PreprintCited by 1,245Cancer-related Molecular PathwaysTelomeres, Telomerase, and SenescenceCell death mechanisms and regulation

The DOI matches its Crossref record; 55 of the 60 references it cites were found in a registry or an index.

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Open access

Zindy, Frederique, Eischen, Christine M., Randle, David H., Kamijo, Takehiko, Cleveland, John L., Sherr, Charles J., Roussel, Martine F.·1998·Genes & Development

DOI 10.1101/gad.12.15.2424PMC PMC317045

Open this paper in CoChat — free account Open PDF

Abstract

Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19(ARF) tumor suppressors, which act in a common biochemical pathway. myc rapidly activates ARF and p53 gene expression in primary MEFs and triggers replicative crisis by inducing apoptosis. MEFs that survive myc overexpression sustain p53 mutation or ARF loss during the process of establishment and become immortal. MEFs lacking ARF or p53 exhibit an attenuated apoptotic response to myc ab initio and rapidly give rise to cell lines that proliferate in chemically defined medium lacking serum. Therefore, ARF regulates a p53-dependent checkpoint that safeguards cells against hyperproliferative, oncogenic signals.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.12.15.2424

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Cancer Cell Cycles
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Self-citation
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 2×
“Expression of activated ras in primary MEFs inhibits cell growth (Serrano et al. 1997), whereas overexpression of myc in these same cells triggers apoptosis, a process further aggravated by withdrawal of serum survival factors (Evan et al. 1992).”
Background
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 2×
“In turn, Mdm2 acts in a feedback loop to catalyze p53 ubiquitination and degrada- tion, limiting the p53 response (Haupt et al. 1997; Honda et al. 1997; Kubbutat et al. 1997).”
Background
Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804

Show all 60 references

Research works printed but not linked: 1

10.1126/science.256.5058.827 · DOI

Sorted by citations

Items 901–1,000 of 1,001

Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c‐ myc in the liver
Klocke, R., Bartels, T., Jennings, G. S., Brand, K., Halter, R., Strauss, M., & Paul, D. (2001) · The FASEB Journal · doi:10.1096/fj.00-0487fje · Cited by 14
Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation
Santamaria, K., Desmots, F., Léonard, S., Caron, G., Haas, M., Delaloy, C., Chatonnet, F., Delphine Rossille, A., Pignarre, A., Monvoisin, C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.744573 · Cited by 14
Inhibition of tumorigenicity by the 5′-untranslated RNA of the human c-myc P0 transcript
Blume, S. W. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00182-4 · Cited by 14
NMDA receptor mediated Ca2+ responses in neurons differentiated from p53−/− immortalized Murine neural stem cells
Yamada, K., Hisatsune, T., Uchino, S., Nakamura, T., Kudo, Y., & Kaminogawa, S. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00134-2 · Cited by 14
p14ARF interacts with N‐Myc and inhibits its transcriptional activity
Amente, S., Gargano, B., Diolaiti, D., Valle, G. D., Lania, L., & Majello, B. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.062 · Cited by 14
p53 mutations and tetraploids under r- and K-selection
Chikatsu, N., Nakamura, Y., Satō, H., Fujita, T., Asano, S., & Motokura, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205413 · Cited by 14
Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line
VASKIVUO, L., Rysä, J., KOIVUPERA, J., MYLLYNEN, P., Vaskivuo, T. E., Chválová, K., Serpi, R., Savolainen, E., Puistola, U., & Vähäkangas, K. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.04.015 · Cited by 14
Expression of Tumor Suppressor Gene Product p14ARF in Endometrioid Adenocarcinoma of the Uterine Corpus
Watanabe, J., Nishizaki, R., Jobo, T., Kamata, Y., Hata, H., Nishimura, Y., Fujisawa, T., Okayasu, I., & Kuramoto, H. (2004) · International Journal of Gynecological Pathology · doi:10.1097/01.pgp.0000130050.27266.9a · Cited by 13
Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia
Volanakis, E. J., Boothby, M. R., & Sherr, C. J. (2012) · Experimental Hematology · doi:10.1016/j.exphem.2012.11.006 · Cited by 13
Self-citation
Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways
Nwosu, V. C., Kissling, G. E., Trempus, C. S., Honeycutt, H., & French, J. E. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.010 · Cited by 13
Inappropriate Activation of Cyclin-dependent Kinases by the Phosphatase Cdc25b Results in Premature Mitotic Entry and Triggers a p53-dependent Checkpoint
Varmeh, S., & Manfredi, J. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900037200 · Cited by 13
Biological effects of induced MYCN hyper-expression in MYCN-amplified neuroblastomas
Tang (2010) · International Journal of Oncology · doi:10.3892/ijo_00000749 · Cited by 13
Spontaneous apoptosis in ovarian carcinomas: a positive association with p53 gene mutation is dependent on growth fraction
Kupryjańczyk, J., Dansonka‐Mieszkowska, A., Szymańska, T., Karpińska, G., Rembiszewska, A., Rusin, M., Konopiński, R., Kraszewska, E., Timorek, A., Yandell, D. W., et al. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.0967 · Cited by 13
Cell Death Signaling in Malignancy
Burns, T. F., & El‐Deiry, W. S. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48158-8_13 · Cited by 13
Effects of Simian Virus 40 T-Antigens on Normal Human Mammary Epithelial Cells Reveal Evidence for Spontaneous Alterations in Addition to Loss of p16INK4a Expression
Huschtscha, L. I., Neumann, A. A., Noble, J. R., & Reddel, R. R. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5178 · Cited by 13
DNA‐damaging drug‐induced apoptosis sensitized by N‐myc in neuroblastoma cells
Li, T., Wang, L., Ke, X., Gong, X., Wan, J., Hao, X., Xu, M., Xiang, Z., Cui, Z., & Cui, H. (2011) · Cell Biology International · doi:10.1042/cbi20110231 · Cited by 12
p14ARF interacts with E2F factors to form p14ARF–E2F/partner‐DNA complexes repressing E2F‐dependent transcription
Zhang, H., Li, W., Gu, Y., Li, S., An, G., Ni, J., & Jia, H. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22446 · Cited by 12
Decreased Mdm2 Expression Inhibits Tumor Development and Extends Survival Independent of Arf and Dependent on p53
Eischen, C. M., & Boyd, K. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046148 · Cited by 12
Self-citation
Identification of a Novel Rb-regulated Gene Associated with the Cell Cycle
Sung, Y. H., Kim, H. J., & Lee, H. (2007) · Molecules and Cells · doi:10.1016/s1016-8478(23)07357-0 · Cited by 12
The p53 Tumour Suppressor Protein
Hickman, E. S., & Helin, K. (2000) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2000.10647992 · Cited by 12
Oncogenes as Novel Targets for Cancer Therapy (Part III)
Zhang, Z., Li, M., Rayburn, E. R., Hill, D. L., Zhang, R., & Wang, H. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505050-00005 · Cited by 12
Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia
Prasher, J. M., Elenitoba‐Johnson, K. S. J., & Kelley, L. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204395 · Cited by 14
Selection for Loss of p53 Function in T-Cell Lymphomagenesis Is Alleviated by Moloney Murine Leukemia Virus Infection in myc Transgenic Mice
Baxter, E. W., Blyth, K., Cameron, E. R., & Neil, J. C. (2001) · Journal of Virology · doi:10.1128/jvi.75.20.9790-9798.2001 · Cited by 12
Correction: Mimicking p14ARF Phosphorylation Influences Its Ability to Restrain Cell Proliferation
Vivo, M., Ranieri, M., Sansone, F., Santoriello, C., Calogero, R., CALABRÒ, V., Pollice, A., & Mantia, G. L. (2013) · PLoS ONE · doi:10.1371/annotation/77e996e1-a18e-47a6-918b-801932929b28 · Cited by 12
Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest
Kubíčková, A., Sanctis, J. B. D., & Hajdúch, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417524 · Cited by 11
A senescence restriction point acting on chromatin integrates oncogenic signals
Lopes‐Paciencia, S., Bourdeau, V., Rowell, M., Amirimehr, D., Guillon, J., Kalegari, P., Barua, A., Trinh, V. Q., Azzi, F., Turcotte, S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114044 · Cited by 13
Deciphering the Role of p53 and TAp73 in Neuroblastoma: From Pathogenesis to Treatment
Almeida, J., Mota, I. N. R., Skoda, J., Sousa, E., Cidade, H. M., & Saraiva, L. (2022) · Cancers · doi:10.3390/cancers14246212 · Cited by 11
Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice
van Oosterwijk, J. G., Li, C., Yang, X., Opferman, J. T., & Sherr, C. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707292114 · Cited by 11
Self-citation
Bach1‐mediated suppression of p53 is inhibited by p19 ARF independently of MDM 2
Nishizawa, H., Ota, K., Dohi, Y., Ikura, T., & Igarashi, K. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02244.x · Cited by 11
Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs
Happo, L., Phipson, B., Smyth, G. K., Strasser, A., & Scott, C. L. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.42 · Cited by 11
An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis
Mendrysa, S. M., Akagi, K., Roayaei, J., Lien, W., Copeland, N. G., Jenkins, N. A., & Eisenman, R. N. (2010) · Genes & Cancer · doi:10.1177/1947601910374875 · Cited by 11
Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene
Rottmann, S., Speckgens, S., Lüscher‐Firzlaff, J., & Lüscher, B. (2007) · The FASEB Journal · doi:10.1096/fj.07-9627com · Cited by 11
Identification of De Novo Enhancers Activated by TGFβ to Drive Expression of CDKN2A and B in HeLa Cells
Liu, Y., Xu, L., Bennett, L. B., Hooks, J. C., Liu, J., Zhou, Q., Liem, P. H., Zheng, Y., & Skapek, S. X. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0289 · Cited by 11
Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant
Klein, M. A., Rüedi, D., Nozaki, M., Dell, E. W., Diserens, A., Seelentag, W. K. F., Janzer, R. C., Aguzzi, A., & Hegi, M. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203941 · Cited by 11
p14ARF inhibits the growth of p53 deficient cells in a cell-specific manner
Li, Y., He, L., Bruce, A., Parihar, K., Ingram, A. J., Liu, L., & Tang, D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.04.011 · Cited by 11
p53 Deficiency Increases Transformation by v-Abl and Rescues the Ability of a C-Terminally Truncated v-Abl Mutant To Induce Pre-B Lymphoma In Vivo
Zou, X., Cong, F., Coutts, M., Cattoretti, G., Goff, S. P., & Calame, K. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.628-633.2000 · Cited by 11
Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland
Foster, C. J., & Lozano, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205441 · Cited by 11
Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.
Hulit, J., Vizio, D. D., & Pestell, R. G. (2001) · Breast Cancer Research · doi:10.1186/bcr297 · Cited by 11
A role for cadherins in cellular signaling and differentiation
Knudsen, K. A., Frankowski, C., Johnson, K. R., & Wheelock, M. J. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1998)72:30/31+ · Cited by 88
Induction of p14ARF by E2F1 Contributes to 8-Chloro-Adenosine-Induced Apoptosis in Human Lung Cancer H1299 Cells
Li, W., Gu, Y., Zhang, H., Zhou, J., & Jia, H. (2009) · Chemotherapy · doi:10.1159/000230697 · Cited by 10
Age-related dysfunction of p53-regulated phagocytic activity in macrophages
Yamaguchi, Y., Kaida, K., Suenaga, Y., Ishigami, A., Kobayashi, Y., & Nagata, K. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.121 · Cited by 11
FIT links c-Myc and P53 acetylation by recruiting RBBP7 during colorectal carcinogenesis
Guo, L., Xia, Y., Li, H., Wang, Z., Xu, H., Dai, X., Zhang, Y., Zhang, H., Fan, W., Wei, F., et al. (2023) · Cancer Gene Therapy · doi:10.1038/s41417-023-00624-z · Cited by 10
KSHV manipulation of the cell cycle and programmed cell death pathways
Moore, P. S. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545313.031 · Cited by 10
Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model
Ramsey, L. B., Janke, L. J., Edick, M. J., Cheng, C., Williams, R. T., Sherr, C. J., Evans, W. E., & Relling, M. V. (2014) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000044 · Cited by 10
Self-citation
IL-6 promotes MYC-induced B cell lymphomagenesis independent of STAT3
Petrenko, O., Li, J., Cimica, V., Mena, P., Shin, H. Y., D’Amico, S., & Reich, N. C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247394 · Cited by 10
A Mouse Bone Marrow Stromal Cell Line with Skeletal Stem Cell Characteristics to Study Osteogenesis In Vitro and In Vivo
Raeth, S., Sacchetti, B., Siegel, G., Mau-Holzmann, U. A., Hansmann, J., Vacun, G., Hauk, T. G., Pfizenmaier, K., & Haußer, A. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0367 · Cited by 10
Abnormalities of the p53 gene in juvenile myelomonocytic leukaemia
Miyauchi, J., Asada, M., Tsunematsu, Y., Kaneko, Y., Kojima, S., & Mizutani, S. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01634.x · Cited by 10
Development of multidrug resistance due to multiple factors including P‐glycoprotein overexpression under K‐selection after MYC and HRAS oncogene activation
Nakamura, Y., Satō, H., & Motokura, T. (2005) · International Journal of Cancer · doi:10.1002/ijc.21691 · Cited by 10
Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery
Sampson, E. R., McMurray, H. R., Hassane, D. C., Newman, L. A., Salzman, P., Jordan, C. T., & Land, H. (2012) · Oncogene · doi:10.1038/onc.2012.389 · Cited by 10
Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3
Hemmati, P., Müer, A., Gillissen, B. F., Overkamp, T., Milojkovic, A., Wendt, J., Dörken, B., & Daniel, P. T. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0606-5 · Cited by 12
Novel Expression of CST1 as Candidate Senescence Marker
Keppler, D., Zhang, J., Bihani, T., & Lin, A. W. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr033 · Cited by 10
Signal Transduction Networks
McCormick, F. P. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-313-2_3 · Cited by 11
Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance
Guo-chang, F. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00524-3 · Cited by 10
Senescence and Cell Cycle Control
Kiyokawa, H. (2006) · Springer eBooks · doi:10.1007/400_001 · Cited by 10
Suppression of E1A-Mediated Transformation by the p50E4F Transcription Factor
Fernandes, E. R., & Rooney, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4739 · Cited by 10
The pan-cancer lncRNA MILIP links c-Myc to p53 repression
Feng, Y., Zhao, X. H., Liu, T., Thorne, R. F., Jin, L., & Zhang, X. D. (2020) · Molecular & Cellular Oncology · doi:10.1080/23723556.2020.1842714 · Cited by 10
Exploring Myc puzzle: Insights into cancer, stem cell biology, and PPI networks
Ghasemi, N., & Azizi, H. (2024) · Gene · doi:10.1016/j.gene.2024.148447 · Cited by 9
Transforming Growth Factor β1 (TGF-β1) Suppresses Growth of B-cell Lymphoma Cells by p14ARF-dependent Regulation of Mutant p53
Chen, G., Ghosh, P., O’Farrell, T. J., Munk, R. B., Rezanka, L. J., Sasaki, C. Y., & Longo, D. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.351411 · Cited by 11
Etoposide induced NMI promotes cell apoptosis by activating the ARF-p53 signaling pathway in lung carcinoma
Song, D., Zhao, J., Chen, S., Jiang, Y., & Hou, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.010 · Cited by 9
Surveillance of nucleolar homeostasis and ribosome maturation by autophagy and the ubiquitin-proteasome system
Mende, H., & Müller, S. P. (2021) · Matrix Biology · doi:10.1016/j.matbio.2021.02.001 · Cited by 9
Aging of Fibroblasts
Kletsas, D. (2003) · Springer eBooks · doi:10.1007/978-94-017-0669-8_3 · Cited by 9
The Intrinsic Pathway of Apoptosis
Kaufmann, S. H. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-221-2_1 · Cited by 10
Exploiting Drug-Induced Senescence in Transgenic Mouse Models
Kılıç, M., & Schmitt, C. A. (2008) · CRC Press eBooks · doi:10.3109/9781420020502-17 · Cited by 9
Apoptosis and Cancer Therapy
Reimann, M., & Schmitt, C. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-200-7_13 · Cited by 9
Long term follow-up of c-myc, p53 and proliferation measurements in malignant melanoma
Ross, D. A., Laing, H., Sanders, R., & Wilson, G. D. (2005) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2005.08.005 · Cited by 9
Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX
Wahl, G. M., Stommel, J. M., Krummel, K. A., & Wade, M. R. (2005) · Springer eBooks · doi:10.1007/978-1-4020-2922-6_4 · Cited by 9
The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis
Korai, A., Lin, X., Tago, K., & Funakoshi‐Tago, M. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110985 · Cited by 8
Regulation of eukaryotic transcription initiation in response to cellular stress
Ferdoush, J., Kadir, R. A., Ogle, M., & Saha, A. (2024) · Gene · doi:10.1016/j.gene.2024.148616 · Cited by 8
Establishment and characterization of a PCOS and a normal human granulosa cell line
Hashemian, Z., Afsharian, P., Farzaneh, P., Eftekhari‐Yazdi, P., Vakhshiteh, F., Amoli, A. D., & Nasimian, A. (2020) · Cytotechnology · doi:10.1007/s10616-020-00426-3 · Cited by 8
Differential cooperation of oncogenes with p53 and Bax to induce apoptosis in rhabdomyosarcoma
Taylor, A. C., Schuster, K., McKenzie, P., & Harris, L. C. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-53 · Cited by 8
High-density growth arrest in Ras-transformed cells: low Cdk kinase activities in spite of absence of p27 Cdk-complexes
Groth, A., & Willumsen, B. M. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.11.021 · Cited by 8
Human Krüppel-related 3 (HKR3) Is a Novel Transcription Activator of Alternate Reading Frame (ARF) Gene
Yoon, J.-H., Choi, W., Jeon, B., Koh, D., Kim, M.-K., Kim, M., Kim, J., Hur, S. S., Kim, K., & Hur, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.526855 · Cited by 8
Cell Growth Inhibition by Okadaic Acid Involves Gut-Enriched Kruppel-like Factor–Mediated Enhanced Expression of c-Myc
Zhang, L., Wali, A., Ramana, C. V., & Rishi, A. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2505 · Cited by 8
PKCα is involved in phorbol ester TPA-mediated stabilization of p14ARF
Inoue, R., & Shiraishi, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.117 · Cited by 9
The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?
del Arroyo, A. G., & Peters, G. G. (2005) · Advances in experimental medicine and biology · doi:10.1007/1-4020-3764-3_8 · Cited by 8
APOPTOTIC PROTEINS
McCarthy, N. J., Mercer, J. R., & Bennett, M. R. (2001) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70196-x · Cited by 8
Three molecular determinants of malignant conversion and their potential as therapeutic targets
Dome, J. S., & Look, A. T. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199901000-00013 · Cited by 8
Transformation of primary murine peritoneal mast cells by constitutive KIT activation is accompanied by loss of Cdkn2a/Arf expression
Capellmann, S., Sonntag, R., Schüler, H. M., Meurer, S. K., Gan, L., Kauffmann, M., Horn, K., Königs‐Werner, H., Weiskirchen, R., Liedtke, C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154416 · Cited by 7
The intervention of B. longum metabolites in Fnevs' carcinogenic capacity: A potential double-edged sword
Xu, J., Xu, X., Yang, L., & Xu, X. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114407 · Cited by 7
Genome-scale transcriptional analysis reveals key genes associated with the development of type II diabetes in mice
Zhang, Y., Han, D., Yu, P., Huang, Q., & Ge, P. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4042 · Cited by 8
Fam60al as a novel factor involved in reprogramming of somatic cell nuclear transfer in zebrafish (Danio rerio)
Hu, H., Tao, B., Chen, J., Zhu, Z., & Hu, W. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.22426 · Cited by 7
Clinicopathological significance of p14ARF expression in lung cancer: a meta-analysis
Wang, F., Li, H., Long, J., & Ye, S. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s131954 · Cited by 7
v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release
MacLaren, A., Clark, W. A., & Gillespie, D. A. (2000) · Oncogene · doi:10.1038/sj.onc.1203954 · Cited by 7
Heterogeneity of Cellular Senescence: Subtype‐Specific Mechanisms and the Emerging Role of Plasma Membrane Damage
Alghamdi, E., & Kono, K. (2025) · Cancer Science · doi:10.1111/cas.70223 · Cited by 7
Characterization of p53/p63/p73 and Myc expressions during embryogenesis of the sea urchin
Grant, B., Buitrago, P. A. S., Mercado, B. C., & Yajima, M. (2023) · Developmental Dynamics · doi:10.1002/dvdy.656 · Cited by 7
Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF
Sui, X.-Y., Ma, X.-Y., Hou, Y., Cao, S.-W., Wang, Z.-Q., Jia, L., Fan, L., Shao, Z.-M., & Zhang, W. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09864-7 · Cited by 7
RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade
Oei, V., Chuang, L. S. H., Matsuo, J., Srivastava, S., Teh, M., & Ito, Y. (2023) · Communications Biology · doi:10.1038/s42003-023-05037-0 · Cited by 6
Restoration of p53 Functions By Suppression of mortalin–p53 Sequestration: an Emerging Target in Cancer Therapy
Akshatha, H. S., Bhagyalalitha, M., Pujar, G. V., Hariharapura, R. C., Sethu, A. K., Singh, M., & Bidye, D. P. (2023) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0061 · Cited by 7
p14ARFinduces apoptosisviaan entirely caspase-3-dependent mitochondrial amplification loop
Milojkovic, A., Hemmati, P., Müer, A., Overkamp, T., Chumduri, C., Jänicke, R. U., Gillissen, B. F., & Daniel, P. T. (2013) · International Journal of Cancer · doi:10.1002/ijc.28279 · Cited by 7
The Role of the Proto-Oncogene c-myc in B Lymphocyte Differentiation
Fernández‐Antorán, D., Lobo, V. J. S.-A., & de Alborán, I. M. (2012) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v32.i4.30 · Cited by 6
Changes in p19 Arf Localization Accompany Apoptotic Crisis during Pre-B-Cell Transformation by Abelson Murine Leukemia Virus
Zimmerman, R., & Rosenberg, N. E. (2008) · Journal of Virology · doi:10.1128/jvi.00348-08 · Cited by 6
Cell-Substrate Interactions Feedback to Direct Cell Migration along or against Morphological Polarization
Kumar, G., Ho, C., & Co, C. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133117 · Cited by 6
Retracted
Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16Ink4a, p19Arf, p53, and p21Waf1/Cip1
Obata, M., Imamura, E., Yoshida, Y., Goto, J., Kishibe, K., Yasuda, A., & Ogawa, K. (2001) · Molecular Carcinogenesis · doi:10.1002/mc.1059 · Cited by 6
Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components
Nakagawa, T., Nakayama, K., & Nakayama, K. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_10 · Cited by 6
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
Muralidharan, S. V., Nilsson, L. M., Lindberg, M. F., & Nilsson, J. A. (2020) · Life Science Alliance · doi:10.26508/lsa.202000671 · Cited by 6
Molecular targets for cell cycle inhibition and cancer therapy
Lee, M., & Yang, H.-Y. (2003) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.13.3.329 · Cited by 6
Chemoprevention of Breast Cancer
Fabian, C., & Kimler, B. (2002) · Drugs & Aging · doi:10.2165/00002512-200219010-00004 · Cited by 8
Identification of the gene immediately downstream of the murine INK4a/ARF locus
Pantoja, C., Palmero, I., & Serrano, M. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00104-8 · Cited by 6
Cellular senescence and cancer
(1999) · doi:10.1002/(sici)1096-9896(199901)187:1
Conserved genetic programs in insect and mammalian brain development
(1999) · doi:10.1002/(sici)1521-1878(199908)21:8

Authors: Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Eischen, Christine M.
Kamijo, Takehiko
Cleveland, John L.
Sherr, Charles J.
Roussel, Martine F.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1998-08-01
Volume: 12
Issue: 15
Pages: 2424-2433
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.12.15.2424
PMC: PMC317045
OpenAlex: W2046958356
Cited by: 1,245
References: 60
Citations by year: 2026: 6 · 2025: 15 · 2024: 14 · 2023: 32 · 2022: 10 · 2021: 27 · 2020: 15 · 2019: 22 · 2018: 15 · 2017: 23 · 2016: 28 · 2015: 19 · 2014: 43 · 2013: 45 · 2012: 46
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: St. Jude Children's Research Hospital (CA21765)
American Lebanese Syrian Associated Charities (CA 21765)
National Institutes of Health (5r01ca056819-08, CA21765))
National Cancer Institute (CA-71907, CA56819, P30CA021765, P01CA071907)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 44158, R01DK044158)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: MYC signaling, ARF tumor suppressor, p53, apoptosis, cell immortalization, p19ARF, TP53 mutation, oncogenic transformation
MeSH terms: Animals, Cell Division, Cell Line, Humans, Models, Biological, Mutation, Proteins, Signal Transduction, Gene Expression, Genes, Tumor Suppressor, Genes, p53, Genes, myc, Apoptosis, Gene Deletion, Tumor Suppressor Protein p14ARF, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks