The DOI matches its Crossref record; 78 of the 86 references it cites were found in a registry or an index.
Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53
Open accessAbstract
Chk2/hcds1, the human homolog of the Saccharomyces cerevisiae RAD53/SPK1 and Schizosaccharomyces pombe cds1 DNA damage checkpoint genes, encodes a protein kinase that is post-translationally modified after DNA damage. Like its yeast homologs, the Chk2/hCds1 protein phosphorylates Cdc25C in vitro, suggesting that it arrests cells in G 2 in response to DNA damage. We expressed Chk2/hCds1 in human cells and analyzed their cell cycle profile. Wild-type, but not catalytically inactive, Chk2/hCds1 led to G 1 arrest after DNA damage. The arrest was inhibited by cotransfection of a dominant-negative p53 mutant, indicating that Chk2/hCds1 acted upstream of p53. In vitro, Chk2/hCds1 phosphorylated p53 on Ser-20 and dissociated preformed complexes of p53 with Mdm2, a protein that targets p53 for degradation. In vivo, ectopic expression of wild-type Chk2/hCds1 led to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2/hCds1 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization. Thus, in response to DNA damage, Chk2/hCds1 stabilizes the p53 tumor suppressor protein leading to cell cycle arrest in G 1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and hChk2, in turn, phosphorylates yet another amino-terminal Ser residue (Ser 20) in p53”
From Cell cycle checkpoint signaling through the ATM and ATR kinases (2001) · cites this paper as Chehab et al. 2000
In the citing paper
“These phosphorylation events contribute to disrupting the p53-Mdm2 (Chehab et al., 2000; Shieh et al., 2000), and Mdm2-DAXX (Tang et al., 2013) interactions, as well as to the degradation of Mdm2 and Mdm4 (Stommel and Wahl, 2004; Chen et al., 2005; Pereg et al., 2005, 2006; LeBron et al., 2006).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Chehab et al., 2000
In the citing paper
“ATM also activates Chk2, which in turn phosphorylates p53 on serine 20 and inhibits MDM2 binding (Shieh et al, 1997;Banin et al, 1998;Chehab et al, 2000;Shieh et al, 2000).”
From ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage (2005) · cites this paper as Chehab et al, 2000
In the citing paper
“Studies using Chk2-null mice, Chk2-null HCT116 cells, and Chk2 siRNA resulted in different conclusions (Zhang et al, 1998;Chehab et al, 2000;Shieh et al, 2000;Ahn et al, 2003; Jallepalli et al, 2003).”
From ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage (2005) · cites this paper as Chehab et al, 2000
In the citing paper
“Although a role of ATM in p53 response is well established, the significance of Chk2 is still a matter of debate.”
From ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage (2005) · cites this paper as Chehab et al, 2000
In the citing paper
“ATM also activates Chk2, which in turn phosphorylates p53 on S20, which is a part of the MDM2-binding site (Shieh et al, 1997(Shieh et al, , 2000;;Banin et al, 1998;Chehab et al, 2000).”
From ATM activates p53 by regulating MDM2 oligomerization and E3 processivity (2009) · cites this paper as Chehab et al, 2000
In the citing paper
“p53 is phosphorylated at Ser20 by the checkpoint kinase Chk2 after IR, which results in p53's dissociation from Mdm2 and its subsequent stabilization”
From USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 (2010) · cites this paper as Chehab et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 2×
“Stabilization of p53 in cells exposed to IR or UV light is due to dissociation from Mdm2 (Shieh et al. 1997), a protein that targets p53 for degradation through the ubiquitin pathway (Haupt et al. 1997; Kubbutat et al. 1997; Midgley and Lane 1997).”
BackgroundMomand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
Thymocyte apoptosis induced by p53-dependent and independent pathways
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206
Flagged first, then by citations
8 of the 86 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 701–800 of 805
Simulated Annealing Based Algorithm for Mutated Driver Pathways Detecting
Yan, C. Y., Li, H., Guo, A.-X., Sha, W., & Zheng, C.-H. (2014) · Lecture notes in computer science · doi:10.1007/978-3-319-09339-0_66 · Cited by 1
Tsuge, M. (2021) · Viruses · doi:10.3390/v13101920 · Cited by 1
Par-4 in Cell Cycle Regulation
Zhang, Y., Mao, F., & Liu, X. (2022) · Springer eBooks · doi:10.1007/978-3-030-73572-2_2 · Cited by 1
Microarray Bioinformatics and Applications in Oncology
Peeters, J. K. (2008) · EUR Research Repository (Erasmus University Rotterdam) · Cited by 1
Nyberg, K. A., & Weinert, T. A. (2003) · Defense Technical Information Center (DTIC) · doi:10.21236/ada418042 · Cited by 1
Interplay of 14-3-3 Family of Proteins with DNA Damage-Regulated Molecules in Checkpoint Control
Lee, M., Yeung, S. J., & Yang, H.-Y. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_5 · Cited by 1
The p53 Transcription Factor as Therapeutic Target in Cancer
Asker, C., Bykov, V. J. N., Méndez‐Vidal, C., Selivanova, G., Wilhelm, M., & Wiman, K. G. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18932-6_7 · Cited by 1
Chk1 and Chk2 as Checkpoint Targets
Zhang, H., Xiao, Z., & Sowin, T. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_16 · Cited by 1
Genetic Predisposition to Male and Female Breast Cancer
Syrjäkoski, K. (2004) · Tampere University Institutional Repository (Tampere University) · Cited by 1
Combined treatment of canine osteosarcoma cells with gene knock-down and chemotherapy
Gallienne, J. (2014) · The Atrium (University of Guelph) · Cited by 1
Systematic transcriptomic analysis and temporal modelling of the senescent human fibroblastPreprint
Scanlan, R.-L., Pease, L., O’Keefe, H., Guimera, A. M., Shanley, D., & Wordsworth, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.16.504144 · Cited by 1
Kinase Liabilities in Early Drug Discovery
Kirchner, S. (2024) · Wiley eBooks · doi:10.1002/9781394182862.ch6 · Cited by 1
DNA Damage and Oxidative Stress Induced-p53 Activity In Astrocytes causes Growth Arrest
Humphrey, S. A. (2012) · Scholarship@Western (Western University)
Calenic, B., & Yaegaki, K. (2013) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4614-9557-4_5
BACTERIAL GENOTOXINS: AN INTERFACE BETWEEN INFECTION AND CANCER BIOLOGY
Levi, L. (2015) · Figshare
CHK2 is Negatively Regulated by Protein Phosphatase 2A
Freeman, A. K. (2010) · Digital Commons - University of South Florida (University of South Florida)
A TATA-kötő fehérje asszociált faktor 3 (TAF3) p53-mal való kölcsönhatásának funkcionális vizsgálata
Buzás-Bereczki, O. (2010) · SZTE Repository of Dissertations (University of Szeged)
Matthews, D. J., & Gerritsen, M. E. (2010) · Wiley eBooks · doi:10.1002/9780470555293.ch6
ATM Deficiency -- A Multifaceted Defect in Lymphocyte Development
Helmink, B. A. (2012) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7k07291
The Role of Phosphorylation in IR-induced p53 Stabilization and Activation
Yamauchi, M., Suzuki, K., Kodama, S., & Watanabe, M. (2005) · Institutional Repositories DataBase (IRDB) · doi:10.11343/amn.50.s51
DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells
Sperka, T., Nalapareddy, K., & Rudolph, K. L. (2010) · Else Kröner-Fresenius Symposia · doi:10.1159/000312653
Life or cell death: identifying c-Myc regulated genes in two distinct tissues
Robson, S. C. (2026) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33480907
DNA Damage Checkpoint Signaling Pathways in Human Cancer
Abraham, R. T., & Halazonetis, T. D. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1216-8_3
Self-citationSarek, G. (2010) · Työväentutkimus Vuosikirja
CHEK2 in Breast and Colorectal Cancer
Kilpivaara, O. (2007) · Työväentutkimus Vuosikirja
Post-translational Modifications of the p53 Transcription Factor
Brooks, C. L., & Gu, W. J. (2007) · Springer eBooks · doi:10.1007/978-0-387-40049-5_15
Role of checkpoint kinase 1 in malignant melanoma
Smith, J. (2013) · Enlighten: Theses (The University of Glasgow)
ROLE OF ING2 (INHIBITOR OF GROWTH FAMILY MEMBER 2) IN CELLUAR RESPONSES TO DNA DAMAGE
Sun, G. (2009) · D-Scholarship@Pitt (University of Pittsburgh)
Accumulation of alanine mutant p53 at Ser15, Thr18, and Ser20 after X-irradiation
Yamauchi, M., Suzuki, K., Kodama, S., & Watanabe, M. (2003) · International Congress Series · doi:10.1016/s0531-5131(03)01202-0
Expression of Chk2 and P53 in Sporadic Breast Cancer
Song, B. J., Han, S., Kim, H. S., Kim, C. N., Chang, S. H., Seo, Y. J., & Jung, S. S. (2003) · Journal of Breast Cancer · doi:10.4048/jkbcs.2003.6.3.141
DNA damage‐inducible phosphorylation of p53 at Ser20 is required for p53 stabilization
Yang, D., Rhee, B. K., Yim, T. H., Lee, H. J., & Kim, J. (2002) · Korean Journal of Biological Sciences · doi:10.1080/12265071.2002.9647661
An oncogene-induced DNA replication stress model for human cancer development
Halazonetis, T. D., Zgheib, O., Gorgoulis, V. G., & Bártek, J. (2008) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(08)71417-4
Self-citationInterplay between ATM and ATR for the regulation of cellular responses to DNA damage
Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)
Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway
Agarwal, A. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7ng4nnv
Cortes-Bratti, X. (2001) · Figshare
The p53 homolog p63 modulates acute and chronic damage in irradiated salivary glands
Mitchell, G. C. (2010) · UA Campus Repository (The University of Arizona)
Characterization of the mechanisms of ATM activation by the MRN complex and DNA
Lee, J. H. (2005) · Texas ScholarWorks (Texas Digital Library)
THE ATTENUATION OF THE P53 RESPONSE TO DNA DAMAGE IN RODENT LIVER PRENEOPLASTIC ENZYME- ALTERED FOCI
Finnberg, N. K. (2003) · Figshare
Synergistic Effects of BubR1 and p53 Deficiency in Tumor Formation
Wiles, W. G. (2006)
Choi, H. (2009) · QSpace (Queen's University Library)
DOCTEUR DE L'UNIVERSITÉ DE GRENOBLE
Vu, H. L. (2011)
Serine 379 Signaling through Autophosphorylation of Regulation of Chk2 Ubiquitination and
Piwnica-Worms, H. M., Lovly, C. M., Yan, L., & Ryan, C. E. (2014)
Aberrations of DNA Damage in Checkpoints in Cancer
Laiho, M. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-200-7_5
The Role of Chk2 and Wee1 Protein Kinases during the Early Embryonic Development of Xenopus laevis
Wroble, B. N. (2005) · VTechWorks (Virginia Tech)
Heterogeneity in Genetic Susceptibility to Prostate Cancer
Seppälä, E. H. (2006) · Tampere University Institutional Repository (Tampere University)
Jeggo, P. A., Elledge, S. J., Mak, T. W., Bristow, R. G., Suda, T., Lowe, S. W., Sarkissian, T., Wong, J. A., Sakai, T., Elia, A., et al. (2014)
Characterization of an autoimmune gene expression signature.
Maas, K. H. (2006)
Johmura, Y., & Nakanishi, M. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_18
p53 Tumor Suppressor Opens Gateways for Cancer Therapy
Dai, M., Gallegos, J. R., & Lu, H. (2008) · CRC Press eBooks · doi:10.1201/9780849387999.ch48
Chapter 16 Chk1 and Chk2 as Checkpoint Targets
Zhang, H., Xiao, Z., & Sowin, T. (2009)
Susceptibility genes in hereditary breast cancer
Vahteristo, P. (2003) · Työväentutkimus Vuosikirja
The interaction between Rad9 and Tousled-like kinase 1 in the cell cycle and the DNA damage response
Kelly, R. M. (2013) · QSpace (Queen's University Library)
Jolliffe, A. K. (2012) · TSpace (University of Toronto)
Loss of BRCA1 in Normal Human Mammary Epithelial Cells Induces a Novel Mechanism of Senescence
Noor, S. (2011) · TSpace (University of Toronto)
The Recognition and Mobility of DNA-Double Strand Breaks
Strecker, J. (2016) · TSpace (University of Toronto)
MicroRNA Function of Some Life Process in the Gene Network
Liu, Z., Shen, J., Cai, S., & Yan, F. (2018) · Springer eBooks · doi:10.1007/978-94-024-1577-3_3
Epigenetic mechanisms in dna replication
Loureiro, R. (2016) · Dialnet (Universidad de la Rioja)
Mechanisms of Gastrointestinal Malignancies
Lynch, J. P., & Rustgi, A. K. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50020-9
An Oncogene-Induced DNA Replication Stress Model for Cancer Development
Halazonetis, T. D. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_3
Self-citationFriedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. E. (2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch21
Gruber, L., Schneider, B., Nothnagel, C., & Beer‐Hammer, S. (2022) · European Journal of Immunology · doi:10.1002/eji.202250017
Reduced autophagy contributes to inefficient DNA damage repair in mouse oocytes
Sun, F. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/94120
Molecular genetics of soft tissue tumors
Lasota, J. P. (2016) · Cambridge University Press eBooks · doi:10.1017/9781107707504.006
Mukhtar, T. K., Wilcox, N., Dennis, J., Yang, X., Naven, M., Mavaddat, N., Perry, J. R. B., Gardner, E. J., & Easton, D. F. (2024) · medRxiv · doi:10.1101/2024.07.01.24309756
Kim, J., Oh, J., Jang, D., Shin, S., Lee, S., Lee, S. E., Yang, Y., Kim, D., Choi, A.-J., Jung, H. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.04.652100
Purvis, K. N., Nichols, K. E., Pandey, A. S., Gheorghe, G. S., Helmig, S. E., Garrett, K., Bag, A. K., Inaba, H., & Ribeiro, R. C. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1569506
Posttranslational Modifications of p53: Upstream Signaling Pathways
Anderson, C. W., & Appella, E. (2007) · Springer eBooks · doi:10.1007/0-387-30127-5_5
The Partial Characterization of the 142R Protein of Tanapox Virus
Seibert, K. N. (2013) · ScholarWorks - WMU (Western Michigan University)
Localisation et fonction de CHK2 en mitose
Chouinard, G. (2012) · Papyrus : Institutional Repository (Université de Montréal) · doi:10.71781/31174
Systematic Modular Approaches to Reveal DNA Damage Responses in Mammalian Cells
Svensson, J. P. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Kim, J. Y., Kim, J., Bandara, B. M. R., Tilakaratne, W. M., & Kim, D. (2022) · Figshare · doi:10.6084/m9.figshare.19069780
Kim, J. Y., Kim, J., Bandara, B. M. R., Tilakaratne, W. M., & Kim, D. (2022) · Figshare · doi:10.6084/m9.figshare.19069786
Kim, J. Y., Kim, J., Bandara, B. M. R., Tilakaratne, W. M., & Kim, D. (2022) · Figshare · doi:10.6084/m9.figshare.19069792
Kim, J. Y., Kim, J., Bandara, B. M. R., Tilakaratne, W. M., & Kim, D. (2022) · Figshare · doi:10.6084/m9.figshare.19069783
Kim, J. Y., Kim, J., Bandara, B. M. R., Tilakaratne, W. M., & Kim, D. (2022) · Figshare · doi:10.6084/m9.figshare.19069771
Kim, J. Y., Kim, J., Bandara, B. M. R., Tilakaratne, W. M., & Kim, D. (2022) · Figshare · doi:10.6084/m9.figshare.19069774
Kim, J. Y., Kim, J., Bandara, B. M. R., Tilakaratne, W. M., & Kim, D. (2022) · Figshare · doi:10.6084/m9.figshare.19069777
Womack, J. A., Sukowaty, A. T., Fellman, A. J., Dash, R. K., & Terhune, S. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.04.703693
Etude de la fonction de HIPK1, sa régulation et son implication en oncologie
Rey, C. (2010) · theses.fr (ABES) · doi:10.70675/4d830220z8b4dz449fzac53zd4e99eac2d5b
Bačević, K. (2016) · theses.fr (ABES) · doi:10.70675/11789f75zbd23z4799zacfbzd7a0d55a3fd3
Les cellules sénecentes comme niche de survie : rôle de la voie TSP1-CD47
Moreau, M. (2017) · theses.fr (ABES) · doi:10.70675/e62d69b6z1f00z4f88z817bzda54e624150f
Etude des défauts héréditaires atypiques de la réparation de l'ADN
Fiévet, A. (2019) · theses.fr (ABES) · doi:10.70675/d981a983z0d97z44f5z8430z501446e5ce4d
Caractérisation fonctionnelle de la tolérance aux endommagements de l’ADN des embryons précoces
Furno, E. L. (2019) · theses.fr (ABES) · doi:10.70675/cf32bcd5z3031z4693z8b1bz62fe76673ccc
Rôle de la protéine ATM dans la régulation des gènes de latences du virus d’Epstein-Barr (EBV)
Tatfi, M. (2019) · theses.fr (ABES) · doi:10.70675/3b654584z65a5z4cbbzbbc2zde0a759cf1ab
Glioblastoma resistance to temozolomide : implication of α5β1 integrin and p53 signalling pathways
Sani, S. (2020) · theses.fr (ABES) · doi:10.70675/9566c585z0508z455bz9064z6bb61435b210
Regulation of the Akt/mTORC1 Pathway by HIV Transcriptional Activator Tat in B Cells
Akbay, B. (2021) · theses.fr (ABES) · doi:10.70675/2b579806z11cfz4545zb88az6987a56822bf · Cited by 1
Criblage de petites molécules d'intérêt thérapeutique et recherche de leur mécanisme d'action
Rozié, A. (2020) · theses.fr (ABES) · doi:10.70675/cfe93a65zdad1z4f4fzb5e3z4c2daf8ea474
Kim, J., Oh, J., Jang, D. G., Shin, S., Lee, S.-J., Lee, S. E., Yang, Y., Kim, D., Choi, A. J., Jung, H. R., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeb3726
蒲友敏, Chang, H., Chen, W., Zhang, H., Chen, W., Zhao, H., & Sun, D. (2026) · Functional & Integrative Genomics · doi:10.1007/s10142-026-02052-2
Advances in p53 Therapies for Oral Squamous Cell Carcinoma: A Literature Review
Aguilar, V. M. M., Trejo‐Solís, C., Magaña-Maldonado, R., Chac-Couoh, K. E., Pitones-Rubio, V., Gallardo‐Pérez, J. C., Carrillo-Ávila, B. A., Camarena, A. H., & Chávez-Cortéz, E. G. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48101013
Reflections on the early days of the DNA damage response pathway in eukaryotes
Elledge, S. J. (2026) · Genetics · doi:10.1093/genetics/iyag202
Metadata
- Authors
- Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D.
- Affiliations
- The Wistar Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-02-01
- Volume
- 14
- Issue
- 3
- Pages
- 278-288
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC316357
- OpenAlex
- W2131833681
- Cited by
- 805
- References
- 86
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 19 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 11 · 2017: 10 · 2016: 25 · 2015: 16 · 2014: 28 · 2013: 27 · 2012: 29
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- National Institutes of Health (CA-25874)
- National Cancer Institute (CA09171, CA-25874, CA-76367, R01CA076367, P01CA025874, T32CA009171)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Chk2, DNA damage checkpoint, p53 stabilization, MDM2, G1 cell cycle arrest, Cdc25C phosphorylation, post-translational modification, tumor suppressor proteins, dominant-negative mutant
- MeSH terms
- DNA Damage, Humans, Nuclear Proteins, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Tumor Cells, Cultured, Tumor Suppressor Protein p53, G1 Phase, Protein Serine-Threonine Kinases, Schizosaccharomyces pombe Proteins, Proto-Oncogene Proteins c-mdm2, Checkpoint Kinase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
