The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Genetic regulation of bone mass and susceptibility to osteoporosis
Open accessAbstract
Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and increased risk of fragility fractures. Twin and family studies have shown that the heritability of bone mineral density (BMD) and other determinants of fracture risk—such as ultrasound properties of bone, skeletal geometry, and bone turnover—is high, although heritability of fracture is modest. Many different genetic variants of modest effect size are likely to contribute to the regulation of these phenotypes by interacting with environmental factors such as diet and exercise. Linkage studies in rare Mendelian bone diseases have identified several previously unknown genes that play key roles in regulating bone mass and bone turnover. In many instances, subtle polymorphisms in these genes have also been found to regulate BMD in the general population. Although there has been extensive progress in identifying the genetic variants that regulate susceptibility to osteoporosis, most of the genes and genetic variants that regulate bone mass and susceptibility to osteoporosis remain to be discovered.
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Citations
Cites
Risk Factors for Hip Fracture in White Women
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“The mechanisms by which SOST inhibits bone formation has been clarified by recent studies, which have shown that SOST directly interacts with LRP5 and LRP6 and antagonizes Wnt signaling both in vitro and in vivo (Li et al. 2005; Semenov et al. 2005).”
BackgroundIncreased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · cited 2×
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Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
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Cited by
Watts, N. B., Bilezikian, J. P., Camacho, P. M., Greenspan, S. L., Harris, S. T., Hodgson, S. F., Kleerekoper, M., Luckey, M. M., McClung, M. R., Pollack, R. P., et al. (2010) · Endocrine Practice · doi:10.4158/ep.16.s3.1 · Cited by 441
Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
Krum, S. A., Miranda‐Carboni, G. A., Hauschka, P. V., Carroll, J. S., Lane, T. F., Freedman, L. P., & Brown, M. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601984 · Cited by 353
BMP signaling in mesenchymal stem cell differentiation and bone formation
Beederman, M., Lamplot, J. D., Nan, G., Wang, J., Liu, X., Yin, L., Li, R., Shui, W., Zhang, H., Kim, S. H., et al. (2013) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2013.68a1004 · Cited by 318
Mineralization of Bones and Teeth
Boskey, A. L. (2007) · Elements · doi:10.2113/gselements.3.6.385 · Cited by 278
Cross-sex pattern of bone mineral density in early onset gender identity disorder
Haraldsen, I. R., Haug, E., Falch, J., Egeland, T., & Opjordsmoen, S. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.012 · Cited by 113
Metadata
- Authors
- Ralston, S. H., & de Crombrugghe, B.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-09-15
- Volume
- 20
- Issue
- 18
- Pages
- 2492-2506
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2170372671
- Cited by
- 364
- References
- 15
- Type
- posted content
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
