The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
TET2 in Normal and Malignant Hematopoiesis
Abstract
The ten-eleven translocation (TET) family of enzymes were originally cloned from the translocation breakpoint of t(10;11) in infant acute myeloid leukemia (AML) with subsequent genomic analyses revealing somatic mutations and suppressed expression of TET family members across a range of malignancies, particularly enriched in hematological neoplasms. The TET family of enzymes is responsible for the hydroxylation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosine (5-hmC), followed by active and passive mechanisms leading to DNA demethylation. Given the complexity and importance of DNA methylation events in cellular proliferation and differentiation, it comes as no surprise that the TET family of enzymes is intricately regulated by both small molecules and regulatory cooperating proteins. Here, we review the structure and function of TET2, its interactions with cooperating mutations and small molecules, and its role in aberrant hematopoiesis.
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“Mechanistically, DNMT3A catalyzes de novo DNA methylation whereas TET2 oxidizes methylated CpG to 5-hydroxymethyl cytosine (5-hmC) facilitating further modification to unmodified cysteine; mutations thus cause dysregulated DNA methylation and demethylation, respectively, altering the expression of genes involved in proliferation, differentiation and inflammation via chromatin-level changes 209,210”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [209]
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
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Clonal haematopoiesis and dysregulation of the immune system
Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.05.006 · Cited by 129
Metadata
- Authors
- Bowman, R. L., & Levine, R. L.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-02-27
- Volume
- 7
- Issue
- 8
- Pages
- a026518
- ISSN
- 2157-1422
- Cited by
- 94
- References
- 73
- Language
- en
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