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Multivariable Mendelian Randomization and Mediation
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The directional effects between diseases and longevity persisted after adjustment for socioeconomic factors.
“the directional effects between diseases and longevity persisted after adjustment for socioeconomic factors73,74.”
From Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans (2026) · cites this paper as [73]
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BackgroundRichardson, T. G., Sanderson, E., Palmer, T. M., Ala-Korpela, M., Ference, B. A., Davey Smith, G., & Holmes, M. V. (2020) · PLOS Medicine · doi:10.1371/journal.pmed.1003062 · Cited by 843
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Sanderson, E., Glymour, M. M., Holmes, M. V., Kang, H., Morrison, J., Munafò, M. R., Palmer, T., Schooling, C. M., Wallace, C., Zhao, Q., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00092-5 · Cited by 2,229
Self-citationMendelian randomisation for mediation analysis: current methods and challenges for implementation
Carter, A. R., Sanderson, E., Hammerton, G., Richmond, R. C., Davey Smith, G., Heron, J., Taylor, A. E., Davies, N. M., & Howe, L. D. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-021-00757-1 · Cited by 1,215
Self-citationMendelian Randomization: Concepts and Scope
Richmond, R. C., & Davey Smith, G. (2022) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040501 · Cited by 841
Using Mendelian Randomization to Improve the Design of Randomized Trials
Ference, B. A., Holmes, M. V., & Smith, G. D. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040980 · Cited by 338
Triangulating Evidence through the Inclusion of Genetically Informed Designs
Munafò, M. R., Higgins, J. P. T., & Smith, G. D. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040659 · Cited by 125
Navarese, E. P., Vine, D., Proctor, S., Grzelakowska, K., Berti, S., Kubica, J., & Raggi, P. (2023) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.123.319297 · Cited by 107
Interpretation of mendelian randomization using one measure of an exposure that varies over time
Morris, T. T., Heron, J., Sanderson, E., Smith, G. D., & Tilling, K. (2021) · doi:10.1101/2021.11.18.21266515 · Cited by 58
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“Standard errors for the effects of genetically proxied lipid-modifying targets on CAVS risk via each potential mediator were derived with the delta method 32 .”
Metadata
- Authors
- Sanderson, E.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2020-04-27
- Volume
- 11
- Issue
- 2
- Pages
- a038984
- ISSN
- 2157-1422
- Cited by
- 827
- References
- 17
- Language
- en
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