The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Endoreplication: polyploidy with purpose
Open accessAbstract
A great many cell types are necessary for the myriad capabilities of complex, multicellular organisms. One interesting aspect of this diversity of cell type is that many cells in diploid organisms are polyploid. This is called endopolyploidy and arises from cell cycles that are often characterized as “variant,” but in fact are widespread throughout nature. Endopolyploidy is essential for normal development and physiology in many different organisms. Here we review how both plants and animals use variations of the cell cycle, termed collectively as endoreplication, resulting in polyploid cells that support specific aspects of development. In addition, we discuss briefly how endoreplication occurs in response to certain physiological stresses, and how it may contribute to the development of cancer. Finally, we describe the molecular mechanisms that support the onset and progression of endoreplication.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Herbig, U., Jobling, W. A., Chen, B. P. C., Chen, D. J., & Sedivy, J. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00256-4 · Cited by 1,344
The E2F transcriptional network: old acquaintances with new faces
Dimova, D. K., & Dyson, N. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208612 · Cited by 715
Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex
Zachariae, W., Schwab, M., Nasmyth, K., & Seufert, W. (1998) · Science · doi:10.1126/science.282.5394.1721 · Cited by 511
Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta
Cross, J. C., Hemberger, M., Lu, Y., Nozaki, T., Whiteley, K., Masutani, M., & Adamson, S. L. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00703-1 · Cited by 293
Lazzerini Denchi, E., Celli, G., & de Lange, T. (2006) · Genes & Development · doi:10.1101/gad.1453606 · Cited by 116
Cited by
DNA methylation and epigenetic inheritance
Holliday, R. (1990) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1990.0015 · Cited by 2,279
Generation of cancer stem-like cells through the formation of polyploid giant cancer cells
Zhang, S., Mercado-Uribe, I., Xing, Z., Sun, B., Kuang, J., & Liu, J. (2014) · Oncogene · doi:10.1038/onc.2013.96 · Cited by 531
The causes and consequences of polyploidy in normal development and cancer
Davoli, T., & de Lange, T. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154234 · Cited by 424
Lloyd, A. C. (2013) · Cell · doi:10.1016/j.cell.2013.08.053 · Cited by 393
Aucamp, J., Bronkhorst, A. J., Badenhorst, C. P. S., & Pretorius, P. J. (2018) · Biological Reviews · doi:10.1111/brv.12413 · Cited by 317
Metadata
- Authors
- Lee, H. O., Davidson, J. M., & Duronio, R. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-11-01
- Volume
- 23
- Issue
- 21
- Pages
- 2461-2477
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W4299711483
- Cited by
- 590
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Endoreplication: polyploidy with purpose. https://app.cochat.ai/papers/10.1101/gad.1829209
- The paper
- Lee, H. O., Davidson, J. M., & Duronio, R. J. (2009). Endoreplication: polyploidy with purpose. Genes & Development. https://doi.org/10.1101/gad.1829209
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
