., Forcelli, P. A., et al. (2018) · Epilepsia · doi:10.1111/epi.13965 · Cited by 284
Self-citationDevelopmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Guerrini, R., Conti, V., Mantegazza, M., Balestrini, S., Galanopoulou, A. S., & Benfenati, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00063.2021 · Cited by 196
Management of epilepsy associated with tuberous sclerosis complex: Updated clinical recommendations
Curatolo, P., Nabbout, R., Lagae, L., Aronica, E., Ferreira, J. C., Feucht, M., Hertzberg, C., Jansen, A. C., Jansen, F., Kotulska, K., et al. (2018) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2018.05.006 · Cited by 190
Metadata
- Authors
- Pitkänen, A., Lukasiuk, K., Dudek, F. E., & Staley, K. J.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-09-18
- Volume
- 5
- Issue
- 10
- Pages
- a022822
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W4241717408
- Cited by
- 357
- References
- 118
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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