The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation
Open accessAbstract
Members of the myc family of cellular oncogenes have been implicated as transcriptional regulators in pathways that govern cellular proliferation and death. In addition, N-myc and c-myc are essential for completion of murine embryonic development. However, the basis for the evolutionary conservation of myc gene family has remained unclear. To elucidate this issue, we have generated mice in which the endogenous c-myc coding sequences have been replaced with N-myc coding sequences. Strikingly, mice homozygous for this replacement mutation can survive into adulthood and reproduce. Moreover, when expressed from the c-myc locus, N-myc is similarly regulated and functionally complementary to c-myc in the context of various cellular growth and differentiation processes. Therefore, the myc gene family must have evolved, to a large extent, to facilitate differential patterns of expression.
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Citations
Cites
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
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Self-citation
Cited by
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390
Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration
Ahuja, P., Sdek, P., & MacLellan, W. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00032.2006 · Cited by 568
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity
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Retinoic acid signaling and neuronal differentiation
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Role of MYC in medulloblastoma
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c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
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Schaafsma, E., Zhao, Y., Zhang, L., Li, Y., & Cheng, C. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0526 · Cited by 12
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Metadata
- Authors
- Malynn, B. A., de Alboran, I. M., O'Hagan, R. C., Bronson, R., Davidson, L., DePinho, R. A., & Alt, F. W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-06-01
- Volume
- 14
- Issue
- 11
- Pages
- 1390-1399
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2146613018
- Cited by
- 335
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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