The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Interleukin-6 Family Cytokines
Open accessAbstract
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine (CLC), and IL-27. They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and IL-11) or one molecule (all others cytokines) of the signaling receptor subunit gp130. IL-6 family cytokines have overlapping but also distinct biologic activities and are involved among others in the regulation of the hepatic acute phase reaction, in B-cell stimulation, in the regulation of the balance between regulatory and effector T cells, in metabolic regulation, and in many neural functions. Blockade of IL-6 family cytokines has been shown to be beneficial in autoimmune diseases, but bacterial infections and metabolic side effects have been observed. Recent advances in cytokine blockade might help to minimize such side effects during therapeutic blockade.
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Citations
Cites
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BackgroundResultInfluentialBlastocyst implantation depends on maternal expression of leukaemia inhibitory factor
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Impaired immune and acute-phase responses in interleukin-6-deficient mice
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“In mice fed a high-fat diet, selective blockade of IL-6 trans-signaling prevented the inflammatory infiltration of macrophages into adipose tissue (Kraakman et al. 2015) without leading to increased insulin resistance or decreased glucose tolerance, which had been observed in IL-62/2 mice (Matthews…”
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Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
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Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
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Cited by
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
Jones, S. A., & Jenkins, B. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0066-7 · Cited by 1,102
Harnessing cytokines and chemokines for cancer therapy
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Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis
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Targeting IL-6 trans-signalling: past, present and future prospects
Rose-John, S., Jenkins, B. J., Garbers, C., Moll, J. M., & Scheller, J. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00856-y · Cited by 524
Self-citationRegulation of Osteoclast Differentiation by Cytokine Networks
Amarasekara, D. S., Yun, H., Kim, S., Lee, N., Kim, H., & Rho, J. (2018) · Immune Network · doi:10.4110/in.2018.18.e8 · Cited by 518
Metadata
- Authors
- Rose-John, S.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-06-15
- Volume
- 10
- Issue
- 2
- Pages
- a028415
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2626842659
- Cited by
- 799
- References
- 127
- Type
- posted content
- Language
- en
- Open access
- bronze
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