Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior
Open accessAbstract
, the "circadian clock" is housed in seven neuronal clusters, which are defined by their expression of the main circadian proteins, Period, Timeless, Clock, and Cycle. These clusters are distributed across the fly brain and are thereby subject to the respective environments associated with their anatomical locations. While these core components are universally expressed in all neurons of the circadian network, additional regulatory proteins that act on these components are differentially expressed, giving rise to "local clocks" within the network that nonetheless converge to regulate coherent behavioral rhythms. In this review, we describe the communication between the neurons of the circadian network and the molecular differences within neurons of this network. We focus on differences in protein-expression patterns and discuss how such variation can impart functional differences in each local clock. Finally, we summarize our current understanding of how communication within the circadian network intersects with intracellular biochemical mechanisms to ultimately specify behavioral rhythms. We propose that additional efforts are required to identify regulatory mechanisms within each neuronal cluster to understand the molecular basis of circadian behavior.
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The human brain has a master 'Body Clock' which resides in the suprachiasmatic nucleus (SCN) of the hypothalamus and it determines our daily rhythms.
“The human brain has a master ‘Body Clock’ which resides in the suprachiasmatic nucleus (SCN) of the hypothalamus and it determines our daily rhythms, a phenomenon also widely described in nature in almost all living organisms 1, 2.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [2]
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The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works
Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis
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Circadian and epigenetic control of depression-like behaviors
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- Authors
- Top, D., & Young, M. W.
- Affiliations
- Rockefeller University (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-09-11
- Volume
- 10
- Issue
- 7
- Pages
- a033589
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC6028074
- OpenAlex
- W2754810736
- Cited by
- 89
- References
- 188
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 8 · 2019: 9 · 2018: 24
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R37GM054339)
- National Institute of Neurological Disorders and Stroke (R37NS053087)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- circadian clock, Drosophila, local clocks, neuronal clusters, period, TIMELESS, clocks, cycles, protein expression patterns, neural communication, behavioral rhythms, circadian activity
- MeSH terms
- Animals, Circadian Rhythm, Motor Activity, Nerve Net, Neurons, Circadian Clocks
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