The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A functional study of miR-124 in the developing neural tube
Open accessAbstract
Neural development is a highly orchestrated process that entails precise control of gene expression. Although microRNAs (miRNAs) have been implicated in fine-tuning gene networks, the roles of individual miRNAs in vertebrate neural development have not been studied in vivo. We investigated the function of the most abundant neuronal miRNA, miR-124, during spinal cord development. Neither inhibition nor overexpression of miR-124 significantly altered the acquisition of neuronal fate, suggesting that miR-124 is unlikely to act as a primary determinant of neuronal differentiation. Two endogenous targets of miR-124, laminin γ1 and integrin β1, were identified, both of which are highly expressed by neural progenitors but repressed upon neuronal differentiation. Thus miR-124 appears to ensure that progenitor genes are post-transcriptionally inhibited in neurons.
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Cites
The cell biology of neurogenesis
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MicroRNAs Regulate Brain Morphogenesis in Zebrafish
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Vertebrate neurogenesis is counteracted by Sox1–3 activity
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Reciprocal actions of REST and a microRNA promote neuronal identity
Conaco, C., Otto, S., Han, J.-J., & Mandel, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511041103 · Cited by 736
Cited by
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation
Ørom, U. A., Nielsen, F. C., & Lund, A. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.001 · Cited by 1,384
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 1,001
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MicroRNA-mediated switching of chromatin-remodelling complexes in neural development
Yoo, A. S., Staahl, B. T., Chen, L., & Crabtree, G. R. (2009) · Nature · doi:10.1038/nature08139 · Cited by 645
Metadata
- Authors
- Cao, X., Pfaff, S. L., & Gage, F. H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-03-01
- Volume
- 21
- Issue
- 5
- Pages
- 531-536
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2149297993
- Cited by
- 336
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- diamond
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