The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
p53-Mediated apoptosis is attenuated in Werner syndrome cells
Open accessAbstract
The WRN DNA helicase is a member of the DExH-containing DNA helicase superfamily that includes XPB, XPD, and BLM. Mutations in WRN are found in patients with the premature aging and cancer susceptibility syndrome known as Werner syndrome (WS). p53 binds to the WRN protein in vivo and in vitro through its carboxyl terminus. WS fibroblasts have an attenuated p53- mediated apoptotic response, and this deficiency can be rescued by expression of wild-type WRN. These data support the hypothesis that p53 can induce apoptosis through the modulation of specific DExH-containing DNA helicases and may have implications for the cancer predisposition observed in WS patients.
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Cites
p53 Mutations in Human Cancers
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Self-citationA biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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p53 is required for radiation-induced apoptosis in mouse thymocytes
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p53-Dependent apoptosis suppresses tumor growth and progression in vivo
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“1358 GENES & DEVELOPMENT ity and preventing tumorigenicity (Yonish-Rouach et al. 1991; Clarke et al. 1993; Lowe et al. 1993; Symonds et al. 1994), the increased risk of cancer associated with WS may be the result, in part, of attenuation of a p53-mediated apoptotic pathway.”
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Cited by
p53 in the DNA–Damage–Repair Process
Williams, A. B., & Schumacher, B. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026070 · Cited by 835
p53: traffic cop at the crossroads of DNA repair and recombination
Sengupta, S., & Harris, C. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1546 · Cited by 544
Self-citationBernstein, C. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00009-1 · Cited by 527
Programmed cell death in aging
Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
Agrelo, R., Cheng, W.-H., Setien, F., Ropero, S., Espada, J., Fraga, M. F., Herranz, M., Paz, M. F., Sanchez-Cespedes, M., Artiga, M. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600645103 · Cited by 264
Metadata
- Authors
- Spillare, E. A., Robles, A. I., Wang, X. W., Shen, J.-C., Yu, C.-E., Schellenberg, G. D., & Harris, C. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-06-01
- Volume
- 13
- Issue
- 11
- Pages
- 1355-1360
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2033985470
- Cited by
- 178
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Spillare, E. A., Robles, A. I., Wang, X. W., Shen, J.-C., Yu, C.-E., Schellenberg, G. D., & Harris, C. C. (1999). p53-Mediated apoptosis is attenuated in Werner syndrome cells. Genes & Development. https://doi.org/10.1101/gad.13.11.1355
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