Cited by 1,270Mitochondrial Function and PathologyCell death mechanisms and regulationAutophagy in Disease and Therapy

The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.

Mitochondrial dynamics and apoptosis

Open access

Suen, Der-Fen, Norris, Kristi L., Youle, Richard J.·2008·Genes & Development

Open this paper in CoChat — free account Open PDF

Abstract

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase activation, yielding more numerous and smaller mitochondria. Recent work shows that proteins involved in mitochondrial fission and fusion also actively participate in apoptosis induction. This review will cover the recent advances and presents competing models on how the mitochondrial fission and fusion machinery may intersect apoptosis pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.1658508

Cites

210 of 210 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,806
Self-citation
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Vaux, D., Cory, S., & Adams, J. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,355
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
The Bcl-2 apoptotic switch in cancer development and therapy
Adams, J. M., & Cory, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210220 · Cited by 2,256
The Role of Mitochondria in Apoptosis
Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987
Self-citation

Flagged first, then by citations

Show all 209 references

Sorted by citations

Items 601–700 of 1,000

Mapping Mitotic Death: Functional Integration of Mitochondria, Spindle Assembly Checkpoint and Apoptosis
Ruan, W., Lim, H. H., & Surana, U. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00177 · Cited by 39
Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity
Musheshe, N., Oun, A., Sabogal-Guáqueta, A. M., Trombetta-Lima, M., Mitchel, S. C., Adžemović, A., Speek, O., Morra, F., van der Veen, C. H. T. J., Lezoualc’h, F., et al. (2022) · Antioxidants · doi:10.3390/antiox11020314 · Cited by 34
A Conserved Motif Mediates both Multimer Formation and Allosteric Activation of Phosphoglycerate Mutase 5
Wilkins, J. M., McConnell, C., Tipton, P. A., & Hannink, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.565549 · Cited by 33
Amelioration of Mitochondrial Dysfunction-Induced Insulin Resistance in Differentiated 3T3-L1 Adipocytes via Inhibition of NF-κB Pathways
Bakar, M. H. A., Sarmidi, M. R., Kai, C. K., Huri, H. Z., & Yaakob, H. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151222227 · Cited by 34
Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis
Liu, Y., Pu, Y., Li, D., Zhou, L., & Wan, L. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.11.024 · Cited by 34
Regulation of mitochondrial function by forkhead transcription factors
Jerome, M. S., Kuthethur, R., Kabekkodu, S. P., & Chakrabarty, S. (2022) · Biochimie · doi:10.1016/j.biochi.2022.03.013 · Cited by 33
Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β
Kaushal, J., Bhatia, R., Kanchan, R., Raut, P., Mallapragada, S., Ly, Q., Batra, S., & Rachagani, S. (2021) · Cancers · doi:10.3390/cancers13133105 · Cited by 35
Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer
Xu, X., Wang, X., Chen, Q., Zheng, A., Li, D., Meng, Z., Li, X., Cai, H., Li, W., Huang, S., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04141-3 · Cited by 38
Mitochondrial damage‐associated molecular patterns: A new insight into metabolic inflammation in type 2 diabetes mellitus
Wang, Y., Wang, J., Tao, S., Liang, Z., xie, R., Liu, N., Deng, R., Zhang, Y., Deng, D., & Jiang, G. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3733 · Cited by 36
Pathologic and therapeutic implications for the cell biology of parkin
Charan, R. A., & LaVoie, M. J. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.02.008 · Cited by 32
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation
Sun, Z., Lan, X., Ahsan, A., Xi, Y., Liu, S., Zhang, Z., Chu, P., Song, Y., Piao, F., Peng, J., et al. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1210-5 · Cited by 34
Morus alba Accumulates Reactive Oxygen Species to Initiate Apoptosis via FOXO-Caspase 3-Dependent Pathway in Neuroblastoma Cells
Kwon, Y. H., Bishayee, K., Rahman, A., Hong, J. S., Lim, S.-S., & Huh, S. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0030 · Cited by 33
Triptolide -induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol
Zhou, L., Zhou, C., Feng, Z., Liu, Z.-P., Zhu, H., & Zhou, X. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.12.033 · Cited by 33
The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders
la Fuente-Muñoz, C. E. D., & Arias, C. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0068 · Cited by 33
Impaired mitochondrial quality control in Rett Syndrome
Crivellari, I., Pecorelli, A., Cordone, V., Marchi, S., Pinton, P., Hayek, J., Cervellati, C., & Valacchi, G. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108790 · Cited by 33
Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease
Mangrulkar, S. V., Wankhede, N. L., Kale, M. B., Upaganlawar, A. B., Taksande, B. G., Umekar, M. J., Anwer, M. K., Dailah, H. G., Mohan, S., & Behl, T. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00647-2 · Cited by 35
Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective
Scheitlin, C. G., Nair, D. M., Crestanello, J. A., Zweier, J. L., & Alevriadou, B. R. (2014) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-014-0357-4 · Cited by 34
The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells
Su, H., Waldron, R. T., Gong, R., Ramanujan, V. K., Pandol, S. J., & Lugea, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148999 · Cited by 33
The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane
Böhler, P., Stuhldreier, F., Anand, R., Kondadi, A. K., Schlütermann, D., Berleth, N., Deitersen, J., Hieke, N., Wu, W., Frank, M., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0312-8 · Cited by 34
Transformations of the macromolecular landscape at mitochondria during DNA-damage-induced apoptotic cell death
Yadav, N., Pliss, A., Kuzmin, A. N., Rapali, P., Sun, L., Prasad, P. N., & Chandra, D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.405 · Cited by 32
Mitochondrial inhibitor sodium azide inhibits the reorganization of mitochondria‐rich cytoplasm and the establishment of the anteroposterior axis in ascidian embryo
Ishii, H., Shirai, T., Makino, C., & Nishikata, T. (2014) · Development Growth & Differentiation · doi:10.1111/dgd.12117 · Cited by 32
Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1α/Mff regulation in head and neck squamous cell carcinoma
Wu, K., Mao, Y., Chen, Q., Zhang, B., Zhang, S., Wu, H., & Li, Y. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00629-6 · Cited by 32
Dynamic regulation of mitochondrial function in preimplantation embryos and embryonic stem cells
Harvey, A. J., Gibson, T. C., Lonergan, T. A., & Brenner, C. A. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.12.013 · Cited by 32
The relationship between mitochondrial fusion/fission and apoptosis in the process of adipose-derived stromal cells differentiation into astrocytes
Zhang, L., Yuan, X., Wang, S., Ou, Y., Zheng, X., & Wang, Q. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.05.025 · Cited by 31
Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system
Harashima, N., Minami, T., Uemura, H., & Harada, M. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-217 · Cited by 32
Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells
Teixeira, V., Medeiros, T., Vilaça, R., Pereira, A. T., Chaves, S. R., Côrte‐Real, M., Moradas‐Ferreira, P., & Costa, V. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.06.001 · Cited by 32
Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion
Xu, H., Wang, Z., Zheng, L., Zhang, W., Lv, H., Jin, S., & Yuan, Y. (2014) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2013-202069 · Cited by 32
Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents
Corrado, M., Scorrano, L., & Campello, S. (2016) · Oncotarget · doi:10.18632/oncotarget.8727 · Cited by 31
Mitochondrial Fission Increases Apoptosis and Decreases Autophagy in Renal Proximal Tubular Epithelial Cells Treated with High Glucose
Lee, W., Chiu, C.-H., Chen, J., Chen, C.-H., & Chang, H. (2016) · DNA and Cell Biology · doi:10.1089/dna.2016.3261 · Cited by 32
T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor
Tak, H., Eun, J. W., Kim, J., Park, S. J., Kim, C., Ji, E., Lee, H., Kang, H., Cho, D., Lee, K., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.90 · Cited by 31
Proteomic profiling of mitochondria: what does it tell us about the ageing brain?
Ingram, T. L., & Chakrabarti, L. (2016) · Aging · doi:10.18632/aging.101131 · Cited by 33
Resveratrol alleviates hypoxia/reoxygenation injury‑induced mitochondrial oxidative stress in cardiomyocytes
Li, T., Chen, L., Yu, Y., Yang, B., Li, P., & Tan, X. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9943 · Cited by 31
Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1
Ando, K., Yokochi, T., Mukai, A., Gao, W., Li, Y., Kramer, S., Ozaki, T., Maehara, Y., & Nakagawara, A. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.22997 · Cited by 32
Mitofusin 2: A link between mitochondrial function and substrate metabolism?
Emery, J., & Ortiz, R. M. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.09.003 · Cited by 34
The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia
Hackenbeck, T., Huber, R., Schietke, R. E., Knaup, K. X., Monti, J., Wu, X., Klanke, B., Frey, B., Gaipl, U. S., Wullich, B., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.019 · Cited by 31
Intrinsic Role of FoxO3a in the Development of CD8+ T Cell Memory
Tzelepis, F., Joseph, J., Haddad, E. K., MacLean, S., Dudani, R., Agenès, F., Peng, S. L., Sékaly, R., & Sad, S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200639 · Cited by 31
Dynamin‐Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus
Chen, S., Zhen, Y., Lin, J., Lin, T., Huang, C., Liou, C., Chan, S. H. H., & Chuang, Y. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12600 · Cited by 31
New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics
Wang, S., Zhao, H., Lin, S., Lv, Y., Lin, Y. N., Liu, Y., Peng, R., & Jin, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1230168 · Cited by 33
Cardiac mitochondria: A surprise about size
Sun, N., & Finkel, T. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.009 · Cited by 29
Co-treatment with conjugated linoleic acid and nitrite protects against myocardial infarction
Qipshidze-Kelm, N., Piell, K. M., Solinger, J. C., & Cole, M. P. (2013) · Redox Biology · doi:10.1016/j.redox.2013.10.009 · Cited by 30
Nucleic acid combinations: A new frontier for cancer treatment
Remant Bahadur, K. C., Thapa, B., Valencia‐Serna, J., Aliabadi, H. M., & Uludağ, H. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.029 · Cited by 30
A lipid perspective on regulated cell death
Flores‐Romero, H., Ros, U., & García‐Sáez, A. J. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.11.004 · Cited by 32
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis
Dharaskar, S. P., Paithankar, K., Kanugovi, A., Kara, H. S., & Subbarao, S. A. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.08.001 · Cited by 32
Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage
Nanni, V., Marco, G. D., Sacchetti, G., Canini, A., & Gismondi, A. (2020) · Foods · doi:10.3390/foods9101486 · Cited by 33
Mitofusin-2: A New Mediator of Pathological Cell Proliferation
Xin, Y., Li, J., Wu, W., & Liu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.647631 · Cited by 30
Downregulation of Pink1 influences mitochondrial fusion–fission machinery and sensitizes to neurotoxins in dopaminergic cells
Rojas-Charry, L., Cookson, M., Niño, A., Arboleda, H., & Arboleda, G. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.04.007 · Cited by 29
Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-xL
Lindenboim, L., Blacher, E., Borner, C., & Stein, R. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.145 · Cited by 30
Dynamic regulation of endosymbiotic organelles by ubiquitination
Ling, Q., & Jarvis, P. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.04.008 · Cited by 31
Optical scatter changes at the onset of apoptosis are spatially associated with mitochondria
Pasternack, R. M., Zheng, J., & Boustany, N. N. (2010) · Journal of Biomedical Optics · doi:10.1117/1.3467501 · Cited by 30
The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA
Wigington, C. P., Morris, K. J., Newman, L. E., & Corbett, A. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.754069 · Cited by 30
Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells
Song, L., Ding, S., Ge, Z., Zhu, X., Qiu, C., Wang, Y., Lai, E., Yang, W., Sun, Y., Chow, S. A., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14036 · Cited by 30
Novel Insights into Insect-Microbe Interactions—Role of Epigenomics and Small RNAs
Kim, D., Thairu, M. W., & Hansen, A. K. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01164 · Cited by 29
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin
Liu, Y., Hu, Y., Qiukai, E., Zuo, J., Yang, L., & Liu, W. (2017) · Scientific Reports · doi:10.1038/srep43097 · Cited by 29
Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer
Han, Y., Cho, U., Kim, S., Park, I. S., Cho, J., Dhanasekaran, D. N., & Song, Y. S. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1459594 · Cited by 28
RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells
Zhang, X., Wang, Z., Shao, Q.-H., Zhang, Z., Li, L., Guo, Z., Sun, H., Zhang, Y., & Chen, N. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.007 · Cited by 29
Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages
Lee, J., Choi, J., Cho, S., Son, S., & Song, C. (2019) · Cells · doi:10.3390/cells8111355 · Cited by 29
NDRG2 in rat liver regeneration: Role in proliferation and apoptosis
Yang, J., Li, Y., Wu, L., Zhang, Z., Han, T.-L., Guo, H., Jiang, N., Tao, K., Ti, Z., Liu, X., et al. (2010) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00614.x · Cited by 29
The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes
Mader, J. S., Marcet‐Palacios, M., Hancock, R. E. W., & Bleackley, R. C. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.11.015 · Cited by 29
Sericin improves heart and liver mitochondrial architecture in hypercholesterolaemic rats and maintains pancreatic and adrenal cell biosynthesis
Ampawong, S., Isarangkul, D., & Aramwit, P. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.07.001 · Cited by 29
Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells
Wen, H., Zhou, S., & Song, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.087 · Cited by 29
NP1 Regulates Neuronal Activity-Dependent Accumulation of BAX in Mitochondria and Mitochondrial Dynamics
Clayton, K. B., Podlesniy, P., Figueiro-Silva, J., López-Doménech, G., Benitez, L., Enguita, M., Abad, M. A., Soriano, E., & Trullas, R. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4604-11.2012 · Cited by 28
A-kinase anchoring proteins: Molecular regulators of the cardiac stress response
Diviani, D., Maric, D., López, I. P., Cavin, S., & del Vescovo, C. D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.07.014 · Cited by 29
TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish
Reverendo, M., Soares, A. R., Pereira, P. M., Carreto, L. C., Ferreira, V., Gatti, E., Pierre, P., Moura, G. R., & Santos, M. A. S. (2014) · RNA Biology · doi:10.4161/rna.32199 · Cited by 27
Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial Fission
Chae, U., Min, J., Leem, H. H., Lee, H., Lee, H. J., Lee, S., & Lee, D. (2017) · Pharmacology · doi:10.1159/000477814 · Cited by 27
MIAT, a potent CVD-promoting lncRNA
Yang, C., Zhang, Y., & Yang, B. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04046-8 · Cited by 28
The therapeutic potential of mitochondrial channels in cancer, ischemia–reperfusion injury, and neurodegeneration
Peixoto, P. M. V., Dejean, L. M., & Kinnally, K. W. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.003 · Cited by 29
Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins
Apaiajai, N., Chunchai, T., Jaiwongkam, T., Kerdphoo, S., Chattipakorn, S. C., & Chattipakorn, N. (2018) · Gerontology · doi:10.1159/000487188 · Cited by 28
Rotaviral nonstructural protein 4 triggers dynamin-related protein 1-dependent mitochondrial fragmentation during infection
Mukherjee, A., Patra, U., Bhowmick, R., & Chawla‐Sarkar, M. (2018) · Cellular Microbiology · doi:10.1111/cmi.12831 · Cited by 29
Penehyclidine hydrochloride regulates mitochondrial dynamics and apoptosis through p38MAPK and JNK signal pathways and provides cardioprotection in rats with myocardial ischemia–reperfusion injury
Feng, M. H., Wang, L., Chang, S., & Yuan, P. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.05.023 · Cited by 28
Mitochondrial function, mitochondrial DNA and ageing: a reappraisal
Passarino, G., Rose, G., & Bellizzi, D. (2010) · Biogerontology · doi:10.1007/s10522-010-9294-3 · Cited by 26
Mps1 kinase regulates tumor cell viability via its novel role in mitochondria
Zhang, X., Ling, Y.-X., Guo, Y., Bai, Y., Shi, X., Gong, F., Tan, P., Zhang, Y., Wei, C., He, X., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.193 · Cited by 30
Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone
Yen, J.-H., Huang, H. S., Chuang, C.-J., & Huang, S. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-1008-8 · Cited by 27
Acute spinal cord injury is associated with mitochondrial dysfunction in mouse urothelium
Kullmann, F. A., Truschel, S. T., Wolf‐Johnston, A., McDonnell, B. M., Lynn, A. M., Kanai, A., Kessler, T. M., Apodaca, G. L., & Birder, L. A. (2019) · Neurourology and Urodynamics · doi:10.1002/nau.24037 · Cited by 28
Advances in drug therapy for mitochondrial diseases
Zhang, L., Zhang, Z., Khan, A., Zheng, H., Yuan, C., & Jiang, H. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2019.10.113 · Cited by 27
Retracted
Suppression of intestinal dysfunction in a Drosophila model of Parkinson’s disease is neuroprotective
Fedele, G., Loh, S. H. Y., Celardo, I., Leal, N. S., Lehmann, S., Costa, A. C. O., & Martins, L. M. (2022) · Nature Aging · doi:10.1038/s43587-022-00194-z · Cited by 29
Parkin: a potential target to promote healthy ageing
Leduc‐Gaudet, J., Hussain, S. N. A., & Gouspillou, G. (2022) · The Journal of Physiology · doi:10.1113/jp282567 · Cited by 27
Widespread RNA hypoediting in schizophrenia and its relevance to mitochondrial function
Choudhury, M., Fu, T., Amoah, K., Jun, H.-I., Chan, T. W., Park, S., Walker, D. W., Bahn, J. H., & Xiao, X. G. (2023) · Science Advances · doi:10.1126/sciadv.ade9997 · Cited by 26
The Drosophila inner-membrane protein PMI controls cristae biogenesis and mitochondrial diameter
Macchi, M., Fissi, N. E., Tufi, R., Bentobji, M., Liévens, J.-C., Martins, L. M., Royet, J., & Rival, T. (2012) · Journal of Cell Science · doi:10.1242/jcs.115675 · Cited by 29
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin
Tang, Q., Ji, F., Wang, J., Guo, L., Li, Y., & Bao, Y. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.08.013 · Cited by 27
Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach.
Peyvandi, H., Peyvandi, A. A., Safaei, A., Azodi, M. Z., & Rezaei–Tavirani, M. (2018) · PubMed Central · Cited by 26
High‐Saturated Fat High‐Sugar Diet Accelerates Left‐Ventricular Dysfunction Faster than High‐Saturated Fat Diet Alone via Increasing Oxidative Stress and Apoptosis in Obese‐Insulin Resistant Rats
Apaijai, N., Arinno, A., Palee, S., Pratchayasakul, W., Kerdphoo, S., Jaiwongkam, T., Chunchai, T., Chattipakorn, S. C., & Chattipakorn, N. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800729 · Cited by 26
A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells
Hack, C. T., Buck, T., Bagnjuk, K., Eubler, K., Kunz, L., Mayr, D. C., & Mayerhofer, A. (2019) · Antioxidants · doi:10.3390/antiox8110518 · Cited by 26
Protective Effect of Adenosine A2B Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat
Dettori, I., Gaviano, L., Ugolini, F., Lana, D., Bulli, I., Magni, G., Rossi, F., Giovannini, M. G., & Pedata, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.588757 · Cited by 26
Effect of Titanium Dioxide and Silver Nanoparticles on Mitochondrial Dynamics in Mouse Testis Tissue
Arslan, N. P., Keleş, O. N., & Baltacı, N. G. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02763-6 · Cited by 30
Apolipoproteins L1 and L3 control mitochondrial membrane dynamics
Lecordier, L., Heo, P., Graversen, J. H., Hennig, D., Skytthe, M. K., d’Elzius, A. C., Pincet, F., Pérez-Morga, D. L., & Pays, E. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113528 · Cited by 26
Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes
Sahyoun, A. H., Hölzer, M., Jühling, F., zu Siederdissen, C. H., Arab, M. A., Tout, K. R., Marz, M., Middendorf, M., Stadler, P. F., & Bernt, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv746 · Cited by 26
Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells
Tan, M., Ouyang, Y., Jin, M., Chen, M., Liu, P., Chao, X., Chen, Z., Chen, X., Ramassamy, C., Gao, Y., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.08.011 · Cited by 26
Mitochondrial protein phosphorylation: instigator or target of lipotoxicity?
Graier, W. F., Malli, R., & Kostner, G. M. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.004 · Cited by 29
Crystal Structure of Mitochondrial Fission Complex Reveals Scaffolding Function for Mitochondrial Division 1 (Mdv1) Coiled Coil
Zhang, Y., Chan, N. C., Ngo, H., Gristick, H. B., & Chan, D. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.329359 · Cited by 27
Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins
Huang, S., Bi, K.-W., Kuo, H., Lin, T., Liao, P.-L., Wang, P., Chuang, J., & Liou, C. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.05.002 · Cited by 26
Effect of oxidative phosphorylation signaling pathway on silkworm midgut following exposure to phoxim
Li, F., Xu, K., Ni, M., Wang, B., Gu, Z., Shen, W., & Li, B. (2015) · Environmental Toxicology · doi:10.1002/tox.22222 · Cited by 27
Interplay between NAD+ and acetyl‑CoA metabolism in ischemia-induced mitochondrial pathophysiology
Klimova, N., Long, A., Scafidi, S., & Kristián, T. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.025 · Cited by 26
Biological Markers for Meat Tenderness of the Three Main French Beef Breeds Using 2-DE and MS Approach
Chaze, T., Hocquette, J.-F. J.-F., Meunier, B., Renand, G., Jurie, C. C., Chambon, C., Journaux, L., Rousset, S., Denoyelle, C., Lepetit, J., et al. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5626-1_8 · Cited by 26
Achyranthoside H methyl ester, a novel oleanolic acid saponin derivative from Achyranthes fauriei roots, induces apoptosis in human breast cancer MCF-7 and MDA-MB-453 cells via a caspase activation pathway
Fukumura, M., Ando, H., Hirai, Y., Toriizuka, K., Ida, Y., & Kuchino, Y. (2009) · Journal of Natural Medicines · doi:10.1007/s11418-008-0311-7 · Cited by 26
Advances in Osteoblast and Mitochondrial Dynamics and Their Transfer in Osteoporosis
Liu, J., Zhang, X., Hou, H., Ouyang, J., & Dai, J. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70299 · Cited by 25
The mitochondrial ubiquitin ligase plays an anti‐apoptotic role in cardiomyocytes by regulating mitochondrial fission
Wang, J., Aung, L. H. H., Prabhakar, B. S., & Li, P. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12914 · Cited by 26
3D Imaging of Tapetal Mitochondria Suggests the Importance of Mitochondrial Fission in Pollen Growth
Chen, P.-Y., Wu, C.-C., Lin, C., Jane, W., & Suen, D. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.19.00183 · Cited by 25
Self-citation
Changes in the Expression of Mitochondrial Morphology-Related Genes during the Differentiation of Murine Embryonic Stem Cells
Lee, J. E., Seo, B. J., Han, M. J., Hong, Y. J., Hong, K., Song, H., Lee, J.-W., & Tae, J. (2020) · Stem Cells International · doi:10.1155/2020/9369268 · Cited by 25
Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death
Thomenius, M. J., Freel, C. D., Horn, S., Krieser, R. J., Abdelwahid, E., Cannon, R., Balasundaram, S., White, K., & Kornbluth, S. A. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.26 · Cited by 25
Delayed blastocyst formation or an extra day culture increases apoptosis in pig blastocysts
Lin, T., Lee, J. E., Oqani, R. K., Kim, S. Y., Cho, E. S., Jeong, Y. D., Baek, J. J., & Jin, D. I. (2017) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2017.08.012 · Cited by 25

Authors: Suen, D.-F., Norris, K. L., & Youle, R. J.
Affiliations: National Institutes of Health (US)
ORCID: Suen, Der-Fen
Youle, Richard J.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2008-06-15
Volume: 22
Issue: 12
Pages: 1577-1590
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1658508
PMC: PMC2732420
OpenAlex: W2104954806
Cited by: 1,270
References: 209
Citations by year: 2026: 27 · 2025: 41 · 2024: 62 · 2023: 65 · 2022: 57 · 2021: 84 · 2020: 81 · 2019: 69 · 2018: 82 · 2017: 86 · 2016: 95 · 2015: 79 · 2014: 89 · 2013: 63 · 2012: 75
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, apoptosis, cytochrome c release, caspase activation, mitochondrial quality control, mitochondrial network, apoptosis induction
MeSH terms: Animals, Cell Division, Cell Fusion, Humans, Membrane Proteins, Mitochondria, Models, Biological, Protein Processing, Post-Translational, Cellular Senescence, Apoptosis, Calcium-Calmodulin-Dependent Protein Kinases, Proto-Oncogene Proteins c-bcl-2, GTP Phosphohydrolases, Mitochondrial Proteins, Drosophila Proteins, Cytochromes c, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Death-Associated Protein Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial dynamics and apoptosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks