The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells
Open accessAbstract
The Ah receptor (AhR), a bHLH/PAS transcription factor, mediates dioxin toxicity in the immune system, skin, testis and liver. Toxic phenomena are associated with altered cell proliferation or differentiation, but signaling pathways of AhR in cell cycle regulation are poorly understood. Here we show that AhR induces the p27(Kip1) cyclin/cdk inhibitor by altering Kip1 transcription in a direct mode without the need for ongoing protein synthesis or cell proliferation. This is the first example of Kip1 being a direct transcriptional target of a toxic agent that affects cell proliferation. Kip1 causes dioxin-induced suppression of 5L hepatoma cell proliferation because Kip1 antisense-expressing cells are resistant to dioxins. Kip1 is also induced by dioxins in cultures of fetal thymus glands concomitant with inhibition of proliferation and severe reduction of thymocyte recovery. Kip1 expression is likely to mediate these effects as thymic glands of Kip1-deficient mice (Kip1(Delta51)) are largely, though not completely, resistant.
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Cites
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
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New functional activities for the p21 family of CDK inhibitors.
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Radiation-induced cell cycle arrest compromised by p21 deficiency
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“Yet, p21-deficient cells are only partially impaired in their capacity to arrest proliferation on DNA damage (Brugarolas et al. 1995; Deng et al. 1995) presumably because of alternate pathways that allow even p21-deficient cells to inhibit proliferation on damage.”
BackgroundAH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
ahr null alleles: distinctive or different?
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Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms
Regoli, F., & Giuliani, M. E. (2014) · Marine Environmental Research · doi:10.1016/j.marenvres.2013.07.006 · Cited by 982
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii-Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 746
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727
Metadata
- Authors
- Kolluri, S. K., Weiss, C., Koff, A., & Gottlicher, M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-07-01
- Volume
- 13
- Issue
- 13
- Pages
- 1742-1753
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2105900029
- Cited by
- 364
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kolluri, S. K., Weiss, C., Koff, A., & Gottlicher, M. (1999). p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes & Development. https://doi.org/10.1101/gad.13.13.1742
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
