Shelterin: the protein complex that shapes and safeguards human telomeres

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Items 501–600 of 1,012

1. Contributions of DNA interstrand cross-links to aging of cells and organisms
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2. Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults
   Najarro, Kevin, Nguyen, Huy, Chen, Guobing, Xu, Mai, Alcorta, Sandy, Yao, Xu, Zukley, Linda, Metter, E. Jeffrey, Truong, Thai, Lin, Yun et al. · 2015 · Journal of Infectious Diseases
3. A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres
   Flores, Ignacio, Blasco, Maria A. · 2009 · PLoS ONE
4. TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells
   Ralph P. Schneider, Ianire Garrobo, Miguel Foronda, José Palacios, Rosa María Marión, Ignacio Flores, Sagrario Ortega, Marı́a A. Blasco · 2013 · Nature Communications
5. Comparative biology of telomeres: Where plants stand
   J. Matthew Watson, Karel Říha · 2010 · FEBS Letters
6. Structural Biology of Telomerase
   Yaqiang Wang, Lukas Sušac, Juli F. Feigon · 2019 · Cold Spring Harbor Perspectives in Biology
7. ANAT: A Tool for Constructing and Analyzing Functional Protein Networks
   Nir Yosef, Einat Zalckvar, Assaf D. Rubinstein, Max Homilius, Nir Atias, Liram Vardi, Igor Berman, Hadas Zur, Adi Kimchi, Eytan Ruppin et al. · 2011 · Science Signaling
8. Telomere biology disorders
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9. Bone Cell Senescence: Mechanisms and Perspectives
   Pierre J. Marie · 2014 · Journal of Bone and Mineral Research
10. Telomerase activity of HIV-1–specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
    Mathias D. Lichterfeld, Danlei Mou, Thai Duong Hong Cung, Katie L. Williams, Michael T. Waring, Jinghe Huang, Florencia Pereyra, Alicja Piechocka‐Trocha, Gordon James Freeman, Eric S. Rosenberg et al. · 2008 · Blood
11. Targeting telomerase-expressing cancer cells
    Michel M. Ouellette, Woodring Erik Wright, Jerry W. Shay · 2011 · Journal of Cellular and Molecular Medicine
12. Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish
    Madalena C. Carneiro, Catarina Martins Henriques, Joana Nabais, Tânia Ferreira, Tânia Carvalho, Miguel Godinho Ferreira · 2016 · PLoS Genetics
13. Telomere length correlations among somatic tissues in adult zebra finches
    Reichert, Sophie, Criscuolo, François, Verinaud, Elodie, Zahn, Sandrine, Massemin, Sylvie · 2013 · PLoS ONE
14. Therapeutic effect of androgen therapy in a mouse model of aplastic anemia produced by short telomeres
    Bar, C., Huber, N., Beier, F., Blasco, M. A. · 2015 · Haematologica
15. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
    Chang, Alex Chia Yu, Ong, Sang-Ging, LaGory, Edward L., Kraft, Peggy E., Giaccia, Amato J., Wu, Joseph C., Blau, Helen M. · 2016 · Proceedings of the National Academy of Sciences
16. Telomere maintenance and the etiology of adult glioma
    Kyle M. Walsh, John K. Wiencke, Daniel Honore Lachance, Joseph Leo Wiemels, Annette M Molinaro, Jeanette E. Eckel‐Passow, Robert Brian Jenkins, Margaret Wrensch · 2015 · Neuro-Oncology
17. The use of telomere length in ecology and evolutionary biology
    Thorsten Horn, Bruce C. Robertson, Neil J. Gemmell · 2010 · Heredity
18. Breast tumor subgroups reveal diverse clinical prognostic power
    Zhaoqi Liu, Xiang‐Sun Zhang, Shihua Zhang · 2014 · Scientific Reports
19. Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
    Irmina Diala, Nicole Wagner, Frédérique Magdinier, Marina Shkreli, Maria Sirakov, Serge Bauwens, Caroline Schluth‐Bolard, Thomas Simonet, Valérie M. Renault, Jing Ye et al. · 2013 · EMBO Reports
20. Dyskeratosis congenita
    Monica Bessler, David Brown Wilson, Philip J. Mason · 2010 · FEBS Letters
21. The mitochondrial genome in aging and senescence
    Lauri, Andrea, Pompilio, Giulio, Capogrossi, Maurizio C. · 2014 · Ageing Research Reviews
22. Telomere transcription in ageing
    Julio Aguado, Fabrizio d’Adda di Fagagna, Ernst Jurgen Wolvetang · 2020 · Ageing Research Reviews
23. Mechanisms of Immunosuppression in Colorectal Cancer
    Yang Zhang, Ashwani Rajput, Ning Yi Jin, Jing Wang · 2020 · Cancers
24. Telomere Length in Peripheral Blood Mononuclear Cells Is Associated with Folate Status in Men ,
    Ligi Paul, Marco Cattaneo, Armando D’Angelo, Francesca Sampietro, Isabella Fermo, Cristina Razzari, Gessica Fontana, Nindra Eugene, Paul F. Jacques, Jacob Selhub · 2009 · Journal of Nutrition
25. Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells
    Peisu Zhang, Michael J. Pazin, Catherine M. Schwartz, Kevin G. Becker, Robert P. Wersto, Caroline M. Dilley, Mark P. Mattson · 2008 · Current Biology
26. Arginine Methylation Regulates Telomere Length and Stability
    Taylor R. H. Mitchell, Kimberly Glenfield, Kajaparan Jeyanthan, Xu‐Dong Zhu · 2009 · Molecular and Cellular Biology
27. Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita
    Beier, Fabian, Foronda, Miguel, Martinez, Paula, Blasco, Maria A. · 2012 · Blood
28. CTCF driven TERRA transcription facilitates completion of telomere DNA replication
    Kate Beishline, Olga V. Vladimirova, Stephen Tutton, Zhuo Wang, Zhong Deng, Paul M. Lieberman · 2017 · Nature Communications
29. Mechanisms Underlying Recurrent Genomic Amplification in Human Cancers
    Hisashi Tanaka, Takaaki Watanabe · 2020 · Trends in cancer
30. Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential
    Stina George Fernandes, Rebecca Dsouza, Gouri Pandya, Anuradha Kirtonia, Vinay Tergaonkar, Sook Y. Lee, Manoj Garg, Ekta Khattar · 2020 · Cancers
31. TRF2-mediated telomere protection is dispensable in pluripotent stem cells
    Marta Markiewicz-Potoczny, Anastasia Lobanova, Anisha M. Loeb, Oktay Kirak, Teresa Olbrich, Sergio Ruiz, Eros Lazzerini Denchi · 2020 · Nature
32. DNA-Dependent Protein Kinase Catalytic Subunit Is Not Required for Dysfunctional Telomere Fusion and Checkpoint Response in the Telomerase-Deficient Mouse
    Richard S. Maser, Kwok‐Kin Wong, Erguen Sahin, Huili Xia, Maria L. Naylor, Herbert Mason Hedberg, Steven E. Artandi, Ronald Anthony DePinho · 2006 · Molecular and Cellular Biology
33. An Optimised Step-by-Step Protocol for Measuring Relative Telomere Length
    Mugdha V. Joglekar, Sarang N. Satoor, Wilson K. M. Wong, Feifei Cheng, Ronald C.W., Anandwardhan A. Hardikar · 2020 · Methods and Protocols
34. Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences
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35. Pif1‐ and Exo1‐dependent nucleases coordinate checkpoint activation following telomere uncapping
    James M. Dewar, David A. Lydall · 2010 · The EMBO Journal
36. CHIP Promotes Human Telomerase Reverse Transcriptase Degradation and Negatively Regulates Telomerase Activity
    Ji Hoon Lee, Prabhat Khadka, Seung Han Baek, In Kwon Chung · 2010 · Journal of Biological Chemistry
37. Specific Binding of Modified RGG Domain in TLS/FUS to G-Quadruplex RNA: Tyrosines in RGG Domain Recognize 2′-OH of the Riboses of Loops in G-Quadruplex
    K. Takahama, Takanori Oyoshi · 2013 · Journal of the American Chemical Society
38. Structure of Long Telomeric RNA Transcripts
    Adrian Randall, Jack D. Griffith · 2009 · Journal of Biological Chemistry
39. DNA damage, metabolism and aging in pro-inflammatory T cells
    Yinyin Li, Jörg J. Goronzy, Cornelia M. Weyand · 2017 · Experimental Gerontology
40. Molecular basis of telomere dysfunction in human genetic diseases
    Grzegorz Sarek, Paulina Marzec, Pol Margalef, Simon J. Boulton · 2015 · Nature Structural & Molecular Biology
41. Pathways for maintenance of telomeres and common fragile sites during DNA replication stress
    Özgün Özer, Ian David Hickson · 2018 · Open Biology
42. Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends
    Ananda Kishore Mukherjee, Shalu Sharma, Suman Sengupta, Dhurjhoti Saha, Pankaj Kumar, Tabish Hussain, Vivek Kumar Srivastava, Sumitabho Deb Roy, Jerry W. Shay, Shantanu Chowdhury · 2018 · PLoS Genetics
43. Evaluating causality of cellular senescence in non-alcoholic fatty liver disease
    Abraham Stijn Meijnikman, Hilde Herrema, Torsten P. M. Scheithauer, Jeffrey Kroon, Max Nieuwdorp, Albert Kornelis Groen · 2021 · JHEP Reports
44. Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
    Protásio Lemos da Luz, Leonardo Y. Tanaka, Patrı́cia C. Brum, Paulo Magno Martins Dourado, Desidério Favarato, José Eduardo Krieger, Francisco Rafael Martins Laurindo · 2012 · Atherosclerosis
45. Chromosomal rearrangements after ex vivo Epstein–Barr virus (EBV) infection of human B cells
    S Lacoste, Emilia Wiecheć, A G dos Santos Silva, Amanda Guffei, Gaynor J. Williams, M. Lowbeer, K Benedek, Marie Arsenian‐Henriksson, George Klein, Sabine Mai · 2009 · Oncogene
46. Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and Capping
    Susan Jean Hsiao, Marc F. Poitras, Brandoch D. Cook, Yie Liu, Susan Harless Smith · 2006 · Molecular and Cellular Biology
47. Chromosomal aberrations involving telomeres and interstitial telomeric sequences
    Alejandro D. Bolzán · 2011 · Mutagenesis
48. Chronic Exercise Modifies Age-Related Telomere Dynamics in a Tissue-Specific Fashion
    Andrew T. Ludlow, Sarah Witkowski, Mallory R. Marshall, Zhinuo Jenny Wang, Laila Lima, Lisa M. Pitchford, Espen E. Spangenburg, Stephen M. Roth · 2012 · The Journals of Gerontology Series A
49. Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells
    Christine Anne Armstrong, Kazunori Tomita · 2017 · Open Biology
50. Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
    Mao, Pingsu, Liu, Jingfan, Zhang, Zepeng, Zhang, Hong, Liu, Haiying, Gao, Song, Rong, Yikang S., Zhao, Yong · 2016 · Nature Communications
51. Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD)
    Wanil Kim, Jerry W. Shay · 2017 · Differentiation
52. Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
    Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W.K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew T. Ludlow, Siyuan Zheng · 2021 · Nature Communications
53. BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage
    Rahul D. Ballal, Tapas Saha, Saijun Fan, Bassam R Haddad, Eliot M. Rosen · 2009 · Journal of Biological Chemistry
54. Timeless preserves telomere length by promoting efficient DNA replication through human telomeres
    Adam R. Leman, Jayaraju Dheekollu, Zhong Deng, Seung Woo Lee, Mukund M. Das, Paul M. Lieberman, Eishi Noguchi · 2012 · Cell Cycle
55. HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction
    Eva Polanská, Zuzana Dobšáková, Martina Dvořáčková, Jiřı́ Fajkus, Michal Štros · 2012 · Chromosoma
56. FEN1 Ensures Telomere Stability by Facilitating Replication Fork Re-initiation
    Abhishek Saharia, Daniel C. Teasley, Julien P. Duxin, Benjamin Dao, Katherine Bakshian Chiappinelli, Sheila A. Stewart · 2010 · Journal of Biological Chemistry
57. Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer
    Hua Hu, Yang Zhang, Zou Mei, Shuai Yang, Xiaoqiu Liang · 2010 · Journal of Cancer Research and Clinical Oncology
58. Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
    Leire Bejarano, Alberto J. Schuhmacher, Marinela Méndez, Diego Megı́as, Carmen Blanco‐Aparicio, Sonia Martı́nez, Joaquı́n Pastor, Massimo Squatrito, Marı́a A. Blasco · 2017 · Cancer Cell
59. Erratum: Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder
    Firoza Mamdani, Brandi L. Rollins, Ling Morgan, R Myers, Jack D. Barchas, Alan F. Schatzberg, Stanley J. Watson, Huda Akil, Steven G. Potkin, William E. Bunney et al. · 2016 · Translational Psychiatry
60. RecQ helicases in DNA double strand break repair and telomere maintenance
    Dharmendra Kumar Singh, Avik K. Ghosh, Deborah L. Croteau, Vilhelm A. Bohr · 2011 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
61. Thymidine nucleotide metabolism controls human telomere length
    William P. Mannherz, Suneet Agarwal · 2023 · Nature Genetics
62. Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance
    John R. Walker, Xu‐Dong Zhu · 2012 · Mechanisms of Ageing and Development
63. Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells
    Ping Li, Mi Hou, Fenglan Lou, Magnus Björkholm, Dawei Xu · 2012 · The International Journal of Biochemistry & Cell Biology
64. The role of telomere biology in bone marrow failure and other disorders
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65. Maternal telomere length inheritance in the king penguin
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66. Genetic variation in five genes important in telomere biology and risk for breast cancer
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67. Telomeres, Reproductive Aging, and Genomic Instability During Early Development
    David Lawrence Keefe · 2016 · Reproductive Sciences
68. Telomerase regulation
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69. Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent
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70. Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: An Overview Comparing Pediatric and Adult Populations
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71. The epigenetic aging, obesity, and lifestyle
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72. Therapeutic targeting of replicative immortality
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73. Telomere regulation and function during meiosis
    Manos Siderakis, Madalena Tarsounas · 2007 · Chromosome Research
74. Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing “stemness”-related markers
    Haeryoung Kim, Jeong Eun Yoo, Jai Young Cho, Bong-Kyeong Oh, Yoo‐Seok Yoon, Ho‐Seong Han, Hye Seung Lee, Ja June Jang, Sook‐Hyang Jeong, Jin‐Wook Kim et al. · 2013 · Journal of Hepatology
75. The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed–Sternberg cells
    Hans Knecht, Bassem Sawan, Daniel Lichtensztejn, Bruno Lemieux, Raymund J. Wellinger, Sabine Mai · 2008 · Leukemia
76. Telomeres and marrow failure
    Rodrigo T. Calado · 2009 · Hematology
77. The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the Shelterin Complex
    Jill R. Donigian, Titia de Lange · 2007 · Journal of Biological Chemistry
78. Metallo-supramolecular Complexes Enantioselectively Eradicate Cancer Stem Cells in Vivo
    Hongshuang Qin, Chuanqi Zhao, Yuhuan Sun, Jinsong Ren, Xiaogang Qu · 2017 · Journal of the American Chemical Society
79. The mTOR pathway is necessary for survival of mice with short telomeres
    Iole Ferrara‐Romeo, Paula Martínez, Sarita Saraswati, Kurt Whittemore, Osvaldo Graña‐Castro, Lydia Thelma Poluha, Rosa Serrano, Elena Hernández-Encinas, Carmen Blanco‐Aparicio, Juana María Flores et al. · 2020 · Nature Communications
80. Role of POT1 in Human Cancer
    Yangxiu Wu, Rebecca C. Poulos, Roger R. Reddel · 2020 · Cancers
81. SIRT6 in Senescence and Aging-Related Cardiovascular Diseases
    Xiao‐Kang Li, Lin Liu, Tian Xiang Li, Manling Liu, Yishi Wang, Heng Ma, Nan Mu, Haiyan Wang · 2021 · Frontiers in Cell and Developmental Biology
82. Structure of the Human Telomeric Stn1-Ten1 Capping Complex
    C. Bryan, C. Rice, M. Harkisheimer, D. Schultz, E. Skordalakes · 2013 · PLoS ONE
83. WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2ΔB-Mediated Telomere Shortening
    Baomin Li, Sonali P. Jog, Sita Reddy, Lucio Comai · 2008 · Molecular and Cellular Biology
84. The molecular biology of human herpesvirus-6 latency and telomere integration
    Jesse H. Arbuckle, Peter G. Medveczky · 2011 · Microbes and Infection
85. “One Ring to Bind Them All”—Part I: The Efficiency of the Macrocyclic Scaffold for G‐Quadruplex DNA Recognition
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86. Telomere repeat binding proteins are functional components of A rabidopsis telomeres and interact with telomerase
    Petra Procházková Schrumpfová, Ivona Vychodilová, Martina Dvořáčková, Jana Majerská, Ladislav Dokládal, Šárka Schořová, Jiřı́ Fajkus · 2014 · The Plant Journal
87. Combined analysis of DNA methylome and transcriptome reveal novel candidate genes with susceptibility to bovine Staphylococcus aureus subclinical mastitis
    Minyan Song, Yanghua He, Huangkai Zhou, Yi Zhang, Xizhi Li, Ying Yu · 2016 · Scientific Reports
88. Telomere Recognition and Assembly Mechanism of Mammalian Shelterin
    Fabian Erdel, Katja Kratz, Smaranda Willcox, Jack D. Griffith, Eric C. Greene, Titia de Lange · 2017 · Cell Reports
89. The role of DNA damage response proteins at telomeres—an “integrative” model
    Predrag Slijepčević · 2006 · DNA repair
90. Vertebrate POT1 Restricts G-Overhang Length and Prevents Activation of a Telomeric DNA Damage Checkpoint but Is Dispensable for Overhang Protection
    Dmitri Churikov, Chao Wei, Carolyn M. Price · 2006 · Molecular and Cellular Biology
91. Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy
    Emily M. Smith, Wei Zhou, Polina Shindiapina, Saïd Sif, Chenglong Li, Robert A. Baiocchi · 2018 · Expert Opinion on Therapeutic Targets
92. Telomere stability and telomerase in mesenchymal stem cells
    Nedime Serakıncı, Jesper Graakjær, Steen Kølvraa · 2007 · Biochimie
93. Experimentally increased reproductive effort alters telomere length in the blue tit (Cyanistes caeruleus)
    Joanna Sudyka, Aneta Arct, Szymon Marian Drobniak, Anna Dubiec, Lars Gustafsson, Mariusz Cichoń · 2014 · Journal of Evolutionary Biology
94. Dyrk2-associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation
    Hae‐Yun Jung, Xin Wang, Sohee Jun, Jae‐Il Park · 2013 · Journal of Biological Chemistry
95. Telomere ResQue and preservation—Roles for the Werner syndrome protein and other RecQ helicases
    Patricia Lynn Opresko · 2007 · Mechanisms of Ageing and Development
96. Bloom’s syndrome: Why not premature aging?
    Christelle de Renty, Nathan A. Ellis · 2016 · Ageing Research Reviews
97. Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome
    Keith Wheaton, Denise Campuzano, Weili Ma, Michal Sheinis, Brandon Ho, Grant W. Brown, Samuel Benchimol · 2017 · Molecular and Cellular Biology
98. Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazole‒carbazole ligands
    Mangesh H. Kaulage, Basudeb Maji, Sanjeev Pasadi, Asfa Ali, Santanu Bhattacharya, Kalappa Muniyappa · 2018 · European Journal of Medicinal Chemistry
99. Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
    Ci Ji Lim, Arthur J. Zaug, Hee Jin Kim, Thomas R. Cech · 2017 · Nature Communications
100. Heart-Breaking Telomeres
     Paula Martínez, María A. Blasco · 2018 · Circulation Research