The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Links between metabolism and cancer
Open accessAbstract
Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic glycolysis. Aerobic glycolysis or the Warburg effect links the high rate of glucose fermentation to cancer. Together with glutamine, glucose via glycolysis provides the carbon skeletons, NADPH, and ATP to build new cancer cells, which persist in hypoxia that in turn rewires metabolic pathways for cell growth and survival. Excessive caloric intake is associated with an increased risk for cancers, while caloric restriction is protective, perhaps through clearance of mitochondria or mitophagy, thereby reducing oxidative stress. Hence, the links between metabolism and cancer are multifaceted, spanning from the low incidence of cancer in large mammals with low specific metabolic rates to altered cancer cell metabolism resulting from mutated enzymes or cancer genes.
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Cites
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Cited by
The Warburg Effect: How Does it Benefit Cancer Cells?
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
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Metadata
- Authors
- Dang, C. V.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-05-01
- Volume
- 26
- Issue
- 9
- Pages
- 877-890
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2105665764
- Cited by
- 998
- References
- 53
- Type
- posted content
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
