p53: traffic cop at the crossroads of DNA repair and recombination

Sengupta, Sagar; Harris, Curtis C.

doi:10.1038/nrm1546

Cited by 544Cancer-related Molecular PathwaysDNA Repair MechanismsGenetic factors in colorectal cancer

p53: traffic cop at the crossroads of DNA repair and recombination

Sengupta, Sagar, Harris, Curtis C.·2005·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm1546

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Abstract

p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.

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Several p53 target genes encode DNA repair proteins.
“Given that p53 is activated in response to DNA damage, it is not surprising that several of its target genes encode for DNA repair proteins.162, 163”
From Census and evaluation of p53 target genes (2017) · cites this paper as [162]
mtp53 cancer cells can have inefficient nucleotide excision repair, rendering them more susceptible to platinum-mediated DNA damage.
“Interestingly, the TMD231 cells were significantly more sensitive to carboplatin than the normal human cells (Fig. 2E), consistent with previous reports that mtp53 cancer cells can have inefficient nucleotide excision repair (30), rendering them more susceptible to platinum-mediated DNA damage.”
From Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model (2015) · cites this paper as [30]
Mutant p53 cancer cells can have nucleotide excision repair defects that make them highly sensitive to platinum agents.
“Previous studies have demonstrated that mutant p53 cancer cells can harbor nucleotide excision repair defects, rendering them highly sensitive to platinum agents (30).”
From Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model (2015) · cites this paper as [30]

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Sengupta, S., Robles, A. I., Linke, S. P., Sinogeeva, N. I., Zhang, R., Pedeux, R., Ward, I. M., Celeste, A., Nussenzweig, A., Chen, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405128 · Cited by 130 · see citing works
Self-citation
Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice.
Bouffler, S. D., Kemp, C. J., Balmain, A., & Cox, R. (1995) · PubMed · Cited by 121 · see citing works
Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint
Saintigny, Y., Rouillard, D., Chaput, B., Soussi, T., & López, B. S. (1999) · Oncogene · doi:10.1038/sj.onc.1202941 · Cited by 121 · see citing works
Microsatellite Instability and p53 Mutations Are Associated With Abnormal Expression of the MSH2 Gene in Adult Acute Leukemia
Zhu, Y.-M., Das-Gupta, E. P., & Russell, N. H. (1999) · Blood · doi:10.1182/blood.v94.2.733 · Cited by 118 · see citing works
Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.
Achanta, G., Pelicano, H., Feng, L., Plunkett, W. K., & Huang, P. (2001) · PubMed · Cited by 115 · see citing works
Implication of p53 in base excision DNA repair: in vivo evidence
Seo, Y. R., Fishel, M. L., Amundson, S. A., Kelley, M. R., & Smith, M. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205129 · Cited by 115 · see citing works
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA
Offer, H., Erez, N., Zurer, I., Tang, X., Milyavsky, M., Goldfinger, N., & Rotter, V. (2002) · Carcinogenesis · doi:10.1093/carcin/23.6.1025 · Cited by 107 · see citing works
P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin.
Lin, X., Ramamurthi, K., Mishima, M., Kondo, A., Christen, R. D., & Howell, S. B. (2001) · PubMed · Cited by 106 · see citing works
p53 Modulates the Exonuclease Activity of Werner Syndrome Protein
Brosh, R. M., Karmakar, P., Sommers, J. A., Yang, Q., Wang, X. W., Spillare, E. A., Harris, C. C., & Bohr, V. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103332200 · Cited by 105 · see citing works
Self-citation
UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2
Wang, Q.-E., Zhu, Q., Wani, G., Chen, J., & Wani, A. A. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh085 · Cited by 104 · see citing works
Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control
Willers, H., McCarthy, E. E., Wu, B., Wunsch, H., Tang, W., Taghian, D. G., Xia, F., & Powell, S. N. (2000) · Oncogene · doi:10.1038/sj.onc.1203142 · Cited by 104 · see citing works
p53 and c-Jun Functionally Synergize in the Regulation of the DNA Repair Gene hMSH2 in Response to UV
Scherer, S. J., Maier, S. M., Seifert, M., Hanselmann, R. G., Zang, K. D., Müller‐Hermelink, H. K., Angel, P. E., Welter, C., & Schartl, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006990200 · Cited by 102 · see citing works
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells
Rooney, S., Sekiguchi, J., Whitlow, S. R., Eckersdorff, M., Manis, J. P., Lee, C., Ferguson, D. O., & Alt, F. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308757101 · Cited by 102 · see citing works
Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response
Ahn, J., Urist, M., & Prives, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213185200 · Cited by 99 · see citing works
p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.
Offer, H., Zurer, I., Bánfalvi, G., Rehak, M., Falcovitz, A., Milyavsky, M., Goldfinger, N., & Rotter, V. (2001) · PubMed · Cited by 99 · see citing works
Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage
Wang, Q. (2003) · DNA repair · doi:10.1016/s1568-7864(03)00002-8 · Cited by 96 · see citing works
Activation of p53 or Loss of the Cockayne Syndrome Group B Repair Protein Causes Metaphase Fragility of Human U1, U2, and 5S Genes
Yu, A., Fan, H.-Y., Liao, D., Bailey, A. D., & Weiner, A. M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80320-2 · Cited by 94 · see citing works
Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair
Therrien, J., Drouin, R., Baril, C., & Drobetsky, E. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15038 · Cited by 92 · see citing works
Sp1-Mediated Transcription of the Werner Helicase Gene Is Modulated by Rb and p53
Yamabe, Y., Shimamoto, A., Goto, M., Yokota, J., Sugawara, M., & Furuichi, Y. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6191 · Cited by 91 · see citing works
p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts.
Tang, W., Willers, H., & Powell, S. N. (1999) · PubMed · Cited by 90 · see citing works
Dissociation of the recombination control and the sequence-specific transactivation function of P53
Dudenhöffer, C., Kurth, M., Janus, F., Deppert, W., & Wiesmüller, L. (1999) · Oncogene · doi:10.1038/sj.onc.1202964 · Cited by 89 · see citing works
Different Capacities for Recombination in Closely Related Human Lymphoblastoid Cell Lines with Different Mutational Responses to X-Irradiation
Xia, F., Amundson, S. A., Nickoloff, J. A., & Liber, H. L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5850-5857.1994 · Cited by 84 · see citing works
p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thryroid cells
Yang, T., Namba, H., Hara, T., Takmura, N., Nagayama, Y., Fukata, S., Ishikawa, N., Kuma, K., Ito, K., & Yamashita, S. (1997) · Oncogene · doi:10.1038/sj.onc.1200979 · Cited by 82 · see citing works
In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes
Wiesmüller, L., Cammenga, J., & Deppert, W. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.737-744.1996 · Cited by 81 · see citing works
ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA Damage
Luo, Y., Lin, F., & Lin, W.-C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6430-6444.2004 · Cited by 79 · see citing works
p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo
Fitch, M. E. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg031 · Cited by 79 · see citing works
p53 Inhibits Strand Exchange and Replication Fork Regression Promoted by Human Rad51
Yoon, D. J., Wang, Y., Stapleford, K. A., Wiesmüller, L., & Chen, J. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.12.050 · Cited by 75 · see citing works
Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48 DDB2 and p53
Itoh, T., O’Shea, C. E., & Linn, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7540-7553.2003 · Cited by 73 · see citing works
Structural and functional involvement of p53 in BER in vitro and in vivo
Offer, H., Milyavsky, M., Erez, N., Matas, D., Zurer, I., Harris, C. C., & Rotter, V. (2001) · Oncogene · doi:10.1038/sj.onc.1204120 · Cited by 73 · see citing works
Self-citation
The role of p53 in base excision repair following genotoxic stress
Zurer, I. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg186 · Cited by 72 · see citing works
The p53-regulated Cyclin-dependent Kinase Inhibitor, p21 (cip1, waf1, sdi1), Is Not Required for Global Genomic and Transcription-coupled Nucleotide Excision Repair of UV-induced DNA Photoproducts
Adimoolam, S., Lin, C., & Ford, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102240200 · Cited by 71 · see citing works
Female embryonic lethality in mice nullizygous for both Msh2 and p53
Cranston, A. N., Bocker, T., Reitmair, A. H., Palazzo, J., Wilson, T., Mak, T. W., & Fishel, R. A. (1997) · Nature Genetics · doi:10.1038/ng0997-114 · Cited by 71 · see citing works
Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
Lebel, M., Cardiff, R. D., & Leder, P. (2001) · PubMed · Cited by 68 · see citing works
Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53
Süße, S., Janz, C., Janus, F., Deppert, W., & Wiesmüller, L. (2000) · Oncogene · doi:10.1038/sj.onc.1203809 · Cited by 64 · see citing works
Enhanced sensitivity to anti-benzo(a)pyrene-diol-epoxide DNA damage correlates with decreased global genomic repair attributable to abrogated p53 function in human cells.
Wani, M. A., Zhu, Q., El-Mahdy, M. A., Venkatachalam, S., & Wani, A. A. (2000) · PubMed · Cited by 63 · see citing works
BLM, the Bloom’s syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins
Sanz, M. M., Proytcheva, M. A., Ellis, N. A., Holloman, W. K., & German, J. (2000) · Cytogenetic and Genome Research · doi:10.1159/000056848 · Cited by 61 · see citing works
Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53
Saintigny, Y., & López, B. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205040 · Cited by 61 · see citing works
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development.
Bishop, A. J. R., Hollander, M. C., Kosaras, B., Sidman, R. L., Fornace, A. J., & Schiestl, R. H. (2003) · PubMed · Cited by 57 · see citing works
Association of p53 and MSH2 with recombinative repair complexes during S phase
Zink, D., Mayr, C., Janz, C., & Wiesmüller, L. (2002) · Oncogene · doi:10.1038/sj.onc.1205614 · Cited by 56 · see citing works
UV wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells
Mathonnet, G., Léger, C., Desnoyers, J., Drouin, R., Therrien, J., & Drobetsky, E. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232161100 · Cited by 56 · see citing works
p53 in the Cytoplasm
Baptiste, N., & Prives, C. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00164-3 · Cited by 55 · see citing works
Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation
Leung, S. Y., Yuen, S. T., Chan, T. L., Chan, A. S. Y., Ho, J. W. C., Kwan, K., Fan, Y. W., Hung, K. N., Chung, L.-P., & Wyllie, A. H. (2000) · Oncogene · doi:10.1038/sj.onc.1203740 · Cited by 51 · see citing works
The p53 Response to DNA Damage In Vivo Is Independent of DNA-Dependent Protein Kinase
Jhappan, C., Yusufzai, T. M., Anderson, S. M., Anver, M. R., & Merlino, G. T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4075-4083.2000 · Cited by 50 · see citing works
The Werner syndrome protein contributes to induction of p53 by DNA damage
Blander, G., Zalle, N., Martínez-Leal, J. F., Bar‐Or, R. L., Yu, C., & Oren, M. (2000) · The FASEB Journal · doi:10.1096/fj.00-0171fje · Cited by 49 · see citing works
p53 protects from replication-associated DNA double-strand breaks in mammalian cells
Kumari, A. R., Schultz, N., & Helleday, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207379 · Cited by 48 · see citing works
p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress
Jiang, M., Axe, T., Holgate, R., Rubbi, C. P., Okorokov, A. L., Mee, T. R., & Milner, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204705 · Cited by 48 · see citing works
A role for p53 in DNA end rejoining by human cell extracts
Bill, C. A., Yu, Y., Miselis, N. R., Little, J. B., & Nickoloff, J. A. (1997) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(97)00040-2 · Cited by 47 · see citing works
Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases
Subramanian, D. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2427 · Cited by 47 · see citing works
ATM: Ready, Set, Go
Shiloh, Y. (2003) · Cell Cycle · doi:10.4161/cc.2.2.342 · Cited by 45 · see citing works
Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation
Bristow, R. G., Hu, Q., Jang, A., Chung, S., Peacock, J. W., Benchimol, S., & Hill, R. P. (1998) · Oncogene · doi:10.1038/sj.onc.1201935 · Cited by 45 · see citing works
The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control
Garkavtsev, I., Kley, N., Grigorian, I. A., & Gudkov, A. V. (2001) · Oncogene · doi:10.1038/sj.onc.1205120 · Cited by 42 · see citing works
p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair
Boehden, G. S., Akyüz, N., Roemer, K., & Wiesmüller, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206632 · Cited by 41 · see citing works
p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation
Janz, C., Süße, S., & Wiesmüller, L. (2002) · Oncogene · doi:10.1038/sj.onc.1205292 · Cited by 36 · see citing works
Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-α, a chemical inhibitor of p53
Lin, Y., Waldman, B. C., & Waldman, A. S. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00183-0 · Cited by 35 · see citing works
Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53
俊輔, 鈴., 範久, 藤., 通良, 阿., Dahm-Daphi, J., & Powell, S. N. (2001) · Carcinogenesis · doi:10.1093/carcin/22.11.1757 · Cited by 33 · see citing works
Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation
Okorokov, A. L. (2002) · Carcinogenesis · doi:10.1093/carcin/23.4.549 · Cited by 32 · see citing works
Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma
Saito, T., Oda, Y., Kawaguchi, K.-I., Takahira, T., Yamamoto, H., Sakamoto, A., Tamiya, S., Iwamoto, Y., & Tsuneyoshi, M. (2003) · Human Pathology · doi:10.1016/s0046-8177(03)00343-5 · Cited by 29 · see citing works
Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients.
Yano, M., Asahara, T., Dohi, K., Mizuno, T., Iwamoto, K. S., & Seyama, T. (1999) · International Journal of Oncology · doi:10.3892/ijo.14.3.447 · Cited by 27 · see citing works
p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non‐small cell lung carcinoma
Xinarianos, G., Liloglou, T., Prime, W., Sourvinos, G., Karachristos, A., Gosney, J. R., Spandidos, D. A., & Field, J. K. (2002) · International Journal of Cancer · doi:10.1002/ijc.10598 · Cited by 25 · see citing works
P53 and hMSH2 expression in basal cell carcinomas and malignant melanomas from photoexposed areas of head and neck region
Staibano, S., Muzio, L. L., Pannone, G., Somma, P., Farronato, G., Franco, R., Bambini, F., Serpico, R., & Rosa, G. D. (2001) · International Journal of Oncology · doi:10.3892/ijo.19.3.551 · Cited by 23 · see citing works
p53 is a rate-limiting factor in the repair of higher-order DNA structure
Aranda‐Anzaldo, A., Orozco-Velasco, F., Garcı́a-Villa, E., & Gariglio, P. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00086-x · Cited by 21 · see citing works
The Tumor Suppressor p53 Can Reduce Stable Transfection in the Presence of Irradiation
Lee, H., Sun, D., Larner, J. M., & Wu, F.-S. (1999) · Journal of Biomedical Science · doi:10.1007/bf02253570 · Cited by 10 · see citing works

Flagged first, then by citations

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DNA damage, aging, and Cancer
Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works
Lung cancer in never smokers — a different disease
Sun, S., Schiller, J. H., & Gazdar, A. F. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2190 · Cited by 1,601 · see citing works
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression
Aubrey, B. J., Kelly, G. L., Janic, A., Herold, M. J., & Strasser, A. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.169 · Cited by 1,395 · see citing works
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080 · see citing works
Modulation of microRNA processing by p53
Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., & Miyazono, K. (2009) · Nature · doi:10.1038/nature08199 · Cited by 1,125 · see citing works
Flexible nets: The roles of intrinsic disorder in protein interaction networks
Dunker, A. K., Cortese, M. S., Romero, P., Iakoucheva, L. M., & Uversky, V. N. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04948.x · Cited by 1,122 · see citing works
Census and evaluation of p53 target genes
Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works
Awakening guardian angels: drugging the p53 pathway
Brown, C. J., Lain, S., Verma, C. S., Fersht, A. R., & Lane, D. P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2763 · Cited by 881 · see citing works
p53 in the DNA–Damage–Repair Process
Williams, A. B., & Schumacher, B. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026070 · Cited by 835 · see citing works
G protein-coupled receptors: novel targets for drug discovery in cancer
Lappano, R., & Maggiolini, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3320 · Cited by 717 · see citing works
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer
Hussain, S. P., Schwank, J., Staib, F., Wang, X. W., & Harris, C. C. (2007) · Oncogene · doi:10.1038/sj.onc.1210279 · Cited by 623 · see citing works
Self-citation
Oxidative stress and pulmonary fibrosis
Cheresh, P., Kim, S.-J., Tulasiram, S., & Kamp, D. W. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.021 · Cited by 527 · see citing works
Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
Solomon, J. M., Pasupuleti, R., Xu, L., McDonagh, T., Curtis, R., DiStefano, P. S., & Huber, L. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.28-38.2006 · Cited by 481 · see citing works
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity
Adriaens, C., Standaert, L., Barra, J., Latil, M., Verfaillie, A., Kalev, P., Boeckx, B., Wijnhoven, P. W. G., Radaelli, E., Vermi, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4135 · Cited by 472 · see citing works
Regulation of gene-activation pathways by PIAS proteins in the immune system
Shuai, K., & Liu, B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1667 · Cited by 447 · see citing works
Liquid–liquid phase separation drives cellular function and dysfunction in cancer
Mehta, S., & Zhang, J. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00444-7 · Cited by 443 · see citing works
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420 · see citing works
The mechanics of base excision repair, and its relationship to aging and disease
WILSONIII, D., & Bohr, V. A. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.017 · Cited by 343 · see citing works
Two-phase dynamics of p53 in the DNA damage response
Zhang, X.-P., Liu, F., & Wang, W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100600108 · Cited by 333 · see citing works
Tumor-Suppressor Functions of the TP53 PathwayPreprint
Aubrey, B. J., Strasser, A., & Kelly, G. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026062 · Cited by 331 · see citing works
Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells
Chen, J., & Russo, J. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.004 · Cited by 330 · see citing works
Prognostic and Predictive Importance of p53 and RAS for Adjuvant Chemotherapy in Non–Small-Cell Lung Cancer
Tsao, M., Aviel‐Ronen, S., Ding, K., Lau, D., Liu, G., Sakurada, A., Whitehead, M., Zhu, C., Livingston, R. B., Johnson, D. H., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.6953 · Cited by 326 · see citing works
p53 and Tumor Suppression: It Takes a Network
Boutelle, A. M., & Attardi, L. D. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.011 · Cited by 322 · see citing works
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
Consoli, V., Sorrenti, V., Grosso, S., & Vanella, L. (2021) · Biomolecules · doi:10.3390/biom11040589 · Cited by 288 · see citing works
Cell fate decision mediated by p53 pulses
Zhang, X.-P., Liu, F., Cheng, Z., & Wang, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813088106 · Cited by 253 · see citing works
p53 in recombination and repair
Gatz, S. A., & Wiesmüller, L. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401903 · Cited by 242 · see citing works
Regulation of Apoptosis and Differentiation by p53 in Human Embryonic Stem Cells
Qin, H., Yu, T., Qing, T., Liu, Y., Zhao, Y., Cai, J., Li, J., Song, Z., Qu, X., Zhou, P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610464200 · Cited by 244 · see citing works
p53 alterations in human cancer: more questions than answers
Soussi, T. (2007) · Oncogene · doi:10.1038/sj.onc.1210280 · Cited by 232 · see citing works
Deciphering p53 signaling in tumor suppression
Mello, S. S., & Attardi, L. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.005 · Cited by 203 · see citing works
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene
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Authors: Sengupta, S., & Harris, C. C.
Affiliations: National Institutes of Health (US)
National Institute of Immunology (IN)
Corresponding author: Harris, Curtis C.
ORCID: Sengupta, Sagar
Harris, Curtis C.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2005-01
Volume: 6
Issue: 1
Pages: 44-55
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm1546
OpenAlex: W2036270526
Cited by: 544
References: 147
Citations by year: 2026: 7 · 2025: 6 · 2024: 11 · 2023: 18 · 2022: 17 · 2021: 13 · 2020: 17 · 2019: 20 · 2018: 18 · 2017: 23 · 2016: 31 · 2015: 23 · 2014: 31 · 2013: 25 · 2012: 35
FWCI: 4.99
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: p53, DNA repair, DNA recombination, tumour suppressor, cancer
MeSH terms: Adenosine Triphosphatases, Animals, DNA Repair, DNA Helicases, DNA-Binding Proteins, Humans, Recombination, Genetic, Tumor Suppressor Protein p53, RecQ Helicases

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p53: traffic cop at the crossroads of DNA repair and recombination

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