MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila
Abstract
MicroRNAs (miRNAs) have been implicated in regulating various aspects of animal development, but their functions in neurogenesis are largely unknown. Here we report that loss of miR-9a function in the Drosophila peripheral nervous system leads to ectopic production of sensory organ precursors (SOPs), whereas overexpression of miR-9a results in a severe loss of SOPs. We further demonstrate a strong genetic interaction between miR-9a and senseless ( sens ) in controlling the formation of SOPs in the adult wing imaginal disc. Moreover, miR-9a suppresses Sens expression through its 3′ untranslated region. miR-9a is expressed in epithelial cells, including those adjacent to SOPs within proneural clusters, suggesting that miR-9a normally inhibits neuronal fate in non-SOP cells by down-regulating Sens expression. These results indicate that miR-9a ensures the generation of the precise number of neuronal precursor cells during development.
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Many examples of spatially exclusive expression domains of miRNAs and their targets have been documented.
“For instance, in zebrafish, miR-430 targets a large number of maternally deposited transcripts at the onset of zygotic transcription [6] and many examples of spatially exclusive expression domains of miRNAs and their targets have been documented (for example, [12,53]).”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [53]
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Cites
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578 · see citing works
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Farh, K. K.-H., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., Lim, L. P., Burge, C. B., & Bartel, D. P. (2005) · Science · doi:10.1126/science.1121158 · Cited by 1,484 · see citing works
Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080 · see citing works
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Research works printed but not linked: 4
- Campos-Ortega, J.A. and Hartenstein, V. 1985. The embryonic development of Drosophila melanogaster. Springer-Verlag, Heidelberg, New York, Tokyo.
- Gong, W.J. and Golic, K.G. 2003. Ends-out, or replacement, gene targeting in Drosophila. Proc. Natl. Acad. Sci. 100: 2556-2561.
- Kwon, C., Han, Z., Olson, E.N., and Srivastava, D. 2005. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc. Natl. Acad. Sci. 102: 18986-18991.
- Vo, N., Klein, M.E., Varlamova, O., Keller, D.M., Yamamoto, T., Goodman, R.H., and Impey, S. 2005. A cAMP-response ele- ment binding protein-induced microRNA regulates neuro- nal morphogenesis. Proc. Natl. Acad. Sci. 102: 16426-16431.
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The role of site accessibility in microRNA target recognition
Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U., & Segal, E. (2007) · Nature Genetics · doi:10.1038/ng2135 · Cited by 2,460 · see citing works
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547 · see citing works
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395 · see citing works
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Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484 · see citing works
“Finally, Drosophila miR-9a is required for sensory organ precursor specification [59], and Drosophila miR-278 is required for energy homeostasis [60].”
BackgroundHomeostatic regulation of MeCP2 expression by a CREB-induced microRNA
Klein, M. E., Lioy, D. T., Ma, L., Impey, S., Mandel, G., & Goodman, R. H. (2007) · Nature Neuroscience · doi:10.1038/nn2010 · Cited by 444 · see citing works
Kapsimali, M., Kloosterman, W. P., de Bruijn, E., Rosa, F., Plasterk, R. H., & Wilson, S. W. (2007) · Genome Biology · doi:10.1186/gb-2007-8-8-r173 · Cited by 376 · see citing works
Peterson, K. J., Dietrich, M. R., & McPeek, M. A. (2009) · BioEssays · doi:10.1002/bies.200900033 · Cited by 252 · see citing works
Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes
Lau, P., Verrier, J. D., Nielsen, J. A., Johnson, K. R., Notterpek, L., & Hudson, L. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1932-08.2008 · Cited by 252 · see citing works
Everything you wanted to know about small RNA but were afraid to ask
Boyd, S. D. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.32 · Cited by 108 · see citing works
- Authors
- Li, Y., Wang, F., Lee, J.-A., & Gao, F.-B.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-10-02
- Volume
- 20
- Issue
- 20
- Pages
- 2793-2805
- ISSN
- 0890-9369
- 1549-5477
- Cited by
- 269
- References
- 3
- Language
- en
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