The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
Open accessAbstract
Hes7 , a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a dynamic manner, which depends on proteasome-mediated degradation. Spatial comparison revealed that Hes7 and Lunatic fringe ( Lfng ) transcription occurs in the Hes7 protein-negative domains. Furthermore, Hes7 and Lfng transcription is constitutively up-regulated in the absence of Hes7 protein and down-regulated by stabilization of Hes7 protein. Thus, periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng , and this negative feedback represents a molecular basis for the segmentation clock.
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Cites
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
Shang, Y., Hu, X., DiRenzo, J., Lazar, M. A., & Brown, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00188-4 · Cited by 1,657
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Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop
Hirata, H., Yoshiura, S., Ohtsuka, T., Bessho, Y., Harada, T., Yoshikawa, K., & Kageyama, R. (2002) · Science · doi:10.1126/science.1074560 · Cited by 763
Self-citationWnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis
Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler, A., Kanzler, B., & Herrmann, B. G. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00055-8 · Cited by 593
Notch signalling and the synchronization of the somite segmentation clock
Jiang, Y.-J., Aerne, B. L., Smithers, L., Haddon, C., Ish-Horowicz, D., & Lewis, J. (2000) · Nature · doi:10.1038/35044091 · Cited by 538
Defects in somite formation in lunatic fringe-deficient mice
Zhang, N., & Gridley, T. (1998) · Nature · doi:10.1038/28625 · Cited by 400
lunatic fringe is an essential mediator of somite segmentation and patterning
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Dynamic expression and essential functions of Hes7 in somite segmentation
Bessho, Y., Sakata, R., Komatsu, S., Shiota, K., Yamada, S., & Kageyama, R. (2001) · Genes & Development · doi:10.1101/gad.930601 · Cited by 364
Self-citationProgression of the cell cycle through mitosis leads to abortion of nascent transcripts
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Cited by
Notch signaling pathway: architecture, disease, and therapeutics
Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,114
Autoinhibition with Transcriptional Delay
Lewis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00534-7 · Cited by 746
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Self-citationRoles of Hes genes in neural development
Kageyama, R., Ohtsuka, T., & Kobayashi, T. (2008) · Development, Growth & Differentiation · doi:10.1111/j.1440-169x.2008.00993.x · Cited by 283
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Metadata
- Authors
- Bessho, Y., Hirata, H., Masamizu, Y., & Kageyama, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-06-03
- Volume
- 17
- Issue
- 12
- Pages
- 1451-1456
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2146639522
- Cited by
- 286
- References
- 25
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Bessho, Y., Hirata, H., Masamizu, Y., & Kageyama, R. (2003). Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes & Development. https://doi.org/10.1101/gad.1092303
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