Changing patterns of transcriptional and post-transcriptional control of liver-specific gene expression during rat development.
Open accessAbstract
Genes coding for unique or tissue-specific (differentiated) functions in the liver are induced at different times during development. It has generally been felt that transcriptional control represents the dominant mechanism for regulating expression of these genes. We have determined the relative transcription rates and mRNA steady-state levels for a series of genes specifically or preferentially expressed in rat liver and find examples of transcriptional control (albumin, alpha-fetoprotein, alpha 1-antitrypsin, tyrosine aminotransferase, transferrin, and cytochrome P450, TF-1) and post-transcriptional control (alpha 1-acid glycoprotein, apolipoproteins A-1 and E, malic enzyme, and ATP citrate lyase), as well as "mixed" regulation (ligandin and cytochrome P450, R17). Examples have been identified in which the predominant mode for regulating expression of preferentially expressed genes changes from transcriptional to post-transcriptional at different stages of liver development and some members of multigene families (cytochrome P450s and apolipoprotein genes) also show independent and sometimes contrasting modes of regulation. Therefore, it appears that regulation of specific gene expression in the liver is a dynamic process, far more complex than heretofore suspected, and a much greater contribution of post-transcriptional regulation accounts for changes in expression of genes representing major functions of the liver.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Whether liver cells exhibit fetal or adult phenotypes is controlled by families of factors that regulate the synthesis, splicing, stability, and translation of mRNAs.
“Whether liver cells exhibit fetal or adult phenotypes is controlled by families of factors that regulate the synthesis, splicing, stability, and translation of mRNAs (Panduro et al. 1987; Bhate et al. 2015; Suzuki et al. 2019; Gong et al. 2020).”
From ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation (2025) · cites this paper as Panduro et al. 1987
The Conclusion (page not available) reports that gene expression changes as rat hepatocytes mature, with some genes regulated transcriptionally and others post-transcriptionally. The Discussion reports changes in apparent mRNA stability, but says the specific factors responsible for regulation are unknown; it does not establish families of factors controlling splicing or translation. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725 · see citing works
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Thomas, P. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5201 · Cited by 7,937 · see citing works
A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane
Gillespie, D. H., & Spiegelman, S. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80331-x · Cited by 1,971 · see citing works
High density lipoprotein metabolism.
Eisenberg, S. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37713-0 · Cited by 1,212 · see citing works
Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors
Abelev, G. I. (1971) · Advances in cancer research · doi:10.1016/s0065-230x(08)60523-0 · Cited by 883 · see citing works
Transcriptional Regulation of Hemoglobin Switching in Chicken Embryos
Groudine, M. T., Peretz, M., & Weintraub, H. M. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.3.281 · Cited by 777 · see citing works
Variety in the level of gene control in eukaryotic cells
Darnell, J. E., Jr. (1982) · Nature · doi:10.1038/297365a0 · Cited by 772 · see citing works
Transcriptional control in the production of liver-specific mRNAs
Derman, E., Krauter, K. S., Walling, L. L., Weinberger, C., Ray, M., & Darnell, J. E., Jr. (1981) · Cell · doi:10.1016/0092-8674(81)90436-0 · Cited by 550 · see citing works
Theiler, K. (1972) · Cited by 550 · see citing works
Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression
Guyette, W. A., Matusik, R. J., & Rosen, J. M. (1979) · Cell · doi:10.1016/0092-8674(79)90340-4 · Cited by 473 · see citing works
Estrogen stabilizes vitellogenin mRNA against cytoplasmic degradation
Brock, M. L., & Shapiro, D. J. (1983) · Cell · doi:10.1016/0092-8674(83)90151-4 · Cited by 431 · see citing works
Lamers, W. H., Hanson, R. W., & Meisner, H. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.17.5137 · Cited by 410 · see citing works
Transcriptional control of the murine albumin/alpha-fetoprotein locus during development.
Tilghman, S. M., & Belayew, A. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.17.5254 · Cited by 362 · see citing works
Clayton, D. F., & Darnell, J. E., Jr. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.9.1552-1561.1983 · Cited by 320 · see citing works
Dependence of Liver-Specific Transcription on Tissue Organization
Clayton, D. F., Harrelson, A. L., & Darnell, J. E., Jr. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.10.2623 · Cited by 222 · see citing works
Rat transferrin gene expression: tissue-specific regulation by iron deficiency.
Idzerda, R. L., Huebers, H. A., Finch, C. A., & McKnight, G. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3723 · Cited by 219 · see citing works
Structure and evolution of the apolipoprotein multigene family
Luo, C., Li, W., Moore, M. N., & Chan, L. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90436-5 · Cited by 211 · see citing works
Vannice, J. L., Taylor, J. M., & RINGOLD, G. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4241 · Cited by 204 · see citing works
Baumann, H., Firestone, G. L., Burgess, T. L., Gross, K. W., Yamamoto, K., & Held, W. A. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33291-5 · Cited by 191 · see citing works
Cell-cycle regulation of histone gene expression
Schümperli, D. (1986) · Cell · doi:10.1016/0092-8674(86)90277-1 · Cited by 183 · see citing works
Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.
Meehan, R. R., Barlow, D. P., Hill, R. E., Hogan, B. L. M., & Hastie, N. D. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02062.x · Cited by 176 · see citing works
Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine
Diamond, D. J., & Goodman, H. M. (1985) · Journal of Molecular Biology · doi:10.1016/0022-2836(85)90323-7 · Cited by 167 · see citing works
Posttranscriptional Modulation of Gene Expression in Cultured Rat Hepatocytes
Jefferson, D. M., Clayton, D. F., Darnell, J. E., Jr., & Reid, L. M. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.9.1929 · Cited by 156 · see citing works
Peterson, J. A., & Weiss, M. C. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.3.571 · Cited by 155 · see citing works
Sala-Trepat, J. M., Dever, J., Sargent, T. D., Thomas, K., Sell, S., & Bonner, J. (1979) · Biochemistry · doi:10.1021/bi00578a006 · Cited by 152 · see citing works
Atchison, M. L., & Adesnik, M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44416-4 · Cited by 136 · see citing works
Panduro, A., Shalaby, F., Weiner, F. R., Biempica, L., Zern, M. Α., & Shafritz, D. A. (1986) · Biochemistry · doi:10.1021/bi00354a034 · Cited by 135 · see citing works
Self-citationRicca, G. A., Hamilton, R. W., McLean, J. W., Conn, A. R., Kalinyak, J. E., & Taylor, J. M. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68627-8 · Cited by 135 · see citing works
Genetic analysis of alpha-fetoprotein synthesis in mice.
Belayew, A., & Tilghman, S. M. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.11.1427 · Cited by 134 · see citing works
Jefferson, L. S., Liao, W. S. ‐., Peavy, D. E., Miller, T. B., Appel, M. C., & Taylor, J. M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33203-4 · Cited by 130 · see citing works
Yap, S. H., STRAIR, R. K., & Shafritz, D. A. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34639-2 · Cited by 122 · see citing works
Self-citationLeys, E. J., Crouse, G. F., & Kellems, R. E. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.1.180 · Cited by 122 · see citing works
Enzymic Differentiation of Human Liver: Comparison with the Rat Model
Greengard, O. (1977) · Pediatric Research · doi:10.1203/00006450-197705000-00009 · Cited by 121 · see citing works
Species- and tissue-specific expression of human alpha 1-antitrypsin in transgenic mice.Preprint
Kelsey, G., Povey, S., Bygrave, A. E., & Lovell-Badge, R. H. (1987) · Genes & Development · doi:10.1101/gad.1.2.161 · Cited by 118 · see citing works
Post-transcriptional regulation of the chicken thymidine kinase gene
Groudine, M. T., & Casimir, C. M. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.3.1427 · Cited by 111 · see citing works
Isolation of cDNA clones coding for rat tyrosine aminotransferase.
Scherer, G., Schmid, W., STRANGE, C. M., Röwekamp, W. G., & Schütz, G. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7205 · Cited by 106 · see citing works
Transcriptional regulation of the tryptophan oxygenase gene in rat liver by glucocorticoids.
Danesch, U., Hashimoto, S., Renkawitz, R., & Schütz, G. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32486-4 · Cited by 106 · see citing works
Powell, D. J., Friedman, J. M., Oulette, A. J., Krauter, K. S., & Darnell, J. E., Jr. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90304-8 · Cited by 102 · see citing works
Gene expression during liver regeneration
Friedman, J. M., Chung, E. Y., & Darnell, J. E., Jr. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90305-x · Cited by 98 · see citing works
Kurtz, D. T., Sippel, A. E., Ansah-Yiadom, R., & Feigelson, P. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33385-9 · Cited by 95 · see citing works
Human Serum Albumin Phenotype Activation in Mouse Hepatoma-Human Leukocyte Cell Hybrids
Darlington, G., Bernhard, H. P., & Ruddle, F. H. (1974) · Science · doi:10.1126/science.185.4154.859 · Cited by 94 · see citing works
Liver-Specific RNA Metabolism in Hepatoma Cells: Variations in Transcription Rates and mRNA Levels
Clayton, D. F., Weiss, M. C., & Darnell, J. E., Jr. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.10.2633-2641.1985 · Cited by 90 · see citing works
Summers, J. W. (1975) · Journal of Virology · doi:10.1128/jvi.15.4.946-953.1975 · Cited by 87 · see citing works
Tissue-specific expression of rat mRNAs homologous to cytochromes P-450b and P-450e
Omiecinski, C. J. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.3.1525 · Cited by 87 · see citing works
Poliard, A., Bernuau, D., Tournier, I., Legrès, L., Schoëvaërt, D., Feldmann, G., & Sala-Trepat, J. M. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.3.777 · Cited by 77 · see citing works
Differential expression of albumin and α-fetoprotein genes in fetal tissues of mouse and rat
Sellem, C. H., Frain, M., Erdös, T., & Sala-Trepat, J. M. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90174-x · Cited by 76 · see citing works
Regulation of expression of the c‐Myc proto‐oncogene
Marcu, K. B. (1987) · BioEssays · doi:10.1002/bies.950060108 · Cited by 75 · see citing works
Paul, J., Conkle, D., & Freshney, R. I. (1969) · Cell Proliferation · doi:10.1111/j.1365-2184.1969.tb00238.x · Cited by 71 · see citing works
Changes in rat alpha 1-fetoprotein and albumin mRNA levels during fetal and neonatal development.
Liao, W. S., Conn, A. R., & Taylor, J. M. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70421-9 · Cited by 69 · see citing works
Developmentally regulated mRNAs in mouse liver.
Barth, R. K., Gross, K. W., Gremke, L., & Hastie, N. D. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.500 · Cited by 69 · see citing works
Jefferson, D. M., Reid, L. M., Giambrone, M. A., Shafritz, D. A., & Zern, M. Α. (1985) · Hepatology · doi:10.1002/hep.1840050105 · Cited by 68 · see citing works
Self-citationPost-transcriptional regulation of rat liver gene expression by glucocorticoids
Fulton, R., Birnie, G. D., & Knowler, J. T. (1985) · Nucleic Acids Research · doi:10.1093/nar/13.18.6467 · Cited by 57 · see citing works
Growth, mitosis and morphogenesis of the simple liver acinus in neonatal rats
LeBouton, A. V. (1974) · Developmental Biology · doi:10.1016/0012-1606(74)90279-6 · Cited by 47 · see citing works
Sul, H. S., Wise, L. S., Brown, M. L., & Rubin, C. S. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43588-5 · Cited by 46 · see citing works
Sul, H. S., Wise, L. S., Brown, M. L., & Rubin, C. S. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43697-0 · Cited by 38 · see citing works
Giachelli, C. M., & Omiecinski, C. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36099-4 · Cited by 33 · see citing works
Insulin Gene Expression in the Developing Rat Pancreas
Kakita, K., Giddings, S. J., Rotwein, P. S., & Permutt, M. A. (1983) · Diabetes · doi:10.2337/diab.32.8.691 · Cited by 27 · see citing works
Expression of the α-Fetoprotein Gene during Development, Regeneration, and Carcinogenesis
Tamaoki, T., & Fausto, N. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-665080-8.50011-8 · Cited by 26 · see citing works
Clonal variation in albumin messenger RNA activity in hepatoma cells.
Peterson, J. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.6.2056 · Cited by 24 · see citing works
José Chianale, B., Dvorak, C., May, M., & Gumucio, J. J. (1986) · Hepatology · doi:10.1002/hep.1840060522 · Cited by 20 · see citing works
Transcriptional control of α-foetoprotein synthesis in developing mouse liver
Koga, K., O'KEEFE, D. W., IIO, T., & Tamaoki, T. (1974) · Nature · doi:10.1038/252495a0 · Cited by 20 · see citing works
Liver-specific gene expression in various pathophysiologic states
Panduro, A., Shalaby, F., & Shafritz, D. A. (1987) · Hepatology · doi:10.1002/hep.1840070703 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Reid, L.M., M. Narita, M. Fujita, Z. Murray, C. Liverpool, and L.C. Rosenberg. 1985. Matrix and hormonal regulation of differentiation in liver cultures. In Isolated and cultured he- patocytes. {ed. A. Guillouzo and C. Guillouzo), pp. 225-258.
- Vannice, J.L., J.M. Taylor, and G. Ringold. 1984. Glucocorti- coid-mediated induction of ~l-acid glycoprotein: Evidence for hormone-regulated RNA processing. Proc. Natl. Acad. Sci. 81" 4241-4245.
Cited by
Sorted by citations
Hay, D. C., Zhao, D., Fletcher, J., Hewitt, Z. A., McLean, D., Urruticoechea-Uriguen, A., Black, J. R., Elcombe, C., Ross, J. A., Wolf, R., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0718 · Cited by 441 · see citing works
Kamiya, A., Kinoshita, T., Ito, Y., Matsui, T., Morikawa, Y., Senba, E., Nakashima, K., Taga, T., Yoshida, K., Kishimoto, T., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2127 · Cited by 425 · see citing works
Mueller, C. R., Maire, P., & Schibler, U. (1990) · Cell · doi:10.1016/0092-8674(90)90808-r · Cited by 384 · see citing works
Cereghini, S., BLUMENFELD, M. L., & Yaniv, M. (1988) · Genes & Development · doi:10.1101/gad.2.8.957 · Cited by 285 · see citing works
Courselaud, B., Pigeon, C., Inoue, Y., Inoue, J., Gonzalez, F. J., Leroyer, P., Gilot, D., Boudjema, K., Guguen-Guillouzo, C., Brissot, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202653200 · Cited by 245 · see citing works
Inhibition of Albumin Synthesis in Chronic Diseases
Chojkier, M. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000155514.17715.39 · Cited by 214 · see citing works
HNF1, a homeoprotein member of the hepatic transcription regulatory network
Tronche, F., & Yaniv, M. (1992) · BioEssays · doi:10.1002/bies.950140902 · Cited by 205 · see citing works
Liu, J. K., DiPersio, C. M., & Zaret, K. S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.2.773 · Cited by 168 · see citing works
Role of Oncostatin M in hematopoiesis and liver development
Miyajima, A., Kinoshita, T., Tanaka, M., Kamiya, A., Mukouyama, Y., & Hara, T. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00003-4 · Cited by 153 · see citing works
Trautwein, C., van der Geer, P., Karin, M., Hunter, T. R., & Chojkier, M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117266 · Cited by 139 · see citing works
Fleming, R. E., & Gitlin, J. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39171-9 · Cited by 138 · see citing works
Cytokine regulation of liver development
Kinoshita, T., & Miyajima, A. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00323-3 · Cited by 136 · see citing works
Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXR alpha and retinoic acid.
Widom, R. L., Rhee, M., & Karathanasis, S. K. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3380 · Cited by 136 · see citing works
Buck, M., Turler, H., & Chojkier, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06328.x · Cited by 133 · see citing works
Milos, P. M., & Zaret, K. S. (1992) · Genes & Development · doi:10.1101/gad.6.6.991 · Cited by 130 · see citing works
Widom, R. L., Ladias, J. A. A., Kouidou, S., & Karathanasis, S. K. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.2.677 · Cited by 126 · see citing works
Hepatic acute phase reaction in vivo and in vitro
Baumann, H. (1989) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02626167 · Cited by 127 · see citing works
Postnatal repression of the alpha-fetoprotein gene is enhancer independent.Preprint
Camper, S. A., & Tilghman, S. M. (1989) · Genes & Development · doi:10.1101/gad.3.4.537 · Cited by 111 · see citing works
Watanabe‐Asaka, T., Nakagawa, K., Ohata, S., Kitagawa, D., Nishitai, G., Seo, J., Tanemura, S., Shimizu, N., Kishimoto, H., Wada, T., et al. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0781 · Cited by 109 · see citing works
Runge, D., Runge, D., Jäger, D., Lubecki, K. A., Stolz, D. B., Karathanasis, S. K., Kietzmann, T., Strom, S. C., Jungermann, K. A., Fleig, W. E., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2215 · Cited by 97 · see citing works
Albumin gene expression is down-regulated by albumin or macromolecule infusion in the rat.
Pietrangelo, A., Panduro, A., Chowdhury, J. R., & Shafritz, D. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115778 · Cited by 91 · see citing works
Self-citationC/EBP-β/LAP Controls Down-regulation of Albumin Gene Transcription during Liver Regeneration
Trautwein, C., Rakemann, T., Pietrangelo, A., Plümpe, J., Montosi, G., & Manns, M. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22262 · Cited by 83 · see citing works
Aloni-Grinstein, R., Peleg, D., & Meyuhas, O. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.2203 · Cited by 82 · see citing works
Kuo, C. F., Xanthopoulos, K. G., & Darnell, J. E., Jr. (1990) · Development · doi:10.1242/dev.109.2.473 · Cited by 78 · see citing works
Acute phase proteins and transformed cells.
Mackiewicz, A. (1997) · International Review of Cytology · doi:10.1016/s0074-7696(08)61623-x · Cited by 79 · see citing works
Liver Gene Expression During Chronic Dietary Iron Overload in Rats
Pietrangelo, A., Rocchi, E., Schiaffonati, L., Ventura, E., & Cairo, G. (1990) · Hepatology · doi:10.1002/hep.1840110513 · Cited by 70 · see citing works
Santarsiero, A., Convertini, P., Todisco, S., Pierri, C. L., Grassi, A., Williams, N. C., Iacobazzi, D., Stefano, G. D., O'Neill, L. A. J., & Infantino, V. (2021) · Cells · doi:10.3390/cells10112962 · Cited by 66 · see citing works
Ilyin, G. P., Glaise, D., Gilot, D., Baffet, G., & Guguen‐Guillouzo, C. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00309.2002 · Cited by 66 · see citing works
Hass, M. A., Iqbal, J., Clerch, L. B., Frank, L., & Massaro, D. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114007 · Cited by 61 · see citing works
Monga, S. P., Hout, M. S., Baun, M., Micsenyi, A., Stock, P., Tummalapalli, S. L., Ranade, A. R., Luo, J., Strom, S. C., & Gerlach, J. C. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61215-1 · Cited by 59 · see citing works
Expression of glutathione S-transferase during rat liver development
Tee, L. B. G., Gilmore, K. S., Meyer, D. J., KETTERER, B., Vandenberghe, Y., & Yeoh, G. C. (1992) · Biochemical Journal · doi:10.1042/bj2820209 · Cited by 54 · see citing works
Dabeva, M. D., Hurston, E., & Shafritz, D. A. (1995) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Self-citationCell Density-Dependent Regulation of Hepatic Development by a gp130-Independent Pathway
Kojima, N., Kinoshita, T., Kamiya, A., Nakamura, K., Nakashima, K., Taga, T., & Miyajima, A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3635 · Cited by 51 · see citing works
Sigal, S. H., Brill, S., Reid, L. M., Zvibel, I., Gupta, S. K., Hixson, D. C., Faris, R. A., & Holst, P. A. (1994) · Hepatology · doi:10.1002/hep.1840190427 · Cited by 51 · see citing works
Early developmental influences on hepatic organogenesis
Hyatt, M. A., Budge, H., & Symonds, M. E. (2008) · Organogenesis · doi:10.4161/org.4.3.6849 · Cited by 50 · see citing works
Changes in albumin, α-fetoprotein and collagen gene transcription in ccl4-induced hepatic fibrosis
Panduro, A., Shalaby, F., Biempica, L., & Shafritz, D. A. (1988) · Hepatology · doi:10.1002/hep.1840080212 · Cited by 50 · see citing works
Self-citationIn vitro differentiation of WB-F344 rat liver epithelial cells into the biliary lineage
Couchie, D., Holic, N., Chobert, M.-N., Corlu, A., & Laperche, Y. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.690414.x · Cited by 50 · see citing works
Zhang, D., Ge, X., Rabek, J. P., & Papaconstantinou, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54837-7 · Cited by 48 · see citing works
Panduro, A., Lin-Lee, Y.-C., Chan, L., & Shafritz, D. A. (1990) · Biochemistry · doi:10.1021/bi00488a033 · Cited by 47 · see citing works
Self-citationDevelopmental expression of elements of hepatic cholesterol metabolism in the rat.
Smith, J. L., Lear, S. R., & Erickson, S. K. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40050-1 · Cited by 46 · see citing works
Heparin releases newly synthesized cell surface-associated apolipoprotein E from HepG2 cells.
Lilly-Stauderman, M., Brown, T., Balasubramaniam, A., & Harmony, J. A. K. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40746-1 · Cited by 44 · see citing works
Sokhi, R. P., Rajvanshi, P., & Gupta, S. K. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.3.g631 · Cited by 42 · see citing works
Runge, D., Runge, D., Bowen, W. C., Locker, J. D., & Michalopoulos, G. K. (1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.8.873 · Cited by 40 · see citing works
Rat lung lectin gene expression is regulated developmentally and by dexamethasone
Clerch, L. B., Whitney, P., & Massaro, D. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.3.c501 · Cited by 38 · see citing works
Salier, J., Chan, P., Raguénez, G., Zwingman, T. A., & Erickson, R. P. (1993) · Biochemical Journal · doi:10.1042/bj2960085 · Cited by 37 · see citing works
A new subfamily of structurally related human F-box proteins
Ilyin, G. P., Sérandour, A., Pigeon, C., Rialland, M., Glaise, D., & Guguen‐Guillouzo, C. (2002) · Gene · doi:10.1016/s0378-1119(02)00867-3 · Cited by 34 · see citing works
Abundance of mRNAs encoding urea cycle enzymes in fetal and neonatal mouse liver
Morris, S. M., Kepka‐Lenhart, D., Sweeney, W. E., & Avner, E. D. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90097-0 · Cited by 34 · see citing works
Zhang, L. P., Stroud, J. C., Walter, C. A., Adrian, G. S., & McCarrey, J. R. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.2.284 · Cited by 33 · see citing works
Comparative metabolome analysis of cultured fetal and adult hepatocytes in humans
Kim, S.-R., Kubo, T., Kuroda, Y., Hojyo, M., Matsuo, T., Miyajima, A., Usami, M., Sekino, Y., Matsushita, T., & Ishida, S. (2014) · The Journal of Toxicological Sciences · doi:10.2131/jts.39.717 · Cited by 31 · see citing works
Lamon‐Fava, S., Sastry, R. A., Ferrari, S., Rajavashisth, T. B., Lusis, A. J., & Karathanasis, S. K. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41508-1 · Cited by 30 · see citing works
Cypermethrin increases apo A-1 and apo B mRNA but not hyperlipidemia in rats
Aldana, L., de Mejı́a, E. G., Craigmill, A. L., Tsutsumi, V., Armendáriz‐Borunda, J., Panduro, A., & Rincón‐Sánchez, A. R. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00013-7 · Cited by 27 · see citing works
Self-citationZvibel, I., Fiorino, A. S., Brill, S., & Reid, L. M. (1998) · Differentiation · doi:10.1111/j.1432-0436.1998.00215.x · Cited by 27 · see citing works
Rollier, A., DiPersio, C. M., Cereghini, S., Stevens, K., Tronche, F., Zaret, K. S., & Weiss, M. C. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.1.59 · Cited by 27 · see citing works
The Developmental Regulation of Albumin and α-Fetoprotein Gene Expression
Camper, S. A., Godbout, R., & Tilghman, S. M. (1989) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60167-1 · Cited by 25 · see citing works
Molecular Mechnisms of Liver‐Specific Albumin and α‐Fetoprotein Gene Regulation: A Review
Papaconstantinou, J., Rabek, J. P., & Zhang, D. (1990) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.1990.00205.x · Cited by 25 · see citing works
Repression by ARP-1 Sensitizes Apolipoprotein A1 Gene Responsiveness to RXRα and Retinoic Acid
Widom, R. L., Rhee, M., & Karathanasis, S. K. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3380-3389.1992 · Cited by 24 · see citing works
Mueller, C. R. (1992) · DNA and Cell Biology · doi:10.1089/dna.1992.11.559 · Cited by 24 · see citing works
Novel Method to Examine Hepatocyte-Specific Gene Expression in a Functional Coculture System
Kurosawa, Y., Taniguchi, A., & Okano, T. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1650 · Cited by 23 · see citing works
Noda, C., Fukushima, C., Fujiwara, T., Matsuda, K., Kobune, Y., & Ichihara, A. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90030-2 · Cited by 17 · see citing works
Panduro, A., Castrillón, L., González, L., & Shafritz, D. A. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90214-t · Cited by 16 · see citing works
Self-citationRegulation of collagen gene expression
Chojkier, M. (1998) · Springer eBooks · doi:10.1007/978-94-011-4932-7_16 · Cited by 14 · see citing works
Regulation of apo B mRNA expression in liver and intestine during liver regeneration induced by CCl4
Maldonado, V., Chan, L., Meléndez-Zajgla, J., Rincón‐Sánchez, A. R., Zhu, H.-J., & Panduro, A. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90131-7 · Cited by 13 · see citing works
Self-citationRath, P. C., & Kanungo, M. S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81031-3 · Cited by 13 · see citing works
Glibetić, M., Bogojević, D., Ivanović‐Matić, S., & Ševaljević, L. (1992) · Differentiation · doi:10.1111/j.1432-0436.1992.tb00483.x · Cited by 13 · see citing works
Tanaka, Y., & Ogra, Y. (2019) · Metallomics · doi:10.1039/c9mt00158a · Cited by 12 · see citing works
Glucocorticoids induce transcription of ribosomal protein genes in rat liver
Flusser, G., Ginzburg, V., & Meyuhas, O. (1989) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(89)90148-2 · Cited by 12 · see citing works
Wang, X., & Evers, B. M. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026637730050 · Cited by 11 · see citing works
Transcriptional Regulation of the Human Apolipoprotein Genes
Zannis, V. I., Kardassis, D., Ogami, K., Hadzopoulou‐Cladaras, M., & Cladaras, C. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5904-3_1 · Cited by 11 · see citing works
KAWASAKI, T., Tamura, S., Kiso, S., Doi, Y., Yoshida, Y., Kamada, Y., Saeki, A., Saji, Y., & Matsuzawa, Y. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.03812.x · Cited by 11 · see citing works
Expression of the Genes of Arginine-Synthesizing Enzymes in the Rat Kidney during Development
Goutal, I., Fairand, A., & Husson, A. (1999) · Neonatology · doi:10.1159/000014166 · Cited by 11 · see citing works
Bastidas‐Ramírez, B. E. (2002) · Hepatology Research · doi:10.1016/s1386-6346(02)00109-2 · Cited by 9 · see citing works
Sugawara, M., Okamoto, K., Kadowaki, T., Kusano, K., Fukamizu, A., & Yoshimura, T. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.030668 · Cited by 9 · see citing works
Nuño‐González, P., Ruiz‐Madrigal, B., Bastidas‐Ramírez, B. E., Martínez‐López, E., Segura, J. E., & Panduro, A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.003 · Cited by 9 · see citing works
Self-citationLin-Lee, Y.-C., Soyal, S. M., Surguchov, A. P., Sanders, S., Strobl, W., & Patsch, W. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39744-3 · Cited by 9 · see citing works
Distinct developmental regulatory mechanisms for two members of the aldolase gene family
Maine, A. B., & Ciejek‐Baez, E. (1991) · Developmental Genetics · doi:10.1002/dvg.1020120608 · Cited by 8 · see citing works
Regulation of albumin synthesis after hepatectomy and in the acute inflammation phase of rat liver
Morimoto, T., Tsujinaka, T., Yano, M., Iijima, S., Ebisui, C., Kan, K., KISHIBUCHI, M., & Mori, T. (1995) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(95)00107-b · Cited by 8 · see citing works
Effects of cyclic and continuous parenteral nutrition on albumin gene transcription in rat liver
Morimoto, T., Tsujinaka, T., Ogaẃa, A., KISHIBUCHI, M., Morita, S., Yano, M., Shiozaki, H., & Monden, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.4.994 · Cited by 7 · see citing works
Leggett, R. W., & Mueller, C. R. (1994) · DNA and Cell Biology · doi:10.1089/dna.1994.13.693 · Cited by 7 · see citing works
Nuño, P., Hernández, A., Mendoza‐Figueroa, T., & Panduro, A. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(96)00150-6 · Cited by 6 · see citing works
Self-citationŠevaljević, L., Petrović, M., & Bogojević, D. (1994) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923485 · Cited by 6 · see citing works
Martínez‐López, E., Nuño‐González, P., Ruiz‐Madrigal, B., Rodríguez‐Sancho, L. C., Nazará, Z., Segura‐Ortega, J. E., & Panduro, A. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01509.x · Cited by 5 · see citing works
Self-citationESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation
Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2025) · Genes & Development · doi:10.1101/gad.352129.124 · Cited by 4 · see citing works
Prenatal glucocorticoid administration accelerates the maturation of fetal rat hepatocytes
Kobayashi, T., Takeba, Y., Ohta, Y., Ootaki, M., Kida, K., Watanabe, M., Iiri, T., & Matsumoto, N. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07358-5 · Cited by 3 · see citing works
Fungwe, T. V. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00015-7 · Cited by 3 · see citing works
Panduro, A., Valencia, J., & Rojkind, M. (1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90660-7 · Cited by 2 · see citing works
Self-citationNishina, H., Watanabe‐Asaka, T., Nakagawa, K., Ohata, S., Asaka, S., & Katada, T. (2004) · Springer eBooks · doi:10.1007/978-4-431-53971-1_1 · Cited by 1 · see citing works
Partial blockage of hepatocyte maturation in hepatoma-derived growth factor transgenic mice
Enomoto, H. (2009) · World Journal of Hepatology · doi:10.4254/wjh.v1.i1.98 · Cited by 1 · see citing works
ESRP2-microRNA-122 axis directs the postnatal onset of liver polyploidization and maturationPreprint
Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602336 · Cited by 1 · see citing works
THREE-DIMENSIONAL CULTURE OF FETAL LIVER CELLS
Qian, L. (2006) · eCommons (Cornell University)
DEVELOPMENTAL AND HORMONAL REGULATIO OF EXPRESSION OF THE RAT SERINE DEHYDRATASE GENE IN RAT LIVER
Noda, C., Matsuda, K., Fujiwara, T., Kobune, Y., & Ichihara, A. (1993) · doi:10.11418/jtca1981.12.1_43
Isolation and characterization of two distinct rainbow trout albumin genes
Gong, Z. (1997) · Library and Archives Canada (Government of Canada)
Hormones and Perinatal Development
Cake, M. H., & Yeoh, G. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00001-8
(1993) · Elsevier eBooks · doi:10.1016/b978-0-12-121070-0.50010-8
Sarker, D., Plummer, R., Meyer, T., Sodergren, M. H., Basu, B., Chee, C. E., Huang, K., Palmer, D. H., Ma, Y. T., Evans, T. R. J., et al. (2023) · doi:10.1158/1078-0432.22477098.v1
Sarker, D., Plummer, R., Meyer, T., Sodergren, M. H., Basu, B., Chee, C. E., Huang, K., Palmer, D. H., Ma, Y. T., Evans, T. R. J., et al. (2023) · doi:10.1158/1078-0432.22477098
Li, Q., Duan, Q., Wang, J., Hu, J., & Chao, T. (2026) · Journal of Animal Science · doi:10.1093/jas/skag061
- Authors
- Panduro, A., Shalaby, F., & Shafritz, D. A.
- Affiliations
- Albert Einstein College of Medicine (US)
- ORCID
- Panduro, A
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1987-12
- Volume
- 1
- Issue
- 10
- Pages
- 1172-1182
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2089275054
- Cited by
- 96
- References
- 62
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2014: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 17609, DK-P30-17702)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- liver development, gene expression regulation, transcriptional regulation, post-transcriptional regulation, tissue-specific genes, transcription rate, albumin, alpha-fetoprotein, alpha-1-antitrypsin, tyrosine aminotransferase, transferrin, cytochrome P450, alpha-1-acid glycoprotein, apolipoprotein A-I, apolipoprotein E, malic enzyme, ATP citrate lyase, ligandin, gene family, rats
- MeSH terms
- Actins, Animals, Apolipoproteins, ATP Citrate (pro-S)-Lyase, Body Weight, Cytochrome P-450 Enzyme System, Gene Expression Regulation, Glutathione Transferase, Liver, Malate Dehydrogenase, Organ Size, Orosomucoid, Transcription, Genetic, Transferrin, Protein Biosynthesis, Tubulin, Tyrosine Transaminase, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
