Cited by 1,270Mitochondrial Function and PathologyCell death mechanisms and regulationAutophagy in Disease and Therapy

The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.

Mitochondrial dynamics and apoptosis

Open access

Suen, Der-Fen, Norris, Kristi L., Youle, Richard J.·2008·Genes & Development

Open this paper in CoChat — free account Open PDF

Abstract

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase activation, yielding more numerous and smaller mitochondria. Recent work shows that proteins involved in mitochondrial fission and fusion also actively participate in apoptosis induction. This review will cover the recent advances and presents competing models on how the mitochondrial fission and fusion machinery may intersect apoptosis pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.1658508

Cites

210 of 210 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,806
Self-citation
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Vaux, D., Cory, S., & Adams, J. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,355
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
The Bcl-2 apoptotic switch in cancer development and therapy
Adams, J. M., & Cory, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210220 · Cited by 2,256
The Role of Mitochondria in Apoptosis
Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987
Self-citation

Flagged first, then by citations

Show all 209 references

Sorted by citations

Items 501–600 of 1,000

Mitochondria: A worthwhile object for ultrastructural qualitative characterization and quantification of cells at physiological and pathophysiological states using conventional transmission electron microscopy
Ďúranová, H., Válková, V., Kňažická, Z., Olexíková, L., & Vašíček, J. (2020) · Acta Histochemica · doi:10.1016/j.acthis.2020.151646 · Cited by 47
Mitochondrial Dynamics and Apoptosis: A Painful Separation
James, D. I., & Martinou, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.011 · Cited by 43
Bax Activates Endophilin B1 Oligomerization and Lipid Membrane Vesiculation
Rostovtseva, T. K., Boukari, H., Antignani, A., Shiu, B. B., Banerjee, S., Neutzner, A., & Youle, R. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021873 · Cited by 44
Self-citation
Trafficking of UL37 Proteins into Mitochondrion-Associated Membranes during Permissive Human Cytomegalovirus Infection
Bozidis, P., Williamson, C. D., Wong, D. S., & Colberg‐Poley, A. M. (2010) · Journal of Virology · doi:10.1128/jvi.00885-10 · Cited by 44
PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma
Kumar, P. R., Saad, M., Hellmich, C., Mistry, J. J., Moore, J. A., Conway, S., Morris, C. J., Bowles, K. M., Moncrieff, M. D., & Rushworth, S. A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01783-w · Cited by 44
Mitochondrial Quality Control and Cell Death
Zhang, Z., Zhang, M., Jin, H., Lv, S., Li, Y., & Li, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211084 · Cited by 51
Phosphorylation of GSK-3β and reduction of apoptosis as targets of troxerutin effect on reperfusion injury of diabetic myocardium
Mokhtari, B., Badalzadeh, R., Alihemmati, A., & Mohammadi, M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.056 · Cited by 42
Regulation of mitochondrial dynamics and neurodegenerative diseases.
Han, X.-J., Tomizawa, K., Fujimura, A., Ohmori, I., Nishiki, T., Matsushita, M., & Matsui, H. (2011) · PubMed · doi:10.18926/amo/43824 · Cited by 41
The Apoptotic Effect of D Rhamnose β-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells
Cheng, L., Xia, T., Wang, Y., Zhou, W., Liang, X.-Q., Xue, J., Shi, L., Wang, Y., & Ding, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090848 · Cited by 42
Ganglioside GD3 as a Raft Component in Cell Death Regulation
Sorice, M., Garofalo, T., Misasi, R., Manganelli, V., Vona, R., & Malorni, W. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012800228670 · Cited by 42
miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
Tak, H., Kim, J., Jayabalan, A. K., Lee, H., Kang, H., Cho, D., Ohn, T., Nam, S. W., Kim, W., & Lee, E. K. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.73 · Cited by 43
Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction
Huang, S., Huang, C., Huang, W., Lin, T., Liao, P.-L., Wang, P., Liou, C., & Chuang, J. (2017) · Scientific Reports · doi:10.1038/srep40382 · Cited by 42
Propofol attenuates H2O2-induced oxidative stress and apoptosis via the mitochondria- and ER-medicated pathways in neonatal rat cardiomyocytes
Liu, X., Cao, L., Li, T., Chen, L., Yu, Y., Huang, W., Liu, L., & Tan, X. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1349-3 · Cited by 42
Mitochondrial dynamics as an underlying mechanism involved in aerobic exercise training-induced cardioprotection against ischemia-reperfusion injury
Ghahremani, R., Damirchi, A., Salehi, I., Komaki‬, A., & Esposito, F. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.035 · Cited by 44
Cinnamomum cassia exhibits antileishmanial activity against Leishmania donovani infection in vitro and in vivo
Afrin, F., Chouhan, G., Islamuddin, M., Want, M. Y., Ozbak, H. A., & Hemeg, H. A. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007227 · Cited by 42
Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells
Zhou, Y., Li, H., Lin, C., Mao, Y., Rao, J., Lou, Y., Yang, X., Xu, X., & Jin, F. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.09.005 · Cited by 41
Modulating mitochondrial dynamics attenuates cardiac ischemia-reperfusion injury in prediabetic rats
Maneechote, C., Palee, S., Kerdphoo, S., Jaiwongkam, T., Chattipakorn, S. C., & Chattipakorn, N. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00626-3 · Cited by 44
Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes
Meng, T.-T., Wang, W., Meng, F.-L., Wang, S.-Y., Wu, H.-H., Chen, J.-M., Zheng, Y., Wang, G.-X., Zhang, M., Li, Y., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.650055 · Cited by 38
Cytotoxicity and genotoxicity of triethyleneglycol-dimethacrylate in macrophages involved in DNA damage and caspases activation
Huang, F., Kuan, Y., Lee, S., & Chang, Y. (2013) · Environmental Toxicology · doi:10.1002/tox.21935 · Cited by 41
Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells
Tauber, J. A., Dlasková, A., Šantorová, J., Smolková, K., Alán, L., Špaček, T., Plecitá‐Hlavatá, L., Jabůrek, M., & Ježek, P. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.11.019 · Cited by 44
The mitochondrial rhomboid protease: Its rise from obscurity to the pinnacle of disease-relevant genes
Chan, E. Y. L., & McQuibban, G. A. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.05.012 · Cited by 40
Mitochondrial fission and fusion and their roles in the heart
Kane, L. A., & Youle, R. J. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0674-6 · Cited by 42
Self-citation
Activation of ER stress and apoptosis by α- and β-zearalenol in HCT116 cells, protective role of Quercetin
Salem, I. B., Prola, A., Boussabbeh, M., Guilbert, A., Bacha, H., Lemaire, C., & Abid‐Essefi, S. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.11.004 · Cited by 41
The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms
Yang, S., Zhang, H., Shi, S., Zhu, Y.-Q., Song, N., Dai, Q., Zhang, W., Gui, M., & Zhang, H. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181126165139 · Cited by 41
Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats
Maneechote, C., Palee, S., Apaijai, N., Kerdphoo, S., Jaiwongkam, T., Chattipakorn, S. C., & Chattipakorn, N. (2019) · Clinical Science · doi:10.1042/cs20190960 · Cited by 41
Liuwei Dihuang prevents postmenopausal atherosclerosis and endothelial cell apoptosis via inhibiting DNMT1-medicated ERα methylation
Chen, Q., Zhang, Y., Meng, Q., Wang, S., Yu, X., Cai, D., Cheng, P., Yu, L., & Bian, H. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112531 · Cited by 41
Formononetin Attenuates Renal Tubular Injury and Mitochondrial Damage in Diabetic Nephropathy Partly via Regulating Sirt1/PGC-1α Pathway
Huang, Q., Chen, H., Yin, K., Shen, Y., Lin, K., Guo, X., Zhang, X., Wang, N., Xin, W., Xu, Y., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.901234 · Cited by 43
Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells
Wang, D., Lü, J., Liu, Y., Meng, Q., Xie, J., Wang, Z., & Teng, L. (2014) · BioMed Research International · doi:10.1155/2014/965316 · Cited by 41
Tetramethylpyrazine: An Active Ingredient of Chinese Herbal Medicine With Therapeutic Potential in Acute Kidney Injury and Renal Fibrosis
Li, J., & Gong, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.820071 · Cited by 41
Current Views of the Structure of the Mammalian Mitochondrial Ribosome
Koc, E. C., Haque, M. E., & Spremulli, L. L. (2010) · Israel Journal of Chemistry · doi:10.1002/ijch.201000002 · Cited by 40
ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics
Fan, Z., Yu, H., Cui, N., Kong, X., Liu, X., Chang, Y., Wu, Y., Sun, L., & Wang, G. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.04.016 · Cited by 42
The PARL family of mitochondrial rhomboid proteases
Hill, R. B., & Pellegrini, L. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.12.011 · Cited by 41
Monitoring Mitophagy in Mammalian Cells
Zhu, Y., Chen, G., Chen, L., Zhang, W., Feng, D., Liu, L., & Chen, Q. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801415-8.00003-5 · Cited by 47
The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis.
Chen, W., Sandoval, H., Kubiak, J., Li, X. C., Ghobrial, R., & Kloc, M. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.11.003 · Cited by 37
A naphthalene-based fluorescent probe with a large Stokes shift for mitochondrial pH imaging
Lin, B., Fan, L., Ge, J., Zhang, W., Zhang, C., Dong, C., & Shuang, S. (2018) · The Analyst · doi:10.1039/c8an01371c · Cited by 39
LPS-induced Apoptosis is Partially Mediated by Hydrogen Sulphide in RAW 264.7 Murine Macrophages
George, L., Tamizhselvi, R., Sirajudeen, K. N. S., & Manickam, V. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1566355 · Cited by 40
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
Chen, Y., Guo, S., Tang, Y., Mou, C., Hu, X., Shao, F., Yan, W. X., & Wu, Q. (2020) · Medical Science Monitor · doi:10.12659/msm.928651 · Cited by 42
Role of endolysosome function in iron metabolism and brain carcinogenesis
Halcrow, P. W., Lynch, M. L., Geiger, J. D., & Ohm, J. E. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.013 · Cited by 40
Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l‐mediated mitochondrial fission
Aung, L. H. H., Li, R., Prabhakar, B. S., & Li, P. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13250 · Cited by 44
Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer’s Disease
Mani, S., Dubey, R., Lai, I., Babu, M. A., Tyagi, S., Swargiary, G., Mody, D., Singh, M., Agarwal, S., Iqbal, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220700 · Cited by 43
Mitochondrial Regulation of Spermatozoa Function: Metabolism, Oxidative Stress and Therapeutic Insights
Xu, Z., Qi, Y., Zhang, K., Lei, Y. J., Zhou, C., Ren, T., Gao, N., Wen, F., & Li, X. (2025) · Animals · doi:10.3390/ani15152246 · Cited by 44
ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα
Sinha, S., Ghildiyal, R., Mehta, V. S., & Sen, E. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.128 · Cited by 39
Shikonin protects chondrocytes from interleukin-1beta-induced apoptosis by regulating PI3K/Akt signaling pathway.
Wang, L., Gai, P., Xu, R., Zheng, Y., Lv, S., Li, Y., & Liu, S. (2015) · Europe PMC (PubMed Central) · Cited by 39
Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV–VIS broadband radiation
Lee, Y., Wang, E., Kumar, N., & Glickman, R. D. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0962-z · Cited by 39
A Functional Interplay between the Small GTPase Rab11a and Mitochondria-shaping Proteins Regulates Mitochondrial Positioning and Polarization of the Actin Cytoskeleton Downstream of Src Family Kinases
Landry, M.-C., Champagne, C., Boulanger, M., Jetté, A., Fuchs, M., Dziengelewski, C., & Lavoie, J. N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.516351 · Cited by 41
TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression
Takamura, H., Koyama, Y., Matsuzaki, S., Yamada, K., Hattori, T., Miyata, S., Takemoto, K., Tohyama, M., & Katayama, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051912 · Cited by 41
Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone
Laar, V. S. V., Berman, S. B., & Hastings, T. G. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.015 · Cited by 38
Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis
Zheng, X. F. S., Chen, M., Meng, X., Chu, X., Cai, C., & Zou, F. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.03.019 · Cited by 39
An in vitro study of the interaction of the chemotherapeutic drug Actinomycin D with lung cancer cell lines using Raman micro‐spectroscopy
Farhane, Z., Bonnier, F., & Byrne, H. J. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201700112 · Cited by 39
Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells
Kim, J., & Cheong, J. (2020) · Cells · doi:10.3390/cells9071691 · Cited by 40
Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson
Tassone, A., Meringolo, M., Ponterio, G., Bonsi, P., Schirinzi, T., & Martella, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087221 · Cited by 42
Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats
Chuang, Y., Lin, T., Yang, D., Yang, J., Liou, C., & Chen, S. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0262-3 · Cited by 38
NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer
Song, X., Liu, L., Chang, M., Wang, X.-W., Wang, W., Wang, W., Chen, T. C., Xie, L., & Song, X. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1249-1 · Cited by 36
Regulation and pathophysiological role of epithelial turnover in the gut
Günther, C., Buchen, B., Neurath, M. F., & Becker, C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.06.004 · Cited by 38
Mitochondrial Fission Is Required for Blue Light-Induced Apoptosis and Mitophagy in Retinal Neuronal R28 Cells
Li, J., Zhang, K., Xu, D., Zhou, W.-T., Fang, W., Wan, Y., Yan, D., Guo, M., Tao, J., Zhou, W., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00432 · Cited by 40
Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach
Ampawong, S., Isarangkul, D., Reamtong, O., & Aramwit, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-33372-4 · Cited by 37
Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability
Xie, W., Koppula, S., Kale, M. B., Ali, L. S., Wankhede, N. L., Umare, M. D., Upaganlawar, A. B., Abdeen, A., Ebrahim, E., El‐Sherbiny, M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1469053 · Cited by 38
HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation
Kim, H.-J., Nagano, Y., Choi, S. J., Park, S. Y., Kim, H., Yao, T., & Lee, J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.111 · Cited by 37
cAMP signalling of Bordetella adenylate cyclase toxin through the SHP‐1 phosphatase activates the BimEL‐Bax pro‐apoptotic cascade in phagocytes
Ahmad, J. N., Černý, O., Linhartová, I., Mašín, J., Osička, R., & Šebo, P. (2015) · Cellular Microbiology · doi:10.1111/cmi.12519 · Cited by 37
Tetrahydrocurcumin ameliorates homocysteine‐mediated mitochondrial remodeling in brain endothelial cells
Vacek, J. C., Behera, J., George, A. K., Kamat, P. K., Kalani, A., & Tyagi, N. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26145 · Cited by 37
Alterations in the Interplay between Neurons, Astrocytes and Microglia in the Rat Dentate Gyrus in Experimental Models of Neurodegeneration
Lana, D., Ugolini, F., Nosi, D., Wenk, G. L., & Giovannini, M. G. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00296 · Cited by 39
A hederagenin saponin isolated from Clematis ganpiniana induces apoptosis in breast cancer cells via the mitochondrial pathway
Cheng, L., Shi, L., Wu, J., Zhou, X., Li, X., Sun, X., Zhu, L., Xia, T., & Ding, Q. (2017) · Oncology Letters · doi:10.3892/ol.2017.7494 · Cited by 37
The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells
Dey, S., Kumari, S., Kalainayakan, S. P., Campbell, J., Ghosh, P., Zhou, H., FitzGerald, K. E., Li, M., Mason, R. P., Li, Z., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23734 · Cited by 36
Dexmedetomidine attenuates H2O2-induced neonatal rat cardiomyocytes apoptosis through mitochondria- and ER-medicated oxidative stress pathways
Liu, X., Li, T., Cao, L., Yu, Y., Chen, L., Fan, X., Yang, B., & Tan, X. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8751 · Cited by 37
Modulation of Host Cell Metabolism by Chlamydia trachomatis
Rother, M., da Costa, A. R. T., Zietlow, R., Meyer, T. F., & Rudel, T. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.bai-0012-2019 · Cited by 39
Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects
Deus, C. M., Pereira, S. P., Cunha‐Oliveira, T., Pereira, F. B., Raimundo, N., & Oliveira, P. J. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165615 · Cited by 37
The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α
Gao, F., Reynolds, M. B., Passalacqua, K. D., Sexton, J. Z., Abuaita, B. H., & O’Riordan, M. X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.593805 · Cited by 38
Cisplatin induces lung cell cilia disruption and lung damage via oxidative stress
Han, Y. K., Kim, J. S., Jang, G., & Park, K. M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.10.032 · Cited by 37
Mitochondrial elongation impairs breast cancer metastasis
Minarrieta, L., Annis, M. G., Audet-Delage, Y., Kuasne, H., Pacis, A., St‐Louis, C., Nowakowski, A., Biondini, M., Khacho, M., Park, M., et al. (2024) · Science Advances · doi:10.1126/sciadv.adm8212 · Cited by 38
The Critical Role of Dynamin‐Related Protein 1 in Hypoxia‐Induced Pulmonary Vascular Angiogenesis
Shen, T., Wang, N., Yu, X., Shi, J., Li, Q., Zhang, C., Fu, L., Wang, S., Xing, Y., Zheng, X., et al. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25154 · Cited by 36
Low Expression of Mfn2 Is Associated with Mitochondrial Damage and Apoptosis of Ovarian Tissues in the Premature Ovarian Failure Model
Chen, W., Xu, X., Wang, L., Bai, G., & Xiang, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136421 · Cited by 36
The ubiquitin/proteasome system-dependent control of mitochondrial steps in apoptosis
Neutzner, A., Li, S., Xu, S., & Karbowski, M. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.03.019 · Cited by 38
Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells
Li, R., SUN, Y., Jiang, A., Wu, Y. F., Li, C., JIN, M., Hairun, Y., & Jin, H. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4904 · Cited by 36
Mitofusin 2 regulates the oocytes development and quality by modulating meiosis and mitochondrial function
Liu, Q., Kang, L., Wang, L.-J., Zhang, L., & Xiang, W.-P. (2016) · Scientific Reports · doi:10.1038/srep30561 · Cited by 32
The neuron-astrocyte-microglia triad in CA3 after chronic cerebral hypoperfusion in the rat: Protective effect of dipyridamole
Lana, D., Ugolini, F., Melani, A., Nosi, D., Pedata, F., & Giovannini, M. G. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.006 · Cited by 36
Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis
Cho, S.-G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S. M., Huang, S., Ding, H., Yoon, Y., Kirken, R. A., et al. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018111117 · Cited by 35
Remodeling of mitochondrial morphology and function: an emerging hallmark of cellular reprogramming
Rastogi, A., Joshi, P. K., Contreras, E., & Gama, V. (2019) · Cell Stress · doi:10.15698/cst2019.06.189 · Cited by 36
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria
Lovy, A., Ahumada-Castro, U., Bustos, G., Farías, P., González-Billault, C. E., Molgó, J., & Cárdenas, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00378 · Cited by 37
Chronic Alcohol Exposure Induces Aberrant Mitochondrial Morphology and Inhibits Respiratory Capacity in the Medial Prefrontal Cortex of Mice
Shang, P., Lindberg, D. M., Starski, P. A., Peyton, L., Hong, S., Choi, S. H., & Choi, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.561173 · Cited by 36
Pardaxin Activates Excessive Mitophagy and Mitochondria-Mediated Apoptosis in Human Ovarian Cancer by Inducing Reactive Oxygen Species
Chen, Y.-P., Shih, P., Feng, C., Wu, C.-C., Tsui, K., Lin, Y.-H., Kuo, H., & Wen, Z. (2021) · Antioxidants · doi:10.3390/antiox10121883 · Cited by 36
Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission
Zhang, X., Shan, P., Homer, R., Zhang, Y., Petrache, I., Mannam, P., & Lee, P. J. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.06.017 · Cited by 36
Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats
Li, G., Shen, F., Fan, Z., Wang, Y., Kong, X., Yu, D., Zhi, X., Lv, G., & Cao, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0252-1 · Cited by 36
Creation of distinctive Bax-lipid complexes at mitochondrial membrane surfaces drives pore formation to initiate apoptosis
Clifton, L. A., Wacklin, H. P., Ådén, J., Mushtaq, A. U., Sparrman, T., & Gröbner, G. (2023) · Science Advances · doi:10.1126/sciadv.adg7940 · Cited by 35
Mitochondrial fission – changing perspectives for future progress
Kamerkar, S. C., Liu, A., & Higgs, H. N. (2025) · Journal of Cell Science · doi:10.1242/jcs.263640 · Cited by 43
Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease
Ribbens, J., Moser, A. B., Hubbard, W. C., Bongarzone, E. R., & Maegawa, G. H. B. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.09.011 · Cited by 35
Neuroprotective effects of PEP-1-carbonyl reductase 1 against oxidative-stress-induced ischemic neuronal cell damage
Kim, Y. N., Jung, H. Y., Eum, W. S., Kim, D. W., Shin, M. J., Ahn, E. H., Kim, S. J., Lee, C. H., Yong, J., Ryu, E. J., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.006 · Cited by 35
Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase
Takeda, T., Tsubaki, M., Kino, T., Yamagishi, M., Iida, M., Itoh, T., Imano, M., Tanabe, G., Muraoka, O., Satou, T., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.03.018 · Cited by 39
Differential Roles of Mitochondrial Translocation of Active Caspase-3 and HMGB1 in Neuronal Death Induced by Status Epilepticus
Kim, J.-E., & Kang, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00301 · Cited by 35
OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion
Yang, L., Tang, H., Lin, X., Wu, Y., Zeng, S., Pan, Y., Li, Y., Xiang, G., Lin, Y.-F., Zhuang, S., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00180 · Cited by 37
Sitagliptin ameliorates renal tubular injury in diabetic kidney disease via STAT3‐dependent mitochondrial homeostasis through SDF‐1α/CXCR4 pathway
Zhang, Q., He, L. N., Dong, Y., Yang, F., Wen, J., Li, X., Guan, J., Liu, F., Zhou, T., Li, Z., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201903038r · Cited by 35
Modulation of host mitochondrial dynamics during bacterial infection
Khan, S., Raj, D., Jaiswal, K., & Lahiri, A. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.05.005 · Cited by 35
Increased Sperm DNA Fragmentation in Infertile Men with Varicocele: Relationship with Apoptosis, Seminal Oxidative Stress, and Spermatic Parameters
Ammar, O., Tekeya, O., Hannachi, I., Sallem, A., Haouas, Z., & Mehdi, M. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00311-6 · Cited by 37
Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells
Yan, Y., Gong, K., Ma, T., Zhang, L., Zhao, N., Zhang, X., Tang, P., & Gong, Y. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.10.043 · Cited by 35
Identification of novel targets for PGC-1α and histone deacetylase inhibitors in neuroblastoma cells
Cowell, R. M., Talati, P., Blake, K. R., Meador‐Woodruff, J. H., & Russell, J. W. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.109 · Cited by 36
A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation
Park, S. J., Park, Y. J., Shin, J. H., Kim, E. S., Hwang, J. J., Jin, D., Kim, J. C., & Cho, D. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.053 · Cited by 35
Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells
Hansakul, P., Aree, K., Tanuchit, S., & Itharat, A. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-413 · Cited by 34
Proteasomes Associated with the Blm10 Activator Protein Antagonize Mitochondrial Fission through Degradation of the Fission Protein Dnm1
Tar, K., Dange, T., Yang, C., Yao, Y., Bulteau, A., Salcedo, E. F., Braigen, S. Z., Bouillaud, F., Finley, D. J., & Schmidt, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554105 · Cited by 37
β-elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cells.
Lee, R. X., Li, Q. Q., & Reed, E. (2012) · PubMed · Cited by 34
Combination of Hydroxyl Acetylated Curcumin and Ultrasound Induces Macrophage Autophagy with Anti-Apoptotic and Anti-Lipid Aggregation Effects
Zheng, L., Li, Y., Li, X., Kou, J., Zhong, Z., Jiang, Y., Liu, Z., Tian, Y., & Yang, L. M. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000447875 · Cited by 34
Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice
Pan, M., Han, Y., Basu, A., Dai, A., Si, R., Willson, C., Balistrieri, A., Scott, B. T., & Makino, A. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00350.2017 · Cited by 34

Authors: Suen, D.-F., Norris, K. L., & Youle, R. J.
Affiliations: National Institutes of Health (US)
ORCID: Suen, Der-Fen
Youle, Richard J.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2008-06-15
Volume: 22
Issue: 12
Pages: 1577-1590
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1658508
PMC: PMC2732420
OpenAlex: W2104954806
Cited by: 1,270
References: 209
Citations by year: 2026: 27 · 2025: 41 · 2024: 62 · 2023: 65 · 2022: 57 · 2021: 84 · 2020: 81 · 2019: 69 · 2018: 82 · 2017: 86 · 2016: 95 · 2015: 79 · 2014: 89 · 2013: 63 · 2012: 75
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, apoptosis, cytochrome c release, caspase activation, mitochondrial quality control, mitochondrial network, apoptosis induction
MeSH terms: Animals, Cell Division, Cell Fusion, Humans, Membrane Proteins, Mitochondria, Models, Biological, Protein Processing, Post-Translational, Cellular Senescence, Apoptosis, Calcium-Calmodulin-Dependent Protein Kinases, Proto-Oncogene Proteins c-bcl-2, GTP Phosphohydrolases, Mitochondrial Proteins, Drosophila Proteins, Cytochromes c, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Death-Associated Protein Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial dynamics and apoptosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks