PreprintCited by 4,216Cell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancerNerve injury and regeneration

The DOI matches its Crossref record; 229 of the 233 references it cites were found in a registry or an index.

Cellular survival: a play in three Akts

Open access

Datta, S. R., Brunet, A., Greenberg, M. E.·1999·Genes & Development

DOI 10.1101/gad.13.22.2905

Open this paper in CoChat — free account Open PDF

Abstract

The programmed cell death that occurs as part of normal mammalian development was first observed nearly a century ago (Collin 1906). It has since been established that approximately half of all neurons in the neuroaxis and >99.9% of the total number of cells generated during the course of a human lifetime go on to die through a process of apoptosis (for review, see Datta and Greenberg 1998; Vaux and Korsmeyer 1999). The induction of developmental cell death is a highly regulated process and can be suppressed by a variety of extracellular stimuli. The purification in the 1950s of the nerve growth factor (NGF), which promotes the survival of sympathetic neurons, set the stage for the discovery that peptide trophic factors promote the survival of a wide variety of cell types in vitro and in vivo (Levi-Montalcini 1987). The profound biological consequences of growth factor (GF) suppression of apoptosis are exemplified by the critical role of target-derived neurotrophins in the survival of neurons and the maintenance of functional neuronal circuits. (Pettmann and Henderson 1998). Recently, the ability of trophic factors to promote survival have been attributed, at least in part, to the phosphatidylinositide 38-OH kinase (PI3K)/c-Akt kinase cascade. Several targets of the PI3K/c-Akt signaling pathway have been recently identified that may underlie the ability of this regulatory cascade to promote survival. These substrates include two components of the intrinsic cell death machinery, BAD and caspase 9, transcription factors of the forkhead family, and a kinase, IKK, that regulates the NF-kB transcription factor. This article reviews the mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI3K/c-Akt pathway promotes cell survival, and the current spectrum of c-Akt targets and their roles in mediating c-Akt-dependent cell survival.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.13.22.2905

Cites

229 of 229 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mitochondria and Apoptosis
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Self-citation
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Self-citation
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Self-citation
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
Hanks, S. K., Quinn, A. M., & Hunter, T. R. (1988) · Science · doi:10.1126/science.3291115 · Cited by 5,040
Apoptosis by Death Factor
Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,934
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063

Flagged first, then by citations

Show all 233 references

4 of the 233 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

Bonni, A., A. Brunet, A.E. West, S.R. Datta, and M.E. Greenberg. 1999. The ras-MAPK signaling pathway promotes cell sur- vival via a dual transcription-dependent and transcription- independent mechanism. Science (in press).
Cheng, J.Q., B. Ruggeri, W.M. Klein, G. Sonoda, D.A. Altomare, D.K. Watson, and J.R. Testa. 1996. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 ex- pression and tunorigeneicity by antisense RNA. Proc. Natl. Acad. Sci. 93: 3636-3641.
Kitamura, T., W. Ogawa, H. Sakaue, Y. Hino, S. Kuroda, M. Takata, M. Matsumoto, T. Maeda, H. Konishi, U. Kikkawa et al. 1998a. Requirement for activation of the serine-threo- nine kinase Akt (PKB) in insulin stimulation of protein syn- thesis but not of glucose transport. Mol. Cell. Biol. 18: 3708- 3717.
Staal, S.P. 1987. Molecular cloning of the akt oncogene and its human homologs Akt1 and Akt2: Amplification of Akt1 in a primary human gastric adenocarcinoma. Proc. Natl. Acad. Sci. 84: 5034-5037.

Sorted by citations

Items 801–900 of 1,017

Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes
Chandrasekar, B., Mummidi, S., Claycomb, W. C., Mestril, R., & Nemer, M. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411787200 · Cited by 125
Cytokine control of developmental programs in normal hematopoiesis and leukemia
Lotem, J., & Sachs, L. (2002) · Oncogene · doi:10.1038/sj.onc.1205319 · Cited by 125
Structural and Functional Impairments of Polysialic Acid by a Mutated Polysialyltransferase Found in Schizophrenia
Isomura, R., Kitajima, K., & Sato, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.221143 · Cited by 122
Adhesion-Mediated Squamous Cell Carcinoma Survival through Ligand-Independent Activation of Epidermal Growth Factor Receptor
Shen, X., & Kramer, R. H. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63390-1 · Cited by 124
A Guide to Signaling Pathways Connecting Protein-Glycan Interaction with the Emerging Versatile Effector Functionality of Mammalian Lectins
Villalobo, A., Nogales, A., & Gabius, H. (2006) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.18.1 · Cited by 124
Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway
DeBusk, L. M., Hallahan, D. E., & Lin, P. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.013 · Cited by 124
PRAS40 Deregulates Apoptosis in Malignant Melanoma
Madhunapantula, S. V., Sharma, A. K., & Robertson, G. P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4234 · Cited by 124
Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway
Ain, R., Kent, L. N., & Soares, M. J. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06039 · Cited by 124
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol
Gagnon, V., Themsche, C. V., Turner, S., Leblanc, V., & Asselin, É. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0165-6 · Cited by 123
The TCL1 family of oncoproteins: co-activators of transformation
Teitell, M. A. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1672 · Cited by 123
Retracted: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells
Wang, Z. P., Zhang, Y., Banerjee, S., Li, Y., & Sarkar, F. H. (2005) · International Journal of Cancer · doi:10.1002/ijc.21589 · Cited by 123
Retracted
Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells
Chaudhary, L. R., & Hruska, K. A. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10495 · Cited by 123
Enhanced protein kinase B/Akt signalling in pituitary tumours
Musat, M., Korbonits, M., Kola, B., Borboli, N., Hanson, M. R., Nanzer, A. M., Grigson, J., Jordan, S., Morris, D. G., Gueorguiev, M., et al. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.00949 · Cited by 124
Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors
Sweeney, C. A., Fambrough, D., Huard, C., Diamonti, A. J., Lander, E. S., Cantley, L. C., & Carraway, K. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100602200 · Cited by 123
Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
Jiang, H., Fan, D., Zhou, G., Li, X., & Deng, H. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-34 · Cited by 122
Rapid steroid hormone actions via membrane receptors
Schwartz, N., Verma, A., Bivens, C. B., Schwartz, Z., & Boyan, B. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.06.004 · Cited by 123
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances
Ali, E. M. H., Abdel‐Maksoud, M. S., & Oh, C. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.02.044 · Cited by 125
Actions of neurotrophic factors and their signaling pathways in neuronal survival and axonal regeneration
Cui, Q. (2006) · Molecular Neurobiology · doi:10.1385/mn:33:2:155 · Cited by 130
Control of MyoD Function during Initiation of Muscle Differentiation by an Autocrine Signaling Pathway Activated by Insulin-like Growth Factor-II
Wilson, E. M., & Rotwein, P. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605445200 · Cited by 125
Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation
Liu, J., Lee, P., Galbiati, F., Kitsis, R. N., & Lisanti, M. P. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.4.c823 · Cited by 122
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways.
Lai, W.-W., Hsu, S., Chueh, F. S., Chen, Y. Y., Yang, J., Lin, J., Lien, J. C., Tsai, C.-H., & Chung, J. (2013) · PubMed · Cited by 121
A Critical Kinase Cascade In Neurological Disorders: Pi3K, Akt and Mtor
Chong, Z. Z., Shang, Y., Wang, S., & Maiese, K. (2012) · Future Neurology · doi:10.2217/fnl.12.72 · Cited by 122
Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation
Kamalati, T., Jolin, H. E., Fry, M., & Crompton, M. R. (2000) · Oncogene · doi:10.1038/sj.onc.1203931 · Cited by 121
C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway
Perianayagam, M. C., Balakrishnan, V. S., King, A. J., Pereira, B. J. G., & Jaber, B. L. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00139.x · Cited by 121
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts
Klotz, L., Schieke, S. M., Sies, H., & Holbrook, N. J. (2000) · Biochemical Journal · doi:10.1042/bj3520219 · Cited by 121
In Mice With Type 2 Diabetes, a Vascular Endothelial Growth Factor (VEGF)-Activating Transcription Factor Modulates VEGF Signaling and Induces Therapeutic Angiogenesis After Hindlimb Ischemia
Li, Y., Hazarika, S., Xie, D., Pippen, A. M., Kontos, C. D., & Annex, B. H. (2007) · Diabetes · doi:10.2337/db06-0999 · Cited by 119
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors
Vizio, D. D., Cito, L., Boccia, A. S., Chieffi, P., Insabato, L., Pettinato, G., Motti, M. L., Schepis, F., D'Amico, W., Fabiani, F., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208368 · Cited by 121
Regulation of Apoptosis by the Ft1 Protein, a New Modulator of Protein Kinase B/Akt
Remy, I., & Michnick, S. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1493-1504.2004 · Cited by 121
Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues
Castillo, S. S., Brognard, J., Petukhov, P. A., Zhang, C., Tsurutani, J., Granville, C. A., Li, M., Jung, M., West, K. A., Gills, J. G., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1530 · Cited by 121
Curcumin Inhibits Prosurvival Pathways in Chronic Lymphocytic Leukemia B Cells and May Overcome Their Stromal Protection in Combination with EGCG
Ghosh, A. K., Kay, N. E., Secreto, C. R., & Shanafelt, T. D. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1511 · Cited by 122
Hepatocyte growth factor promotes cell survival from Fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression
Suzuki, A., Hayashida, M., Kawano, H., Sugimoto, K., Nakano, T., & Shiraki, K. (2000) · Hepatology · doi:10.1053/jhep.2000.17738 · Cited by 121
Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes
Berggreen, C., Gormand, A., Omar, B., Degerman, E., & Göransson, O. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90596.2008 · Cited by 118
Uptake of Gold Nanoparticles by Intestinal Epithelial Cells: Impact of Particle Size on Their Absorption, Accumulation, and Toxicity
Yao, M., He, L., McClements, D. J., & Xiao, H. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b03242 · Cited by 120
A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology
Wie, J., Liu, Z., Song, H., Tropea, T. F., Yang, L., Wang, H., Liang, Y., Cang, C., Aranda, K., Lohmann, J., et al. (2021) · Nature · doi:10.1038/s41586-021-03185-z · Cited by 120
B lymphocyte activation by contact-mediated interactions with T lymphocytes
Bishop, G. A., & Hostager, B. S. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00216-8 · Cited by 120
In Vivo Restoration of Physiological Levels of Truncated TrkB.T1 Receptor Rescues Neuronal Cell Death in a Trisomic Mouse Model
Dorsey, S. G., Renn, C. L., Carim‐Todd, L., Barrick, C. A., Bambrick, L. L., Krueger, B. K., Ward, C. W., & Tessarollo, L. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.009 · Cited by 120
Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim
Møller, C., Alfredsson, J., Engström, M., Wootz, H., Xiang, Z., Lennartsson, J., Jönsson, J., & Nilsson, G. P. (2005) · Blood · doi:10.1182/blood-2004-12-4792 · Cited by 121
Angiotensin II Potentiates Vascular Endothelial Growth Factor-Induced Proliferation and Network Formation of Endothelial Progenitor Cells
Imanishi, T., Hano, T., & Nishio, I. (2004) · Hypertension Research · doi:10.1291/hypres.27.101 · Cited by 120
Cross-Talk between Phosphatidylinositol 3-Kinase/AKT and c-Jun NH2-Terminal Kinase Mediates Survival of Isolated Human Islets
Aikin, R. A., Maysinger, D., & Rosenberg, L. C. (2004) · Endocrinology · doi:10.1210/en.2004-0488 · Cited by 119
3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling
Störz, P. (2002) · Frontiers in bioscience · doi:10.2741/storz · Cited by 119
Rapid Cerebral Ischemic Preconditioning in Mice Deficient in Endothelial and Neuronal Nitric Oxide Synthases
Atochin, D. N., Clark, J. W., It, D., Moskowitz, M. A., & Huang, P. L. (2003) · Stroke · doi:10.1161/01.str.0000066870.70976.57 · Cited by 119
Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3′-Kinase/Akt Pathwayin Vitroandin Vivo
West, K. A., Linnoila, I. R., Belinsky, S. A., Harris, C. C., & Dennis, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3241 · Cited by 120
FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins
Scheijen, B., Ngo, H. T., Kang, H. K., & Griffin, J. D. (2004) · Oncogene · doi:10.1038/sj.onc.1207456 · Cited by 120
Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8.
Karashima, T., Sweeney, P., Kamat, A. M., Huang, S., Kim, S. J., Bar‐Eli, M., McConkey, D. J., & Dinney, C. P. (2003) · PubMed · Cited by 121
Akt2 and Akt3 play a pivotal role in malignant gliomas
Mure, H., Matsuzaki, K., Kitazato, K. T., Mizobuchi, Y., Kuwayama, K., Kageji, T., & Nagahiro, S. (2009) · Neuro-Oncology · doi:10.1093/neuonc/nop026 · Cited by 120
Over-Expression of PDGFR-β Promotes PDGF-Induced Proliferation, Migration, and Angiogenesis of EPCs through PI3K/Akt Signaling Pathway
Wang, H., Yin, Y., Li, W., Zhao, X., Yu, Y., Zhu, J., Qin, Z., Wang, Q., Wang, K., Lü, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030503 · Cited by 120
Cyclic GMP-dependent Protein Kinase Iα Attenuates Necrosis and Apoptosis Following Ischemia/Reoxygenation in Adult Cardiomyocyte
Das, A., Smolenski, A., Lohmann, S. M., & Kukreja, R. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606142200 · Cited by 119
Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway
Ou, H., Lee, W., Lee, S., Huang, C., Chiu, T.-H., Tsai, K., Hsu, W.-C., & Sheu, W. H. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.07.025 · Cited by 119
A Novel Protein Kinase B (PKB)/AKT-binding Protein Enhances PKB Kinase Activity and Regulates DNA Synthesis
Anai, M., Shojima, N., Katagiri, H., Ogihara, T., Sakoda, H., Onishi, Y., Ono, H., Fujishiro, M., Fukushima, Y., Horike, N., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500586200 · Cited by 117
Tauroursodeoxycholic Acid Prevents Amyloid-β Peptide-Induced Neuronal Death Via a Phosphatidylinositol 3-Kinase-Dependent Signaling Pathway
Solá, S., Castro, R. E., Laires, P. A., Steer, C. J., & Rodrigues, C. M. P. (2003) · Molecular Medicine · doi:10.2119/2003-00042.rodrigues · Cited by 117
Systemically Administered Brain-Targeted Nanoparticles Transport Peptides across the Blood—Brain Barrier and Provide Neuroprotection
Yemisci, M., Caban, S., Gursoy-Ozdemir, Y., Lule, S., Novoa-Carballal, R., Riguera, R., Fernandez-Megia, E., Andrieux, K., Couvreur, P., Capan, Y., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.220 · Cited by 118
Side population and cancer stem cells: Therapeutic implications
Moserle, L., Ghisi, M., Amadori, A., & Indraccolo, S. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.05.020 · Cited by 122
Identification of a Cytokine-induced Antiapoptotic Molecule Anamorsin Essential for Definitive Hematopoiesis
Shibayama, H., Takai, E., Matsumura, I., Kouno, M., Morii, E., Kitamura, Y., Takeda, J., & Kanakura, Y. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031858 · Cited by 118
Single Injection of Naked Plasmid Encoding Hepatocyte Growth Factor Prevents Cell Death and Ameliorates Acute Renal Failure in Mice
Dai, C., Yang, J., & Liu, Y. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v132411 · Cited by 118
Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides
Xu, J., Liu, D., Gill, G. N., & Zhou, S.-Y. (2001) · Journal of Cell Biology · doi:10.1083/jcb.200105089 · Cited by 120
Human Amniotic Fluid Stem Cell Preconditioning Improves Their Regenerative Potential
Rota, C., Imberti, B., Pozzobon, M., Piccoli, M., Coppi, P. D., Atala, A., Gagliardini, E., Xinaris, C., Benedetti, V., Fabricio, A. S. C., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0333 · Cited by 117
A new era: melanoma genetics and therapeutics
Ko, J., & Fisher, D. E. (2010) · The Journal of Pathology · doi:10.1002/path.2804 · Cited by 117
Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells
Cecchinato, V., Chiaramonte, R., Nizzardo, M., Cristofaro, B., Basile, A., Sherbet, G. V., & Comi, P. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.001 · Cited by 117
Granulocyte Colony-Stimulating Factor Attenuates Neuronal Death and Promotes Functional Recovery After Spinal Cord Injury in Mice
Nishio, Y., Koda, M., Kamada, T., Someya, Y., 門田, 領., Mannoji, C., Miyashita, T., Okada, S., Okawa, A., Moriya, H., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181257176 · Cited by 117
Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity
Esposito, F., Chirico, G., Gesualdi, N. M., Posadas, I., Ammendola, R., Russo, T., Cirino, G., & Cimino, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211841200 · Cited by 117
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine
Mesa, R. A., Loegering, D. A., Powell, H. L., Flatten, K. S., Arlander, S. J. H., Dai, N. T., Heldebrant, M. P., Vroman, B. T., Smith, B. D., Karp, J. E., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3523 · Cited by 116
Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
Lee, D., Szczepański, M. J., & Lee, Y. J. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22098 · Cited by 118
A Phosphatidylinositol 3-Kinase Docking Site in the Cytoplasmic Tail of the Jaagsiekte Sheep Retrovirus Transmembrane Protein Is Essential for Envelope-Induced Transformation of NIH 3T3 Cells
Palmarini, M., Maeda, N., Murgia, C., De‐Fraja, C., Hofacre, A., & Fan, H. (2001) · Journal of Virology · doi:10.1128/jvi.75.22.11002-11009.2001 · Cited by 117
SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
Li, H., Rajendran, G. K., Liu, N., Ware, C. B., Rubin, B. P., & Gu, Y. (2007) · Breast Cancer Research · doi:10.1186/bcr1632 · Cited by 118
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
Kim, E. K., Yun, S. J., Ha, J. M., Kim, Y. W., Jin, I. H., Yun, J., Shin, H. K., Song, S. H., Kim, J. H., Lee, J. S., et al. (2011) · Oncogene · doi:10.1038/onc.2011.22 · Cited by 116
PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells
Jeong, S., Dasgupta, A., Jung, K., Um, J., Burke, A., Park, H. U., & Brady, J. N. (2007) · Virology · doi:10.1016/j.virol.2007.09.003 · Cited by 116
Beginnings of a signal-transduction pathway for bioenergetic control of cell survival
Hammerman, P. S., Fox, C. J., & Thompson, C. B. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.09.008 · Cited by 117
Endothelial cell integrins and COX-2: mediators and therapeutic targets of tumor angiogenesis
Rüegg, C., Dormond, O., & Mariotti, A. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2003.09.003 · Cited by 115
Activation of the Akt/Protein Kinase B Signaling Pathway Is Associated with Granulosa Cell Survival1
Johnson, A. L., Bridgham, J. T., & Swenson, J. A. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.5.1566 · Cited by 116
Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications
Valdés-Rives, S. A., Casique‐Aguirre, D., German‐Castelan, L., Velasco-Velázquez, M. A., & González‐Arenas, A. (2017) · BioMed Research International · doi:10.1155/2017/7403747 · Cited by 117
IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT
Kelly, E., Won, A., Refaeli, Y., & Parijs, L. V. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.597 · Cited by 115
Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways.
Grana, T. M., Rusyn, E. V., Zhou, H., Sartor, C. I., & Cox, A. D. (2002) · PubMed · Cited by 115
Raf-MEK-Erk Cascade in Anoikis Is Controlled by Rac1 and Cdc42 via Akt
Zugasti, O., Rul, W., Roux, P., Peyssonnaux, C., Eychène, A., Franke, T. F., Fort, P., & Hibner, U. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6706-6717.2001 · Cited by 115
C5b-9 Terminal Complement Complex Protects Oligodendrocytes from Death by Regulating Bad Through Phosphatidylinositol 3-Kinase/Akt Pathway
Soane, L., Cho, H.-J., Niculescu, F. I., Rus, H., & Shin, M. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2305 · Cited by 115
Redox Control of Signal Transduction, Gene Expression and Cellular Senescence
Esposito, F., Ammendola, R., Faraonio, R., Russo, T., & Cimino, F. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014832.78725.1a · Cited by 113
Akt Signaling and Growth of the Heart
Walsh, K. (2006) · Circulation · doi:10.1161/circulationaha.106.615138 · Cited by 115
IL‐1β induces expression of matrix metalloproteinase‐9 and cell migration via a c‐Src‐dependent, growth factor receptor transactivation in A549 cells
Cheng, C., Kuo, C., Lin, C., Hsieh, H., & Yang, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00858.x · Cited by 119
Dexamethasone attenuated bupivacaine-induced neuron injury in vitro through a threonine–serine protein kinase B-dependent mechanism
Ma, R., Wang, X., Lu, C., Li, C., Cheng, Y., Ding, G., Liu, L., & Ding, Z. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.049 · Cited by 114
Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway
Zhao, Z., Li, C., Xi, H., Gao, Y.-X., & Xu, D. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4060 · Cited by 114
Secretion of Matrix Metalloproteinase-2 and -9 after Mechanical Trauma Injury in Rat Cortical Cultures and Involvement of MAP Kinase
Wang, X., Mori, T., Jung, J., Fini, M. E., & Lo, E. H. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753754082 · Cited by 114
Macrophage EP4 Deficiency Increases Apoptosis and Suppresses Early Atherosclerosis
Babaev, V. R., Chew, J. D., Ding, L., Davis, S., Breyer, M. D., BREYER, R. M., Oates, J. A., Fazio, S., & Linton, M. F. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.005 · Cited by 114
STAT1 Is Activated in Neurons After Ischemia and Contributes to Ischemic Brain Injury
Takagi, Y., Harada, J., Chiarugi, A., & Moskowitz, M. A. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000034148.72481.f4 · Cited by 113
Proto‐oncogene, Pim‐3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad‐mediated apoptosis
Popivanova, B. K., Li, Y., Zheng, H., Omura, K., Fujii, C., Tsuneyama, K., & Mukaida, N. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00390.x · Cited by 116
Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts
Buckley, D. A., Cheng, A., Kiely, P. A., Tremblay, M. L., & O’Connor, R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.1998-2010.2002 · Cited by 114
The Phospholipids Sphingosine-1-Phosphate and Lysophosphatidic Acid Prevent Apoptosis in Osteoblastic Cells via a Signaling Pathway Involving Gi Proteins and Phosphatidylinositol-3 Kinase
Grey, A. B., Chen, Q., Callon, K. E., Xu, X., Reid, I. R., & Cornish, J. (2002) · Endocrinology · doi:10.1210/en.2002-220347 · Cited by 114
Shc signaling in differentiating neural progenitor cells
Conti, L., Sipione, S., Magrassi, L., Bonfanti, L., Rigamonti, D., Pettirossi, V., Peschanski, M., Haddad, B., Pelicci, P. G., Milanesi, G., et al. (2001) · Nature Neuroscience · doi:10.1038/88395 · Cited by 114
Role of PI 3-kinase, Akt and Bcl-2–related proteins in sustaining the survival of neurotrophic factor–independent adult sympathetic neurons
Orike, N., Middleton, G., Borthwick, E. B., Buchman, V. L., Cowen, T., & Davies, A. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200101068 · Cited by 117
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase
Su, F., Overholtzer, M., Besser, D., & Levine, A. J. (2002) · Genes & Development · doi:10.1101/gad.942902 · Cited by 153
Oscillations and bistability in the stochastic model of p53 regulation
Puszyński, K., Hat, B., & Tomasz Lipniacki, B. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.05.039 · Cited by 116
Glutamate Signaling to Ras-MAPK in Striatal Neurons: Mechanisms for Inducible Gene Expression and Plasticity
Wang, J. Q., Tang, Q., Parelkar, N. K., Liu, Z., Samdani, S., Choe, E. S., Yang, L., & Mao, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:1:01 · Cited by 113
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch
Rao, S., Lobov, I. B., Vallance, J. E., Tsujikawa, K., Shiojima, I., Akunuru, S., Walsh, K. X., Benjamin, L. E., & Lang, R. A. (2007) · Development · doi:10.1242/dev.012187 · Cited by 111
Induction of caspase‐mediated apoptosis and cell‐cycle G1 arrest by selenium metabolite methylselenol
Wang, Z., Jiang, C., & Lü, J. (2002) · Molecular Carcinogenesis · doi:10.1002/mc.10056 · Cited by 113
Adhesion-linked kinases in cancer; emphasis on Src, focal adhesion kinase and PI 3-kinase
Jones, R. J., Brunton, V., & Frame, M. C. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00153-2 · Cited by 117
Curcumin enhances dasatinib‐induced inhibition of growth and transformation of colon cancer cells
Nautiyal, J., Banerjee, S., Kanwar, S. S., Yu, Y., Patel, B. B., Sarkar, F. H., & Majumdar, A. P. N. (2010) · International Journal of Cancer · doi:10.1002/ijc.25410 · Cited by 113
Clinicopathological, Cytogenetic, and Prognostic Analysis of 131 Myeloid Sarcoma Patients
Kawamoto, K., Miyoshi, H., Yoshida, N., Takizawa, J., Sone, H., & Ohshima, K. (2016) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000727 · Cited by 113
Translational Control of the Antiapoptotic Function of Ras
Polunovsky, V. A., Gingras, A., Sonenberg, N., Peterson, M., Tan, A., Rubins, J. B., Manivel, J. C., & Bitterman, P. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001938200 · Cited by 111
Regulation of phosphatidylinositol 3‐kinase (PI3K)/Akt and nuclear factor‐kappa B signaling pathways in dystrophin‐deficient skeletal muscle in response to mechanical stretch
Dogra, C., Changotra, H., Wergedal, J. E., & Kumar, A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20696 · Cited by 112
CD44 signaling through focal adhesion kinase and its anti‐apoptotic effect
Fujita, Y., Kitagawa, M., Nakamura, S., Azuma, K., Ishii, G., Higashi, M., Kishi, H., Hiwasa, T., Koda, K., Nakajima, N., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03262-3 · Cited by 114
Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.
Lee, J., Lim, E., Kim, Y., Li, E., & Park, S. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0040 · Cited by 119
Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.
Nimmanapalli, R., O’Bryan, E., Huang, M., Bali, P., Burnette, P. K., Loughran, T. P., Tepperberg, J. H., Jove, R., & Bhalla, K. N. (2002) · PubMed · Cited by 112

Authors: Datta, S. R., Brunet, A., & Greenberg, M. E.
Affiliations: Boston Children's Hospital (US)
ORCID: Datta, S. R.
Brunet, A.
Greenberg, M. E.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1999-11-15
Volume: 13
Issue: 22
Pages: 2905-2927
ISSN: 0890-9369 (ISSN-L)
DOI: 10.1101/gad.13.22.2905
OpenAlex: W2147114673
Cited by: 4,216
References: 233
Citations by year: 2026: 27 · 2025: 36 · 2024: 45 · 2023: 47 · 2022: 60 · 2021: 68 · 2020: 87 · 2019: 86 · 2018: 81 · 2017: 94 · 2016: 90 · 2015: 140 · 2014: 136 · 2013: 149 · 2012: 150
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: Bentham-Moxon Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: cell survival, apoptosis, PI3K/Akt signaling, neurotrophins, trophic factors, developmental cell death, Bad, caspase-9, forkhead transcription factor, IκB kinase, NF-kB, neuronal survival, growth factor signaling
MeSH terms: Animals, Carrier Proteins, Cell Survival, Cell Transformation, Neoplastic, Humans, Phosphatidylinositols, Phosphorylation, Protein Processing, Post-Translational, Proto-Oncogene Proteins, Substrate Specificity, Transcription Factors, Signal Transduction, NF-kappa B, Sequence Alignment, Apoptosis, Protein Serine-Threonine Kinases, Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Protein Isoforms, Caspases, Glycogen Synthase Kinase 3, bcl-Associated Death Protein, Proto-Oncogene Proteins c-akt, Mice, Rats, I-kappa B Kinase, Caspase 9

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cellular survival: a play in three Akts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks