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WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes
Open accessAbstract
WT1 is essential for normal kidney development, and genetic alterations are associated with Wilms’ tumor, Denys Drash (DDS), and Frasier syndromes. Although generally considered a transcription factor this study has revealed that WT1 interacts with an essential splicing factor, U2AF65, and associates with the splicing machinery. WT1 is alternatively spliced and isoforms that include three amino acids, KTS, show stronger interaction with U2AF65 in vitro and better colocalization with splicing factors in vivo. Interestingly a mutation associated with DDS enhanced both −KTS WT1 binding to U2AF65 and splicing-factor colocalization. These data illustrate the functional importance of WT1 isoforms and suggest that WT1 plays a role in pre-mRNA splicing.
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Cited by
Mechanisms of Alternative Pre-Messenger RNA Splicing
Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704
Pre-mRNA splicing and human disease
Faustino, N. A., & Cooper, T. A. (2003) · Genes & Development · doi:10.1101/gad.1048803 · Cited by 1,256
Zhong, S., Li, H., Bodi, Z., Button, J., Vespa, L., Herzog, M., & Fray, R. G. (2008) · The Plant Cell · doi:10.1105/tpc.108.058883 · Cited by 668
Temperature-Dependent Sex Determination in Vertebrates
(2018) · Open Monographs · doi:10.5479/si.9781944466213 · Cited by 522
Direct Coupling of Transcription and mRNA Processing through the Thermogenic Coactivator PGC-1
Monsalve, M., Wu, Z., Adelmant, G., Puigserver, P., Fan, M., & Spiegelman, B. M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00031-9 · Cited by 395
Metadata
- Authors
- Davies, R. C., Calvio, C., Bratt, E., Larsson, S. H., Lamond, A. I., & Hastie, N. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-10-15
- Volume
- 12
- Issue
- 20
- Pages
- 3217-3225
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2121457746
- Cited by
- 246
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Davies, R. C., Calvio, C., Bratt, E., Larsson, S. H., Lamond, A. I., & Hastie, N. D. (1998). WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes & Development. https://doi.org/10.1101/gad.12.20.3217
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