Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589

A Laboratory manual

Ashburner, M. (1989) · Cold Spring Harbor Laboratory eBooks · Cited by 6,756

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

Hayes, J. D., & Pulford, D. J. (1995) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239509083491 · Cited by 3,464

Dietary Carcinogens and Anticarcinogens

Ames, B. N. (1983) · Science · doi:10.1126/science.6351251 · Cited by 2,975

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607

pEF-BOS, a powerful mammalian expression vector

Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,594

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

MILLER, J. A. (1970) · PubMed · Cited by 1,453

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Sims, P. H., Grover, P. L., Swaisland, A. J., Pal, K., & Hewer, A. J. (1974) · Nature · doi:10.1038/252326a0 · Cited by 1,134

p62/ SQSTM 1—Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

Taniguchi, K., Yamachika, S., He, F., & Karin, M. (2016) · FEBS Letters · doi:10.1002/1873-3468.12301 · Cited by 117

WDR23 regulates NRF2 independently of KEAP1

Lo, J. Y., Spatola, B. N., & Curran, S. P. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006762 · Cited by 116

Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease

Sharma, V., Kaur, A., & Singh, T. G. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110373 · Cited by 116

Pharmacotherapy against Oxidative Stress in Chronic Kidney Disease: Promising Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling

Uddin, M. J., Kim, E. H., Hannan, M. A., & Ha, H. (2021) · Antioxidants · doi:10.3390/antiox10020258 · Cited by 112

Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

Gnanaprakasam, J. R., Kushwaha, B., Liu, L., Chen, X., Kang, S., Wang, T., Cassel, T., Adams, C. M., Higashi, R. M., Scott, D. A., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00856-1 · Cited by 112

Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity

Ni, M., Li, X., Yin, Z., Sidoryk‐Wȩgrzynowicz, M., Jiang, H., Farina, M., da Rocha, J. B. T., Syversen, T. L. M., & Aschner, M. (2011) · Glia · doi:10.1002/glia.21153 · Cited by 116

Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells

Gong, H., Singh, S. V., Singh, S. P., Mu, Y., Lee, J. H., Saini, S. P. S., Toma, D., Ren, S., Kagan, V. E., Day, B. W., et al. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0205 · Cited by 111

Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes

Keum, Y. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.2.144 · Cited by 114

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

Ni, M., Li, X., Yin, Z., Jiang, H., Sidoryk‐Wȩgrzynowicz, M., Milatović, D., Cai, J., & Aschner, M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq126 · Cited by 112

Resveratrol protects quail hepatocytes against heat stress: modulation of the Nrf2 transcription factor and heat shock proteins

Şahin, K., Orhan, C., Akdemir, F., Tuzcu, M., Iben, C., & Şahin, N. (2011) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2010.01123.x · Cited by 114

Molecular Evolution of Keap1

Li, L., Kobayashi, M., Kaneko, H., Nakajima‐Takagi, Y., Nakayama, Y., & Yamamoto, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708702200 · Cited by 111

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Bruns, D. R., Drake, J. C., Biela, L. M., Peelor, F. F., Miller, B. F., & Hamilton, K. L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/732596 · Cited by 113

Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes

Kanzaki, H., Shinohara, F., Itohiya, K., Yamaguchi, Y., Fukaya, S., Miyamoto, Y., Wada, S., & Nakamura, Y. (2016) · Redox Biology · doi:10.1016/j.redox.2016.01.006 · Cited by 111

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

Tao, S., Liu, P., Luo, G., de la Vega, M. R., Chen, R., Wu, T., Tillotson, J., Chapman, E., & Zhang, D. D. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00660-16 · Cited by 116

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

Pallesen, J. S., Tran, K. T., & Bach, A. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00358 · Cited by 112

Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation

Lv, H., Zhu, C., Wei, W., Lv, X., Yu, Q., Deng, X., & Ci, X. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153241 · Cited by 112

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

Zhang, J., Hosoya, T., Maruyama, A., Nishikawa, K., Maher, J. M., Ohta, T., Motohashi, H., Fukamizu, A., Shibahara, S., Itoh, K., et al. (2007) · Biochemical Journal · doi:10.1042/bj20061611 · Cited by 111

Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53-SIRT1 axis

Yoon, D. S., Choi, Y., & Lee, J. W. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.3 · Cited by 105

Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats

Ağca, C. A., Tuzcu, M., Hayırlı, A., & Şahin, K. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.05.023 · Cited by 110

Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status

Klammer, H., Mladenov, E., Li, F., & Iliakis, G. E. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.12.017 · Cited by 120

The NRF2‐related interactome and regulome contain multifunctional proteins and fine‐tuned autoregulatory loops

Papp, D., Lenti, K., Módos, D., Fazekas, D., Dúl, Z., Türei, D., Földvári-Nagy, L., Nussinov, R., Csermely, P., & Korcsmaros, T. D. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.016 · Cited by 109

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

Hybertson, B. M., Gao, B., & Doan, A. (2014) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s35078 · Cited by 113

Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

Meccariello, R., & D’Angelo, S. (2021) · Antioxidants · doi:10.3390/antiox10040507 · Cited by 110

Inflammation and Oxidative Stress: Potential Targets for Improving Prognosis After Subarachnoid Hemorrhage

Wu, F., Liu, Z., Li, G., Zhou, L., Huang, K., Wu, Z., Zhan, R., & Shen, J. F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.739506 · Cited by 110

Anticarcinogenesis by dietary phytochemicals: Cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells

Gopalakrishnan, A., & Kong, A. T. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.082 · Cited by 110

Crosstalk between Nrf2 and Notch signaling

Wakabayashi, N., Chartoumpekis, D. V., & Kensler, T. W. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.017 · Cited by 109

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction

Steel, R., Cowan, J., Payerne, E., O'Connell, M. A., & Searcey, M. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml300041g · Cited by 113

Clinical review: Oxygen as a signaling molecule

Bartz, R. R., & Piantadosi, C. A. (2010) · Critical Care · doi:10.1186/cc9185 · Cited by 116

Nrf2 promotes survival following exposure to ionizing radiation

Sekhar, K. R., & Freeman, M. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.035 · Cited by 109

NRF2 and p53: Januses in cancer?

Rotblat, B., Melino, G., & Knight, R. A. (2012) · Oncotarget · doi:10.18632/oncotarget.754 · Cited by 114

Induction of Phase 2 Antioxidant Enzymes by Broccoli Sulforaphane: Perspectives in Maintaining the Antioxidant Activity of Vitamins A, C, and E

Boddupalli, S. S., Mein, J. R., Lakkanna, S., & James, D. R. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00007 · Cited by 112

Bovine embryo survival under oxidative‐stress conditions is associated with activity of the NRF2‐mediated oxidative‐stress‐response pathway

Amin, A., Gad, A. Y., Salilew‐Wondim, D., Prastowo, S., Held-Hoelker, E., Hoelker, M., Rings, F., Tholen, E., Neuhoff, C., Looft, C., et al. (2014) · Molecular Reproduction and Development · doi:10.1002/mrd.22316 · Cited by 109

Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation

Keleku-Lukwete, N., Suzuki, M., Otsuki, A., Tsuchida, K., Katayama, S., Hayashi, M., Naganuma, E., Moriguchi, T., Tanabe, O., Engel, J. D., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509158112 · Cited by 108

Lycopene activates antioxidant enzymes and nuclear transcription factor systems in heat-stressed broilers

Şahin, K., Orhan, C., Tuzcu, M., Şahin, N., Hayırlı, A., Bilgili, S., & Kucuk, O. (2016) · Poultry Science · doi:10.3382/ps/pew012 · Cited by 109

The neurobiology of acetyl-L-carnitine

Traina, G. (2016) · Frontiers in bioscience · doi:10.2741/4459 · Cited by 115

The KEAP1-NRF2 System and Neurodegenerative Diseases

Uruno, A., & Yamamoto, M. P. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0234 · Cited by 113

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

Tian, H., Zhang, B., Di, J., Jiang, G., Chen, F., Li, H., Li, L., Pei, D., & Zheng, J. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.06.007 · Cited by 110

Redox regulation of the transcriptional repressor Bach1

Ishikawa, M., Numazawa, S., & Yoshida, T. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.021 · Cited by 112

Chemistry of the Cysteine Sensors in Kelch-Like ECH-Associated Protein 1

Holland, R., & Fishbein, J. C. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3273 · Cited by 109

Inhibition of Nuclear Factor κB by Phenolic Antioxidants: Interplay between Antioxidant Signaling and Inflammatory Cytokine Expression

Ma, Q., Kinneer, K., Ye, J., & Chen, B. J. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.211 · Cited by 107

Cellular Mechanisms of Oxidative Stress and Action in Melanoma

Venza, M., Visalli, M., Beninati, C., Gaetano, G. V. D., Teti, D. V., & Venza, I. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/481782 · Cited by 110

Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway

Campbell, M. R., Karaca, M., Adamski, K. N., Chorley, B. N., Wang, X., & Bell, D. A. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/120305 · Cited by 112

Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway

Li, M., Zhou, F., Xu, T., Song, H., & Lu, B. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.06.018 · Cited by 108

A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

Tran, K. T., Pallesen, J. S., Solbak, S. M. Ø., Narayanan, D., Baig, A., Zang, J., Aguayo‐Orozco, A., Carmona, R. M., Garcia, A. D., & Bach, A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00723 · Cited by 108

Resveratrol Prevents Estrogen-DNA Adduct Formation and Neoplastic Transformation in MCF-10F Cells

Lü, F., Zahid, M., Wang, C., SAEED, M. K., Cavalieri, E. L., & Rogan, E. G. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0037 · Cited by 109

Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity

Weng, C., Chen, M.-J., Yeh, C., & Yen, G. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.05.003 · Cited by 106

Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Glia · doi:10.1002/glia.23136 · Cited by 111

Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α

Pullikotil, P., Chen, H., Muniyappa, R., Greenberg, C. C., Yang, S., Reiter, C. E. N., Lee, J.-W., Chung, J. H., & Quon, M. J. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.007 · Cited by 106

Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells

Lu, C., Yang, Y., Li, C., Liu, K., Lii, C., & Chen, H. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.06.024 · Cited by 107

Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death

Zou, X., Gao, J., Zheng, Y., Wang, X., Chen, C., Cao, K., Xu, J., Li, Y., Lu, W., Liu, J., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.190 · Cited by 106

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model

Kim, S., Viswanath, A. N. I., Park, J., Lee, H. E., Park, A. Y., Choi, J., Kim, H. J., Londhe, A. M., Jang, B. K., Lee, J., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107989 · Cited by 108

Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice

Aleksunes, L. M., Reisman, S. A., Yeager, R. L., Goedken, M. J., & Klaassen, C. D. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162271 · Cited by 106

Oxidative Stress Abolishes Leptomycin B-sensitive Nuclear Export of Transcription Repressor Bach2 That Counteracts Activation of Maf Recognition Element

Hoshino, H., Kobayashi, A., Yoshida, M., Kudo, N. R., Oyake, T., Motohashi, H., Hayashi, N., Yamamoto, M. P., & Igarashi, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15370 · Cited by 106

Insecticides induce the co-expression of glutathione S-transferases through ROS/CncC pathway in Spodoptera exigua

Hu, B. H., Hu, S., Huang, H., Wei, Q., Ren, M., Huang, S., Tian, X., & Su, J. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.01.008 · Cited by 107

Luteolin Attenuates Cardiac Ischemia/Reperfusion Injury in Diabetic Rats by Modulating Nrf2 Antioxidative Function

Xiao, C., Xia, M., Wang, J., Zhou, X., Lou, Y.-Y., Tang, L., Zhang, F., Yang, J.-T., & Qian, L.-B. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2719252 · Cited by 105

Sinapic Acid Ameliorates the Progression of Streptozotocin (STZ)-Induced Diabetic Nephropathy in Rats via NRF2/HO-1 Mediated Pathways

Alaofi, A. L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01119 · Cited by 109

Ferroptosis regulation by the NGLY1/NFE2L1 pathway

Forcina, G. C., Pope, L. E., Murray, M. B., Dong, W., Abu-Remaileh, M., Bertozzi, C. R., & Dixon, S. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118646119 · Cited by 103

Oxidative stress in neurodegeneration and available means of protection

Fatokun, A. A. (2008) · Frontiers in bioscience · doi:10.2741/2926 · Cited by 105

Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition

Hanssen, K. M., Haber, M., & Fletcher, J. I. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100795 · Cited by 102

Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma.

Bao, L.-J., Jaramillo, M. C., Zhang, Z.-B., Zheng, Y.-X., Yao, M., Zhang, D. D., & Yi, X.-F. (2014) · Europe PMC (PubMed Central) · Cited by 103

Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2)

Timme‐Laragy, A. R., Karchner, S. I., Franks, D. G., Jenny, M. J., Harbeitner, R. C., Goldstone, J. V., McArthur, A. G., & Hahn, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.260125 · Cited by 105

A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking

O'Mealey, G. B., Plafker, K. S., Berry, W. L., Janknecht, R., Chan, J. Y., & Plafker, S. M. (2017) · Journal of Cell Science · doi:10.1242/jcs.203216 · Cited by 99

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

Probst, B., Isaac, T., Lyndsey, M., Bumeister, R., Dulubova, I., Wigley, W. C., & Ferguson, D. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122942 · Cited by 103

Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate

Hu, Y., Lu, W., Chen, G., Zhang, H., Jia, Y., Wei, Y., Yang, H., Zhang, W., Fiskus, W. C., Bhalla, K. N., et al. (2010) · Blood · doi:10.1182/blood-2009-11-256354 · Cited by 104

Mutations in Plasmodium falciparum K13 propeller gene from Bangladesh (2009–2013)

Mohon, A. N., Alam, M. S., Bayih, A. G., Folefoc, A., Shahinas, D., Haque, R., & Pillai, D. R. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-431 · Cited by 106

The NRF 2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis

Hammer, A., Waschbisch, A., Kuhbandner, K., Bayas, A., Lee, D., Duscha, A., Haghikia, A., Gold, R., & Linker, R. A. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.553 · Cited by 103

Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin

Jin, Y. N., Yu, Y. V., Gundemir, S., Jo, C., Cui, M., Tieu, K., & Johnson, G. V. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057932 · Cited by 107

5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction

Fujino, M., Nishio, Y., Ito, H., Tanaka, T., & Li, X. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.11.034 · Cited by 103

Glycosylation of KEAP1 links nutrient sensing to redox stress signaling

Chen, P., Smith, T. J., Wu, J., Siesser, P. F., Bisnett, B. J., Khan, F., Hogue, M., Soderblom, E. J., Tang, F., Marks, J. R., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696113 · Cited by 105

Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease

Wang, Y., Gao, L., Chen, J., Li, Q., Huo, L., Wang, Y., Wang, H., & Du, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.757161 · Cited by 107

Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases

Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 116

Effects of interventions on oxidative stress and inflammation of cardiovascular diseases

Lee, S. (2011) · World Journal of Cardiology · doi:10.4330/wjc.v3.i1.18 · Cited by 103

NF-E2-Related Factor 1 (Nrf1) Serves as a Novel Regulator of Hepatic Lipid Metabolism through Regulation of the Lipin1 and PGC-1 β Genes

Hirotsu, Y., Hataya, N., Katsuoka, F., & Yamamoto, M. P. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06706-11 · Cited by 102

Induction of Rat UDP-Glucuronosyltransferases in Liver and Duodenum by Microsomal Enzyme Inducers That Activate Various Transcriptional Pathways

Shelby, M. K., & Klaassen, C. D. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.010397 · Cited by 104

Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics

Li, W., Guo, Y., Zhang, C., Wu, R., Yang, Y., Gaspar, J. M., & Kong, A. T. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00413 · Cited by 101

Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)

Tian, W., de la Vega, M. R., Schmidlin, C. J., Ooi, A., & Zhang, D. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000428 · Cited by 101

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

Sova, M., & Saso, L. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s172612 · Cited by 104

Blockade of Glutathione Metabolism in IDH1 -Mutated Glioma

Tang, X., Fu, X., Liu, Y., Yu, D., Cai, S. J., & Yang, C. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0103 · Cited by 100

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Wang, X., Li, Y., Li, Z., Lin, S., Wang, H., Sun, J., Lan, C., Wu, L., Sun, D., Huang, C., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3230 · Cited by 105

Optimization of Fluorescently Labeled Nrf2 Peptide Probes and the Development of a Fluorescence Polarization Assay for the Discovery of Inhibitors of Keap1-Nrf2 Interaction

Inoyama, D., Chen, Y., Huang, X., Beamer, L. J., Kong, A. T., & Hu, L. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111430124 · Cited by 101

Site-directed mutagenesis of cysteine to serine in the DNA binding regionof Nrf2 decreases its capacity to upregulate antioxidant responseelement-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

Bloom, D. A., Dhakshinamoorthy, S., & Jaiswal, A. K. (2002) · Oncogene · doi:10.1038/sj.onc.1205288 · Cited by 102

Polymorphisms in the K13-Propeller Gene in Artemisinin-Susceptible Plasmodium falciparum Parasites from Bougoula-Hameau and Bandiagara, Mali

Ouattara, A., Koné, A., Adams, M., Fofana, B., Maiga, A. W., Hampton, S., Coulibaly, D., Thera, M. A., Diallo, N., Dara, A., et al. (2015) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.14-0605 · Cited by 105

NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer

Kim, J., & Keum, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2746457 · Cited by 101

Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway

Ma, J., Li, S., Zhu, L., Guo, S., Yi, X., Cui, T., He, Y., Chang, Y., Liu, B., Li, C., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.421 · Cited by 100

A STING to inflammation and autoimmunity

Kumar, V. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir1018-397rr · Cited by 100

The intricacies of NRF2 regulation in cancer

Schmidlin, C. J., Shakya, A., Dodson, M. B., Chapman, E., & Zhang, D. D. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.016 · Cited by 103

Mouse translation elongation factor eEF1A‐2 interacts with Prdx‐I to protect cells against apoptotic death induced by oxidative stress

Chang, R., & Wang, E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20969 · Cited by 100

Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish

Suzuki, T., Takagi, Y., Osanai, H., Li, L., TAKEUCHI, M., Katoh, Y., Kobayashi, M., & Yamamoto, M. P. (2005) · Biochemical Journal · doi:10.1042/bj20041860 · Cited by 100

Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage

Kang, E. S., Woo, I. S., Kim, H. J., Eun, S. Y., Paek, K. S., Kim, H. J., Chang, K. C., Lee, J. H., Lee, H. T., Kim, J., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.006 · Cited by 100

Nrf2–ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice

Miller, D. M., Singh, I. N., Wang, J. A., & Hall, E. D. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.008 · Cited by 98

Respiratory Viral Infections and Subversion of Cellular Antioxidant Defenses

Casola, A. (2014) · Journal of Pharmacogenomics & Pharmacoproteomics · doi:10.4172/2153-0645.1000141 · Cited by 99

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression

Sekine, H., Okazaki, K., Ota, N., Shima, H., Katoh, Y., Suzuki, N., Igarashi, K., Ito, M., Motohashi, H., & Yamamoto, M. P. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00785-15 · Cited by 99

Till Death Do Us Part: The Marriage of Autophagy and Apoptosis

Cooper, K. F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4701275 · Cited by 104

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Naidu, S. D., Muramatsu, A., Saito, R., Asami, S., Honda, T., Hosoya, T., Itoh, K., Yamamoto, M. P., Suzuki, T., & Dinkova‐Kostova, A. T. (2018) · Scientific Reports · doi:10.1038/s41598-018-26269-9 · Cited by 99

The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review

Iranshahy, M., Iranshahi, M., Abtahi, S. R., & Karimi, G. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.07.024 · Cited by 100

Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress

Abo‐Al‐Ela, H. G., El‐Kassas, S., El‐Naggar, K., Abdo, S. E., Jahejo, A. R., & Wakeel, R. A. A. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01204-6 · Cited by 99

Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process

Süntar, I. P., Çetinkaya, S., Panieri, E., Saha, S., Buttari, B., Profumo, E., & Saso, L. (2021) · Molecules · doi:10.3390/molecules26092424 · Cited by 103

How to Increase Cellular Glutathione

Giustarini, D., Milzani, A., Dalle‐Donne, I., & Rossi, R. (2023) · Antioxidants · doi:10.3390/antiox12051094 · Cited by 108

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

Kaspar, J. W., & Jaiswal, A. K. (2010) · The FASEB Journal · doi:10.1096/fj.10-171553 · Cited by 101

CAND1-Mediated Substrate Adaptor Recycling Is Required for Efficient Repression of Nrf2 by Keap1

Lo, S., & Hannink, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1235-1244.2006 · Cited by 99

Chapter 3 Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression

Liebler, D. C., Hong, F., Sekhar, K. R., & Freeman, M. L. (2006) · Advances in molecular toxicology · doi:10.1016/s1872-0854(06)01003-4 · Cited by 3

Regulatory mechanisms of cellular response to oxidative stress

Itoh, K., Ishii, T., Wakabayashi, N., & Yamamoto, M. P. (1999) · Free Radical Research · doi:10.1080/10715769900300881 · Cited by 349

The Nrf2-Keap1 signalling pathway: Mechanisms of ARE transcription regulation in antioxidant cellular defence

Atia, A., & Abdullah, A. (2014) · International Journal of PharmTech Research · Cited by 7

[18] Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements

Ishii, T., Itoh, K., & Yamamoto, M. P. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)48637-5 · Cited by 161

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

Itoh, K., Mimura, J., & Yamamoto, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3222 · Cited by 521