The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Targeting mitochondria metabolism for cancer therapy
Open accessAbstract
Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer.
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Citations
Cites
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Cited by
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“indicating that the lack of mitochondrial substrates caused by glycolytic inhibition also contributes to ATP depletion in mutant cells (21).”
Background
Metadata
- Authors
- Weinberg, S. E., & Chandel, N. S.
- Venue
- Nature Chemical Biology
- Published
- 2014-12-17
- Volume
- 11
- Issue
- 1
- Pages
- 9-15
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2074847845
- Cited by
- 1,381
- References
- 102
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Weinberg, S. E., & Chandel, N. S. (2015). Targeting mitochondria metabolism for cancer therapy. Nature Chemical Biology. https://doi.org/10.1038/nchembio.1712
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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