Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651

Cancer Cell Cycles

Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 2×

Mdm2 promotes the rapid degradation of p53

Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506

p21 is a universal inhibitor of cyclin kinases

Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650

Regulation of p53 stability by Mdm2

Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 2×

Induction of apoptosis in fibroblasts by c-myc protein

Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

Hales, E. C., Taub, J. W., & Matherly, L. H. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.09.021 · Cited by 187

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALLPreprint

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., et al. (2008) · Genes & Development · doi:10.1101/gad.1621808 · Cited by 192

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

Onoyama, I., Tsunematsu, R., Matsumoto, A., Kimura, T., de Alborán, I. M., Nakayama, K., & Nakayama, K. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062299 · Cited by 186

Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis

Eischen, C. M., Roussel, M. F., Korsmeyer, S. J., & Cleveland, J. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7653-7662.2001 · Cited by 186

(−)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance

Oliver, C. L., Miranda, M. B., Shangary, S. K., Land, S. R., Wang, S., & Johnson, D. E. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.23.4.1 · Cited by 182

Gene expression changes in response to E2F1 activation

Stanelle, J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.8.1859 · Cited by 181

Advances in the understanding of MYC‐induced lymphomagenesis

Klapproth, K., & Wirth, T. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08159.x · Cited by 180

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Bergö, M. O., Gavino, B. J., Hong, C., Beigneux, A. P., McMahon, M., Casey, P. J., & Young, S. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18829 · Cited by 185

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Bergo, M. O., Gavino, B. J., Hong, C., Beigneux, A. P., McMahon, M., Casey, P. J., & Young, S. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418829 · Cited by 180

Cytokine-Dependent Imatinib Resistance in Mouse Bcr-Abl(+), Arf-Null Lymphoblastic Leukemia.Preprint

Williams, R. T., den Besten, W., Boulos, N., & Sherr, C. J. (2007) · Genes & Development · doi:10.1101/gad.1588607 · Cited by 178

c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations

Luo, H., Li, Q., O’Neal, J., Kreisel, F. H. C., Beau, M. M. L., & Tomasson, M. H. (2005) · Blood · doi:10.1182/blood-2005-02-0734 · Cited by 179

Contributions of Myc to tumorigenesis

Lutz, W., Leon, J., & Eilers, M. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00036-7 · Cited by 177

Tumor suppressor genes

Macleod, K. F. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00041-6 · Cited by 180

Integrative Modelling of the Influence of MAPK Network on Cancer Cell Fate Decision

Grieco, L., Calzone, L., Bernard‐Pierrot, I., Radvanyi, F., Kahn‐Perlès, B., & Thieffry, D. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003286 · Cited by 182

Aberrant Expression of Nucleostemin Activates p53 and Induces Cell Cycle Arrest via Inhibition of MDM2

Dai, M., Sun, X., & Lu, H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01662-07 · Cited by 174

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

Phan, J., Li, Z., Kasprzak, A., Li, B., Sebti, S., Guida, W., Schönbrunn, E., & Chen, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.073056 · Cited by 173

Mechanism of transcriptional activation by the Myc oncoproteins

Cowling, V. H., & Cole, M. D. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.08.001 · Cited by 178

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kineticsPreprint

Aslanian, A., Iaquinta, P. J., Verona, R. I., & Lees, J. A. (2004) · Genes & Development · doi:10.1101/gad.1196704 · Cited by 176

The role of ubiquitin modification in the regulation of p53

Hock, A. K., & Vousden, K. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.022 · Cited by 168

DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility

Maillet, M., Purcell, N. H., Sargent, M. A., York, A. J., Bueno, O. F., & Molkentin, J. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806085200 · Cited by 172

Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1

Eischen, C. M., Packham, G., Nip, J., Fee, B. E., Hiebert, S. W., Zambetti, G. P., & Cleveland, J. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204892 · Cited by 167

p19ARF targets certain E2F species for degradation

Martelli, F., Hamilton, T., Silver, D. P., Sharpless, N. E., Bardeesy, N. M., Rokas, M., DePinho, R. A., Livingston, D. M., & Grossman, S. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081061398 · Cited by 167

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

Bardeesy, N., Bastian, B. C., Hezel, A., Pinkel, D., DePinho, R. A., & Chin, L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2144-2153.2001 · Cited by 166

Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts

Hess, P., Pihan, G. A., Sawyers, C. L., Flavell, R. A., & Davis, R. J. (2002) · Nature Genetics · doi:10.1038/ng946 · Cited by 165

Elimination of p19ARF-expressing cells enhances pulmonary function in mice

Hashimoto, M., Asai, A., Kawagishi, H., Mikawa, R., Iwashita, Y., Kanayama, K., Sugimoto, K., Sato, T., Maruyama, M., & Sugimoto, M. (2016) · JCI Insight · doi:10.1172/jci.insight.87732 · Cited by 162

Molecular and Genetic Aspects of Lung Cancer

Rom, W. N., Hay, J. G., Lee, T. C., Jiang, Y., & Tchou-Wong, K.-M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.4.9908012 · Cited by 163

Genome Stability Requires p53

Eischen, C. M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026096 · Cited by 161

Human ARF binds E2F1 and inhibits its transcriptional activity

Eymin, B., Karayan, L., Seité, P., Brambilla, C., Brambilla, E. M., Larsen, C., & Gazzéri, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204220 · Cited by 161

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

Chen, D., Shan, J., Zhu, W.-G., Qin, J., & Gu, W. (2010) · Nature · doi:10.1038/nature08820 · Cited by 160

The T-box Repressors TBX2 and TBX3Specifically Regulate the Tumor Suppressor Genep14 via a Variant T-site in the Initiator

Lingbeek, M. E., Jacobs, J. J. L., & van Lohuizen, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200403200 · Cited by 160

ARF Impedes NPM/B23 Shuttling in an Mdm2-Sensitive Tumor Suppressor Pathway

Brady, S. N., Yu, Y., Maggi, L. B., & Weber, J. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9327-9338.2004 · Cited by 163

Regulation of growth arrest in senescence: Telomere damage is not the end of the story

Herbig, U., & Sedivy, J. M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.002 · Cited by 163

Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA

Kim, J.-S., Lee, C. S., Bonifant, C. L., Ressom, H. W., & Waldman, T. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00537-06 · Cited by 165

p53 -Altered FBXW7 Expression Determines Poor Prognosis in Gastric Cancer Cases

Yokobori, T., Mimori, K., Iwatsuki, M., Ishii, H., Onoyama, I., Fukagawa, T., Kuwano, H., Nakayama, K. I., & Mori, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2846 · Cited by 159

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis

Wagner, K., & Wagner, N. (2022) · Cells · doi:10.3390/cells11121966 · Cited by 161

c-Jun NH 2 -Terminal Kinase Is Essential for the Regulation of AP-1 by Tumor Necrosis Factor

Ventura, J., Kennedy, N. J., Lamb, J. A., Flavell, R. A., & Davis, R. J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2871-2882.2003 · Cited by 156

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

Nishimura, K., Kumazawa, T., Kuroda, T., Katagiri, N., Tsuchiya, M., Goto, N., Furumai, R., Murayama, A., Yanagisawa, J., & Kimura, K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.055 · Cited by 167

TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

Brummelkamp, T. R., Kortlever, R. M., Lingbeek, M., Trettel, F., MacDonald, M. E., van Lohuizen, M., & Bernards, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110492200 · Cited by 154

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

Rao, S., Lee, S.-Y., Gutiérrez, A., Perrigoue, J., Thapa, R. J., Tu, Z., Jeffers, J. R., Rhodes, M. R., Anderson, S. J., Oravecz, T., et al. (2012) · Blood · doi:10.1182/blood-2012-03-415349 · Cited by 161

Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis

Bursać, S., Brdovčak, M. C., Donati, G., & Volarević, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.014 · Cited by 166

Mammalian MYC Proteins and Cancer

Tansey, W. P. (2014) · New Journal of Science · doi:10.1155/2014/757534 · Cited by 166

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex

Wang, X., Sansam, C. G., Thom, C. S., METZGER, D., Evans, J. A., Nguyen, P. T. L., & Roberts, C. W. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0733 · Cited by 153

p53 Gene Status as a Predictor of Tumor Response to Induction Chemotherapy of Patients With Locoregionally Advanced Squamous Cell Carcinomas of the Head and Neck

Temam, S., Flahault, A., Périé, S., Monceaux, G., Coulet, F., Callard, P., Bernaudin, J., Guily, J. L. S., & Fouret, P. J. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.2.385 · Cited by 153

The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo

Verschuren, E. W., Klefström, J. T., Evan, G. I., & Jones, N. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00123-x · Cited by 153

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc

Pusapati, R. V., Rounbehler, R. J., Hong, S., Powers, J. T., Yan, M., Kiguchi, K., McArthur, M. J., Wong, P. K. Y., & Johnson, D. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507367103 · Cited by 157

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

Sluss, H. K., Armata, H., Gallant, J., & Jones, S. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.976-984.2004 · Cited by 152

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

Michalak, E. M., Jansen, E. S., Happo, L., Cragg, M. S., Tai, L., Smyth, G. K., Strasser, A., Adams, J. M., & Scott, C. L. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2008.195 · Cited by 156

Tumor suppressor p53: regulation and function

Somasundaram, K. (2000) · Frontiers in bioscience · doi:10.2741/somasund · Cited by 155

Inducible Activation of c-Myc in Adult Myocardium In Vivo Provokes Cardiac Myocyte Hypertrophy and Reactivation of DNA Synthesis

Xiao, G., Mao, S., Baumgarten, G., Serrano, J., Jordan, M. C., Roos, K. P., Fishbein, M. C., & MacLellan, W. R. (2001) · Circulation Research · doi:10.1161/hh2401.100742 · Cited by 152

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

Zindy, F., Williams, R. T., Baudino, T. A., Rehg, J. E., Skapek, S. X., Cleveland, J. L., Roussel, M. F., & Sherr, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536808100 · Cited by 152

E2F1 Uses the ATM Signaling Pathway to Induce p53 and Chk2 Phosphorylation and Apoptosis

Powers, J. T., Hong, S., Mayhew, C. N., Rogers, P. M., Knudsen, E. S., & Johnson, D. G. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.203.2.4 · Cited by 152

c-Myc Functionally Cooperates with Bax To Induce Apoptosis

Juin, P. P., Hunt, A. E., Littlewood, T. D., Griffiths, B. L., Swigart, L. B., Korsmeyer, S. J., & Evan, G. I. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6158-6169.2002 · Cited by 149

Strategies for manipulating the p53 pathway in the treatment of human cancer

Hupp, T. R., Lane, D. P., & Ball, K. L. (2000) · Biochemical Journal · doi:10.1042/bj3520001 · Cited by 148

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

Zhang, D., Hirota, T., Marumoto, T., Shimizu, M., Kunitoku, N., Sasayama, T., Arima, Y., Feng, L., Suzuki, M., Takeya, M., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208153 · Cited by 147

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma

Fulci, G., Labuhn, M., Maier, D., Lachat, Y., Hausmann, O., Hegi, M. E., Janzer, R. C., Merlo, A., & Van Meir, E. G. (2000) · Oncogene · doi:10.1038/sj.onc.1203700 · Cited by 146

Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis

Garrison, S. P., Jeffers, J. R., Yang, C., Nilsson, J. A., Hall, M. A., Rehg, J. E., Yue, W., Yu, J., Zhang, L., Onciu, M. M., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00907-07 · Cited by 151

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

Baptiste, N., Friedlander, P. A., Chen, X., & Prives, C. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205015 · Cited by 149

Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1

Inoue, K., Roussel, M. F., & Sherr, C. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3993 · Cited by 144

E2F-1 induced apoptosis

Phillips, A. C., & Vousden, K. H. (2001) · APOPTOSIS · doi:10.1023/a:1011332625740 · Cited by 144

Risk of prostate carcinoma death in patients with lymph node metastasis

Liang Cheng, C., Zincke, H., Blute, M. L., Bergstralh, E. J., Scherer, B. G., & Bostwick, D. G. (2001) · Cancer · doi:10.1002/1097-0142(20010101)91:1 · Cited by 359

Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation.

Alarcon, R. M., Koumenis, C., Geyer, R. K., Maki, C. G., & Giaccia, A. J. (1999) · PubMed · Cited by 143

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescencePreprint

Zou, X., Ray, D., Aziyu, A., Christov, K. T., Boiko, A. D., Gudkov, A. V., & Kiyokawa, H. (2002) · Genes & Development · doi:10.1101/gad.1033002 · Cited by 146

Ink4a/Arf links senescence and aging

Sharpless, N. E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.025 · Cited by 142

Massively regulated genes: the example of TP53

Hollstein, M. C., & Hainaut, P. L. (2009) · The Journal of Pathology · doi:10.1002/path.2637 · Cited by 149

Developmental Context Determines Latency of MYC-Induced Tumorigenesis

Beer, S., Zetterberg, A., Ihrie, R. A., McTaggart, R., Yang, Q., Bradon, N., Arvanitis, C., Attardi, L. D., Feng, S., Ruebner, B. H., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020332 · Cited by 142

Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation

Bergö, M. O., Ambroziak, P., Gregory, C., George, A. M., Otto, J. C., Kim, E. J.-H., Nagase, H., Casey, P. J., Balmain, A., & Young, S. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.171-181.2002 · Cited by 142

The Emerging p53 Gene Family

Kaelin, W. G. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.594 · Cited by 143

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19 ARF –p53 signalingPreprint

Shvarts, A., Brummelkamp, T. R., Scheeren, F., Koh, E., Daley, G. Q., Spits, H., & Bernards, R. (2002) · Genes & Development · doi:10.1101/gad.929302 · Cited by 145

Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers

Halberg, R. B., Katzung, D. S., Hoff, P. D., Moser, A. R., Cole, C. E., Lubet, R. A., Donehower, L. A., Jacoby, R. F., & Dove, W. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3461 · Cited by 139

Suppression of Ras-stimulated transformation by the JNK signal transduction pathwayPreprint

Kennedy, N. J., Sluss, H. K., Jones, S. N., Bar‐Sagi, D., Flavell, R. A., & Davis, R. J. (2003) · Genes & Development · doi:10.1101/gad.1062903 · Cited by 139

p19 Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation

Radfar, A., Unnikrishnan, I., Lee, H., DePinho, R. A., & Rosenberg, N. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13194 · Cited by 140

Oncogenes Induce and Activate Endogenous p73 Protein

Zaika, A. I., Irwin, M. S., Sansome, C., & Moll, U. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005737200 · Cited by 138

Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis

Golomb, L., Bublik, D. R., Wilder, S., Nevo, R., Kiss, V., Grabusic, K., Volarevic, S., & Oren, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.11.022 · Cited by 137

Overexpression of MYC causes p53 -dependent G 2 arrest of normal fibroblasts

Felsher, D. W., Zetterberg, A., Zhu, J., Tlsty, T. D., & Bishop, J. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190327097 · Cited by 137

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal agingPreprint

Matheu, A., Pantoja, C., Efeyan, A., Criado, L. M., Martín‐Caballero, J., Flores, J. M., Klatt, P., & Serrano, M. (2004) · Genes & Development · doi:10.1101/gad.310304 · Cited by 140

The emerging role of E2F-1 in the DNA damage response and checkpoint control

Stevens, C., & Thangue, N. B. L. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.034 · Cited by 136

The mSin3A Chromatin-Modifying Complex Is Essential for Embryogenesis and T-Cell Development

Cowley, S. M., Iritani, B. M., Mendrysa, S. M., Xu, T., Cheng, P. F., Yada, J. J., Liggitt, H. D., & Eisenman, R. N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6990-7004.2005 · Cited by 136

The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation.

Bhattacharya, A., Deng, J. M., Zhang, Z., Behringer, R. R., Crombrugghe, B. D., & Maity, S. N. (2003) · PubMed · Cited by 135

Taming of the beast: shaping Myc-dependent amplification

Wolf, E., Lin, C. Y., Eilers, M., & Levens, D. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.10.006 · Cited by 138

Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies

Solary, É., Droin, N. M., Bettaı̈eb, A., Corcos, L., Dimanche‐Boitrel, M., & Garrido, C. (2000) · Leukemia · doi:10.1038/sj.leu.2401902 · Cited by 137

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Bonetti, P., Davoli, T., Sironi, C., Amati, B. B., Pelicci, P. G., & Colombo, E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711040 · Cited by 140

Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation

Deneen, B., & Denny, C. T. (2001) · Oncogene · doi:10.1038/sj.onc.1204875 · Cited by 134

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

Wang, Y., Fisher, J. C., Mathew, R., Li, O., Otieno, S. B., Sublet, J., Xiao, L., Chen, J., Roussel, M. F., & Kriwacki, R. W. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.536 · Cited by 133

p53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma

Chen, L., Iraci, N., Gherardi, S., Gamble, L. D., Wood, K. M., Perini, G., Lunec, J., & Tweddle, D. A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2598 · Cited by 132

Mdm2 Binds to Nbs1 at Sites of DNA Damage and Regulates Double Strand Break Repair

Alt, J. R., Bouska, A., Fernandez, M. R., Cerny, R. L., Xiao, H., & Eischen, C. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413387200 · Cited by 131

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Dang, C. V. (2008) · Ernst Schering Research Foundation workshop/Ernst Schering Foundation Symposium proceedings · doi:10.1007/2789_2008_088 · Cited by 131

Mdm2 haplo‐insufficiency profoundly inhibits Myc‐induced lymphomagenesis

Alt, J. R., Greiner, T. C., Cleveland, J. L., & Eischen, C. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg133 · Cited by 129

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Wu, K., Li, A., Rao, M., Liu, M., Dailey, V. K., Yang, Y., Vizio, D. D., Wang, C., Lisanti, M. P., Sauter, G., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00268-06 · Cited by 129

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

MacLaine, N. J., & Hupp, T. R. (2009) · Aging · doi:10.18632/aging.100047 · Cited by 134

Immortalization of Primary Human Prostate Epithelial Cells by c-Myc

Gil, J., Kerai, P., LLeonart, M. E., Bernard, D., Cigudosa, J. C., Peters, G. G., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-03-4030 · Cited by 129

Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis

Timme, T. L., Goltsov, A. A., Tahir, S. A., Li, L., Wang, J., Ren, C., Johnston, R. N., & Thompson, T. C. (2000) · Oncogene · doi:10.1038/sj.onc.1203654 · Cited by 129

Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma

Gladden, A. B., Woolery, R., Aggarwal, P., Wasik, M. A., & Diehl, J. A. (2005) · Oncogene · doi:10.1038/sj.onc.1209147 · Cited by 129

c-Myc Overexpression Uncouples DNA Replication from Mitosis

Li, Q., & Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5339 · Cited by 129

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X L

Maclean, K. H., Keller, U. B., Galindo, C. R., Nilsson, J. A., & Cleveland, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7256-7270.2003 · Cited by 128

Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts — a possible mechanism for arsenite’s comutagenicity

Vogt, B. L., & Rossman, T. G. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00137-3 · Cited by 128

Attenuating the p53 Pathway in Human Cancers: Many Means to the Same EndPreprint

Wasylishen, A. R., & Lozano, G. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026211 · Cited by 131

The Oscar-worthy role of Myc in apoptosis

Meyer, N., Kim, S. S., & Penn, L. Z. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.011 · Cited by 132

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Immortalisation and transformation revisited

Drayton, S. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00271-4 · Cited by 129

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Eischen, C. M., Weber, J. D., Roussel, M. F., Sherr, C. J., & Cleveland, J. L. (1999) · Genes & Development · doi:10.1101/gad.13.20.2658 · Cited by 819

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Sarkar, D., & Fisher, P. B. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.6.2939 · Cited by 6

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Qi, Y., Gregory, M. A., Li, Z., Brousal, J. P., West, K. A., & Hann, S. (2004) · Nature · doi:10.1038/nature02958 · Cited by 214

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Benanti, J. A., Wang, M. L., Myers, H. E., Robinson, K. L., Grandori, C., & Galloway, D. A. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0372 · Cited by 39