Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification

Defining the Epithelial Stem Cell Niche in Skin

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Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche

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The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

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Three clonal types of keratinocyte with different capacities for multiplication.

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Capturing and profiling adult hair follicle stem cells

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Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

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Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ

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Endoreplication Cell Cycles

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

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Drosophila myc Regulates Cellular Growth during Development

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Drosophila Myc Regulates Organ Size by Inducing Cell Competition

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dMyc Transforms Cells into Super-Competitors

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A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.Preprint

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Direct activation of RNA polymerase III transcription by c-Myc

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c-Myc regulates mammalian body size by controlling cell number but not cell size

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Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

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Analysis of C-MYC Function in Normal Cells via Conditional Gene-Targeted Mutation

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Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia.

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Plant cell-size control: growing by ploidy?

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c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

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N-myc can functionally replace c-myc in murine development, cellular growth, and differentiationPreprint

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c-Myc promotes differentiation of human epidermal stem cells

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Deregulated expression of c-Myc depletes epidermal stem cells

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Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain

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Terminal differentiation of epidermal keratinocytes

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Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

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Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

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p63 and the epithelial stem cell: more than status quo?Preprint

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A keratin K5Cre transgenic line appropriate for tissue‐specific or generalized cre‐mediated recombination

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Endoreduplication and development: rule without dividing?

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Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

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Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

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Myc and Max Homologs in Drosophila

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dMyc is required for larval growth and endoreplication in Drosophila

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Developmental Context Determines Latency of MYC-Induced Tumorigenesis

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C-myc overexpression and p53 loss cooperate to promote genomic instability

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Disentangling the MYC web

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Drosophila dMyc is required for ovary cell growth and endoreplication

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c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver

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Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype

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Label-retaining keratinocytes and Langerhans cells in mouse epithelia

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Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication

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Contrasting roles for c‐Myc and L‐Myc in the regulation of cellular growth and differentiation in vivo.

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Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation

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Congenital contractures, edema, hyperkeratosis, and intrauterine growth retardation: A fatal syndrome in hutterite and mennonite kindreds

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B-Myc Inhibits Neoplastic Transformation and Transcriptional Activation by c-Myc

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Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

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Historical note on restrictive dermopathy and report of two new cases

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Lower Extremity Purpura

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Tight Skin and Dysmorphic Features in a Newborn

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Scratching the surface of skin development

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Epidermal Stem Cells of the Skin

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MYC, Metabolism, Cell Growth, and TumorigenesisPreprint

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Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

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Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence

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Lactate dehydrogenase activity drives hair follicle stem cell activation

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Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

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Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc

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More than one way to skin . . .

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Epidermal stem cells: an update

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Transcriptional Control of Wound Repair

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Sebocytes, multifaceted epithelial cells: Lipid production and holocrine secretion

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Resting no more: re‐defining telogen, the maintenance stage of the hair growth cycle

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Epigenetic reprogramming during wound healing: loss of polycomb‐mediated silencing may enable upregulation of repair genes

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Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division

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MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

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Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation

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The MAX-interacting transcription factor network

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Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc

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Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme

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Cancer stem cells and cell size: A causal link?

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The Role of MIZ-1 in MYC-Dependent TumorigenesisPreprint

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A Mitosis Block Links Active Cell Cycle with Human Epidermal Differentiation and Results in Endoreplication

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Shh Controls Epithelial Proliferation via Independent Pathways that Converge on N-Myc

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Myc's other life: stem cells and beyond

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miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration

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Of Myc and Mnt

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Skin epidermis lacking the c-myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21 Cip1 genePreprint

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MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer

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2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro

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N6‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness

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Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research

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Targeting MYC Proteins for Tumor Therapy

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Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage

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The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint

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Universal encoding of pan-cancer histology by deep texture representations

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Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle Arrest

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Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion

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Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis

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Role of c-Myc in intestinal tumorigenesis of the Apc min/+ mouse1

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Unveiling Hair Follicle Stem Cells

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Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro

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N-myc functions in transcription and development

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Neuregulin3 alters cell fate in the epidermis and mammary gland

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C‐myc as a modulator of renal stem/progenitor cell population

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Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage

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Cyclin E drives human keratinocyte growth into differentiation

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Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells

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Control of Vertebrate Development by MYCPreprint

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Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

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Myc in model organisms: A view from the flyroom

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Conditional Deletion ofc-mycDoes Not Impair Liver Regeneration

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Epidermal Receptor Activator of NF-κB Ligand Controls Langerhans Cells Numbers and Proliferation,

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The Proto-Oncogene Myc Is Essential for Mammary Stem Cell Function

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Effects and mechanisms of polycyclic aromatic hydrocarbons in inflammatory skin diseases

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Hierarchy of cellular decisions in collective behavior: Implications for wound healing

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Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion

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c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland

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Transcriptional regulation of wound inflammation

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The Candidate Tumor Suppressor Gene ZAC Is Involved in Keratinocyte Differentiation and Its Expression Is Lost in Basal Cell Carcinomas

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Transcriptional control of skin reepithelialization

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Myc Prevents Apoptosis and Enhances Endoreduplication Induced by Paclitaxel

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CIP2A increases self-renewal and is linked to Myc in neural progenitor cells

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Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1

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Magnetic separation and characterization of keratinocyte stem cells from human gingiva

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Genetically modified laboratory mice with sebaceous glands abnormalities

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B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor

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Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex

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Transient cardiomyocyte fusion regulates cardiac development in zebrafish

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The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation

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Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)

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Pim-3 protects against cardiomyocyte apoptosis in anoxia/reoxygenation injury via p38-mediated signal pathway

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The δ-Opioid Receptor Affects Epidermal Homeostasis via ERK-Dependent Inhibition of Transcription Factor POU2F3

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Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway

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Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulatingβ-Catenin, c-Myc, and Cyclin Expression

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Cell proliferation dynamics of somatic and germline tissues during zooidal life span in the colonial tunicate Botryllus primigenus

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Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation

Bernabé‐Rubio, M., Ali, S., Bhosale, P. G., Goss, G., Mobasseri, S. A., Tapia‐Rojo, R., Zhu, T., Hiratsuka, T., Battilocchi, M., Tomás, I. M., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01234-5 · Cited by 24 · see citing works

Irs2 Inactivation Suppresses Tumor Progression in Pten+/− Mice

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Cutaneous stem cells: something new and something borrowed

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MYC accelerates p21CIP‐induced megakaryocytic differentiation involving early mitosis arrest in leukemia cells

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Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion

Cooper, F., Overmiller, A. M., Loder, A., Brennan-Crispi, D. M., McGuinn, K. P., Marous, M. R., Freeman, T. A., Galdo, N. A. R., Siracusa, L. D., Wahl, J. K., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.04.024 · Cited by 19 · see citing works

Epidermal stem cell fate: what can we learn from embryonic stem cells?

Aberdam, D. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0497-0 · Cited by 18 · see citing works

Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma

Wang, X., Langer, E. M., Daniel, C. J., Janghorban, M., Wu, V. F., Wang, X., & Sears, R. C. (2020) · Oncogenesis · doi:10.1038/s41389-020-00261-3 · Cited by 18 · see citing works

Miz1 Is a Critical Repressor of cdkn1a during Skin Tumorigenesis

Hönnemann, J., Sanz‐Moreno, A., Wolf, E., Eilers, M., & Elsässer, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034885 · Cited by 17 · see citing works

In vitro differentiation of murine embryonic stem cells into keratinocyte-like cells

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mrtl—A translation/localization regulatory protein encoded within the human c‐myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network

Choi, H., Jackson, N. L., Shaw, D. R., Emanuel, P. D., Liu, Y. L., Tousson, A., Meng, Z., & Blume, S. W. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21909 · Cited by 17 · see citing works

Myc in Stem Cell Behaviour: Insights from Drosophila

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Chloracne: From clinic to research

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Decreased p53 is associated with a decline in asymmetric stem cell self‐renewal in aged human epidermis

Charruyer, A., Weisenberger, T., Li, H., Khalifa, A., Schroeder, A., Belzer, A., & Ghadially, R. (2021) · Aging Cell · doi:10.1111/acel.13310 · Cited by 16 · see citing works

Manipulating Myc for reparative regeneration

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The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair

Portal, C., Wang, Z., Scott, D. K., Wolosin, J. M., & Iomini, C. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.2.3 · Cited by 13 · see citing works

Meibomian gland development: Where, when and how?

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Wound Healing

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Oh, the Mutations You’ll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma

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KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

Shimoda, M., Lyu, Y., Wang, K.-H., Kumar, A., Miura, H., Meckler, J. F., Davis, R. R., Chantarasrivong, C., Izumiya, C., Tepper, C. G., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02853-0 · Cited by 11 · see citing works

The inhibition of the expression of the small Rho GTPase Rac1 induces differentiation with no effect on cell proliferation in growing human adult keratinocytes

Nikolova, E., Mitev, V., Minner, F., Deroanne, C., & Poumay, Y. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21455 · Cited by 11 · see citing works

Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers

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Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

Yanku, Y., Bitman-Lotan, E., Zohar, Y., Kurant, E., Zilke, N., Eilers, M., & Orian, A. (2018) · Cells · doi:10.3390/cells7100151 · Cited by 9 · see citing works

Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier Formation

Wang, J., Eming, S. A., & Ding, X. (2022) · Biology · doi:10.3390/biology11060931 · Cited by 8 · see citing works

c-Myc and Activated Ras During Skin Tumorigenesis: Cooperation at the Cancer Stem Cell Level?

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MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation

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Analysis of c-Myc function in mouse epidermis

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c-Myc promotes differentiation of human epidermal stem cells

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c-Myc regulates mammalian body size by controlling cell number but not cell size

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c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

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