The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
The generation of antibody diversity through somatic hypermutation and class switch recombination
Open accessAbstract
Characteristics of class switch recombinationIn CSR, the Cµ region is replaced by downstream C␥, C, or C␣ segments to generate IgG, IgE, and IgA antibodies, respectively.This process is mediated by an intrachromosomal recombinational event between the switch (S) region of the Cµ region (Sµ) and one of the downstream S regions (Fig. 2).These S regions are located immediately upstream of each of the C regions (except for ␦; Fig. 2A) and contain imperfect G-C-rich pentameric repeats that serve as the donors and recipients for a recombinational process that is region specific but not sequence specific (for review, see Stavnezer 2000; Kenter 2003).
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Somatic generation of antibody diversity
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Somatic generation of antibody diversity.
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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
Pasqualucci, L., Neumeister, P., Goossens, T., Nanjangud, G., Chaganti, R. S. K., Küppers, R., & Dalla-Favera, R. (2001) · Nature · doi:10.1038/35085588 · Cited by 1,032
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
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R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
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Transcription-targeted DNA deamination by the AID antibody diversification enzyme
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The multifaceted mismatch-repair system
Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,370
Kunkel, T. A., & Erie, D. A. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133243 · Cited by 1,367
DNA Mismatch Repair: Functions and Mechanisms
Iyer, R. R., Pluciennik, A., Burdett, V., & Modrich, P. L. (2006) · Chemical Reviews · doi:10.1021/cr0404794 · Cited by 905
The Biochemistry of Somatic Hypermutation
Peled, J. U., Kuang, F. L., Iglesias-Ussel, M. D., Roa, S., Kalis, S. L., Goodman, M. F., & Scharff, M. D. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090236 · Cited by 462
Self-citationThe APOBEC Protein Family: United by Structure, Divergent in Function
Salter, J. D., Bennett, R. P., & Smith, H. C. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.001 · Cited by 408
Metadata
- Authors
- Li, Z., Woo, C. J., Iglesias-Ussel, M. D., Ronai, D., & Scharff, M. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-01-01
- Volume
- 18
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2103735815
- Cited by
- 342
- References
- 81
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Li, Z., Woo, C. J., Iglesias-Ussel, M. D., Ronai, D., & Scharff, M. D. (2004). The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes & Development. https://doi.org/10.1101/gad.1161904
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