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Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53
Open accessAbstract
Chk2/hcds1, the human homolog of the Saccharomyces cerevisiae RAD53/SPK1 and Schizosaccharomyces pombe cds1 DNA damage checkpoint genes, encodes a protein kinase that is post-translationally modified after DNA damage. Like its yeast homologs, the Chk2/hCds1 protein phosphorylates Cdc25C in vitro, suggesting that it arrests cells in G 2 in response to DNA damage. We expressed Chk2/hCds1 in human cells and analyzed their cell cycle profile. Wild-type, but not catalytically inactive, Chk2/hCds1 led to G 1 arrest after DNA damage. The arrest was inhibited by cotransfection of a dominant-negative p53 mutant, indicating that Chk2/hCds1 acted upstream of p53. In vitro, Chk2/hCds1 phosphorylated p53 on Ser-20 and dissociated preformed complexes of p53 with Mdm2, a protein that targets p53 for degradation. In vivo, ectopic expression of wild-type Chk2/hCds1 led to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2/hCds1 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization. Thus, in response to DNA damage, Chk2/hCds1 stabilizes the p53 tumor suppressor protein leading to cell cycle arrest in G 1.
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In the citing paper
“and hChk2, in turn, phosphorylates yet another amino-terminal Ser residue (Ser 20) in p53”
From Cell cycle checkpoint signaling through the ATM and ATR kinases (2001) · cites this paper as Chehab et al. 2000
In the citing paper
“These phosphorylation events contribute to disrupting the p53-Mdm2 (Chehab et al., 2000; Shieh et al., 2000), and Mdm2-DAXX (Tang et al., 2013) interactions, as well as to the degradation of Mdm2 and Mdm4 (Stommel and Wahl, 2004; Chen et al., 2005; Pereg et al., 2005, 2006; LeBron et al., 2006).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Chehab et al., 2000
In the citing paper
“ATM also activates Chk2, which in turn phosphorylates p53 on serine 20 and inhibits MDM2 binding (Shieh et al, 1997;Banin et al, 1998;Chehab et al, 2000;Shieh et al, 2000).”
From ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage (2005) · cites this paper as Chehab et al, 2000
In the citing paper
“Studies using Chk2-null mice, Chk2-null HCT116 cells, and Chk2 siRNA resulted in different conclusions (Zhang et al, 1998;Chehab et al, 2000;Shieh et al, 2000;Ahn et al, 2003; Jallepalli et al, 2003).”
From ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage (2005) · cites this paper as Chehab et al, 2000
In the citing paper
“Although a role of ATM in p53 response is well established, the significance of Chk2 is still a matter of debate.”
From ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage (2005) · cites this paper as Chehab et al, 2000
In the citing paper
“ATM also activates Chk2, which in turn phosphorylates p53 on S20, which is a part of the MDM2-binding site (Shieh et al, 1997(Shieh et al, , 2000;;Banin et al, 1998;Chehab et al, 2000).”
From ATM activates p53 by regulating MDM2 oligomerization and E3 processivity (2009) · cites this paper as Chehab et al, 2000
In the citing paper
“p53 is phosphorylated at Ser20 by the checkpoint kinase Chk2 after IR, which results in p53's dissociation from Mdm2 and its subsequent stabilization”
From USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 (2010) · cites this paper as Chehab et al., 2000
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Cites
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 2×
“Stabilization of p53 in cells exposed to IR or UV light is due to dissociation from Mdm2 (Shieh et al. 1997), a protein that targets p53 for degradation through the ubiquitin pathway (Haupt et al. 1997; Kubbutat et al. 1997; Midgley and Lane 1997).”
BackgroundMomand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
Thymocyte apoptosis induced by p53-dependent and independent pathways
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206
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Items 201–300 of 805
Piecing Together the p53 Puzzle
Carr, A. M. (2000) · Science · doi:10.1126/science.287.5459.1765 · Cited by 113
Serrano, M. A., Li, Z., Dangeti, M., Musich, P. R., Patrick, S., Roginskaya, M., Cartwright, B., & Zou, Y. (2012) · Oncogene · doi:10.1038/onc.2012.257 · Cited by 124
Regulation of p53 Stability and Function in HCT116 Colon Cancer Cells
Kaeser, M. D., Kaeser-Pebernard, S., & Iggo, R. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311732200 · Cited by 113
E2F1 Induces Phosphorylation of p53 That Is Coincident with p53 Accumulation and Apoptosis
Rogoff, H. A., Pickering, M., Debatis, M. E., Jones, S. N., & Kowalik, T. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5308-5318.2002 · Cited by 111
Santos, C. R., Rodriguez-Pinilla, M. S., Vega, F. M. D. L., Rodríguez‐Peralto, J. L., Blanco, S., Sevilla, A., Valbuena, A., Hernández, T., van Wijnen, A. J., Li, F., et al. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0212 · Cited by 107
Sakai, D., Dixon, J., Achilleos, A., Dixon, M. J., & Trainor, P. A. (2016) · Nature Communications · doi:10.1038/ncomms10328 · Cited by 117
Irarrázabal, C. E., Liu, J. C., Burg, M. B., & Ferraris, J. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403062101 · Cited by 109
Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor
McGowan, C. H. (2002) · BioEssays · doi:10.1002/bies.10101 · Cited by 109
Cell-cycle responses to DNA damage in G2
Cuddihy, A. R., & O'Connell, M. J. (2003) · International Review of Cytology · doi:10.1016/s0074-7696(02)22013-6 · Cited by 89
Cdk5 phosphorylates p53 and regulates its activity
Zhang, J., Krishnamurthy, P., & Johnson, G. V. W. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00824.x · Cited by 108
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks
Buscemi, G., Perego, P., Carenini, N., Nakanishi, M., Chessa, L., Chen, J., Khanna, K. K., & Delia, D. (2004) · Oncogene · doi:10.1038/sj.onc.1207986 · Cited by 110
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors
Wang, L., Yang, L., Wang, C., Wei, Z., Ju, Z., Zhang, W., Shen, J., Peng, Y., An, C., Luu, Y. T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci130445 · Cited by 106
Thelestam, M. (2004) · Springer eBooks · doi:10.1007/s10254-004-0030-8 · Cited by 106
Hershko, T., Chaussepied, M., Oren, M., & Ginsberg, D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401575 · Cited by 107
Regulation of p53 - insights into a complex process
Boehme, K. A., & Blattner, C. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409230903401507 · Cited by 107
Neganova, I. E., Tilgner, K., Buskin, A., Paraskevopoulou, I., Atkinson, S. P., Peberdy, D., Passos, J. F., & Lako, M. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.464 · Cited by 103
Liu, G., & Chen, X. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1398-1413.2006 · Cited by 104
Mutation of Mouse p53 Ser23 and the Response to DNA Damage
Wu, Z., Earle, J., Saito, S., Anderson, C. W., Appella, E., & Xu, Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2441-2449.2002 · Cited by 103
Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents
Tanasova, M., & Sturla, S. J. (2012) · Chemical Reviews · doi:10.1021/cr2001367 · Cited by 101
Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response
Ahn, J., Urist, M., & Prives, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213185200 · Cited by 99
MicroRNAs and DNA damage response
Wang, Y., & Taniguchi, T. (2012) · Cell Cycle · doi:10.4161/cc.23051 · Cited by 104
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.
Satyamoorthy, K., Chehab, N. H., Waterman, M. J. F., Lien, M. C., El‐Deiry, W. S., Herlyn, M., & Halazonetis, T. D. (2000) · PubMed · Cited by 98
Self-citationLimoli, C. L., Giedzinski, E., Morgan, W. F., & Cleaver, J. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130182897 · Cited by 99
Miller, C. W., Ikezoe, T., Krug, U. O., Hofmann, W., Tavor, S., Vegesna, V. R., Tsukasaki, K., Takeuchi, S., & Koeffler, H. P. (2001) · Genes Chromosomes and Cancer · doi:10.1002/gcc.1207 · Cited by 98
Daujat, S., NEEL, H., & PIETTE, J. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02369-1 · Cited by 97
Wei, J., Chou, Y., Ou, Y.-H., Yeh, Y.-H., Tyan, S., Sun, T.-P., Shen, C., & Shieh, S.-Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410152200 · Cited by 99
Mußil, B., Suspène, R., Aynaud, M.-M., Gauvrit, A., Vartanian, J., & Wain–Hobson, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073641 · Cited by 98
Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation
McCoy, M. A., Gesell, J. J., Senior, M. M., & Wyss, D. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0334477100 · Cited by 96
Chrisanthar, R., Knappskog, S., Løkkevik, E., Anker, G. B., Østenstad, B., Lundgren, S., Berge, E. O., Risberg, T., Mjaaland, I., Mæhle, L., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003062 · Cited by 98
Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1
Xia, Z., Morales, J. C., Dunphy, W. G., & Carpenter, P. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007665200 · Cited by 96
Haoudi, A., Daniels, R. C., Wong, E. B., Kupfer, G. M., & Semmes, O. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301649200 · Cited by 98
Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila
Peters, M., DeLuca, C., Hirao, A., Stambolic, V., Potter, J., Zhou, L., Silvester, J., Snow, B. E., Arya, S., Wong, J. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172382899 · Cited by 93
hADA3 is required for p53 activity
Wang, T., Kobayashi, T., Takimoto, R., Denes, A. E., Snyder, E. L., El‐Deiry, W. S., & Brachmann, R. K. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6404 · Cited by 93
Li, D. W.-C., Liu, J.-P., Schmid, P. C., Schlosser, R., Feng, H., Liu, W.-B., Yan, Q., Gong, L., Sun, S.-M., Deng, M., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209334 · Cited by 98
Gurgis, F., Ziaziaris, W. A., & Munoz, L. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.090365 · Cited by 93
ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres
Thanasoula, M., Escandell, J. M., Suwaki, N., & Tarsounas, M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.191 · Cited by 99
Tse, A. N., & Schwartz, G. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0841 · Cited by 94
Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export
Shinozaki, T., Nota, A., Taya, Y., & Okamoto, K. (2003) · Oncogene · doi:10.1038/sj.onc.1207176 · Cited by 93
Cisplatinum and Taxol Induce Different Patterns of p53 Phosphorylation
Damia, G. L. M., Filiberti, L., Vikhanskaya, F., Carrassa, L., Taya, Y., D’Incalci, M., & Broggini, M. (2001) · Neoplasia · doi:10.1038/sj.neo.7900122 · Cited by 96
Concomitant inactivation of p53 and Chk2 in breast cancer
Sullivan, A., Yuille, M., Repellin, C., Reddy, A., Reelfs, O., Bell, A., Dunne, B., Gusterson, B. A., Osin, P., Farrell, P. J., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205207 · Cited by 91
Petsalaki, E., & Zachos, G. (2020) · FEBS Journal · doi:10.1111/febs.15240 · Cited by 98
Stoichiometric Phosphorylation of Human p53 at Ser315Stimulates p53-dependent Transcription
Blaydes, J. P., Luciani, M. G., Pospı́šilová, Š., Ball, H. M.-L., Vojtesek, B., & Hupp, T. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m003485200 · Cited by 91
Discovery of co-occurring driver pathways in cancer
Zhang, J., Wu, L., Zhang, X., & Zhang, S. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-271 · Cited by 90
Wichmann, A., Jaklevic, B. R., & Su, T. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510528103 · Cited by 89
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts
Bell, D. W., Kim, S. H., Godwin, A. K., Schiripo, T. A., Harris, P. L., Haserlat, S. M., Wahrer, D. C. R., Haiman, C. A., Daly, M. B., Niendorf, K. B., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.23026 · Cited by 90
The cytolethal distending toxins induce DNA damage and cell cycle arrest
Cortes-Bratti, X., Frisan, T., & Thelestam, M. (2001) · Toxicon · doi:10.1016/s0041-0101(01)00159-3 · Cited by 88
Zgheib, O., Huyen, Y., DiTullio, R. A., Snyder, A. R., Venere, M., Stavridi, E. S., & Halazonetis, T. D. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.026 · Cited by 90
Self-citationHypoxia-Induced Phosphorylation of Chk2 in an Ataxia Telangiectasia Mutated–Dependent Manner
Gibson, S. L., Bindra, R. S., & Glazer, P. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1160 · Cited by 85
Drosophila Chk2 is required for DNA damage‐mediated cell cycle arrest and apoptosis
Xu, J., Xin, S., & Du, W. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03103-9 · Cited by 87
Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress
Klibanov, S. A., O’Hagan, H. M., & Ljungman, M. E. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.10.1867 · Cited by 88
Mendoza, M. J., Mandani, G., & Momand, J. A. (2013) · BioMolecular Concepts · doi:10.1515/bmc-2013-0027 · Cited by 88
MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation
Jin, Y., Zeng, S. X., Dai, M., Yang, X., & Lu, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204078200 · Cited by 86
Stress-induced Premature Senescence in hTERT-expressing Ataxia Telangiectasia Fibroblasts
Naka, K., Tachibana, A., Ikeda, K., & Motoyama, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309457200 · Cited by 91
Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein
Kimura, S. H., & Nojima, H. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00564.x · Cited by 85
The CHEK2 I157T Variant and Colorectal Cancer Susceptibility: A Systematic Review and Meta-analysis
Liu, C., Wang, Q., & Wang, Y. (2012) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2012.13.5.2051 · Cited by 85
The Spectrum of Genetic Mutations in Breast Cancer
Sheikh, A., Hussain, S. A., Ghori, Q., Naeem, N., Fazil, A., Giri, S., Sathian, B., Mainali, P., & Tamimi, D. M. A. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.6.2177 · Cited by 93
Versatile functions of p53 protein in multicellular organisms
Chumakov, P. M. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907130019 · Cited by 85
p53 Activation by Nitric Oxide Involves Down-regulation of Mdm2
Wang, X., Michael, D., de MURCIA, G., & Oren, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112068200 · Cited by 84
Balance of Yin and Yang: Ubiquitylation-Mediated Regulation of p53 and c-Myc
Dai, M., Jin, Y., Gallegos, J. R., & Lu, H. (2006) · Neoplasia · doi:10.1593/neo.06334 · Cited by 85
Regulation of MDMX Expression by Mitogenic Signaling
Gilkes, D. M., Pan, Y., Coppola, D., Yeatman, T., Reuther, G. W., & Chen, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01633-07 · Cited by 82
Alternative splicing and mutation status of CHEK2 in stage III breast cancer
Staalesen, V., Falck, J., Geisler, S. B., Bártková, J., Børresen‐Dale, A., Lukas, J., Lillehaug, J. R., Bártek, J., & Lønning, P. E. (2004) · Oncogene · doi:10.1038/sj.onc.1207928 · Cited by 88
FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
Cui, D., Xiong, X., Shu, J., Dai, X.-Q., Sun, Y., & Zhao, Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.12.032 · Cited by 82
Luo, Y., Lin, F., & Lin, W.-C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6430-6444.2004 · Cited by 81
Choudhuri, T., Verma, S. C., Lan, K., Murakami, M., & Robertson, E. S. (2007) · Journal of Virology · doi:10.1128/jvi.00053-07 · Cited by 80
Retrograde signaling from autophagy modulates stress responses
Simon, H., Friis, R. R., Tait, S. W. G., & Ryan, K. M. (2017) · Science Signaling · doi:10.1126/scisignal.aag2791 · Cited by 79
Haruki, N., Saito, H., Tatematsu, Y., Konishi, H., Harano, T., Masuda, A., Osada, H., Fujii, Y., & Takahashi, T. (2000) · PubMed · Cited by 80
Lin, H.-P., Lin, C., Huo, C., Hsiao, P.-H., Su, L., Jiang, S. S., Chan, T.-M., Chang, C.-H., Chen, L., Kung, H.-J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3246 · Cited by 82
Ahn, J., & Prives, C. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208321200 · Cited by 82
New link in a web of human genes
Wang, J. Y. J. (2000) · Nature · doi:10.1038/35013171 · Cited by 79
Baer, A., Austin, D. M., Narayanan, A., Popova, T., Kainulainen, M. H., Bailey, C., Kashanchi, F., Weber, F., & Kehn‐Hall, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.296608 · Cited by 80
Phosphorylation and hsp90 Binding Mediate Heat Shock Stabilization of p53
Wang, C., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206697200 · Cited by 75
Kohn, K. W., & Pommier, Y. G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb07021.x · Cited by 76
Bougeard, G., Limacher, J. M., Martin, C., CHARBONNIER, F., Killian, A., Delattre, O., Longy, M., Jonveaux, P., FRICKER, J.-P., Stoppa‐Lyonnet, D., et al. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.4.253 · Cited by 75
A TPR Motif Cofactor Contributes to p300 Activity in the p53 Response
Demonacos, C., Krstic–Demonacos, M., & Thangue, N. B. L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00277-5 · Cited by 76
Dumaz, N., Milne, D., Jardine, L., & Meek, D. W. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590459 · Cited by 75
Sakai, D., & Trainor, P. A. (2016) · Development Growth & Differentiation · doi:10.1111/dgd.12305 · Cited by 78
Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma.
Sakai, M., Sohda, M., Miyazaki, T., Suzuki, S., Sano, A., Tanaka, N., Inose, T., Nakajima, M., Kato, H., & Kuwano, H. (2010) · PubMed · Cited by 74
Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
Guo, N., Faller, D. V., & Vaziri, C. (2002) · PubMed · Cited by 73
Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20
She, Q., Ma, W., & Dong, Z. (2002) · Oncogene · doi:10.1038/sj.onc.1205239 · Cited by 73
Wu, H., THOMAS, J. A., & Momand, J. A. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510087 · Cited by 72
Karyopherin-α2 Protein Interacts with Chk2 and Contributes to Its Nuclear Import
Zannini, L., Lecis, D., Lisanti, S., Benetti, R., Buscemi, G., Schneider, C., & Delia, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303304200 · Cited by 73
Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage
Cheng, Q., Cross, B. L., Li, B., Chen, L., Li, Z., & Chen, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05553-11 · Cited by 78
Yu, Q., Rose, J. H. L., Zhang, H., & Pommier, Y. G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02756-9 · Cited by 72
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Metadata
- Authors
- Chehab, N. H., Malikzay, A., Appel, M., & Halazonetis, T. D.
- Affiliations
- The Wistar Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-02-01
- Volume
- 14
- Issue
- 3
- Pages
- 278-288
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC316357
- OpenAlex
- W2131833681
- Cited by
- 805
- References
- 86
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 19 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 11 · 2017: 10 · 2016: 25 · 2015: 16 · 2014: 28 · 2013: 27 · 2012: 29
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- National Institutes of Health (CA-25874)
- National Cancer Institute (CA09171, CA-25874, CA-76367, R01CA076367, P01CA025874, T32CA009171)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Chk2, DNA damage checkpoint, p53 stabilization, MDM2, G1 cell cycle arrest, Cdc25C phosphorylation, post-translational modification, tumor suppressor proteins, dominant-negative mutant
- MeSH terms
- DNA Damage, Humans, Nuclear Proteins, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Tumor Cells, Cultured, Tumor Suppressor Protein p53, G1 Phase, Protein Serine-Threonine Kinases, Schizosaccharomyces pombe Proteins, Proto-Oncogene Proteins c-mdm2, Checkpoint Kinase 2
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