The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus
Open accessAbstract
The murine beta-globin locus control region (LCR) was deleted from its native chromosomal location. The approximately 25 kb deletion eliminates all sequences and structures homologous to those defined as the human LCR. In differentiated ES cells and erythroleukemia cells containing the LCR-deleted chromosome, DNasel sensitivity of the beta-globin domain is established and maintained, developmental regulation of the locus is intact, and beta-like globin RNA levels are reduced 5%-25% of normal. Thus, in the native murine beta-globin locus, the LCR is necessary for normal levels of transcription, but other elements are sufficient to establish the open chromatin structure, transcription, and developmental specificity of the locus. These findings suggest a contributory rather than dominant function for the LCR in its native location.
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“previous studies deleting the entire β-globin SE showed that the β-globin genes remain accessible and marked by histone acetylation;55–57”
From Super-enhancers include classical enhancers and facilitators to fully activate gene expression (2023) · cites this paper as [56]
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Cites
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Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J., & Blobel, G. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.028 · Cited by 490
Self-citationLooping versus linking: toward a model for long-distance gene activationPreprint
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Eukaryotic regulatory RNAs: an answer to the ‘genome complexity’ conundrumPreprint
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Metadata
- Authors
- Epner, E., Reik, A., Cimbora, D., Telling, A., Bender, M. A., Fiering, S., Enver, T., Martin, D. I. K., Kennedy, M., Keller, G., & Groudine, M.
- Affiliations
- Fred Hutch Cancer Center (US)
- National Jewish Health (US)
- University of Washington (US)
- Corresponding author
- Groudine, Mark
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 2
- Issue
- 4
- Pages
- 447-455
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2070298061
- Cited by
- 183
- References
- 60
- Citations by year
- 2025: 2 · 2023: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 1
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institutes of Health (5p30hd028834-10)
- National Heart, Lung, and Blood Institute (HL 48834)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK52854)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30 HD28834)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- beta-globin locus control region, beta-globin gene expression, DNase I sensitivity, embryonic stem cells, erythroleukemia cells, chromatin accessibility
- MeSH terms
- Animals, Chromatin, Deoxyribonucleases, Leukemia, Erythroblastic, Acute, Globins, Humans, Phenotype, Protein Conformation, Tumor Cells, Cultured, Transcriptional Activation, Gene Expression, Gene Deletion, Protein Structure, Tertiary, Mice
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