The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus
Open accessAbstract
We have investigated the mechanism, structural correlates, and cis-acting elements involved in chromatin opening and gene activation, using the human β-globin locus as a model. Full transcriptional activity of the human β-globin locus requires the locus control region (LCR), composed of a series of nuclease hypersensitive sites located upstream of this globin gene cluster. Our previous analysis of naturally occurring and targeted LCR deletions revealed that chromatin opening and transcriptional activity in the endogenous β-globin locus are dissociable and dependent on distinct cis-acting elements. We now report that general histone H3/H4 acetylation and relocation of the locus away from centromeric heterochromatin in the interphase nucleus are correlated and do not require the LCR. In contrast, LCR-dependent promoter activation is associated with localized histone H3 hyperacetylation at the LCR and the transcribed β-globin-promoter and gene. On the basis of these results, we suggest a multistep model for gene activation; localization away from centromeric heterochromatin is required to achieve general hyperacetylation and an open chromatin structure of the locus, whereas a mechanism involving LCR/promoter histone H3 hyperacetylation is required for high-level transcription of the β-globin genes.
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Cites
Histone acetylation and transcriptional regulatory mechanisms
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Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes
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Cited by
Li, Q., Peterson, K. R., Fang, X., & Stamatoyannopoulos, G. (2002) · Blood · doi:10.1182/blood-2002-04-1104 · Cited by 456
Chromatin Higher-order Structure and Dynamics
Woodcock, C. L., & Ghosh, R. P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000596 · Cited by 384
Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain
Forsberg, E. C., Downs, K. M., Christensen, H. M., Im, H., Nuzzi, P. A., & Bresnick, E. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14494 · Cited by 226
Evolution of Hemoglobin and Its Genes
Hardison, R. C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011627 · Cited by 217
Rb regulates proliferation and rod photoreceptor development in the mouse retina
Zhang, J., Gray, J., Wu, L., Leone, G., Rowan, S., Cepko, C. L., Zhu, X., Craft, C. M., & Dyer, M. A. (2004) · Nature Genetics · doi:10.1038/ng1318 · Cited by 190
Metadata
- Authors
- Schübeler, D., Francastel, C., Cimbora, D. M., Reik, A., Martin, D. I. K., & Groudine, M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-04-15
- Volume
- 14
- Issue
- 8
- Pages
- 940-950
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2140475749
- Cited by
- 308
- References
- 8
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Schübeler, D., Francastel, C., Cimbora, D. M., Reik, A., Martin, D. I. K., & Groudine, M. (2000). Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus. Genes & Development. https://doi.org/10.1101/gad.14.8.940
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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