Transcriptional dynamics of endodermal organ formation
Open accessAbstract
Although endodermal organs including the liver, pancreas, and intestine are of significant therapeutic interest, the mechanism by which the endoderm is divided into organ domains during embryogenesis is not well understood. To better understand this process, global gene expression profiling was performed on early endodermal organ domains. This global analysis was followed up by dynamic immunofluorescence analysis of key transcription factors, uncovering novel expression patterns as well as cell surface proteins that allow prospective isolation of specific endodermal organ domains. Additionally, a repressive interaction between Cdx2 and Sox2 was found to occur at the prospective stomach–intestine border, with the hepatic and pancreatic domains forming at this boundary, and Hlxb9 was revealed to have graded expression along the dorsal–ventral axis. These results contribute to understanding the mechanism of endodermal organogenesis and should assist efforts to replicate this process using pluripotent stem cells. Developmental Dynamics 238:29–42, 2009. © 2008 Wiley‐Liss, Inc.
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Common endodermal genes are expressed by both PrE and DE cell types, hampering marker-based discrimination of embryonic and extra-embryonic descendants.
“Common endodermal genes are expressed by both cell types hampering marker-based discrimination of embryonic and extra-embryonic descendants8,9.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [8]
The Results section on microarray analysis describes markers shared across or restricted to embryonic endodermal organ populations, but does not compare primitive endoderm (PrE) with definitive endoderm (DE). Searches for primitive endoderm, extraembryonic endoderm, and shared markers found no passage addressing whether common genes hamper discrimination between those lineages. No page number is available in our copy. (LLM, conf=0.76)
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- Authors
- Sherwood, R. I., Chen, T. A., & Melton, D. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Melton, Douglas A.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2008-12-18
- Volume
- 238
- Issue
- 1
- Pages
- 29-42
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- PMC
- PMC3756511
- OpenAlex
- W1966424854
- Cited by
- 191
- References
- 54
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 5 · 2023: 14 · 2022: 6 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 20 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 10 · 2012: 17
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Developmental Dynamics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute of General Medical Sciences (R01GM044653)
- National Institute of Diabetes and Digestive and Kidney Diseases (RL1DK081184)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
- Keywords
- transcriptional dynamics, CDX2, SOX2, HLXB9, dorsal-ventral axis, liver development, pancreatic development, transcription factors, cell surface markers, pluripotent stem cell differentiation, gene expression profiling
- MeSH terms
- Animals, Embryo, Mammalian, Endoderm, Morphogenesis, Transcription Factors, Transcription, Genetic, Homeodomain Proteins, Gene Expression Regulation, Developmental, Body Patterning, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice
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