Brunet, Anne

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development

Cell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer

Cited by 4,216

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science

FOXO transcription factor regulationSirtuins and Resveratrol in Medicine

Cited by 3,239

Geroscience: Linking Aging to Chronic Disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 2,764

The FoxO code

Calnan, D. R., & Brunet, A. (2008) · Oncogene

FOXO transcription factor regulationMetabolism, Diabetes, and Cancer

Cited by 1,170

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

Brunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A., & Greenberg, M. E. (2001) · Molecular and Cellular Biology

FOXO transcription factor regulationPI3K/AKT/mTOR signaling in cancer

Cited by 860

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

Hardie, D. G., Schaffer, B. E., & Brunet, A. (2016) · Trends in Cell Biology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 859

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology

Genetics, Aging, and Longevity in Model OrganismsFOXO transcription factor regulation

Cited by 801

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 660

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

Wapinski, O. L., Vierbuchen, T., Qu, K., Lee, Q. Y., Chanda, S., Fuentes, D. R., Giresi, P. G., Ng, Y. H., Marro, S., Neff, N. F., et al. (2013) · Cell

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 627

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 610

FoxO transcription factors in the maintenance of cellular homeostasis during aging

Salih, D. A., & Brunet, A. (2008) · Current Opinion in Cell Biology

FOXO transcription factor regulationGenetics, Aging, and Longevity in Model Organisms

Cited by 604

FoxO3 Regulates Neural Stem Cell Homeostasis

Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A. M., Brett, J. O., Webb, A. E., Villeda, S. A., Thekkat, P. U., Guillerey, C., Denko, N. C., et al. (2009) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsFOXO transcription factor regulation

Cited by 586

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging

Liu, L., Cheung, T. H., Charville, G. W., Hurgo, B. M. C., Leavitt, T., Shih, J., Brunet, A., & Rando, T. A. (2013) · Cell Reports

Muscle Physiology and DisordersGenomics and Chromatin Dynamics

Cited by 544

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 543

H3K4me3 breadth is linked to cell identity and transcriptional consistency

Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 536

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Leeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., et al. (2018) · Science

Neurogenesis and neuroplasticity mechanismsAutophagy in Disease and Therapy

Cited by 528

Single-cell analysis reveals T cell infiltration in old neurogenic niches

Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 521

The Aging Epigenome

Booth, L. N., & Brunet, A. (2016) · Molecular Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 499

Personal aging markers and ageotypes revealed by deep longitudinal profiling

Ahadi, S., Zhou, W., Schüssler-Fiorenza Rose, S. M., Sailani, M. R., Contrepois, K., Avina, M., Ashland, M., Brunet, A., & Snyder, M. (2020) · Nature Medicine

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 408

Ageing and rejuvenation of tissue stem cells and their niches

Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology

Genetics, Aging, and Longevity in Model OrganismsHematopoietic Stem Cell Transplantation

Cited by 407

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Benayoun, B. A., Pollina, E. A., Singh, P. P., Mahmoudi, S., Harel, I., Casey, K. M., Dulken, B. W., Kundaje, A., & Brunet, A. (2019) · Genome Research

Genomics and Chromatin DynamicsGenetics, Aging, and Longevity in Model Organisms

Cited by 360

Single-cell transcriptomic analysis defines heterogeneity and transcriptional dynamics in the adult neural stem cell lineage

Dulken, B. W., Leeman, D. S., Boutet, S. C., Hebestreit, K., & Brunet, A. (2017) · Cell Reports

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 334

Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing

Mahmoudi, S., Mancini, E., Xu, L., Moore, A., Jahanbani, F., Hebestreit, K., Srinivasan, R., Li, X., Devarajan, K., Prélot, L., et al. (2019) · Nature

Wound Healing and TreatmentsPluripotent Stem Cells Research

Cited by 285

The Genetics of Aging: A Vertebrate Perspective

Singh, P. P., Demmitt, B. A., Nath, R. D., & Brunet, A. (2019) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 259