The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Targeting genes for self-excision in the germ line
Open accessAbstract
A procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Cre was linked to the selectable marker Neor, and the two genes flanked with loxP elements. This cassette was targeted to the Hoxa3 gene in mouse ES cells that were in turn used to generate chimeric mice. In these chimeras, somatic cells derived from the ES cells retained the cassette, but self-excision occurred in all ES-cell-derived sperm.
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Cites
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Repeat-induced gene silencing in mammals
Garrick, D., Fiering, S., Martin, D. I. K., & Whitelaw, E. (1998) · Nature Genetics · doi:10.1038/ng0198-56 · Cited by 887 · cited 2×
“…of chromosomal rearrangements typically mediated by Cre-catalyzed recombination (Ramrez-Solis et al. 1995; Smith et al. 1995; Hé rault et al. 1998) or in the condensation of tandem repeats resulting from the random integration of transgenes following pronuclear injection (Garrick et al. 1998).”
Background
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Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
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Self-citationLiang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111421200 · Cited by 669
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Metadata
- Authors
- Bunting, M., Bernstein, K. E., Greer, J. M., Capecchi, M. R., & Thomas, K. R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-06-15
- Volume
- 13
- Issue
- 12
- Pages
- 1524-1528
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2121082491
- Cited by
- 234
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Bunting, M., Bernstein, K. E., Greer, J. M., Capecchi, M. R., & Thomas, K. R. (1999). Targeting genes for self-excision in the germ line. Genes & Development. https://doi.org/10.1101/gad.13.12.1524
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