Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882 · see citing works

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618 · see citing works

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works

Biological, clinical and population relevance of 95 loci for blood lipids

Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,527 · see citing works

Perceptions of epigenetics

Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011 · see citing works

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies

Law, M. R., Morris, J. K., & Wald, N. J. (2009) · BMJ · doi:10.1136/bmj.b1665 · Cited by 2,775 · see citing works

Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563 · see citing works

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177 · see citing works

Identifiability and exchangeability for direct and indirect effects

Robins, J. M., & Greenland, S. (1992) · Epidemiology · doi:10.1097/00001648-199203000-00013 · Cited by 1,793 · see citing works

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Jablonka, E., & Raz, G. (2009) · The Quarterly Review of Biology · doi:10.1086/598822 · Cited by 1,659 · see citing works

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D. P., Heath, S. C., Depner, M., Berg, A. V., Bufe, A., Rietschel, E., et al. (2007) · Nature · doi:10.1038/nature06014 · Cited by 1,590 · see citing works

Principles and challenges of genome-wide DNA methylation analysis

Laird, P. W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2732 · Cited by 1,574 · see citing works

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Gerken, T., Girard, C. A. J., Tung, Y. L., Webby, C. J., Saudek, V., Hewitson, K. S., Yeo, G. S. H., McDonough, M. A., Cunliffe, S. L., McNeill, L. A., et al. (2007) · Science · doi:10.1126/science.1151710 · Cited by 1,518 · see citing works

Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction

Kamstrup, P. R. (2009) · JAMA · doi:10.1001/jama.2009.801 · Cited by 1,357 · see citing works

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327 · see citing works

Genetics of gene expression and its effect on disease

Emilsson, V., Thorleifsson, G., Zhang, B., Leonardson, A. S., Zink, F., Zhu, J., Carlson, S., Helgason, A., Walters, G. B., Gunnarsdottir, S., et al. (2008) · Nature · doi:10.1038/nature06758 · Cited by 1,296 · see citing works

Epigenome-wide association studies for common human diseases

Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3000 · Cited by 1,272 · see citing works

Evolution in four dimensions: genetic, epigenetic, behavioral, and symbolic variation in the history of life

Blackwell, A. D. (2014) · Choice Reviews Online · doi:10.5860/choice.185702 · Cited by 1,261 · see citing works

Problems of reporting genetic associations with complex outcomes

Colhoun, H. M., McKeigue, P., & Smith, G. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12715-8 · Cited by 1,203 · see citing works

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

Carone, B. R., Fauquier, L., Habib, N., Shea, J. M., Hart, C. E., Li, R., Bock, C., Li, C., Gu, H., Zamore, P. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.12.008 · Cited by 1,157 · see citing works

An introduction to instrumental variables for epidemiologists

Greenland, S. (2000) · International Journal of Epidemiology · doi:10.1093/ije/29.4.722 · Cited by 1,156 · see citing works

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

The Tobacco and Genetics Consortium (2010) · Nature Genetics · doi:10.1038/ng.571 · Cited by 1,098 · see citing works

Increased methylation variation in epigenetic domains across cancer types

Hansen, K. D., Timp, W., Bravo, H. C., Sabunciyan, S., Langmead, B., McDonald, O. G., Wen, B., Wu, H., Liu, Y., Diep, D. H., et al. (2011) · Nature Genetics · doi:10.1038/ng.865 · Cited by 1,053 · see citing works

An integrative genomics approach to infer causal associations between gene expression and disease

Schadt, E. E., Lamb, J., Yang, X., Zhu, J., Edwards, S., GuhaThakurta, D., Sieberts, S. K., Monks, S., Reitman, M., Zhang, C., et al. (2005) · Nature Genetics · doi:10.1038/ng1589 · Cited by 1,043 · see citing works

Genetical genomics: the added value from segregation

Jansen, R. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02310-1 · Cited by 1,010 · see citing works

RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

Rassoulzadegan, M., Grandjean, V., Gounon, P., Vincent, S. D., Gillot, I., & Cuzin, F. (2006) · Nature · doi:10.1038/nature04674 · Cited by 921 · see citing works

Variations in DNA elucidate molecular networks that cause disease

Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J., Zhang, C., Lamb, J., Edwards, S., Sieberts, S. K., et al. (2008) · Nature · doi:10.1038/nature06757 · Cited by 887 · see citing works

Genetically elevated C-reactive protein and ischemic vascular disease

Zacho, J., Tybjærg-Hansen, A., Jensen, J. S., Grande, P., Sillesen, H., & Nordestgaard, B. G. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707402 · Cited by 839 · see citing works

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

Bell, J. T., Pai, A. A., Pickrell, J. K., Gaffney, D. J., Pique-Regi, R., Degner, J. F., Gilad, Y., & Pritchard, J. K. (2011) · Genome Biology · doi:10.1186/gb-2011-12-1-r10 · Cited by 838 · see citing works

Molecular networks as sensors and drivers of common human diseases

Schadt, E. E. (2009) · Nature · doi:10.1038/nature08454 · Cited by 806 · see citing works

Epigenetics: Definition, Mechanisms and Clinical Perspective

Dupont, C., Armant, D. R., & Brenner, C. A. (2009) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1237423 · Cited by 805 · see citing works

Illustrating bias due to conditioning on a collider

Cole, S. R., Platt, R. W., Schisterman, E. F., Chu, H., Westreich, D., Richardson, D., & Poole, C. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyp334 · Cited by 796 · see citing works

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain

Gibbs, J. R., van der Brug, M. P., Hernandez, D. G., Traynor, B. J., Nalls, M. A., Lai, S.-L., Arepalli, S., Dillman, A., Rafferty, I. P., Troncoso, J., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000952 · Cited by 769 · see citing works

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity

Godfrey, K. M., Sheppard, A. M., Gluckman, P. D., Lillycrop, K. A., Burdge, G. C., McLean, C. A., Rodford, J., Slater-Jefferies, J. L., Garratt, E. S., Crozier, S., et al. (2011) · Diabetes · doi:10.2337/db10-0979 · Cited by 754 · see citing works

Sex hormone-binding globulin and risk of type 2 diabetes in women and men

Ding, E. L., Song, Y., Manson, J. E., Hunter, D. J., Lee, C. C., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804381 · Cited by 726 · see citing works

Transgenerational inheritance of epigenetic states at the murine Axin Fu allele occurs after maternal and paternal transmission

Rakyan, V. K., Chong, S., Blewitt, M. E., Cuthbert, P. C., Morgan, H. D., Luu, K. V. K., & Whitelaw, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436776100 · Cited by 642 · see citing works

Tobacco-smoking-related differential DNA methylation: 27K discovery and replication

Breitling, L. P., Yang, R., Korn, B., Burwinkel, B., & Brenner, H. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.03.003 · Cited by 640 · see citing works

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

Ji, H., Ehrlich, L. I. R., Seita, J., Murakami, P. N., Doi, A., Lindau, P., Lee, H.-J., Aryee, M. J., Irizarry, R. A., Kim, K., et al. (2010) · Nature · doi:10.1038/nature09367 · Cited by 636 · see citing works

DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing

Brenet, F. A., Moh, M., Funk, P., Feierstein, E., Viale, A. J., Socci, N. D., & Scandura, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014524 · Cited by 627 · see citing works

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

Urdinguio, R. G., Sanchez-Mut, J. V., & Esteller, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70262-5 · Cited by 581 · see citing works

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

Smith, G. D., Lawlor, D. A., Harbord, R., Timpson, N., Day, I., & Ebrahim, S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040352 · Cited by 569 · see citing works

W. H. Fox Talbot and the history of photography

Gernsheim, H. (1977) · Endeavour · doi:10.1016/0160-9327(77)90005-9 · Cited by 565 · see citing works

Fallibility in estimating direct effects

Cole, S. R., & Hernán, M. A. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.163 · Cited by 548 · see citing works

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

Smith, G. D., & Ebrahim, S. (2005) · BMJ · doi:10.1136/bmj.330.7499.1076 · Cited by 545 · see citing works

Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease

Feinberg, A. P., & Irizarry, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906183107 · Cited by 524 · see citing works

Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

Waterland, R. A., Kellermayer, R., Laritsky, E., Rayco‐Solon, P., Harris, R. A., Travisano, M., Zhang, W., Torskaya, M. S., Zhang, J., Shen, L., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001252 · Cited by 454 · see citing works

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

McGowan, P. O., Suderman, M., Sasaki, A., Huang, T. C. T., Hallett, M., Meaney, M. J., & Szyf, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014739 · Cited by 452 · see citing works

Genomic Medicine — An Updated Primer

Feero, W. G., Guttmacher, A. E., & Collins, F. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0907175 · Cited by 440 · see citing works

Methyl donor supplementation prevents transgenerational amplification of obesity

Waterland, R. A., Travisano, M., Tahiliani, K. G., Rached, M.-T., & Mirza, S. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.100 · Cited by 414 · see citing works

Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?

Ebrahim, S., & Davey Smith, G. (2008) · Human Genetics · doi:10.1007/s00439-007-0448-6 · Cited by 410 · see citing works

Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

Zhang, D., Cheng, L., Badner, J. A., Chen, C., Chen, Q., Luo, W., Craig, D. W., Redman, M., Gershon, E. S., & Liu, C. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.02.005 · Cited by 388 · see citing works

Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome

Shoemaker, R., Deng, J., Wang, W., & Zhang, K. (2010) · Genome Research · doi:10.1101/gr.104695.109 · Cited by 380 · see citing works

Distinct DNA methylation changes highly correlated with chronological age in the human brain

Hernandez, D. G., Nalls, M. A., Gibbs, J. R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D. L., Cookson, M., Traynor, B. J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq561 · Cited by 376 · see citing works

Mendelian Randomisation and Causal Inference in Observational Epidemiology

Sheehan, N. A., Didelez, V., Burton, P. R., & Tobin, M. D. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050177 · Cited by 373 · see citing works

Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability

(2011) · Epigenetics · doi:10.4161/epi.6.7.16537 · Cited by 368 · see citing works

An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer

Teschendorff, A. E., Menon, U., Gentry‐Maharaj, A., Ramus, S. J., Gayther, S. A., Apostolidou, S., Jones, A., Lechner, M., Beck, S., Jacobs, I. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008274 · Cited by 357 · see citing works

Epigenetics and transgenerational transfer: a physiological perspective

Ho, D. H., & Burggren, W. W. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.019752 · Cited by 353 · see citing works

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

Timpson, N. J., Lawlor, D. A., Harbord, R. M., Gaunt, T. R., Day, I. N. M., Palmer, L. J., Hattersley, A. T., Ebrahim, S. B. J., Lowe, G. D. O., Rumley, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67786-0 · Cited by 344 · see citing works

Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

Feinberg, A. P., Irizarry, R. A., Fradin, D. D., Aryee, M. J., Murakami, P. N., Aspelund, T., Eiríksdóttir, G., Harris, T. B., Launer, L. J., Gudnason, V. G., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001262 · Cited by 335 · see citing works

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

Seong, K.-H., Li, D., Shimizu, H., Nakamura, R., & Ishii, S. (2011) · Cell · doi:10.1016/j.cell.2011.05.029 · Cited by 322 · see citing works

DNA methylation in white blood cells

Terry, M. B., Delgado‐Cruzata, L., Vin‐Raviv, N., Wu, H. C., & Santella, R. M. (2011) · Epigenetics · doi:10.4161/epi.6.7.16500 · Cited by 318 · see citing works

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

Chen, L., Davey Smith, G., Harbord, R. M., & Lewis, S. J. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050052 · Cited by 314 · see citing works

A Unified Approach to the Evolutionary Consequences of Genetic and Nongenetic Inheritance

Day, T., & Russell Bonduriansky, A. (2011) · The American Naturalist · doi:10.1086/660911 · Cited by 305 · see citing works

Transgenerational epigenetic inheritance: More questions than answersPreprint

Daxinger, L., & Whitelaw, E. (2010) · Genome Research · doi:10.1101/gr.106138.110 · Cited by 305 · see citing works

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

Bell, C. G., Teschendorff, A. E., Rakyan, V. K., Maxwell, A. P., Beck, S., & Savage, D. A. (2010) · BMC Medical Genomics · doi:10.1186/1755-8794-3-33 · Cited by 302 · see citing works

Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study

Scott, J. A. G., Berkley, J. A., Mwangi, I., Ochola, L., Uyoga, S., Macharia, A., Ndila, C., Lowe, B. S., Mwarumba, S., Bauni, E., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60888-x · Cited by 294 · see citing works

Long-term gene silencing by RNAi

Vastenhouw, N. L., Brunschwig, K., Okihara, K. L., Müller, F., Tijsterman, M., & Plasterk, R. H. A. (2006) · Nature · doi:10.1038/442882a · Cited by 288 · see citing works

SHOX2 DNA Methylation Is a Biomarker for the Diagnosis of Lung Cancer in Plasma

Kneip, C., Schmidt, B., Seegebarth, A., Weickmann, S., Fleischhacker, M., Liebenberg, V., Field, J. K., & Dietrich, D. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318220ef9a · Cited by 265 · see citing works

Assessing Intrauterine Influences on Offspring Health Outcomes: Can Epidemiological Studies Yield Robust Findings?

Smith, G. D. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00191.x · Cited by 257 · see citing works

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

Bell, C. G., Finer, S., Lindgren, C. M., Wilson, G. A., Rakyan, V. K., Teschendorff, A. E., Akan, P., Stupka, E., Down, T. A., Prokopenko, I., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014040 · Cited by 255 · see citing works

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

Relton, C. L., & Davey Smith, G. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000356 · Cited by 254 · see citing works

The rate of polygenic mutation

Lynch, M. F. (1988) · Genetics Research · doi:10.1017/s0016672300024150 · Cited by 249 · see citing works

Mechanisms of epigenetic inheritance

Martin, C. C., & Zhang, Y. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.04.002 · Cited by 236 · see citing works

Shaking the tree: mapping complex disease genes with linkage disequilibrium

Palmer, L. J., & Cardon, L. R. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67485-5 · Cited by 234 · see citing works

Reverse engineering the genotype–phenotype map with natural genetic variation

Rockman, M. V. (2008) · Nature · doi:10.1038/nature07633 · Cited by 231 · see citing works

The epigenetics revolution: how modern biology is rewriting our understanding of genetics, disease, and inheritance

(2012) · Choice Reviews Online · doi:10.5860/choice.49-6870 · Cited by 218 · see citing works

Commentary: The concept of 'Mendelian Randomization'

Thomas, D. C. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh048 · Cited by 217 · see citing works

Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature

Wright, M. W., & Bruford, E. A. (2011) · Human Genomics · doi:10.1186/1479-7364-5-2-90 · Cited by 213 · see citing works

Association of C-Reactive Protein With Blood Pressure and Hypertension

Smith, G. D., Lawlor, D. A., Harbord, R. M., Timpson, N. J., Rumley, A., Lowe, G. D. O., Day, I. N. M., & Ebrahim, S. B. J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160351.95181.d0 · Cited by 210 · see citing works

A Genome-Wide Study of DNA Methylation Patterns and Gene Expression Levels in Multiple Human and Chimpanzee Tissues

Pai, A. A., Bell, J. T., Marioni, J. C., Pritchard, J. K., & Gilad, Y. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001316 · Cited by 209 · see citing works

Mendelian Randomization

Thanassoulis, G., & O’Donnell, C. J. (2009) · JAMA · doi:10.1001/jama.2009.812 · Cited by 209 · see citing works

Cardiovascular Epigenetics

Baccarelli, A., Rienstra, M., & Benjamin, E. J. (2010) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.110.958744 · Cited by 200 · see citing works

Diet‐induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female

Waterland, R. A., Travisano, M., & Tahiliani, K. G. (2007) · The FASEB Journal · doi:10.1096/fj.07-8229com · Cited by 193 · see citing works

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

Sovio, U., Mook-Kanamori, D. O., Warrington, N. M., Lawrence, R., Briollais, L., Palmer, C. N. A., Cecil, J. E., Sandling, J. K., Syvänen, A., Kaakinen, M., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001307 · Cited by 192 · see citing works

Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?

Timpson, N. J., Harbord, R. M., Smith, G. D., Zacho, J., Tybjærg‐Hansen, A., & Nordestgaard, B. G. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130005 · Cited by 187 · see citing works

Allele-specific DNA methylation: beyond imprinting

Tycko, B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq376 · Cited by 178 · see citing works

Weismann Rules! OK? Epigenetics and the Lamarckian temptation

Haig, D. (2006) · Biology & Philosophy · doi:10.1007/s10539-006-9033-y · Cited by 175 · see citing works

Insight into the nature of the CRP–coronary event association using Mendelian randomization

Casas, J. P., Shah, T., Cooper, J. A., Hawe, E., McMahon, A. D., Gaffney, D. F., Packard, C. J., O’Reilly, D. S. J., Juhan-Vague, I., Yudkin, J. S., et al. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl041 · Cited by 172 · see citing works

Acetate, the Key Modulator of Inflammatory Responses in Acute Alcoholic Hepatitis

Kendrick, S. F. W., O’Boyle, G., Mann, J., Zeybel, M., Palmer, J. M., Jones, D. E. J., & Day, C. (2010) · Hepatology · doi:10.1002/hep.23572 · Cited by 169 · see citing works

Low-Density Lipoprotein Cholesterol and the Risk of Cancer: A Mendelian Randomization Study

Benn, M., Tybjærg‐Hansen, A., Stender, S., Frikke‐Schmidt, R., & Nordestgaard, B. G. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr008 · Cited by 167 · see citing works

Epigenetic Programming of Phenotypic Variations in Reproductive Strategies in the Rat Through Maternal Care

Cameron, N. M., Shahrokh, D. K., Corpo, A. D., Dhir, S. K., Moshe Szyf, A., Champagne, F. A., & Meaney, M. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01725.x · Cited by 167 · see citing works

The case for transgenerational epigenetic inheritance in humans

Morgan, D. K., & Whitelaw, E. (2008) · Mammalian Genome · doi:10.1007/s00335-008-9124-y · Cited by 163 · see citing works

Epigenetics and parental effects

Kappeler, L., & Meaney, M. J. (2010) · BioEssays · doi:10.1002/bies.201000015 · Cited by 150 · see citing works

Fibrinogen and coronary heart disease: test of causality by ‘Mendelian randomization’

Keavney, B. D., Danesh, J., Parish, S., Palmer, A., Clark, S., Youngman, L. D., Délepine, M., Lathrop, M. G., Peto, R., & Collins, R. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl114 · Cited by 142 · see citing works

Allele-specific methylation in the human genome: Implications for genetic studies of complex disease

Meaburn, E. L., Schalkwyk, L. C., & Mill, J. (2010) · Epigenetics · doi:10.4161/epi.5.7.12960 · Cited by 132 · see citing works

A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder

Kaminsky, Z. A., Tochigi, M., Jia, P., Pal, M., Mill, J. S., Kwan, A., Ioshikhes, I. P., Vincent, J. B., Kennedy, J. L., Strauss, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.64 · Cited by 132 · see citing works

The inheritance of acquired epigenetic variations.

Jablonka, E., & Lamb, M. (1989) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(89)80058-x · Cited by 129 · see citing works

DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer

Marsit, C. J., Koestler, D. C., Christensen, B. C., Karagas, M. R., Houseman, E. A., & Kelsey, K. T. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.3577 · Cited by 128 · see citing works

Genome-scale approaches to the epigenetics of common human disease

Feinberg, A. P. (2009) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0847-2 · Cited by 126 · see citing works

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

Reynard, L. N., Bui, C., Canty‐Laird, E. G., Young, D. A., & Loughlin, J. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr253 · Cited by 123 · see citing works

Long non-coding RNAs and enhancers

Ørom, U. A., & Shiekhattar, R. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.01.020 · Cited by 122 · see citing works

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

Freathy, R. M., Kazeem, G., Morris, R. W., Johnson, P., Paternoster, L., Ebrahim, S. B. J., Hattersley, A. T., Hill, A., Hingorani, A. D., Holst, J. J., et al. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr077 · Cited by 122 · see citing works

Extensive sequence-influenced DNA methylation polymorphism in the human genome

Hellman, A., & Chess, A. J. (2010) · Epigenetics & Chromatin · doi:10.1186/1756-8935-3-11 · Cited by 120 · see citing works

Genomic Imprinting Syndromes and Cancer

Lim, D., & Maher, E. R. (2010) · Advances in genetics · doi:10.1016/b978-0-12-380866-0.60006-x · Cited by 117 · see citing works

Genetical genomics: combining genetics with gene expression analysis

Li, J. Z., & Burmeister, M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi267 · Cited by 109 · see citing works

Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype

Brennan, P., McKay, J., Moore, L. E., Zaridze, D., Mukeria, A., Szeszenia‐Dąbrowska, N., Lissowska, J., Rudnai, P., Fabiánová, E., Mateș, D., et al. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp162 · Cited by 108 · see citing works

Global Methylation in Exposure Biology and Translational Medical Science

Nelson, H. H., Marsit, C. J., & Kelsey, K. T. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1103423 · Cited by 98 · see citing works

How Does Body Fat Influence Bone Mass in Childhood? A Mendelian Randomization Approach

Timpson, N. J., Sayers, A. E., Smith, G. D., & Tobias, J. H. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081109 · Cited by 94 · see citing works

Transgenerational inheritance of stress pathology

Matthews, S. G., & Phillips, D. I. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.01.009 · Cited by 91 · see citing works

Bookmarking the Genome: Maintenance of Epigenetic Information

Zaidi, S. K., Young, D. W., Montecino, M. A., van Wijnen, A. J., Stein, J. L., Lian, J. B., & Stein, G. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.197061 · Cited by 89 · see citing works

Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice

Drake, T. A., Schadt, E. E., & Lusis, A. J. (2006) · Mammalian Genome · doi:10.1007/s00335-005-0175-z · Cited by 79 · see citing works

A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice

Li, C. C. Y., Cropley, J. E., Cowley, M. J., Preiß, T., Martin, D. I. K., & Suter, C. M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001380 · Cited by 75 · see citing works

Genetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine Levels, and Risk of Lung Cancer in EPIC

Timofeeva, M. N., McKay, J., Smith, G. D., Johansson, M., Byrnes, G. B., Chabrier, A., Relton, C. L., Ueland, P. M., Vollset, S. E., Midttun, Ø., et al. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0496 · Cited by 69 · see citing works

Epigenesis for epidemiologists: does evo-devo have implications for population health research and practice?

Davey Smith, G. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys016 · Cited by 68 · see citing works

Epigenetics: the ultimate mystery of inheritance

(2011) · Choice Reviews Online · doi:10.5860/choice.49-1441 · Cited by 66 · see citing works

Evidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility

Crépin, M., Dieu, M., Lejeune, S., Escande, F., Boidin, D., Porchet, N., Morin, G., Manouvrier‐Hanu, S., Mathieu, M., & Buisine, M. (2011) · Human Mutation · doi:10.1002/humu.21617 · Cited by 66 · see citing works

HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombinationPreprint

Sigurdsson, M. I., Smith, A. V., Bjornsson, H. T., & Jónsson, J. J. (2009) · Genome Research · doi:10.1101/gr.086181.108 · Cited by 66 · see citing works

A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women

Zuccolo, L., Fitz-Simon, N., Gray, R., Ring, S. M., Sayal, K. S., Smith, G. D., & Lewis, S. J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp388 · Cited by 63 · see citing works

Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass

Groom, A., Potter, C., Swan, D., Fatemifar, G., Evans, D. M., Ring, S. M., Turcot, V., Pearce, M. S., Embleton, N. D., Smith, G. D., et al. (2011) · Diabetes · doi:10.2337/db11-1039 · Cited by 60 · see citing works

The impact of epigenomics on future drug design and new therapies

Hamm, C. A., & Costa, F. F. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.04.007 · Cited by 59 · see citing works

Mendelian Randomization: Application to Cardiovascular Disease

Timpson, N. J., Wade, K. H., & Smith, G. D. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0242-7 · Cited by 59 · see citing works

Fibrinogen, C-reactive protein and coronary heart disease: does Mendelian randomization suggest the associations are non-causal?

Smith, G. D., Harbord, R. M., & Ebrahim, S. B. J. (2004) · QJM · doi:10.1093/qjmed/hch025 · Cited by 53 · see citing works

Confounding of Indirect Effects: A Sensitivity Analysis Exploring the Range of Bias Due to a Cause Common to Both the Mediator and the Outcome

Hafeman, D. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr173 · Cited by 51 · see citing works

Random Allocation in Observational Data

Smith, G. D. (2011) · Epidemiology · doi:10.1097/ede.0b013e31821d0426 · Cited by 48 · see citing works

Commentary: Estimating direct and indirect effects—fallible in theory, but in the real world?

Blakely, T. A. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.166 · Cited by 46 · see citing works

Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts

Ebrahim, S. B. J., Lawlor, D. A., Ben‐Shlomo, Y., Timpson, N. J., Harbord, R. M., Christensen, M. B., Baban, J., Kiessling, M., Day, I. N. M., Gaunt, T. R., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.02.002 · Cited by 37 · see citing works

Can we apply the Mendelian randomization methodology without considering epigenetic effects?

Ogbuanu, I. U., Zhang, H., & Karmaus, W. (2009) · Emerging Themes in Epidemiology · doi:10.1186/1742-7622-6-3 · Cited by 30 · see citing works

Biomarkers and Cardiovascular Disease

Shah, S. H., & de Lemos, J. A. (2009) · JAMA · doi:10.1001/jama.2009.949 · Cited by 29 · see citing works

Genome-wide association studies may be misinterpreted: genes versus heritability

Vineis, P., & Pearce, N. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr087 · Cited by 29 · see citing works

The hunt for the epiallele

Finer, S., Holland, M. L., Nanty, L., & Rakyan, V. K. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20590 · Cited by 26 · see citing works

Global DNA Methylation Analysis Using the Luminometric Methylation Assay

Karimi, M., Luttropp, K., & Ekström, T. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-316-5_11 · Cited by 24 · see citing works

The disappointments of the double helix: a master theory

Fanu, J. L. (2010) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2009.09k077 · Cited by 13 · see citing works

Dietary regulation of developmental programming in ruminants: epigenetic modifications in the germline

Sinclair, K. D., Karamitri, A., & Gardner, D. S. (2010) · Reproduction in Domestic Ruminants · doi:10.5661/rdr-vii-59 · Cited by 10 · see citing works

Integration of Genomic and Epigenomic DNA Methylation Data in Common Complex Diseases by Haplotype-Specific Methylation Analysis

Bell, C. G. (2011) · Personalized Medicine · doi:10.2217/pme.11.14 · Cited by 7 · see citing works

The Human Epigenome

Jones, P. A., & Liang, G. (2011) · Springer eBooks · doi:10.1007/978-94-007-2495-2_2 · Cited by 6 · see citing works

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

Davey Smith, G., & Hemani, G. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu328 · Cited by 4,677 · see citing works

Orienting the causal relationship between imprecisely measured traits using GWAS summary data.

Hemani, G., Tilling, K., & Davey Smith, G. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007081 · Cited by 2,607 · see citing works

Mendelian Randomization as an Approach to Assess Causality Using Observational Data

Sekula, P., Del Greco M, F., Pattaro, C., & Köttgen, A. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016010098 · Cited by 2,351 · see citing works

Mendelian randomization

Sanderson, E., Glymour, M. M., Holmes, M. V., Kang, H., Morrison, J., Munafò, M. R., Palmer, T., Schooling, C. M., Wallace, C., Zhao, Q., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00092-5 · Cited by 2,229 · see citing works

Evaluating the potential role of pleiotropy in Mendelian randomization studies

Hemani, G., Bowden, J., & Davey Smith, G. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy163 · Cited by 1,496 · see citing works

Guidelines for performing Mendelian randomization investigations

Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Holmes, M. V., Minelli, C., Relton, C. L., et al. (2020) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15555.2 · Cited by 1,273 · see citing works

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

Carter, A. R., Sanderson, E., Hammerton, G., Richmond, R. C., Davey Smith, G., Heron, J., Taylor, A. E., Davies, N. M., & Howe, L. D. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-021-00757-1 · Cited by 1,215 · see citing works

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings

Sanderson, E., Davey Smith, G., Windmeijer, F., & Bowden, J. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyy262 · Cited by 1,085 · see citing works

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P.-C., Ried, J. S., Zhang, W., Yang, Y., et al. (2017) · Nature · doi:10.1038/nature20784 · Cited by 945 · see citing works

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology · doi:10.1186/s13059-019-1824-y · Cited by 1,025 · see citing works

Mendelian Randomization: Concepts and Scope

Richmond, R. C., & Davey Smith, G. (2022) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040501 · Cited by 841 · see citing works

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways.

Burgess, S., Daniel, R. M., Butterworth, A. S., Thompson, S. G., & the EPIC-InterAct Consortium (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu176 · Cited by 543 · see citing works

Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases

Sun, Y. V., & Hu, Y.-J. (2016) · Advances in Genetics · doi:10.1016/bs.adgen.2015.11.004 · Cited by 459 · see citing works

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Richmond, R. C., Simpkin, A. J., Woodward, G., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Smith, A. D. A. C., Timpson, N. J., Tilling, K., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu739 · Cited by 372 · see citing works

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.

Swerdlow, D. I., Kuchenbaecker, K. B., Shah, S., Sofat, R., Holmes, M. V., White, J., Mindell, J. S., Kivimaki, M., Brunner, E. J., Whittaker, J. C., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw088 · Cited by 387 · see citing works

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study.

Richardson, T. G., Sanderson, E., Elsworth, B., Tilling, K., & Davey Smith, G. (2019) · doi:10.1101/19008011 · Cited by 321 · see citing works

Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships

Cortessis, V. K., Thomas, D. C., Levine, A. J., Breton, C. V., Mack, T. M., Siegmund, K. D., Haile, R. W., & Laird, P. W. (2012) · Human Genetics · doi:10.1007/s00439-012-1189-8 · Cited by 319 · see citing works

Associating cellular epigenetic models with human phenotypes

Lappalainen, T., & Greally, J. M. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.32 · Cited by 282 · see citing works

Prenatal and early life influences on epigenetic age in children: A study of mother–offspring pairs from two cohort studies

Simpkin, A. J., Hemani, G., Suderman, M., Gaunt, T. R., Lyttleton, O., Mcardle, W. L., Ring, S. M., Sharp, G. C., Tilling, K., Horvath, S., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddv456 · Cited by 246 · see citing works

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

Richardson, T. G., Harrison, S., Hemani, G., & Davey Smith, G. (2019) · eLife · doi:10.7554/elife.43657 · Cited by 198 · see citing works

An epigenome-wide association study of total serum immunoglobulin E concentration

Liang, L., Willis-Owen, S. A. G., Laprise, C., Wong, K. C. C., Davies, G. A., Hudson, T. J., Binia, A., Hopkin, J. M., Yang, I. V., Grundberg, E., et al. (2015) · Nature · doi:10.1038/nature14125 · Cited by 213 · see citing works

Maternal adiposity—a determinant of perinatal and offspring outcomes?

Lawlor, D. A., Relton, C., Sattar, N., & Nelson, S. M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.176 · Cited by 192 · see citing works

Annual research review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology

Barker, E. D., Walton, E., & Cecil, C. A. M. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12782 · Cited by 134 · see citing works

Epigenetic Research in Neuropsychiatric Disorders: the “Tissue Issue”

Bakulski, K. M., Halladay, A., Hu, V. W., Mill, J., & Fallin, M. D. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0083-4 · Cited by 127 · see citing works

The Society for Social Medicine John Pemberton Lecture 2011. Developmental overnutrition—an old hypothesis with new importance?*

Lawlor, D. A. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys209 · Cited by 114 · see citing works

Origins of human disease: the chrono-epigenetic perspective

Oh, E. S., & Petronis, A. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00348-6 · Cited by 108 · see citing works

Epigenetics in eating disorders: a systematic review

Hübel, C., Marzi, S. J., Breen, G., & Bulik, C. M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0254-7 · Cited by 116 · see citing works

DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence

Cecil, C. A. M., Walton, E., Smith, R. G., Viding, E., McCrory, E. J., Relton, C. L., Suderman, M., Pingault, J.-B., McArdle, W., Gaunt, T. R., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.247 · Cited by 101 · see citing works

Biological embedding of early‐life exposures and disease risk in humans: a role for <scp>DNA</scp> methylation

Demetriou, C. A., van Veldhoven, K., Relton, C., Stringhini, S., Kyriacou, K., & Vineis, P. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12406 · Cited by 95 · see citing works

Epigenesis for epidemiologists: does evo-devo have implications for population health research and practice?

Davey Smith, G. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys016 · Cited by 68 · see citing works

Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study

Cecil, C. A. M., Walton, E., Jaffee, S. R., O'Connor, T., Maughan, B., Relton, C. L., Smith, R. G., McArdle, W., Gaunt, T. R., Ouellet-Morin, I., et al. (2018) · Development and Psychopathology · doi:10.1017/s095457941700092x · Cited by 46 · see citing works

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood

Sallis, H. M., Croft, J., Havdahl, A., Jones, H. J., Dunn, E. C., Davey Smith, G., Zammit, S., & Munafò, M. R. (2021) · Psychological Medicine · doi:10.1017/s0033291720000537 · Cited by 38 · see citing works

The influences of genetic and environmental factors on methylome-wide association studies for human diseases

Sun, Y. V. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0058-2 · Cited by 27 · see citing works

Mendelian randomisation approaches to the study of prenatal exposures: A systematic review

Diemer, E. W., Labrecque, J. A., Neumann, A., Tiemeier, H., & Swanson, S. A. (2021) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12691 · Cited by 21 · see citing works

Placental DNA methylation key topics: Sex- and cell-type specificity, mediation, multi-omics, and biomarker discovery

Cohen, N. J., Lesseur, C., Cardenas, A., Ward-Caviness, C. K., Spring, A. C., Rager, J. E., Fry, R. C., & Eaves, L. A. (2025) · Epigenomics · doi:10.1080/17501911.2025.2533115 · Cited by 2 · see citing works

Serum Triglycerides and Atherosclerotic Cardiovascular Disease: Insights from Clinical and Genetic Studies

Tada, H., Nohara, A., & Kawashiri, M. (2018) · Nutrients · doi:10.3390/nu10111789 · Cited by 50 · see citing works

Re: “Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects”

Burgess, S., Dudbridge, F., & Thompson, S. G. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv017 · Cited by 945 · see citing works

Health Effects of Vitamin D: Evidence from Mendelian Randomization studies v1Preprint

Fang, A. (2022) · doi:10.17504/protocols.io.eq2ly7nzmlx9/v1 · Cited by 2 · see citing works

Polynomial Mendelian randomization reveals non-linear causal effects for obesity-related traits

Sulc, J., Sjaarda, J., & Kutalik, Z. (2022) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2022.100124 · Cited by 20 · see citing works

Causality/Causation

Phillips, C. V., & Goodman, K. J. (2008) · Encyclopedia of Quantitative Risk Analysis and Assessment · doi:10.1002/9780470061596.risk0640