The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
Open accessAbstract
Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because of mechanisms that suppress multipolar mitoses. A genome-wide RNAi screen in Drosophila S2 cells and a secondary analysis in cancer cells defined mechanisms that suppress multipolar mitoses. In addition to proteins that organize microtubules at the spindle poles, we identified novel roles for the spindle assembly checkpoint, cortical actin cytoskeleton, and cell adhesion. Using live cell imaging and fibronectin micropatterns, we found that interphase cell shape and adhesion pattern can determine the success of the subsequent mitosis in cells with extra centrosomes. These findings may identify cancer-selective therapeutic targets: HSET, a normally nonessential kinesin motor, was essential for the viability of certain extra centrosome-containing cancer cells. Thus, morphological features of cancer cells can be linked to unique genetic requirements for survival.
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Citations
Cites
Identification of Microtubule Binding Sites in the Ncd Tail Domain
Karabay, A., & Walker, R. A. (1999) · Biochemistry · doi:10.1021/bi981850i · Cited by 82 · cited 1×
“Ncd is a minus enddirected motor that bundles MTs at the spindle poles (Karabay and Walker 1999).”
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Cited by
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Mitotic catastrophe: a mechanism for avoiding genomic instability
Vitale, I., Galluzzi, L., Castedo, M., & Kroemer, G. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3115 · Cited by 834
Micropatterning as a tool to decipher cell morphogenesis and functions
Théry, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.075150 · Cited by 730
Self-citationShared and separate functions of polo-like kinases and aurora kinases in cancer
Lens, S. M. A., Voest, E. E., & Medema, R. H. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2964 · Cited by 597
Mechanisms generating cancer genome complexity from a single cell division error
Umbreit, N. T., Zhang, C.-Z., Lynch, L. D., Blaine, L. J., Cheng, A. M., Tourdot, R., Sun, L., Almubarak, H. F., Judge, K., Mitchell, T. J., et al. (2020) · Science · doi:10.1126/science.aba0712 · Cited by 439
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Metadata
- Authors
- Kwon, M., Godinho, S. A., Chandhok, N. S., Ganem, N. J., Azioune, A., Thery, M., & Pellman, D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-07-28
- Volume
- 22
- Issue
- 16
- Pages
- 2189-2203
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2156393663
- Cited by
- 651
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kwon, M., Godinho, S. A., Chandhok, N. S., Ganem, N. J., Azioune, A., Thery, M., & Pellman, D. (2008). Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes & Development. https://doi.org/10.1101/gad.1700908
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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