The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation
Open accessAbstract
Hormonal induction of 3T3-L1 preadipocytes triggers a cascade of events that initiate differentiation into adipocytes. CCAAT/enhancer-binding proteins beta and delta (C/EBPbeta/delta) are expressed early in the differentiation program, but are not immediately active. After a long lag, C/EBPbeta/delta become competent to bind to the C/EBP regulatory element in the C/EBPalpha gene promoter, C/EBPalpha being a transcriptional activator of numerous adipocyte genes. As C/EBPbeta/delta acquire binding activity, they become localized to centromeres as preadipocytes synchronously enter S phase at the onset of mitotic clonal expansion. Localization to centromeres occurs through C/EBP consensus-binding sites in centromeric satellite DNA. C/EBPalpha, which is antimitotic, becomes centromere-associated much later in the differentiation program as mitotic clonal expansion ceases and the cells become terminally differentiated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins
Hendrich, B., & Bird, A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6538 · Cited by 1,360
TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION DURING ADIPOCYTE DIFFERENTIATION
MacDougald, O. A., & Lane, M. D. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002021 · Cited by 1,061
Self-citationDescombes, P., & Schibler, U. (1991) · Cell · doi:10.1016/0092-8674(91)90531-3 · Cited by 990
Yeh, W. C., Cao, Z., Classon, M., & McKnight, S. L. (1995) · Genes & Development · doi:10.1101/gad.9.2.168 · Cited by 935
Impaired Energy Homeostasis in C/EBPα Knockout Mice
Wang, N.-D., Finegold, M. J., Bradley, A., Ou, C. N., Abdelsayed, S. V., Wilde, M. D., Taylor, L. R., Wilson, D. R., & Darlington, G. J. (1995) · Science · doi:10.1126/science.7652557 · Cited by 929
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene
Tanaka, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7432 · Cited by 805
CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch
Umek, R. M., Friedman, A. D., & McKnight, S. L. (1991) · Science · doi:10.1126/science.1987644 · Cited by 712
Masumoto, H., Masukata, H., Muro, Y., Nozaki, N., & Okazaki, T. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.5.1963 · Cited by 685
Regulation of Adipocyte Development
Cornelius, P., MacDougald, O. A., & Lane, M. D. (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.000531 · Cited by 652
Self-citation
Cited by
CCAAT/enhancer-binding protein β is required for mitotic clonal expansion during adipogenesis
Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337434100 · Cited by 485
Self-citationCommitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403100101 · Cited by 417
Self-citationGuo, L., Li, X., & Tang, Q.-Q. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.619957 · Cited by 353
Self-citationNuclear compartmentalization and gene activity
Francastel, C., Schübeler, D., Martin, D. I. K., & Groudine, M. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040083 · Cited by 297
Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis model 3T3-L1
Kramer, A. H., Edkins, A. L., Hoppe, H. C., & Prinsloo, E. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25076 · Cited by 15
Metadata
- Authors
- Tang, Q.-Q., & Lane, M. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-09-01
- Volume
- 13
- Issue
- 17
- Pages
- 2231-2241
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W1989278316
- Cited by
- 383
- References
- 40
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. https://app.cochat.ai/papers/10.1101/gad.13.17.2231
- The paper
- Tang, Q.-Q., & Lane, M. D. (1999). Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. Genes & Development. https://doi.org/10.1101/gad.13.17.2231
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
