Cited by 1,270Mitochondrial Function and PathologyCell death mechanisms and regulationAutophagy in Disease and Therapy

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Mitochondrial dynamics and apoptosis

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Suen, Der-Fen, Norris, Kristi L., Youle, Richard J.·2008·Genes & Development

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Abstract

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase activation, yielding more numerous and smaller mitochondria. Recent work shows that proteins involved in mitochondrial fission and fusion also actively participate in apoptosis induction. This review will cover the recent advances and presents competing models on how the mitochondrial fission and fusion machinery may intersect apoptosis pathways.

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The human dynamin‐related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter‐membrane space
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A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2
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The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast
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MARCH‐V is a novel mitofusin 2‐ and Drp1‐binding protein able to change mitochondrial morphology
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Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA
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Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise
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Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network
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Mitochondrial membrane remodelling regulated by a conserved rhomboid protease
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Mutation spectrum and splicing variants in the OPA1 gene
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Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA
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A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics
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Mdv1p Is a Wd Repeat Protein That Interacts with the Dynamin-Related Gtpase, Dnm1p, to Trigger Mitochondrial Division
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Dynamin-like protein 1 is involved in peroxisomal fission
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Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae
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Dysregulation of HSG triggers vascular proliferative disorders
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Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission
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Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics
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Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2
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The Dynamin-Related Gtpase, Mgm1p, Is an Intermembrane Space Protein Required for Maintenance of Fusion Competent Mitochondria
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Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins
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Mitochondrial Function and Actin Regulate Dynamin-Related Protein 1-Dependent Mitochondrial Fission
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Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
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Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
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Fzo1, a Protein Involved in Mitochondrial Fusion, Inhibits Apoptosis
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Endoplasmic reticulum BIK initiates DRP1‐regulated remodelling of mitochondrial cristae during apoptosis
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Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis
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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans
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Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway
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The Dynamin-like Protein DLP1 Is Essential for Normal Distribution and Morphology of the Endoplasmic Reticulum and Mitochondria in Mammalian Cells
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Mitochondrial fission proteins regulate programmed cell death in yeastPreprint
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Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization
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Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell Line
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Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
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Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization
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Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion
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Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis
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Regulation of mitochondrial fusion and division
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The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria
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Release of OPA1 during Apoptosis Participates in the Rapid and Complete Release of Cytochrome c and Subsequent Mitochondrial Fragmentation
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Endophilin B1 is required for the maintenance of mitochondrial morphology
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The SUMO protease SENP5 is required to maintain mitochondrial morphology and function
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Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin.Preprint
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Molecular Machinery of Mitochondrial Fusion and Fission
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The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion
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Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1
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The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells
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Bcl-xL increases mitochondrial fission, fusion, and biomass in neurons
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Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature
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Bax/Bak-Dependent Release of DDP/TIMM8a Promotes Drp1-Mediated Mitochondrial Fission and Mitoptosis during Programmed Cell Death
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Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis
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OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis
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The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission
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Bcl-x L induces Drp1-dependent synapse formation in cultured hippocampal neurons
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Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria
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Mitofusin 2 Triggers Vascular Smooth Muscle Cell Apoptosis via Mitochondrial Death Pathway
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A dynamin-like protein (ADL2b), rather than FtsZ, is involved in Arabidopsis mitochondrial division
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Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis
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Role for CED-9 and Egl-1 as Regulators of Mitochondrial Fission and Fusion Dynamics
Delivani, P., Adrain, C., Taylor, R. C., Duriez, P. J., & Martin, S. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.034 · Cited by 193
Metalloprotease‐mediated OPA1 processing is modulated by the mitochondrial membrane potential
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Mitofusin-2 Is a Major Determinant of Oxidative Stress-mediated Heart Muscle Cell Apoptosis
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Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical Activity
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Mitofusin 2 Protects Cerebellar Granule Neurons against Injury-induced Cell Death
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GDAP1, the protein causing Charcot–Marie–Tooth disease type 4A, is expressed in neurons and is associated with mitochondria
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Ubiquitin–Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion
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The Yeast Dynamin-like Protein, Mgm1p, Functions on the Mitochondrial Outer Membrane to Mediate Mitochondrial Inheritance
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OPA1 Processing Reconstituted in Yeast Depends on the Subunit Composition of them-AAA Protease in Mitochondria
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Mitochondrial Disruption in Drosophila Apoptosis
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Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations
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The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals
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Emerging Role for ERK as a Key Regulator of Neuronal Apoptosis
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The Solution Structure of Human Mitochondria Fission Protein Fis1 Reveals a Novel TPR-like Helix Bundle
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Rapid constriction of lipid bilayers by the mechanochemical enzyme dynamin
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Primary Structure of a Dynamin-related Mouse Mitochondrial GTPase and Its Distribution in Brain, Subcellular Localization, and Effect on Mitochondrial Morphology
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Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent of ced-9
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Disruption of Mitochondrial Networks by the Human Cytomegalovirus UL37 Gene Product Viral Mitochondrion-Localized Inhibitor of Apoptosis
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Knockdown of MTP18, a Novel Phosphatidylinositol 3-Kinase-dependent Protein, Affects Mitochondrial Morphology and Induces Apoptosis
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Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene
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Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli
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Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion
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The Mitochondrial Fission Protein hFis1 Requires the Endoplasmic Reticulum Gateway to Induce Apoptosis
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An RNAi Screen for Mitochondrial Proteins Required to Maintain the Morphology of the Organelle in Caenorhabditis elegans
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An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria
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Role of Mitochondrial Remodeling in Programmed Cell Death in Drosophila melanogaster
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Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1
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Remodeling for Demolition
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Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP
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Authors: Suen, D.-F., Norris, K. L., & Youle, R. J.
Affiliations: National Institutes of Health (US)
ORCID: Suen, Der-Fen
Youle, Richard J.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2008-06-15
Volume: 22
Issue: 12
Pages: 1577-1590
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1658508
PMC: PMC2732420
OpenAlex: W2104954806
Cited by: 1,270
References: 209
Citations by year: 2026: 27 · 2025: 41 · 2024: 62 · 2023: 65 · 2022: 57 · 2021: 84 · 2020: 81 · 2019: 69 · 2018: 82 · 2017: 86 · 2016: 95 · 2015: 79 · 2014: 89 · 2013: 63 · 2012: 75
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, apoptosis, cytochrome c release, caspase activation, mitochondrial quality control, mitochondrial network, apoptosis induction
MeSH terms: Animals, Cell Division, Cell Fusion, Humans, Membrane Proteins, Mitochondria, Models, Biological, Protein Processing, Post-Translational, Cellular Senescence, Apoptosis, Calcium-Calmodulin-Dependent Protein Kinases, Proto-Oncogene Proteins c-bcl-2, GTP Phosphohydrolases, Mitochondrial Proteins, Drosophila Proteins, Cytochromes c, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Death-Associated Protein Kinases

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