The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
Abstract
The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of α–myosin heavy chain (αMHC) and up-regulation of βMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the α MHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of β MHC in response to stress and hypothyroidism. Thus, the α MHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.
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The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,524
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
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Satellite Cells and the Muscle Stem Cell Niche
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Metadata
- Authors
- van Rooij, E., Sutherland, L. B., Qi, X., Richardson, J. A., Hill, J., & Olson, E. N.
- Venue
- Science
- Published
- 2007-04-27
- Volume
- 316
- Issue
- 5824
- Pages
- 575-579
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2118105142
- Cited by
- 1,657
- References
- 4
- FWCI
- 83.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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