The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Animal models of traumatic brain injury
Open accessAbstract
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling changes in cognition, sensorimotor function and personality. Over the past three decades, animal models have been developed to replicate the various aspects of human TBI, to better understand the underlying pathophysiology and to explore potential treatments. Nevertheless, promising neuroprotective drugs that were identified as being effective in animal TBI models have all failed in Phase II or Phase III clinical trials. This failure in clinical translation of preclinical studies highlights a compelling need to revisit the current status of animal models of TBI and therapeutic strategies.
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Cites
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A controlled cortical impact model of traumatic brain injury in the rat
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Cited by
Neuroinflammation: The Devil Is in the Details
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The hubs of the human connectome are generally implicated in the anatomy of brain disorders
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Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift
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Self-citation
Metadata
- Authors
- Xiong, Y., Mahmood, A., & Chopp, M.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-01-18
- Volume
- 14
- Issue
- 2
- Pages
- 128-142
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2071425128
- Cited by
- 1,408
- References
- 21
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
