Introduction to Chronobiology
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A diverse range of species, from cyanobacteria to humans, evolved endogenous biological clocks that allow for the anticipation of daily variations in light and temperature. The ability to anticipate regular environmental rhythms promotes optimal performance and survival. Herein we present a brief historical timeline of how circadian concepts and terminology have emerged since the early observation of daily leaf movement in plants made by an astronomer in the 1700s.
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The human brain has a master 'Body Clock' which resides in the suprachiasmatic nucleus (SCN) of the hypothalamus and it determines our daily rhythms.
“The human brain has a master ‘Body Clock’ which resides in the suprachiasmatic nucleus (SCN) of the hypothalamus and it determines our daily rhythms, a phenomenon also widely described in nature in almost all living organisms 1, 2.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [1]
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Otsuka, K., Cornélissen, G., & Franz Halberg, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-54631-3_14 · Cited by 2 · see citing works
Gamsızkan, Z., & Gönüllü, İ. (2022) · Advanced Education · doi:10.20535/2410-8286.256136 · Cited by 2 · see citing works
No evidence of time–place learning in juvenile lemon sharks, Negaprion brevirostris
Heinrich, D. D. U., Dhellemmes, F., Guttridge, T. L., Brown, C., & Huveneers, C. P. M. (2023) · Animal Behaviour · doi:10.1016/j.anbehav.2023.06.008 · Cited by 2 · see citing works
Chronotherapie affektiver Störungen: Grundlagen und klinische Aspekte
Ludwig, V. M., Münch, I., Wirz‐Justice, A., & Ritter, P. S. (2022) · Der Nervenarzt · doi:10.1007/s00115-022-01323-0 · Cited by 1 · see citing works
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Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats
Jones, A. A., Marciante, A. B., Berardi, P., & Mitchell, G. S. (2026) · Function · doi:10.1152/function.016.2026 · Cited by 1 · see citing works
Chronobiological aspects of the excretory system (review)
Bezruk, V. V., Ivanov, D. D., & Shkrobanets, І. D. (2022) · KIDNEYS · doi:10.22141/2307-1257.11.3.2022.377 · Cited by 1 · see citing works
Clark, A. D., Cumpstey, A. F., Santolini, J., Jackson, A. A., & Feelisch, M. (2023) · Open Biology · doi:10.1098/rsob.230151 · Cited by 1 · see citing works
Human primary cells can tell body time: Dedicated to Steven A. Brown
Katsioudi, G., Biancolin, A. D., Jiménez‐Sánchez, C., & Dibner, C. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16453 · Cited by 1 · see citing works
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Vinterhalter, D., Motyka, V., & Vinterhalter, B. (2025) · International Journal of Plant Biology · doi:10.3390/ijpb16010008 · Cited by 1 · see citing works
From Chronobiology to Chronomedicine: Early Days
Otsuka, K., Cornélissen, G., & Franz Halberg, A. (2016) · Springer eBooks · doi:10.1007/978-4-431-54631-3_1 · Cited by 1 · see citing works
Chronobiology and Chronotherapy in Depression: Current Knowledge and Chronotherapeutic Promises
Rojas, M., Chávez-Castillo, M., Pírela, D., Ortega, Á., Salazar, J. J., Cano, C., Chacín, M., Riaño-Garzón, M., Batista, M. J., Díaz-Camargo, E. A., et al. (2020) · Current Psychiatry Research and Reviews · doi:10.2174/2666082216999201124152432 · Cited by 1 · see citing works
A trio of biological rhythms and their relevance in rhythmic mechanical stimulation of cell cultures
Kwak, D., Olsen, P. A., Danielsen, A., & Jensenius, A. R. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.867191 · Cited by 2 · see citing works
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“What Is Life?” Cycles Tipping the Scale Between Death and Survival
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Introduction to Chronobioengineering
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- Authors
- Kuhlman, S. J., Craig, L. M., & Duffy, J. F.
- Affiliations
- Center for the Neural Basis of Cognition (US)
- Brigham and Women's Hospital (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-10-16
- Volume
- 10
- Issue
- 9
- Pages
- a033613
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC6120700
- OpenAlex
- W2766819754
- Cited by
- 107
- References
- 43
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 11 · 2023: 16 · 2022: 20 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32HL007901)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Social Sciences › Arts and Humanities › History and Philosophy of Science › History of Science and Medicine
- Keywords
- chronobiology, circadian rhythm, biological clock, circadian clock evolution, cyanobacteria
- MeSH terms
- Shift Work Schedule, Adaptation, Physiological, Animals, Circadian Rhythm, Gene Expression Regulation, Humans, Terminology as Topic, Temperature, History, 16th Century, History, 17th Century, History, 18th Century, History, 19th Century, History, 20th Century, History, 21st Century, Chronobiology Discipline
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