The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
Open accessAbstract
In embryonic stem (ES) cells, a well-characterized transcriptional network promotes pluripotency and represses gene expression required for differentiation. In comparison, the transcriptional networks that promote differentiation of ES cells and the blastocyst inner cell mass are poorly understood. Here, we show that Sox17 is a transcriptional regulator of differentiation in these pluripotent cells. ES cells deficient in Sox17 fail to differentiate into extraembryonic cell types and maintain expression of pluripotency-associated transcription factors, including Oct4 , Nanog , and Sox2 . In contrast, forced expression of Sox17 down-regulates ES cell-associated gene expression and directly activates genes functioning in differentiation toward an extraembryonic endoderm cell fate. We show these effects of Sox17 on ES cell gene expression are mediated at least in part through a competition between Sox17 and Nanog for common DNA-binding sites. By elaborating the function of Sox17, our results provide insight into how the transcriptional network promoting ES cell self-renewal is interrupted, allowing cellular differentiation.
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Cites
Chazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898
Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Lim, C. Y., Tam, W.-L., Zhang, J., Ang, H. S., Jia, H., Lipovich, L., Ng, H.-H., Wei, C.-L., Sung, W. K., Robson, P., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.08.004 · Cited by 224
Transcriptional dynamics of endodermal organ formation
Sherwood, R. I., Chen, T. A., & Melton, D. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21810 · Cited by 191
Self-citation
Cited by
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
Klein, A. M., Mazutis, L., Akartuna, I., Tallapragada, N., Veres, A., Li, V., Peshkin, L., Weitz, D. A., & Kirschner, M. W. (2015) · Cell · doi:10.1016/j.cell.2015.04.044 · Cited by 3,356
Embryonic stem cell potency fluctuates with endogenous retrovirus activity
Macfarlan, T. S., Gifford, W. D., Driscoll, S., Lettieri, K., Rowe, H. M., Bonanomi, D., Firth, A., Singer, O., Trono, D., & Pfaff, S. L. (2012) · Nature · doi:10.1038/nature11244 · Cited by 981
van den Brink, S. C., Baillie-Johnson, P., Balayo, T., Hadjantonakis, A.-K., Nowotschin, S., Turner, D. A., & Martinez Arias, A. (2014) · Development · doi:10.1242/dev.113001 · Cited by 478
Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation
Bedzhov, I., & Zernicka-Goetz, M. (2014) · Cell · doi:10.1016/j.cell.2014.01.023 · Cited by 448
Boroviak, T., Loos, R., Bertone, P., Smith, A., & Nichols, J. (2014) · Nature Cell Biology · doi:10.1038/ncb2965 · Cited by 441
Metadata
- Authors
- Niakan, K. K., Ji, H., Maehr, R., Vokes, S. A., Rodolfa, K. T., Sherwood, R. I., Yamaki, M., Dimos, J. T., Chen, A. E., Melton, D. A., McMahon, A. P., & Eggan, K.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-02-01
- Volume
- 24
- Issue
- 3
- Pages
- 312-326
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2159747138
- Cited by
- 308
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- The paper
- Niakan, K. K., Ji, H., Maehr, R., Vokes, S. A., Rodolfa, K. T., Sherwood, R. I., Yamaki, M., Dimos, J. T., Chen, A. E., Melton, D. A., McMahon, A. P., & Eggan, K. (2010). Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes & Development. https://doi.org/10.1101/gad.1833510
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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